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病理学改变

病理学改变的相关文献在1992年到2020年内共计151篇,主要集中在内科学、外科学、神经病学与精神病学 等领域,其中期刊论文139篇、会议论文11篇、专利文献22620篇;相关期刊121种,包括中国保健营养(中旬刊)、中国社区医师、全科护理等; 相关会议11种,包括河南省第八届神经内科医师年会、第四届中医药现代化国际科技大会、中华医学会第三次全国肝纤维化、肝硬化学术会议等;病理学改变的相关文献由482位作者贡献,包括刘大维、周继红、朱佩芳等。

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期刊论文>

论文:139 占比:0.61%

会议论文>

论文:11 占比:0.05%

专利文献>

论文:22620 占比:99.34%

总计:22770篇

病理学改变—发文趋势图

病理学改变

-研究学者

  • 刘大维
  • 周继红
  • 朱佩芳
  • 李晓炎
  • 杨志焕
  • 王泰龄
  • 蒋建新
  • 万东君
  • 何敏华
  • 刘志锋
  • 期刊论文
  • 会议论文
  • 专利文献

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    • 梁礼堪; 刘小刚; 龚飞; 李建伟; 黄建军; 唐慧淳; 曹艳杰; 张景春
    • 摘要: 目的 探究低、中、高三种不同剂量rESWT对幼龄家兔膝胫骨骺板的生长影响,为探究ESWT治疗儿童骺板周围疾病的安全剂量.方法 分别给予8-10周龄新西兰幼兔右膝胫骨低(1bar)、中(2bar)、高(4bar)三个剂量的rESWT冲击,每周1次,于24小时、2周、4周分批处死冲击后的家兔,不同时间段分别测量双小腿长度并观察其外形,骺板组织HE染色后,光镜下对比实验侧与对照侧骺板组织病理学变化.结果 低、中、高三种剂量冲击后,分别于24小时、2周、4周测量双侧小腿长度,发现冲击的右侧(实验侧)与自身未冲击的左侧(对照侧)比较,差异无统计学意义(P>0.05);不同时间段实验侧的骺板、增殖层、肥厚层长度及冲击侧骺板的内、中、外侧区域长度较对照侧差异亦无统计学意义(P>0.05);三种不同剂量的冲击侧骺板增值层细胞数量较对照侧增多.结论 低、中、高三种剂量rESWT冲击后不损伤幼龄兔骺板,且冲击侧骺板中增殖层细胞数量增多,虽骺板长度无变化,但骺板增殖层细胞的增多可能促进骨的纵向生长.
    • 田甜; 唐颖; 葛红岩
    • 摘要: 视频终端干眼是由于长时间在视频终端前操作和注视显示屏而出现的眼部不适的一类疾病.随着电子产品应用,视频终端干眼发病率升高,对视频终端干眼发病机制也越来越重视.视频终端干眼主要致病因素有视频终端操作时间、视频终端操作期间眨眼模式以及视频终端操作者眼表暴露等,除此之外,眼部本身基础疾病或全身疾病也会引起视频终端干眼疾病.同时,视频终端干眼患者眼部会出现病理生理学改变,主要表现为眼部组织变化以及泪液中细胞因子表达改变等症状.
    • 曾文超; 巩茹; 郭洪敏; 巩超; 王福宁; 赵阳; 岳震
    • 摘要: Objective To study the effect of blood glucose level on the wound healing of diabetic rats.Methods Diabetes mellitus model was built by streptozotocin injection in male rats aged 3~4 months.The diabetes mellitus rats were divided into four groups according to the level of blood gulcose regulated by insulin.The wound model was formed by operation.Afterwards, rats were killed at 0 (the same day of injury), 3, 7 and 14 days after injury.The wound healing area was measured, in combination with the observation of the pathological changes of wound tissues.Results When the blood sugar concentration was controlled at 160~190 mg/dL, the wound healing rate was the fastest, followed by at the level lower than 160 mg/dL with no significant difference in macrophages.At higher blood sugar levels, the healing rate of wounds was delayed obviously, and macrophages in surrounding tissues exhibited remarkable decrease.Conclusion It is beneficial to wound healing at low levels of high blood sugar concentration in diabetic rats.%目的 探讨不同血糖浓度对糖尿病大鼠伤口愈合的影响.方法 选取普通3~4个月龄雄性大白鼠,通过链唑霉素诱导大白鼠糖尿病模型.将诱导成功的大白鼠根据胰岛素调控血糖水平分为四组,I组:糖尿病诱导后给予胰岛素控制血糖在160~190mg/dL;Ⅱ组:糖尿病诱导后给予胰岛素控制血糖在190~240mg/dL;Ⅲ组:糖尿病诱导后给予胰岛素控制血糖在240mg/dL以上;Ⅳ组:糖尿病诱导后给予胰岛素控制血糖在160mg/dL以下.手术形成创面模型.分别于伤后0(伤后当天)、3、7、14d处死大鼠.测量伤口愈合面积,观察创面组织病理学改变.结果 血糖浓度控制在160~190mg/dL时,伤口愈合速度最快,其次为血糖低于160mg/dL时,巨噬细胞无明显差异.血糖在更高水平时,伤口愈合速度明显减慢,伤口周围组织的巨噬细胞明显减少.结论 糖尿病大鼠在低水平高血糖浓度下有利于伤口愈合.
    • 张子蓓; 翟华蕾; 刘廷; 孔倩倩; 程钧
    • 摘要: 目的:观察倒睫相关的继发性淀粉样角膜变性的临床特征.方法:回顾性系列病例研究.收集2014年1月至2015年12月期间在山东省眼科研究所青岛眼科医院接受治疗的倒睫相关的继发性淀粉样角膜变性患者的临床资料.对患者的年龄、性别、病史、临床表现、诊断方法、治疗和组织病理学检查结果进行总结分析.通过光学相干断层扫描(OCT)和超声生物显微镜(UBM)评估病变累及角膜的深度.结果:共纳入7例患者,其中男5例,女2例,年龄11 ~ 86岁.所有患者均有倒睫病史.角膜病变表现为单眼发病、角膜表面有新生物隆起,新生物具有表面欠平整、边界清晰和形状不规则等特征.OCT和UBM结果显示所有病例中病变深度均未累及后弹力层.有3例患者接受板层角膜移植术;1例患者行角膜病变切除联合羊膜覆盖术;3例患者行睑内翻及倒睫矫正术,因病灶对视力无明显影响,未行角膜病变切除术.组织病理学检查结果显示,角膜上皮下方有大量无定形的嗜酸性物质沉积,刚果红染色阳性,在偏振光下呈现“苹果绿”双折射现象.结论:与倒睫相关的继发性淀粉样角膜变性的临床特点主要表现为患眼同时存在倒睫及角膜新生物2种病变,且新生物的发病位置与倒睫刺激角膜的位置一致;角膜病变特点为倒睫刺激角膜的部位有新生物隆起,新生物表面欠平整,边界清晰、形状不规则.%Objective:To report clinical observations of secondary corneal amyloidosis (SCA) related to trichiasis diagnosed and treated at Qingdao Eye Hospital.Methods:In this retrospective series of case study,medical records of 7 patients with trichiasis-related SCA from January 2014 to December 2015 were reviewed.Patient age,gender,history of disease,clinical manifestation,diagnosis methods,treatments,and histopathological results were analyzed.The depth of amyloid deposition in the corneal stroma was examined with optical coherence tomography (OCT) or ultrasound biomicroscopy (UBM).Results:The patients were 5 males and 2 females,age 11-86 years.All patients had a history of trichiasis.The common characteristics of the corneal lesions were a unilateral and well-circumscribed mass,with an irregular and mulberry-like surface,protuberant from the corneal surface at the position irritated by trichiasis.OCT or UBM showed Descemet's membrane was uninvolved in all cases.Lamellar keratoplasties were performed for 3 patients,and 1 patient underwent lesion excision combined with amniotic membrane covering.For the other 3 patients,the entropion and trichiasis were corrected with surgeries,but the mass was not resected because visual acuity was not obviously affected.Amorphous eosinophilic materials,with positive Congo red stain and apple-green birefringence beneath the epithelium were revealed by histopathology.Conclusions:SCA related to trichiasis typically presents a unilateral,well-circumscribed,irregular,and mulberry-like mass protuberant from the corneal surface at the position irritated by trichiasis.
    • 张子蓓12; 翟华蕾2; 刘廷2; 孔倩倩2; 程钧2
    • 摘要: 目的观察倒睫相关的继发性淀粉样角膜变性的临床特征.方法:回顾性系列病例研究.收集2014年1 月至2015年12 月期间在山东省眼科研究所青岛眼科医院接受治疗的倒睫相关的继发性淀粉样角膜变性患者的临床资料.对患者的年龄、性别、病史、临床表现、诊断方法、治疗和组织病理学检查结果进行总结分析.通过光学相干断层扫描(OCT)和超声生物显微镜(UBM)评估病变累及角膜的深度.结果:共纳入7 例患者,其中男5 例,女2 例,年龄11~86 岁.所有患者均有倒睫病史.角膜病变表现为单眼发病、角膜表面有新生物隆起,新生物具有表面欠平整、边界清晰和形状不规则等特征.OCT和UBM结果显示所有病例中病变深度均未累及后弹力层.有3 例患者接受板层角膜移植术;1 例患者行角膜病变切除联合羊膜覆盖术;3 例患者行睑内翻及倒睫矫正术,因病灶对视力无明显影响,未行角膜病变切除术.组织病理学检查结果显示,角膜上皮下方有大量无定形的嗜酸性物质沉积,刚果红染色阳性,在偏振光下呈现“苹果绿”双折射现象.结论:与倒睫相关的继发性淀粉样角膜变性的临床特点主要表现为患眼同时存在倒睫及角膜新生物2 种病变,且新生物的发病位置与倒睫刺激角膜的位置-致;角膜病变特点为倒睫刺激角膜的部位有新生物隆起,新生物表面欠平整,边界清晰、形状不规则.
    • 李敏
    • 摘要: 原发性干燥综合征(Primary sjogren's syndrome,PSS)是一种累及多器官的自身免疫性疾病,腺体是主要累及组织,而呼吸系统是腺体以外最易累及的系统.PSS若出现肺部受累,则在疾病发展、预后等均有所下降.本文概述PSS与常见呼吸系统疾病相关性,对于PSS合并呼吸系统疾病做到早发现、早治疗,通过早期治疗有望改善预后.
    • 王芳; 熊培政; 冯雪梅
    • 摘要: 目的:观察竹沥颗粒与鲜竹沥口服液对慢性支气管炎模型大鼠肺组织病理学改变和NO含量的影响.方法:将40只SD大鼠随机分为对照组、模型组、鲜竹沥组、竹沥颗粒组4组并复制慢性支气管炎动物模型.造模各组大鼠分别以生理盐水、鲜竹沥和竹沥颗粒进行灌胃干预,测定大鼠血清中一氧化氮(NO)含量,并于光镜、电镜下观察其肺组织病理改变.结果:①模型组大鼠较对照组NO含量明显降低(P<0.01);②鲜竹沥组、竹沥颗粒组大鼠较模型组NO含量升高(P<0.05);③竹沥颗粒组大鼠与鲜竹沥组NO含量未见明显差异(P>0.05);④在光镜、电镜下,对照组大鼠无明显病理损害,模型组病理损害显著,鲜竹沥组、竹沥颗粒组较模型组病理损害减轻,以竹沥颗粒组效果最为明显.结论:鲜竹沥、竹沥颗粒均可提高大鼠血清中NO含量,改善其肺血管损伤程度,对慢性支气管炎模型大鼠肺组织和支气管具有明显的保护作用.
    • 王志翊; 汪春龙; 王贤亲; 陈进; 孙来芳; 马建设
    • 摘要: Objective: To observe the toxicokinetics of acute methomyl poisoning in rabbits, and to explore its damaging effects on tissue and organ.Methods: Disposable gavageing methomyl dose 12 mg/kg, to observed symptoms and signs at different time points. The process of metabolism and absorption of methomyl were de-tected by Liquid chromatography-mass spectrometry/mass spectrometry in rabbit plasma, drawing concentration-time curve. The toxicokinetic parameters were analyzed and calculated by DAS 2.0 software. The pathological changes of brain, heart, liver, kidney were observed under inverted lfuorescence microscope. Blood biochemistry was analyzed with biochemical analyzer at each time point.Results: The parameters were AUC0-t(1 209.734± 219.542)μg/L·h. MRT0-t(1.731±0.144) h, t1/2z (1.471±0.277) h, Tmax 0.25 h, CLz/F (9.576±1.816) L·h-1·kg-1, Vz/F (20.225±4.703) L/kg in methomyl toxicokinetics. The pathological changes, cellular inifltration and edema were visible under light microscope in heart, liver, brain. Compared with previous exposure, the Alanine amino-transferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (CK) elevated after exposure for 6 h, the differences were statistically signiifcant (P<0.05). Troponin-I (cTn-I) increased at 2 h after exposure, the differences were statistically signiifcant (P<0.05). Cholinesterase (AchE) activity decreased rapidly after 0.25 h exposure, the differences were statistically signiifcant (P<0.05), returned to normal levels after exposure for 6 h.Conclusion: The toxicokinetics of Methomyl gavaged poison is in accordance with two-compartment model, its half-life in vivo is short, metabolism is rapid after poisoning, different degrees damages are detected in the brain, heart, liver, kidney organs.%目的:观察兔急性灭多威中毒的毒代动力学,探讨其对组织器官的损害作用。方法:一次性予灭多威剂量12 mg/kg灌胃染毒,观察其不同时间点的症状与体征;采用液相色谱-质谱/质谱联用(LC-MS/MS)技术检测兔血浆中灭多威吸收、代谢过程,并绘制浓度-时间曲线;用DAS 2.0软件分析并计算毒代动力学参数;荧光倒置显微镜观察兔脑、心、肝、肾脏器病理学改变;生化仪分析各时间点的血生化指标。结果:灭多威毒代动力学参数分别为AUC0-t(1209.734±219.542)μg/h·L、MRT0-t(1.731±0.144)h、t1/2z(1.471±0.277)h、Tmax 0.25 h、CLz/F(9.576±1.816)L·h-1·kg-1和Vz/F(20.225±4.703)L/kg;光镜下观察,心肌、肝、脑组织均可见充血、水肿、细胞浸润等病理学改变。谷丙转氨酶(ALT)、谷草转氨酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶(CK)在染毒后6 h时升高,与染毒前相比差异有统计学意义(P<0.05);肌钙蛋白-I(cTn-I)在染毒后2 h时升高,与染毒前相比差异有统计学意义(P<0.05);胆碱酯酶(AchE)活性在染毒后0.25 h迅速降低,与染毒前相比差异有统计学意义(P<0.05),6 h后恢复至正常水平。结论:灭多威灌胃染毒后的毒物代谢动力学符合二室模型,其体内半衰期短,中毒后代谢迅速,对脑、心、肝、肾等脏器均有不同程度损害作用。
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