黄疸,梗阻性

摘要： 目的 比较经内镜鼻胆管引流术(ENBD)和经内镜胆道支架置入术(EBS)在低位恶性梗阻性黄疸术前胆道引流中的有效性及安全性.方法 在中英文数据库中检索从建库至2020年8月发表的有关ENBD与EBS在低位恶性梗阻性黄疸术前胆道引流疗效对照研究的所有中英文文献,对纳入的研究进行质量评价和数据提取后,采用RevMan 5.3软件进行Meta分析,比较ENBD与EBS术前胆管炎发生率、术前胰腺炎发生率、支架障碍率、术前术后总并发症发生率、术后胰漏率的差异.结果 最终纳入6项研究,包括1182例患者.Meta分析结果显示,在术前胰腺炎发生率、支架障碍率、术前术后总并发症发生率方面,ENBD组与EBS组比较差异均无统计学意义(OR分别为0.66、1.14、0.69,95％CI分别为0.44～0.99、0.56～2.31、0.41～1.15,P值分别为0.05、0.72、0.15).但是,ENBD组相较于EBS降低了术前胆管炎发生率和术后胰漏率,差异均有统计学意义(OR分别为0.34、0.53,95％CI分别为0.23～0.50、0.32～0.88,P值分别为<0.00001、0.01).结论 对于诊断明确的低位恶性胆道梗阻患者,术前胆道引流使用ENBD优于使用EBS.未来需要更多的多中心大样本随机对照试验来验证这一结论.

摘要： 目的 观察2种复合胆道引流术治疗Bismuth Ⅳ型Klatskin肿瘤所致恶性梗阻性黄疸(MOJ)的疗效.方法 回顾性分析46例Bismuth Ⅳ型Klatskin肿瘤所致MOJ、且接受胆道内外引流治疗的患者资料,根据引流方法分为经皮肝胆管引流术(PTBD)双侧引流组(19例)及经内镜鼻胆管引流术(ENBD)联合PTBD单侧引流组(27例),对比分析2组间胆道引流效果、术后患者生存时间及并发症发生率的差异结果 2组胆道引流技术成功率均为100％,引流有效率差异无统计学意义[89.47％(17/19) vs 92.59％(25/27);x2=0.02,P=0.831].PTBD双侧引流组术后患者平均生存时间明显长于ENBD联合PTBD单侧引流组[(318.37±167.39)天vs (267.57±145.21)天;t=7.31,P=0.007],且并发症发生率明显低于ENBD联合PTBD单侧引流组[10.53％(2/19)vs 14.81％(4/27);x2 =1.92,P=0.028].结论 2种复合介入技术均可有效缓解Bismuth Ⅳ型Klatskin肿瘤所致MOJ.PTBD双侧引流较ENBD联合单侧PTBD更有利于延长患者生存期.%Objective To explore the effect of two kinds of combined biliary drainage in the treatment of malignant obstructive jaundice (MOJ) caused by Bismuth Ⅳ Klatskin tumor.Methods Data of 46 MOJ patients caused by Bismuth Ⅳ Klatskin tumor who received combined biliary drainage were retrospectively analyzed.The patients were divided into bilateral percutaneous transhepatic biliary drainage (PTBD) group (n =19) and endoscopic nasobiliary drainage (ENBD) combined with unilateral PTBD group (n=27).Internal and external drainage of the biliary tract were performed.The clinical effect of drainage,survival time and complication rate after drainage were compared between the two groups.Results The technical success rates of drainage in both groups were 100％.There was no statistically significant difference in the effective rate of drainage between the two groups (89.47％ [17/19] vs 92.59％ [25/27];x2=0.02,P=0.831).Compared with ENBD combined with unilateral PTBD group,patients in bilateral PTBD group showed longer survival time ([318.37±167.39] days vs [267.57±145.21] days;t=7.31,P=0.007) and lower complication rate (10.52 ％[2/19] vs 14.81％ [4/27];x2 =1.92,P=0.028) after drainage.Conclusion Combined biliary drainage techniques can effectively alleviate MOJ caused by Bismuth 1Ⅳ Klatskin tumors and improve liver function.Bilateral PTBD is more beneficial to prolong patients;survival time than ENBD combined PTBD.

摘要： 目的 评估携带125I粒子的胆道内照射支架治疗肝门部胆管癌致恶性梗阻性黄疸的有效性及安全性.方法 选取43例因肝门部胆管癌致恶性梗阻性黄疸患者,采用经皮经肝分别穿刺左右侧胆道分支,于肝门部狭窄处植入125I粒子胆道内照射支架,术后留置引流管3～5天,经造影确认支架通畅后予以拔管,封闭穿刺道.记录患者术前与术后的肝功能变化,并观察术后患者生存时间.结果 Bismuth工型5例,植入支架5个;Ⅱ型18例,植入支架36个;Ⅲ型4例,植入支架8个;Ⅳ型16例,植入支架25个,患者术前血清总胆红素和直接胆红素分别为(145.54±65.35) μmol/L和(124.73±35.04) μmol/L,术后分别为(65.91±29.43)μmol/L和(35.50±15.12) μmol/L;与术前相比,术后总胆红素、直接胆红素、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、碱性磷酸酶、C-反应蛋白、γ-谷氨酸转肽酶均显著降低(P均＜0.05),乳酸脱氢酶手术前后差异无统计学意义(P=1.050).患者中位生存期为13个月(3.0～22.5个月),未出现相关胆道穿孔、胰腺炎、严重胆道感染以及胆道出血等并发症.结论 125I粒子胆道内照射支架不仅可引流胆汁,减轻黄疸症状,还可近距离内照射胆道肿瘤,起到治疗作用,可延长患者生存时间,有效治疗肝门部胆管癌致恶性梗阻性黄疸.%Objective To evaluate the efficacy and safety of biliary stent loaded with 125I seeds in treatment of hilar cholangiocarcinoma with malignant obstructive jaundice.Methods Totally 43 patients with malignant obstructive jaundice caused by cholangiocarcinoma were included.All the patients underwent percutaneous transhepatic puncture of the left and right side branch of the bile duct.In the hilar stenosis,the biliary stent with 125I seeds were implanted,and the biliary drainage tube had been kept in 3 to 5 days after procedures.The drainage tube was removed and the puncture road was closed after the patency of stents were confirmed by cholangiography.The changes of liver function before and after procedures were recorded,and the survival time was observed.Results Five biliary stents loaded with 125I seeds were implanted in type I (n=5),36 in type Ⅱ (n=18),8 in type Ⅲ (n=4) and 25 in type Ⅳ (n=16).The serum total bilirubin and direct bilirubin of patients before procedures were (145.54 ± 65.35) μmol/L and (124.73 ± 35.04) μmol/L,respectively,and (65.91±29.43)μmol/L and (35.50±15.12)μmol/L respectively after procedures.Compared with preoperative,the total bilirubin,direct bilirubin,alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,C-reactive protein and gamma glutamic transaminase decreased significantly (all P＜0.05).The lactate dehydrogenase had no significant difference before and after operation (P=1.050).The median survival time was 13 months (3.0 to 22.5 months).The serious complications such as biliary puncture,pancreatitis,severe biliary tract infection or biliary bleeding were not occurred.Conclusion Biliary stent loaded with 125 I seeds is an effective therapy to alleviate symptoms of jaundice and prolong the survival time of patients with malignant obstructive jaundice caused by hilar cholangiocarcinoma.

摘要： 目的 探讨经皮肝穿刺胆道活检对恶性梗阻性黄疸的诊断价值.方法 回顾性分析42例接受经皮肝穿刺胆道活检的恶性梗阻性黄疸患者资料.所有患者均接受经皮肝穿刺胆道造影引流术(PTCD).术中利用PTCD通路行病理检查.结果 42例中41例获得活检病理结果,操作成功率97.62％ (41/42);31例获得阳性结果,阳性率73.81％(31/42).经皮肝穿刺胆道造影(PTC)诊断为低位梗阻的12例中,3例活检病理获得阳性结果,阳性率25.00％(3/12).PTC诊断为高位梗阻的30例中,28例活检病理获得阳性结果,阳性率93.33％ (28/30).高位梗阻患者的阳性率高于低位梗阻患者(x2 =20.704,P＜0.05).42例术中及术后均未发生严重并发症.31例活检阳性患者中6例于肝功能好转后接受手术治疗,术后病理与活检病理结果相符.结论 经皮肝穿刺胆道活检对恶性梗阻性黄疸患者安全、有效且成功率及阳性率均较高,尤其适用于高位梗阻患者.%Objective To explore the diagnostic value of percutaneous transhepatic cholangial biopsy for malignant obstructive jaundice.Methods Data of 42 cases suspected of malignant obstructive jaundice who underwent percutaneous transhepatic cholangial biopsy and percutaneous transhepatic cholangial drainage (PTCD) were retrospectively analyzed.And during the examination,the biopsy tissues were obtained for pathology.Results The pathologic results were obtained successfully in 41 of 42 cases and the success rate of operation was 97.62％ (41/42).There were 31 cases with positive results.The positive rate was 73.81％ (31/42).In 12 cases diagnosed as distal biliary tract obstruction by percutaneous transhepatic cholangiography (PTC),positive pathology results were found in 3 cases;the positive rate was 25.00％ (3/12).In 30 cases diagnosed as perihilar biliary tract obstruction by PTC,positive pathology results were found in 28 cases;the positive rate was 93.33％ (28/30).The accuracy of perihilar biliary tract obstruction was higher than that of distal biliary tract obstruction (x2=20.704,P＜0.05).In all 42 cases,there were no severe complications during or after surgery.In the 31 cases with positive biopsy pathological results,6 cases underwent surgery after improved liver function.The postsurgical pathological results were agree with biopsy pathological results.Conclusion Percutaneous transhepatic cholangial biopsy is safe and efficient for malignant obstructive jaundice.The successful rate and positive rate are high,especially for perihilar biliary tract obstruction.

摘要： Objective To investigate the prevention and treatment of biliary cardiac reflex in the interventional treatment of obstructive jaundice.Methods Totally 600 patients with obstructive jaundice were selected and divided into group A (without any preventive measures) and group B (with prevention and treatment,injection of atropine),and each group had 300 cases.The incidence of biliary cardiac reflex was observed in two groups.The relationship between the incidence of biliary cardiac reflex and gender,age,ECG abnormalities were analyzed in both groups.The timing of biliary cardiac reflex in interventional surgery was observed.Results The incidence of biliary cardiac reflex in group A was 30.67％ (92/300),which was significantly higher than that in group B (22/300,7.33 ％),and the difference was statistically significant (x2 =53.06,P＜0.05).But there was no significant difference between group A (4/300,1.33％) and group B (0) in the incidence of severe biliary cardiac reflex (x2 =0.45,P＞0.05).The incidence of biliary cardiac reflex in both groups was not associated with gender (both Φ=0.022,P＞0.05),but the incidence of biliary cardiac reflex in both groups was positively correlated with age and ECG abnormalities (Φage =0.593,0.229,ΦEcG =0.508,0.216,all P＜0.05).The incidence of biliary cardiac reflex was the highest in the balloon catheter on the stenosis or occlusion of the expansion in group A (55.43％,51/92) and group B (63.64％,14/22),which were higher than those of in puncture and angiography (all P＜0.05).Conclusion Preoperative injection of atropine can effectively prevent the occurrence of biliary cardiac reflex in interventional therapy,meanwhile the patients' own conditions are still need to be attention.%目的 探讨梗阻性黄疸介入治疗中胆心反射的防治方法.方法 选取接受治疗的梗阻性黄疸患者600例,根据是否采取防治措施分为A组(无任何防治措施)和B组(有防治措施,术前注射阿托品),每组300例.观察两组胆心反射发生率,其与性别、年龄、心电图表现异常的关系以及胆心反射在介入手术中发生的时机.结果 A组胆心反射发生率为30.67％(92/300),显著高于B组(22/300,7.33％),差异有统计学意义(x2=53.06,P＜0.05),但严重胆心反射发生率A组(4/300,1.33％)与B组(0)差异无统计学意义(x2=0.45,P＞0.05).两组患者胆心反射发生率与性别无关联(Φ均=0.022,P均＞0.05),但两组患者胆心反射发生率与年龄和心电图异常存在正向关联(中年龄=0.593、0.229,Φ心电图=0.508、0.216,P均＜0.05).两组患者均为在球囊导管对狭窄或闭塞部位进行扩张时胆心反射发生率最高,分别为55.43％(51/92)和63.64％(14/22),显著高于穿刺和造影时,差异有统计学意义(P均＜0.05).结论 术前注射阿托品可有效防治介入治疗中胆心反射的发生,同时需要对患者不良自身条件提高警惕.

摘要： Objective To evaluate GGT in combination with B ultrasound for the diagnosis of biliary atresia (BA) infants suffering from obstructive jaundice.Methods A retrospective analysis was made on 69 sick infants including 55 BAs and 14 non-BAs as identified by intraoperative cholangiography.The preoperative laboratory GGT and ultrasound data were collected and analyzed.The sensitivity,specificity,positive predictive value,negative predictive value and accuracy were compared.Results BA patients had significantly higher GGT than Non-BA patients (t =-4.164,P ＜ 0.05).The sensitivity,specificity,positive predictive value,negative predictive value and accuracy of GGT ＞ 306 U/L were 69.1％,92.9％,97.4％,43.3％,73.9％,respectively.In BA group,abnormal gallbladder was significantly associated with proadening portal vein,broadening hepatic artery compared with Non-BA patients (x2 =9.995,P ＜0.05).The accuracy of abnormal gallbladder on ultrasound was 78.3％.When two method combined for the diagnosis of BA,the sensitivity,specificity,positive predictive value,negative predictive value were 92.7％,92.9％,98.1％ and 76.5％ and accuracy can reach 92.8％.Conclusions For obstructive jaundice infants with GGT ＞ 306 U/L and abdominal gallbladder ultrasound finding intraoperative cholangiography should be carried out to make definite diagnosis of BA.%目的 探讨谷氨酰转肽酶联合超声对胆道闭锁(biliary atresia,BA)的诊断价值.方法 回顾性分析梗阻性黄疸患儿69例,其中BA组55例,非BA组(Non-BA) 14例.诊断均经术中造影证实.收集两组患者术前实验室检查和超声检查各指标,比较其灵敏度(sensitivity,Se),特异度(specificity,Sp),阳性预测值(positive predictive value,+PV),阴性预测值(negative predictive value,-PV)及准确度(accuracy). 结果 BA组GGT高于Non-BA组(t=-4.164,P＜0.05).以GGT＞306 U/L诊断BA时Se、Sp、+PV、-PV及准确度分别为69.1％、92.9％、97.4％、43.3％及73.9％.BA组和Non-BA组超声检查中胆囊异常情况比较差异有统计学意义(x2=9.995,P＜0.05),其诊断BA的准确度为78.3％,其诊断BA的Se、Sp、+PV、-PV、准确度分别为83.6％、57.1％、88.5％、47.1％、78.3％.GGT和胆囊异常两者联合诊断BA的Se、Sp、+PV、-PV为92.7％、92.9％、98.1％、76.5％,准确度为92.8％.结论 对于梗阻性黄疸的患儿,当GGT＞ 306 U/L,腹部超声提示胆囊异常者,应尽早行术中造影以明确是否存在胆道闭锁.

摘要： 目的：评估经皮经肝穿刺置入胆道内支架（PTCS）和内外引流管（PTCD）2种引流法治疗恶性胆道梗阻的价值。方法：回顾性分析48例恶性胆道梗阻患者，其中28例行PTCS，20例行PTCD。比较术后生存期、引流通畅及并发症情况，分析原发肿瘤类型对胆道支架通畅时间的影响。结果：2组减黄有效率、支架通畅时间、术后生存期差异均无统计学意义（均P>0.05）。2组胆道感染发生率差异有统计学意义（P0.05）。结论：2种内引流法均能安全、有效地减轻黄疸，原发性肿瘤类型不能作为胆道支架置入的参考因素。

摘要： 目的：观察治疗性ERCP在治疗肝吸虫病梗阻性黄疸中的临床应用。方法：对52例肝吸虫病合并梗阻性黄疸患者，先行ERCP治疗，于治疗结束后第3日开始口服吡喹酮(总剂量为210mg/kg，每日3次，连服3日)。每天用生理盐水冲洗（50ml，q6h）引流管，每天于引流管中抽出胆汁送检，检查有无肝吸虫卵。结果：治疗前、后（1周）对比，治疗后患者血清TBIL（18.4±5.2μmol/l）、ALP（102.4±28.8μ/L）、GGT（52.9±18.6μ/L）及ALT（32.3±8.2μ/L）比治疗前血清TBIL（58.5±9.3μmol/l）、ALP（214.7±32.6μ/L）、GGT（112.3±29.7μ/L）及ALT（98.6±23.1μ/L）均明显降低，P均＜0.01。并发症：3例出现一过性血淀粉酶升高，1例出现轻型胰腺炎，3例出现轻度胆管炎，均经内科保守治疗2～3日恢复正常，无出血、穿孔并发症。结论：对肝吸虫病合并梗阻性黄疸患者采用口服吡喹酮基础治疗上给予治疗性ERCP，是明显有效且安全的。

摘要： 本发明提供了GGPPS基因作为靶点治疗梗阻性黄疸肝脏损伤的应用，具体为，肝脏特异性敲除GGPPS基因模型、靶向抑制肝脏GGPPS蛋白活性的试剂及靶向抑制肝脏GGPPS基因表达的试剂在治疗梗阻性黄疸肝脏损伤中和在制备治疗梗阻性黄疸肝脏损伤药物中的用途。其中，本发明中的肝脏特异性敲除GGPPS基因模型可以减轻梗阻性黄疸肝脏损伤，降低肝脏和血液中疏水性胆汁酸含量，降低血液中天冬氨酸转氨酶(AST)以及总胆红素(TB)水平，保护肝脏功能；靶向抑制肝脏GGPPS蛋白活性的试剂能够减少梗阻性黄疸引起的死亡，并且显著减少梗阻性黄疸后肝脏损伤及肝脏液化性坏死区域面积。

摘要： 本发明涉及生物技术领域，具体是TEX11基因致病性突变在制备检测非梗阻性无精子症诊断试剂盒中的应用。本发明按照先将外周血DNA提取，然后进行PCR扩增目的基因，最后采用Sanger测序检测基因突变位点的方法，最终分别在4个家系中验证了TEX11基因致病性突变：家系1：NM_001003811:c.G2613T:p.W871C；家系2：NM_001003811:c.1426‑1C>T；家系3：NM_001003811:c.1796+2T>G；家系4：NM_001003811:c.857delA:p.K286R fs*5。其优点表现在：本发明为非梗阻性无精子症基因诊断、产前基因筛查及遗传咨询提供了一种有效的的途径。

摘要： 本发明涉及一种非梗阻性无精子症的检测试剂盒，所述试剂盒包括检测与非梗阻性无精子症相关的遗传标记的引物对，所述遗传标记的核苷酸序列是HFM1基因的序列，所述序列的突变位点是c.1006+1GT。本发明还提供了检测试剂盒在诊断非梗阻性无精子症的应用和HFM1基因在制备检测非梗阻性无精子症诊断试剂盒中的应用。本发明提供了HFM1基因的新的用途，从而提供了一种有效的进行非梗阻性无精子症基因诊断、产前基因筛查及遗传咨询的途径，应用效果表明本发明所提供的基因的SNP位点及检测引物可以有效的用于临床患者及胎儿绒毛或羊水进行HFM1基因突变位点的快速检测。

摘要： 本发明提供了GGPPS基因作为靶点治疗梗阻性黄疸肝脏损伤的应用，具体为，肝脏特异性敲除GGPPS基因模型、靶向抑制肝脏GGPPS蛋白活性的试剂及靶向抑制肝脏GGPPS基因表达的试剂在治疗梗阻性黄疸肝脏损伤中和在制备治疗梗阻性黄疸肝脏损伤药物中的用途。其中，本发明中的肝脏特异性敲除GGPPS基因模型可以减轻梗阻性黄疸肝脏损伤，降低肝脏和血液中疏水性胆汁酸含量，降低血液中天冬氨酸转氨酶(AST)以及总胆红素(TB)水平，保护肝脏功能；靶向抑制肝脏GGPPS蛋白活性的试剂能够减少梗阻性黄疸引起的死亡，并且显著减少梗阻性黄疸后肝脏损伤及肝脏液化性坏死区域面积。

摘要： 本发明提供了一种可复性梗阻性黄疸大鼠模型的建立方法，属于一种医学动物模型的建立方法，所述的建立方法是，选择无特定病原体的♂Wistar大鼠为实验动物，取剑突下、脐上腹部正中纵行手术切口入腹，以不可吸收聚丙烯缝线将胆管与经外周静脉置入的中心静脉导管一并三叠结结扎，经外周静脉置入的中心静脉导管的肝门端游离于腹腔；实验动物术中腹腔注射5万单位青霉素预防感染，依次双层关腹，分笼喂养，以血管钳夹住导管末端轻轻向外拔出经外周静脉置入的中心静脉导管，完成建立。这种建立方法的优点是，更加贴近OJ的临床发展过程和治疗过程，更加符合OJ研究的需要。模型制作简便，解除黄疸不需二次开腹手术，创伤小，成功率高、死亡率低。

摘要： 本发明涉及基于Eppin抗体检测梗阻性和非梗阻性无精子症的试剂盒。包括牛血清白蛋白、磷酸盐缓冲液、TBST洗脱液、兔抗人Eppin抗体、羊抗兔IgG抗体、显色剂、微量过滤器及置于其间的硝酸纤维素膜，测试时待检精浆经磷酸盐缓冲液稀释后吸附固定在微量过滤器中的硝酸纤维素膜上并用牛血清白蛋白封闭，用TBST洗脱液对经所述蛋白封闭的硝酸纤维素膜进行第一次洗涤，再经兔抗人Eppin抗体孵育后用TBST进行第二次洗涤，尔后经羊抗兔IgG抗体孵育，最后用显色剂显色鉴别。其优点是：无创伤，以此可减轻病人接受精道造影和睾丸活检的痛苦，同时可节省原精道造影等相关检测所需的大量的检测费用；灵敏度高，可达分子水平，并且简单易行和快速，具有重要的应用前景和实用价值。

摘要： 本发明涉及生物技术领域，具体是TEX11基因致病性突变在制备检测非梗阻性无精子症诊断试剂盒中的应用。本发明按照先将外周血DNA提取，然后进行PCR扩增目的基因，最后采用Sanger测序检测基因突变位点的方法，最终分别在4个家系中验证了TEX11基因致病性突变：家系1：NM_001003811:c.G2613T:p.W871C；家系2：NM_001003811:c.1426‑1C>T；家系3：NM_001003811:c.1796+2T>G；家系4：NM_001003811:c.857delA:p.K286R fs*5。其优点表现在：本发明为非梗阻性无精子症基因诊断、产前基因筛查及遗传咨询提供了一种有效的的途径。

摘要： 本发明公开了一种肥厚性梗阻性心肌病HOCM心脏模型的建立方法及系统。其中，该方法至少包括：采集心脏图像数据；对所述心脏图像数据进行三维重建，得到三维模型；对所述三维模型进行3D打印，得到HOCM心脏模型，可以使用工具测量分析和判断心肌肥厚的范围，以及观察室间隔的增厚情况及其和二尖瓣装置、传导束的关系，从而使医师可以更加清晰直观地观察心室内部肥厚心肌情况，以及与瓣膜系统、传导束的相互关系，得到传统影像学技术所无法提供的直观心脏模型。

摘要： 本实用新型公开了恶性梗阻性黄疸放射性粒子条外壳，包括粒子管，所述粒子管的一端固定连接有封闭板，所述封闭板上且在粒子管的内部固定连接有辅助管，所述辅助管与粒子管之间形成移动腔，所述移动腔内设有伸缩管，所述伸缩管远离封闭板的端面设有封闭装置，所述伸缩管外表面远离封闭装置的一端设有螺纹A，所述粒子管内表面的两端对称设有与螺纹A配合使用的螺纹B，粒子管的一端用封闭板固定连接，有效的节省了医生手动对粒子管一端的手动封口的操作，在使用时，向粒子管内投入需要使用的粒子，当放入好粒子后，通过封闭装置能够快速进行密封，有效的减少了医生的操作步骤，减少对医生的辐射。

摘要： 本实用新型涉及胶囊灌装装置技术领域，且公开了一种梗阻性黄疸自体胆汁胶囊灌装装置，包括载板，所述载板的顶部左侧固定安装有过滤箱，所述过滤箱的内部固定安装有过滤板，所述过滤箱的内部且位于过滤板的下方固定安装有杀菌板，所述过滤箱的内部且位于杀菌板的下方固定安装有隔离板，所述过滤箱的内腔底部固定安装有驱动电机，所述驱动电机的输出轴固定安装有一端贯穿并延伸到隔离板上方的延伸杆。本实用新型通过设置在蒸发筒上的发热棒和过滤箱上的杀菌板，杀灭胆汁内细菌的同时浓缩胆汁，最后将胆汁装入胶囊中，便于服用，解决了引流出的胆汁含有细菌和颗粒，口感较苦，不适合直接服用，使用者对此颇为烦恼的问题。