苏芬太尼

摘要： 目的 探讨苏芬太尼对人肺癌A549细胞增殖、凋亡、迁移和侵袭的影响及对PI3K/Akt信号通路的调控作用.方法 采用不同浓度的苏芬太尼干预肺癌A549细胞,CCK-8法检测苏芬太尼对A549细胞活力的影响,流式细胞术检测苏芬太尼对A549细胞凋亡的影响,Transwell实验检测苏芬太尼对A549细胞迁移和侵袭能力的影响,Western blot检测A549细胞中Bax、Bcl-2、MMP-2、MMP-9及PI3K/Akt信号通路关键蛋白的表达水平.结果 CCK 8实验结果显示,苏芬太尼能够显著抑制A549细胞活力,且与处理浓度呈依赖关系;流式细胞术检测结果显示,苏芬太尼能够诱导A549细胞凋亡;Transwell实验结果显示,苏芬太尼能够抑制A549细胞迁移和侵袭能力;Western blot结果显示,苏芬太尼能够上调A549细胞中Bax的表达,下调Bcb2、MMP 2、MMP-9和p-PI3K和p-Akt蛋白的表达.结论 苏芬太尼可能通过阻断PI3K/Akt信号通路抑制肺癌A549细胞增殖、迁移和侵袭,诱导细胞凋亡.

摘要： 目的:观察不同麻醉方法用于气管镜检查的效果.方法:选取气管镜检患者60例,随机分为单一组和复合组,每组患者30例,单一组使用丙泊酚进行麻醉,首量按1～2mg/kg静注,继以1.5～4mg/(kg·h)泵注;复合组在使用丙泊酚首量1～2mg/kg静注基础上,静注苏芬太尼0.1μg/kg,继以丙泊酚1.5～4mg/(kg·h)泵注.观察记录气管镜检查过程中患者呛咳程度,比较检查顺利情况及麻醉效果.结果:复合组患者呛咳程度明显低于单一组(P<0.01),复合组患者麻醉效果优良率明显大于单一组(P<0.05).结论:苏芬太尼复合丙泊酚用于气管镜检查,麻醉效果优良率高、呛咳发生率低,是一种较好的麻醉方法.

摘要： Objective To explore the clinical value of combined treatment of sufentanil and propofol in children during anesthesia induction.Methods 72 children were selected,and they were randomly divided into three groups by full random allocation method:observation group A,observation group B and control group,24 cases in each group.The observation group A was given intravenous infusion of sufentanil(0.01g · kg-1 · min-1),the observation group B was given intravenous infusion of sufentanil (0.02g · kg-1 · min-1),the control group was given intravenous saline infusion,then given propofol target controlled infusion after 30min.The bispectral index (BIS),propofol effect chamber (EC),OAA/S score and time of induction of anesthesia (LOC) time were recorded in the three groups.Results There was a significant correlation between BIS and propofol EC and OAA/S scores in the three groups,and there was a negative correlation between BIS and propofol EC (r =-0.82,-0.79,-0.88,all P ＜ 0.01).BIS and OAA/S score was positively correlated (r =0.86,0.81,0.89,all P ＜ 0.01).Compared with the control group [(9.11 ± 1.04) min],the LOC time of the observation group A and B [(5.37 ± 0.89) min,(4.49 ± 0.63) min] was significantly shortened (t =13.39,18.61,all P ＜ 0.01).The propofol EC of control group was (2.44 ± 0.5) μg/mL,the propofol EC of the observation group A and B [(1.38 ± 0.35) μg/mL,(1.14 ± 0.27) μg/mL] decreased during anesthesia induction (t =8.40,11.04,all P ＜ 0.01),and the effect of the observation group B was better than that of the observation group A (t =3.95,2.67,all P ＜ 0.05).There was no statistically significant difference in BIS between the observation group A and control group [(70 ± 4) vs.(69 ± 7),t =0.61,P ＞ 0.05].The BIS of observation group B (78 ± 5) was significantly higher than that of the observation group A and control group (t =6.12,5.13,all P ＜ 0.01).Conclusion Sufentanil combined with propofol for anesthesia in children has a synergistic effect,which is beneficial to reduce the amount of propofol EC during anesthesia induction,shorten the time of LOC and enhance the sedative effect of propofol,and it is worthy of further clinical application.%目的 观察苏芬太尼与丙泊酚联合用于小儿麻醉诱导期的临床效果.方法 选取72例手术治疗的患儿,采用完全随机分配法分为三组,观察组A、观察组B和对照组,各24例.观察组A静脉输注苏芬太尼0.01 μg·kg-1·min-1,观察组B静脉输注苏芬太尼0.02 μg·kg-1·min-1,对照组给予0.9％氯化钠注射液静脉滴注,30 min后给予丙泊酚靶控输注.记录三组患儿的脑电双频指数(BIS)、丙泊酚效应室浓度(EC)、OAA/S评分和麻醉诱导(LOC)时间.结果 三组患儿的BIS与丙泊酚EC及OAA/S评分均具有较好的相关性,BIS与丙泊酚EC之间呈负相关(r=-0.82、-0.79、-0.88,均P＜0.01),BIS与OAA/S评分呈正相关(r=0.86、0.81、0.89,均P＜0.01).与对照组的LOC时间[(9.11±1.04)min]相比,观察组A、B的LOC时间明显缩短[(5.37±0.89) min、(4.49±0.63)min](t=13.39、18.61,均P＜0.01);与麻醉诱导期间对照组的丙泊酚EC (2.44±0.5) μg/mL相比较,观察组A、B的丙泊酚EC明显降低降低[(1.38±0.35)、(1.14±0.27) μg/mL],差异有统计学意义(t=8.40、11.04,均P＜0.01),且观察组B的效果均优于观察组A(t=3.95、2.67,均P＜0.05).观察组A的BIS值(70±4),与对照组(69±7)差异无统计学意义(t=0.61,P＞0.05);观察组B的BIS(78±5),显著高于观察组A和对照组(t=6.12、5.13,均P＜0.01).结论 苏芬太尼与丙泊酚联合用于小儿麻醉有协同作用,有利于减少麻醉诱导期间一定量的丙泊酚EC,缩短LOC时间,增强丙泊酚的镇静作用,值得临床进一步推广应用.

摘要： Objective To evaluate whether low-dose ropivacaine in combination with sufentanil could produce effective spinal anaesthesia for severe preeclamptic parturients during cesarean section.Methods 40 severe preeclampsia parturients undergoing elective caesarean delivery under combined spinal-epidural anaesthesia were randomly divided into two groups based on a computer-generated grouping number sheet,each group in 20 cases.Group A received intrathecal ropivacaine 15mg (1.5mL)+10% dextrose 1mL with normal saline 0.5mL.Group B received intrathecal ropivacaine 10mg (1mL) + sufentanil 5μg(1mL) + 10% dextrose 1mL.Blood pressure,heart rate and oxygen saturation were documented at 2 min intervals for 10 min after local anaesthetic was administered.Sensory and motor block were assessed at 2.5 min intervals after spinal injection.The side effects such as hypotension,nausea and vomiting during surgery were recorded.Results The onset of motor block was longer[(4.8±2.1) min vs.(4.2±1.5) min,t=-2.83,P<0.01],and the duration was shorter[(75.9±25.2) min vs.(115.4±29.5)min,t=10.75,P<0.01] in group B than those in group A.The number of patients who had Bromage score 3 in group A was more than that in group B.Compared with group A,the duration of complete analgesia[(180±35) min vs.(120±27) min,t=15.48,P<0.001]and effective analgesia[(245±29)min vs.(184±34)min;t=16.21,P<0.001] increased in group B.More patients were sleepy but easily rousable in group B than in group A (9cases vs.0cases,χ2=8.53,P<0.01).The incidence rate of hypotension was significantly higher(45.0% vs.20.0%,χ2=4.29,P<0.05) in group A than that in group B.Compared with group A,the incidence rate of hypotension(45.0% vs.20.0%,χ2=4.29,P<0.05),vomiting(30.0% vs.5.0%,χ2=4.33,P<0.05) and shivering (50.0% vs.10.0%,χ2=7.62,P<0.01) were lower in group B.The incidence of pruritus was significantly higher in group B (χ2=10.16,P<0.01).Conclusion Hyperbaric ropivacaine 10 mg with sufentanil 5μg could produce effective spinal anaesthesia for severe preeclamptic parturients during cesarean section with less hypotension,vomiting and shivering,and longer lasting analgesia than hyperbaric ropivacaine 15 mg.%目的 探讨低剂量罗哌卡因混合苏芬太尼用于重度子痫前期腰麻下剖宫产术的效果.方法择期拟在腰麻下行剖宫产术的重度子痫前期产妇40例,年龄20~30岁.采用随机数字表法分为两组,每组20例.常规剂量罗哌卡因组(A组)采用1%罗哌卡因15 mg(1.5 mL)+10%葡萄糖注射液1 mL+0.9%氯化钠注射液0.5 mL行腰麻;低剂量罗哌卡因组(B组)采用1%罗哌卡因10 mg(1 mL)+苏芬太尼1 mL(5 μg)+10%葡萄糖注射液1 mL行腰麻,蛛网膜下腔给药后10 min每间隔2 min记录一次BP、HR和SpO2,每间隔2.5 min评估感觉和运动阻滞情况,记录术中低血压、恶心、呕吐等不良反应发生情况.结果 B组下肢运动神经阻滞起效时间长于A组[(4.8±2.1)min比(4.2±1.5)min,t=-2.83,P<0.01],B组下肢运动神经阻滞总时间明显短于A组[(75.9±25.2)min比(115.4±29.5)min,t=10.75,P<0.01].A组下肢运动神经阻滞达到3级的产妇明显多于B组(χ2=14.54,P<0.01).B组术后完全镇痛时间[(180.0±35.0)min比(120.0±27.0)min,t=15.48,P<0.001)]和有效镇痛时间[(245.0±29.0)min比(184±34)min,t=16.21,P<0.001)]明显长于A组.B组意识评分为3分产妇明显多于A组(χ2=8.53,P<0.01).与A组比较,B组低血压(45.0%比20.0%,χ2=4.29,P<0.05)、呕吐(30.0%比5.0%,χ2=4.33,P<0.05)和寒战(50.0%比10.0%,χ2=7.62,P<0.01)发生率降低,瘙痒发生率升高(χ2=10.16,P<0.01).结论 低剂量罗哌卡因(10 mg)混合5 μg苏芬太尼腰麻能完全满足重度子痫前期剖宫产手术的需要,其术中低血压、恶心和寒颤发生率明显降低且其完全镇痛时间和有效镇痛时间明显延长.

摘要： Objective To study the influence of anesthetic effect,maternal and infant outcomes and safety of subarachnoid block used sulfentanyl combined with ropivacaine for patients with gestational hypertension in the cesarean section.Methods 180 cases of gestational hypertension ready to cesarean section were selected as study subjects,and they were randomly divided into A group,B group and C group by digital table method,60 cases in each group.A group used 10mg ropivacaine,B group used 13mg ropivacaine,C group used 5μg sulfentanyl combined with 10mg ropivacaine.The anesthetic effect,circulation function,duration of pain,operation time,neonatal Apgar score at 1 and 5 min after birth,neonatal weight,motor block evaluation after operation,adverse reaction and complication were compared in three groups.Results The anesthetic effect between B group and C group had no statistical difference (x2 =1.233,1.465,all P ＞ 0.05).The anesthetic effect of B group and C group was better than that of A group(F =5.633,7.299,all P ＜0.05).The HR and MAP of every time points between A group and C group had no statisticaldifferences (F =1.313,1.265,all P ＞ 0.05).Compared with T0,the HR and MAP of B group at T1,T2,T3,T4 had statistical differences compared with A group and C group(F =5.633,7.299,all P ＜0.05).The operation time of the three groups had no statistical difference(F =0.933,P ＞ 0.05).The duration of pain between B group and C group had no statistical difference(t =0.822,P ＞ 0.05).The duration of pain of A group was longer than that of B group and C group(F =8.316,P ＜0.05).The neonatal Apgar scores at 1 and 5 min after birth and neonatal weight of the three group had no statistical differences(F =0.822,0.929,all P ＞ 0.05).The improved Bromage score between A group and C group had no statistical difference (t =2.627,1.991,all P ＞ 0.05).The improved Bromage score between B group and A,C group had statistical differences(F =6.371,5.693,all P ＜ 0.05).The complete recovery time of motor nerve of B group was much longer than that of A group and C group (F =8.924,P ＜ 0.05).The incidence rates of vomit and nausea of A group and B group were much higher than that of C group(F =3.561,12.581,all P ＜ 0.05).The incidence rate of bradycardia and hypotension of B group was much higher than that of A group and C group (F =8.273,10.833,all P ＜ 0.05).Conclusion During subarachnoid block anaethesia using 5 μg sulfentanyl combined with l0mg ropivacaine can be applied to mild and moderate gestational hypertension,it has advantages such as less adverse reaction,good analgesic effect,less hemodynamic effect,and it is worthy of clinical promotion.%目的 研究妊娠期高血压疾病患者剖宫产术中采用苏芬太尼联合罗哌卡因蛛网膜下腔阻滞对麻醉效果、母婴结局及安全性的影响.方法 选取180例拟行剖宫产术的妊娠期高血压疾病患者为研究对象,将其按数字表法随机分为A组、B组、C组,各60例.A组10 mg盐酸罗哌卡因、B组13 mg盐酸罗哌卡因、C组10 mg盐酸罗哌卡因联合5μg枸橼酸苏芬太尼麻醉.观察三组患者的麻醉效果、循环功能、镇痛持续时间、手术时间、新生儿出生后Apgar评分、新生儿体质量、术毕运动阻滞情况、不良反应及并发症.结果 B组与C组之间麻醉效果差异均无统计学意义(x2=1.233、1.465,均P＞0.05),B组及C组的麻醉效果均优于A组(x2 =4.293、1.394,均P＜0.05).A组和C组对比各时间点HR、MAP值差异均无统计学意义(F=1.313、1.265,均P＞0.05),与T0比较,B组T1、T2、T3、T4时HR、MAP与A组、C组差异均有统计学意义(F=5.633、7.299,均P＜0.05).三组手术时间差异无统计学意义(F=0.933,P＞0.05);B组与C组疼痛持续时间差异无统计学意义(t=0.822,P＞0.05),A组的疼痛持续时间均比B组与C组长,差异有统计学意义(F=8.316,P＜0.05);三组新生儿出生后1 min、5 min的Apgar评分和新生儿出生体质量差异均无统计学意义(F =0.822、0.929,均P＞0.05),A组与C组间改良Bromage评分差异均无统计学意义(t=2.627、1.991,均P＞0.05),B组与A组和C组改良Bromage评分差异均有统计学意义(F=6.371、5.693,均P＜0.05).B组的运动神经完全恢复时间明显长于A组和C组(F=8.924,P＜0.05),A组、B组的呕吐、恶心概率明显高于C组(F=3.561、12.581,均P＜0.05),B组心动过缓及低血压发生率均明显高于A组、C组(F=8.273、10.833,均P＜0.05).B组阿托品、麻黄碱的用量和使用概率明显高于A组、C组(F=8.316、10.291,均P＜0.05).结论 蛛网膜下腔阻滞麻醉时采用5μg苏芬太尼加入10 mg盐酸罗哌卡因可应用于轻、中度妊娠期高血压疾病剖宫产术中麻醉,其不良反应轻,镇痛效果好,对血流动力学影响小,值得临床推广.

摘要： 目的：比较罗哌卡因复合芬太尼或苏芬太尼在分娩镇痛中的疗效。方法选取分娩的初产妇116例进行研究。按数字表法将产妇随机分成观察组（58例，接受罗哌卡因及苏芬太尼镇痛）以及对照组（接受罗哌卡因及芬太尼镇痛），分别在两组产妇麻醉诱导前（T0），给药后30 min（T1），60 min（T2），180 min（T3）时检测其平均动脉压（MAP）和心率（HR），并进行疼痛数字评价量表（NRS 评分）评定，记录两组母婴并发症情况。分析两组分娩镇痛后分娩方式与新生儿 Apgar 评分水平的变化。结果两组产妇 T0～T3时期的 MAP及 HR 水平比较差异均无统计学意义（tMAP ＝0．123、1．078、0．212、0．047，P ＝0．903、0．283、0．832、0．963；tHR ＝0．033、0．289、0．288、0．036，P ＝0．974、0．773、0．774、0．972）；两组 T1～T3时的 NRS 评分均显著低于 T0时；观察组 T1～T3时的 NRS 评分为（2．21±0．36）分、（1．78±0．24）分、（1．83±0．25）分，均显著低于对照组的（3．61±0．75）分，（3．22±0．12）分，（2．84±0．26）分，差异有统计学意义（t ＝12．816、40．871、21．325，P ＝0．000、0．000、0．000）；观察组共有0例（0．00％）心动过缓，显著少于对照组的4例（6．90％），差异有统计学意义（χ2＝4．143，P ＝0．042）。两组分娩镇痛后产妇的分娩方式及新生儿出生后1 min、5 min 的 Apgar 评分相比，差异无统计学意义（χ2＝0．703、t ＝0．631、1．149，P ＝0．402、0．530、0．253）。结论罗哌卡因联合苏芬太尼或者芬太尼应用于分娩镇痛过程中，对产妇的生命体征和新生儿均无影响，均有良好的镇痛效果，其中罗哌卡因联合苏芬太尼镇痛效果更强，安全性更高。%Objective To compare the effect oropivacaine combined with fentanyl or sufentanil in labor anal-gesia.Methods 116 cases of maternal birth in obstetrics and gynecology were selected.According to the random number table method,116 cases of parturients were randomly divided into observation group (58 cases,received ropiv-acaine and sufentanil analgesia)and control group (received ropivacaine and fentanyl).In two groups of maternal anesthesia before induction (T0 ),used the drug after 30min(T1 ),60min(T2 ),180min(T3 )detection of the mean arterial pressure (MAP)and heart rate (HR),and digital evaluation table Rating Scale (NRS).The complications of maternal and infant in the two groups were recorded,the change of the mode of delivery and the Apgar score of neo-nates in the two groups were analyzed.Results There were no significant differences in the levels of MAP and HR between the two groups in T0-T3 (tMAP =0.123,1.078,0.212,0.047;P =0.903,0.283,0.832,0.963;tHR =0.033, 0.289,0.288,0.036;P =0.974,0.773,0.774,0.972).The NRS scores in T1 -T3 of the two groups were significantly lower than those in the T0;the T1 -T3 scores of the observation group were (2.21 ±0.36 )points,(1.78 ± 0.24)points,(1.83 ±0.25)points,which were significantly lower than (3.61 ±0.75)points,(3.22 ±0.12)points, (2.84 ±0.26)points of the control group(t =12.816,40.871,21.325,P =0.000,0.000,0.000).In the observation group,there was 0 case (0.00%)had cardiac arrhythmia,the control group had 4 cases (6.90%),and the differ-ence was statistically significant(χ2 =4.143,P =0.042).Two groups of labor analgesia,the way of delivery and birth of the newborn after birth,1min,5min of Apgar score were compared,the differences were not statistically significant (χ2 =0.703,t =0.631,1.149,P =0.402,0.530,0.253).Conclusion Ropivacaine combined with sufentanil or fentanyl in analgesia have no effect in childbirth and maternal vital signs and neonatal,and have good analgesic effect, but ropivacaine combined with sufentanil has stronger analgesic effect,higher safety.

摘要： 目的：对罗哌卡因与苏芬太尼联合用于混合痔术中麻醉的效果加以探讨。方法选取2014年11月～2015年12月我院收治的混合痔患者96例，将之随机分成观察组与对照组各48例。其中，对照组予单纯以罗哌卡因骶管进行术中麻醉，观察组则予以罗哌卡因与苏芬太尼联合骶管行手术麻醉，对2组患者麻醉起效时间、术后VAS评分及不良反应发生率等加以对比。结果本研究观察组患者在阻滞起效时间、术后手术位置疼痛发作时间、术后VAS评分最高值方面相比于对照组有显著优势，对比差异有统计学意义（t=7.066，8.306，14.012，P＜0.05）；观察组、对照组不良反应发生率分别为20.8%与25.0，对比差异无统计学意义（P＞0.05）；但观察组患者镇痛药使用例数为8例（16.7%），显著少于对照组的19例（39.6%），对比差异有统计学意义（x2=0.236，6.235，P＜0.05）。结论以罗哌卡因联合苏芬太尼应用于混合痔患者术中麻醉可有效提高麻醉效果，且可降低不良反应发生率，疗效良好且安全可靠，故可于临床中推广应用。

摘要： 目的：分析罗哌卡因联合苏芬太尼用于剖宫产手术麻醉的效果。方法方便收集2015年1月—2015年6月该院收治的90例接受剖宫产术的产妇为研究对象，将90例产妇随机分为观察组与对照组，观察组给予罗哌卡因+苏芬太尼进行麻醉处理，对照组给予罗哌卡因+吗啡进行麻醉处理，对比分析两组患者术中牵拉反应发生情况及不良反应发生率。结果观察组疼痛﹑鼓肠﹑恶心/呕吐﹑腹肌紧张等术中牵拉反应发生率分别为0.00%﹑0.00%﹑2.22%﹑2.22%，明显低于对照组的8.89%﹑6.67%﹑13.33%﹑8.89%，差异有统计学意义(P<0.05)；且观察组不良反应发生率为6.67%，低于对照组的20.00%，差异有统计学意义。结论罗哌卡因联合苏芬太尼在剖宫产手术麻醉中的应用效果良好，建议在临床上推广。%Objective To analyze the effect of ropivacaine combined with sufentanil for cesarean section anesthesia. Meth-ods Convenient collection rom January 2015 -2015 year in June in our hospital 90 cases underwent cesarean section as the research object, 90 cases were randomly divided into observation group and control group, the observation group was given ropivacaine plus sufentanil anesthesia treatment, the control group was given ropivacaine + morphine anesthesia treatment, comparative analysis of pull reactions and the incidence of adverse reactions in the two groups led by the. Results The ob-servation group pain, nausea / vomiting, drum, intestinal muscle tension and intraoperative traction reaction rates were 0%, 0%, 2.22%, 2.22%, significantly lower than the control group 8.89%, 6.67%, 13.33%, 8.89%, the difference was statically stgnificant (P<0.05);and the incidence of adverse reactions was 6.67%, lower than the the control group was 20%. Conclu-sion The application effect of ropivacaine combined with sufentanil anesthesia in caesarean operation is good, recommended in clinical practice.

摘要： Objective To evaluate the effects of different sequences of intravenous administration on sufenta-nyl-induced cough during induction of general anesthesia.Methods One hundred patients,aged 20 ~60 years,weig-hing 45 ~82 kg,ASA Ⅰ or Ⅱ,scheduled for elective surgery under general anesthesia,were equally randomized to two groups by using a random number table:sufentanyl-propofol group(group SP)and propofol-sufentanyl group(group PS).In group SP,sufentanyl 0.4μg/kg was injected intravenously over 5s,and then propofol 2mg/kg was injected intravenously.In group PS,propofol 2mg/kg was injected intravenously,and then sufentanyl 0.4μg/kg was injected intravenously over 5s.The occurrence,intensity and the time of cough were recorded within 1 min after sufentanyl injection.Results The incidence of cough was 38%(19 /50)in group SP which was significantly higher than the 12%(6 /50)in group PS(χ2 =9.013,P 0.05).Conclusion Administration in the propofol-sufentanyl sequence can effectively reduce the occurrence of sufentanyl-induced cough as compared with that in the sufentanyl-propofol sequence during induction of general anesthesia.%目的：评价全麻诱导时不同给药顺序对苏芬太尼诱发呛咳反应的影响。方法拟全麻下行择期手术患者100例，年龄20～60岁，体质量45～82 kg，ASA Ⅰ或Ⅱ级。采用随机数字表法分为两组，各50例。苏芬太尼-丙泊酚组（SP 组）静脉注射苏芬太尼0．4μg／kg，5 s 注射完毕，随即静脉注射丙泊酚2 mg／kg；丙泊酚-苏芬太尼组（PS 组）先静脉注射丙泊酚2 mg／kg，随即注射苏芬太尼0．4μg／kg，5 s 注射完毕。分别记录注射完苏芬太尼后1 min 内呛咳反应的发生情况、程度和出现时间。结果SP 组呛咳反应发生率为38％（19／50），高于 PS 组的12％（6／50），差异有统计学意义（χ2＝9．013，P ＜0．01）；SP 组呛咳反应出现时间为（20．6±5．8）s，PS 组为（18．8±8．4）s，两组呛咳反应出现时间差异无统计学意义（t ＝1．247，P ＞0．05）。结论与苏芬太尼-丙泊酚给药相比，丙泊酚-苏芬太尼给药可有效减少全麻诱导期间苏芬太尼诱发的呛咳反应。

摘要： Objective To explore the effect and value of sufentanyl combined with different concentrations of ropivacaine in labor analgesia.Methods 120 analgesia childbirth pregnant women were divided into 3 groups(group A 0.5g/L,group B 1.0g/L,group C 2.0g/L)by random number table method,40 cases in each group,they were giv-en sufentanyl combined with different concentrations of ropivacaine in labor analgesia.The labor analgesia effect of three groups of pregnant women was recorded.Results The postpartum 2 h blood loss and total labor time of group A were (147.55 ±25.39)mL and (727.54 ±56.38)min,which of group B were (131.03 ±18.73)mL,(573.53 ± 40.09)min,which of group C were (120.03 ±14.84)mL,(493.82 ±34.51)min,there were statistically significant differences among the three groups(F =3.342 7,7.551 7,all P 0.05).Conclusion Using 1.5g/L ropivacaine combined with sufentanyl in labor analgesia is remarkable,high safety,neonatal and maternal prognosis is good,and therefore should be preferred to 1.5g/L ropivacaine combined with sufentanyl in labor analgesia.%目的：探讨苏芬太尼联合不同浓度罗哌卡因应用在分娩镇痛中的效果及价值。方法将120例行镇痛分娩的孕妇采用随机数字表法分为三组，每组40例。分别给予苏芬太尼复合不同浓度罗哌卡因镇痛（A 组0．5 g／L，B 组1．0 g／L，C 组2．0 g／L），记录三组孕妇镇痛效果和产程情况。结果 A 组产后2 h 出血量（147．55±25．39）mL，总产程时间（727．54±56．38）min；B 组产后2 h 出血量（131．03±18．73）mL，总产程时间（573．53±40．09）min；C 组产后2 h 出血量（120．03±14．84）mL，总产程时间（493．82±34．51）min。三组间产后2 h 出血量、总产程时间差异均有统计学意义（F ＝3．3427、7．5517，均 P ＜0．05）。A 组 VAS 疼痛评分（3．15±1．14）分，氧分压（17．11±1．43）mmHg，二氧化碳分压（52．73±2．59）mmHg；B 组 VAS 疼痛评分（2．01±0．76）分，氧分压（18．24±2．03）mmHg，二氧化碳分压（50．01±1．68）mmHg；C 组 VAS 疼痛评分（1．51±0．35）分，氧分压（19．41±2．76）mmHg，二氧化碳分压（47．21±1．02）mmHg。三组间 VAS 疼痛评分、氧分压、二氧化碳分压差异均有统计学意义（F ＝4．6514、2．8525、5．6814，均 P ＜0．05）。A 组并发症发生率7．50％， B 组并发症发生率10．00％，C 组并发症发生率15．00％，三组间差异无统计学意义（χ2＝0．4571，P ＞0．05）。结论采用1．5 g／L 罗哌卡因复合苏芬太尼在分娩镇痛中效果显著，安全性高，新生儿和产妇预后较好，因此应首选1．5 g／L 罗哌卡因复合苏芬太尼应用在分娩镇痛中。

摘要： 目的:观察罗哌卡因联合小剂量苏芬太尼膝关节腔内注射用于膝关节镜手术后镇痛的效果. 方法:80例硬膜外腔麻醉下膝关节镜手术,随机单盲将患者分为4组,每组20人.关节腔内分别注射罗哌卡因联合苏芬太尼(RS组)、苏芬太尼(S组)、罗哌卡因(R组)、等容量生理盐水(N组).记录术后2h、4h、8h、12h、24h、48h患者直立和屈膝90°的条件下进行视觉模拟评分(VAS),并观察有无不良反应. 结果: VAS评分RS组、S组、R组3组间术后2h、4h、8h,12h差异无显著性;术后24h、48h S组、R组评分低于RS组,而S组、R组组间差异无显著性,RS不良反应较少. 结论:罗哌卡因联合小剂量苏芬太尼膝关节腔内注射用于膝关节镜手术后镇痛,可有效缓解术后疼痛.

摘要： 本文研究目的:研究不同剂量苏芬太尼对靶控异丙酚血流动力学和脑电双频指数的影响. 　　研究方法:选择ASAⅠ～Ⅱ级下腹部手术病人30例,随机分为两组,每组各15例,分别为A组(苏芬太尼0.5μg.kg),B组(苏芬太尼1.0μg/kg),观察两个不同剂量的苏芬太尼对麻醉诱导过程靶控异丙酚血流动力学和脑电双频指数的影响. 　　研究结果:(1)与麻醉诱导前(T0)相比、病人入睡时(Ts)、异丙酚达到靶控血药浓度时(T1),异丙酚达到靶控血药浓度1min(T2),推注苏芬太尼后1min(T3),推注苏芬太尼后3min(T4),推注苏芬太尼后5min(T5)的SBP、DBP、MAP和BIS值均下降(P＜0.05).推注苏芬太尼后以上值下降更明显(P＜0.01),尤以B组明显;(2)A组气管插管后1min(T11)、3min(T3)的SBP、DBP、MAP及HR值较插管前升高明显(P＜0.05). 　　研究结论:在抑制插管应激反应方面,1μg/kg的苏芬太尼优于0.5μg/kg的苏芬太尼,尽管插管前引起比较明显的血流动力学变化.

摘要： 本发明公开了阿芬太尼、舒芬太尼的制备方法及用于制备阿芬太尼、舒芬太尼的化合物，其中制备式V所示化合物的方法包括：使式IV所示化合物发生脱BOC反应，以便获得所述式V所示化合物，利用该方法能够方便、高效、安全地制备获得阿芬太尼、舒芬太尼合成的中间产物——式V所示化合物，进而，该式V所示化合物能够有效用于制备阿芬太尼、舒芬太尼。

摘要： 本发明公开了阿芬太尼、舒芬太尼的制备方法及用于制备阿芬太尼、舒芬太尼的化合物，其中制备式V所示化合物的方法包括：使式IV所示化合物发生脱BOC反应，以便获得所述式V所示化合物，利用该方法能够方便、高效、安全地制备获得阿芬太尼、舒芬太尼合成的中间产物——式V所示化合物，进而，该式V所示化合物能够有效用于制备阿芬太尼、舒芬太尼。

摘要： 本发明提供了一种改进的用于止痛药物，即芬太尼和苏芬太尼的电输送药物输送系统。芬太尼/苏芬太尼作为可溶于水的盐(例如芬太尼盐酸盐)最好以水凝胶的成分提供，以便用于电输送装置(10)。按照本发明，提供的芬太尼/苏芬太尼经皮肤输送的剂量足以制止病人(例如成人)遭受的和主要外科手术相关的疼痛。

摘要： 本发明提供了一种改进的用于止痛药物例如芬太尼和苏芬太尼的电输送药物输送系统。芬太尼/苏芬太尼作为可溶于水的盐(例如芬太尼盐酸盐)被提供，并被分散到电输送装置(10)所使用的水凝胶成分中。按照本发明，在阳极供体容器(26)溶液中的芬太尼/苏芬太尼的浓度被维持在一个最小浓度以上，借以使经皮肤电输送的芬太尼/苏芬太尼的通量保持和溶液中的芬太尼/苏芬太尼的浓度无关。

摘要： 本发明提供一种改进的输送止痛药物即芬太尼和苏芬太尼的电输送系统。芬太尼/苏芬太尼以可溶于水的卤化物盐(例如芬太尼盐酸盐)的形式提供，最好被含在一种水凝胶组成中，以便利用电输送装置(10)。按照本发明，电输送装置(10)的供体电极(22)由银构成，供体容器(26)基本上没有补充的氯化物离子源，并含有芬太尼/苏芬太尼的预定的“过量”的加载，用于阻止银离子迁移而引起皮肤变色。

摘要： 本发明提供有效使包含苏芬太尼(sufentanil)的固体剂型中氧化降解产物的存在降至最低或消除的组合物和方法。

摘要： 本发明提供一种改进的输送止痛药物即芬太尼和苏芬太尼的电输送系统。芬太尼/苏芬太尼以可溶于水的卤化物盐(例如芬太尼盐酸盐)的形式提供,最好被含在一种水凝胶组成中,以便利用电输送装置(10)。按照本发明,电输送装置(10)的供体电极(22)由银构成,供体容器(26)基本上没有补充的氯化物离子源,并含有芬太尼/苏芬太尼的预定的“过量”的加载,用于阻止银离子迁移而引起皮肤变色。

摘要： 本发明提供了一种改进的用于止痛药物例如芬太尼和苏芬太尼的电输送药物输送系统。芬太尼/苏芬太尼作为可溶于水的盐(例如芬太尼盐酸盐)被提供,并被分散到电输送装置(10)所使用的水凝胶成分中。按照本发明,在阳极供体容器(26)溶液中的芬太尼/苏芬太尼的浓度被维持在一个最小浓度以上,借以使经皮肤电输送的芬太尼/苏芬太尼的通量保持和溶液中的芬太尼/苏芬太尼的浓度无关。

摘要： 本发明提供了一种改进的用于止痛药物,即芬太尼和苏芬太尼的电输送药物输送系统。芬太尼/苏芬太尼作为可溶于水的盐(例如芬太尼盐酸盐)最好以水凝胶的成分提供,以便用于电输送装置(10)。按照本发明,提供的芬太尼/苏芬太尼经皮肤输送的剂量足以制止病人(例如成人)遭受的和主要外科手术相关的疼痛。

摘要： 本发明提供有效使包含苏芬太尼(sufentanil)的固体剂型中氧化降解产物的存在降至最低或消除的组合物和方法。