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氧耗量

氧耗量的相关文献在1982年到2022年内共计185篇,主要集中在外科学、内科学、药学 等领域,其中期刊论文174篇、会议论文3篇、专利文献182366篇;相关期刊107种,包括体育科研、微循环学杂志、心肺血管病杂志等; 相关会议3种,包括第九届人-机-环境系统工程大会、环境与职业医学研究生联谊会第一届学术研讨会、中国航空学会人体工程、航医、救生专业分会第五届学术年会等;氧耗量的相关文献由582位作者贡献,包括王伟、段瑞峰、汪海等。

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论文:174 占比:0.10%

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论文:3 占比:0.00%

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论文:182366 占比:99.90%

总计:182543篇

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氧耗量

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  • 王伟
  • 段瑞峰
  • 汪海
  • 南文考
  • 崔文玉
  • 张志清
  • 张芳
  • 曾祥芝
  • 纪佳丽
  • 龙超良
  • 期刊论文
  • 会议论文
  • 专利文献

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    • 王文文; 霍建臻; 曹婷
    • 摘要: 目的 比较硬膜外麻醉与全身麻醉在老年骨科手术患者中的应用效果。方法 根据麻醉方案将2019年1月至2020年6月在我院进行骨科手术的88例老年患者分为对照组和观察组,各44例。对照组行全身麻醉,观察组行硬膜外麻醉。比较两组患者的麻醉效果、氧耗情况、血流动力学指标、苏醒质量及认知功能。结果 观察组的Ramsay镇静评分高于对照组,感觉阻滞维持时间、运动阻滞维持时间长于对照组,VAS评分低于对照组(P<0.05)。两组麻醉10、30、60 min的VO_(2)、VCO_(2)均高于麻醉前,DO_(2)均低于麻醉前(P<0.05);观察组麻醉10、30、60 min的VO_(2)、VCO_(2)低于对照组,DO_(2)高于对照组(P<0.05)。麻醉30 min,两组的HR均高于麻醉前,MVP、CVP均低于麻醉前(P<0.05);观察组麻醉30 min、术后10 min的HR低于对照组,MVP、CVP高于对照组(P<0.05)。观察组的唤醒睁眼时间、拔管时间、意识恢复时间均短于对照组,POCD发生率低于对照组(P<0.05)。两组术后6、24、48 h的MMSE评分均低于术前(P<0.05);观察组术后6、24、48 h的MMSE评分高于对照组(P<0.05)。结论 硬膜外麻醉在老年骨科手术患者中的应用效果优于全身麻醉,可提高镇痛、镇静效果,改善氧耗情况,减少术中血流动力学波动,提高苏醒质量,且有利于术后认知功能的恢复。
    • YU Xiao-qing; ZHONG Gen-shen; XIONG Xi-wen; LIANG Yin-ming; WANG Hui; ZHANG Xiao-ying; YE Jian-ping
    • 摘要: 目的 探讨三磷腺苷合酶抑制因子1(ATPIF1)基因敲除对小鼠巨噬细胞内三磷腺苷(ATP)水平及线粒体功能的影响.方法 选取5只野生型C57BL/6小鼠为WT组,5只ATPIF1基因敲除小鼠为KO组.处死小鼠后,提取小鼠骨髓细胞进行培养,并诱导其分化成熟为骨髓来源巨噬细胞(BMDM).在未加脂多糖(LPS)的基础状态及LPS刺激2、4h后收集细胞,应用ATP检测试剂盒检测细胞内ATP水平,应用细胞能量代谢分析仪检测细胞氧消耗率,采用实时荧光定量聚合酶链反应检测细胞内三羧酸循环中关键酶丙酮酸激酶(PKm)、异柠檬酸脱氢酶(IDH)、柠檬酸合酶(CS)、α-酮戊二酸脱氢酶(OGDC) mRNA相对表达量.结果 与WT组比较,在基础状态下KO组小鼠BMDM内ATP水平、基础氧耗量、用于ATP合成的氧耗量、最大氧耗量及PKm、IDH、CS、OGDC mRNA相对表达量显著增加(P<0.05,P<0.01);LPS刺激2、4h后,KO组小鼠BMDM内ATP水平、基础氧耗量、用于ATP合成的氧耗量和最大氧耗量及CS、OGDC mRNA相对表达量均显著增加(P<0.05).结论 ATPIF1基因敲除可增加小鼠BMDM内ATP水平,并提高三羧酸循环相关酶mRNA表达和线粒体氧化磷酸化水平.
    • 李亚南; 刘祥; 杨淑红; 张琦; 王亮; 台艳蕾; 王秋筠
    • 摘要: 目的 评价尼莫地平对老年腔隙性脑梗患者术后谵妄的影响.方法 择期全麻下拟行脊柱手术腔隙性脑梗死患者60例,性别不限,年龄65~80岁,ASA分级Ⅱ或Ⅲ级.采用随机数字表法分为2组(n=30):对照组(C组)和尼莫地平组(N组).N组于麻醉诱导前30 min开始静脉输注尼莫地平7.5μg·kg-1·h-1至术毕.于尼莫地平给药前即刻(T1)、气管插管后即刻(T2)、切皮后1 h(T3)及术毕(T4)进行动脉及颈静脉球部血气分析,并计算颈静脉球部血氧含量、动脉-颈静脉球部血氧含量差、脑氧摄取率及颈静脉-动脉血乳酸浓度差.采用ELISA法测定颈静脉球部血清S100β蛋白和脑源性神经营养因子(BDNF)的浓度.记录术后3 d内谵妄的发生情况.结果 与C组比较,N组T3,4时颈静脉球部血氧含量升高,动脉-颈静脉球部血氧含量差及脑氧摄取率降低,T2-4时血清S100β 蛋白浓度降低,脑源性神经营养因子浓度升高,术后谵妄发生率降低(P0.05).结论 尼莫地平可减少老年腔隙性脑梗死患者术后谵妄的发生,其机制可能与改善术中脑氧代谢及减轻脑损伤有关.%Objective To evaluate the effect of nimodipine on postoperative delirium (POD) in elderly patients with lacunar infarction. Methods Sixty patients with lacunar infarction of both sexes, aged 65-80 yr, of American Society of Anesthesiologists physical status Ⅱor Ⅲ, scheduled for elective spinal surgery under general anesthesia, were divided into 2 groups (n= 30 each) using a random number table: control group (group C) and nimodipine group (group N). Nimodipine 7. 5 μg·kg-1 ·h-1 was in-travenously infused starting from 30 min before anesthesia induction until the end of surgery in group N, while the equal volume of normal saline was given in group C. At 30 min before infusing nimodipine (T1 ), immediately after tracheal intubation (T2 ), at 1 h after skin incision (T3 ) and at the end of surgery (T4 ), blood samples were taken from the radial artery and jugular bulb for blood gas analysis. Jugular bulb oxygen content, arterial-jugular bulb oxygen content difference, cerebral oxygen uptake rate and jugular-arterial lactate concentration difference were calculated. The concentrations of S100β protein and brain-derived neurotrophic factor (BDNF) in serum of the jugular bulb were measured by enzyme-linked immunosorbent as-say. The occurrence of POD was recorded within 3 days after operation. Results Compared with group C, jugular bulb oxygen content was significantly increased, and arterial-jugular bulb oxygen content difference and cerebral oxygen uptake rate were decreased at T3,4 , the concentrations of serum S100β protein were de-creased and the concentrations of brain-derived neurotrophic factor were increased at T2-4 , the incidence of POD was decreased (P0. 05). Conclusion Nimodipine can reduce the devel-opment of POD, and the mechanism may be related to improving intraoperative cerebral oxygen metabolism and reducing brain injury in elderly patients.
    • 王静; 蔡林; 陈学伟; 安改红; 申慧祥; 马强
    • 摘要: 目的 探讨心率作为评价体力劳动强度优选指标的可能性.方法 于2015年9至10月,选择111名男性青年为研究对象,采用功率自行车运动方式,进行不同强度(20、40、60、80、100、120、140、160、180W)的运动人体试验,每一运动强度持续6 min;受试者佩戴K4b2便携式心肺功能仪,实时监测运动中的心率(HR)、肺通气量(Ve)、氧耗量(VO2)和能量代谢率(E).采用Origin分析软件,对各强度下采集的HR、Ve、VO2和E进行相关分析和回归分析,建立Ve-HR、VO2-HR、E-HR回归关系方程.结果 不同运动强度下,HR与Ve、VO2、E均呈正相关(r=0.898 5、0.873 3、0.897 3,P<0.01);HR与Ve、VO2和E建立回归方程的R2值分别为0.807 0、0.762 5、0.804 9,差异均有统计学意义(P<0.01).验证结果显示,经方程推算值与实际测量值差异无统计学意义(P>0.05).结论 HR可能替代Ve、VO2和E,作为评价体力劳动强度的优选指标.%Objective To investigate the possibility of heart rate as an optimum index for evaluating physical labor intensity.Methods From September to October,2015,a total of 111 male young adults were selected as study subjects.A cycle ergometer was used for exercise at different intensities (20,40,60,80,100,120,140,160,and 180 W),and the exercise at each intensity lasted for 6 minutes.The subjects wore the K4b2 portable cardiopulmonary function testing instrument for the real-time monitoring of heart rate (HR),pulmonary ventilation volume (Ve),oxygen consumption (VO2),and energy metabolic rate (E).The origin software was used for correlation and regression analyses of HR,Ve,VO2,and E collected at different intensities to establish VeHR,VO2-HR,and E-HR regression equations.Results At different intensities,HR was positively correlated with Ve,VO2,and E(r=0.8985,0.8733,and 0.8973,all P<0.01).There was a significant difference in the R2 value of Ve-HR,VO2-HR,and E-HR regression equations (R2=0.8070,0.7625,and 0.8049,all P <0.01).The validation results showed that there was no significant difference between the calculated values and the measured ones (P> 0.05).Conclusion HR can replace Ve,VO2,and E and be used as an optimum index for evaluating physical labor intensity.
    • 罗小波; 蔡昆; 罗明春
    • 摘要: Objective To explore the difference between delirium and oxygen extraction ratio ,to provide basic data for the timely diagnosis and treatment of delirium and further study .Methods According to whether the occurrence of delirium ,we divided pa-tients into two groups :the control group had 24 patients without delirium ;observation group had 27 patients with delirium .These patients in ICU ward were placed with pulmonary artery catheter to detect the oxygen extraction ratio .The three periods of monito-ring were before the occurrence of delirium (T1) ,delirium(T2) ,delirium after (T3) ,we select the appropriate time to collect the data of the control group .The following items were monitored :hemoglobin Hb ,arterial oxygen saturation SaO2 ,arterial partial pressure of oxygen PaO2 ,mixed venous oxygen saturation SvO2 ,mixed venous oxygen partial pressure PvO2 ,heart index CI .Then the following items were calculated by monitoring indicators :arterial oxygen content CaO2 ,venous oxygen content of CvO2 ,oxygen transport DO2 ,oxygen consumption VO2 ,oxygen extraction ratio O2 ER .By means of statistical analysis of monitoring data ,we ana-lyzed the relationship between oxygen extraction ratio changes and delirium .Results In T1 ,T2 and T3 time period ,the average val-ue of actual monitoring indicators CI ,PvO2 and Hb in the observation group were similar to those in the control group ,PaO2 and SvO2 in the observation group were lower than those in the control group ,the calculated indexes SaO2 ,DO2 ,VO2 and O2 ER were higher than those of the control group ,the difference was not statisticauy significant (P>0 .05) .Conclusion There was no differ-ence in changes of delirium and oxygen extraction ratio .%目的 研究氧摄取率与谵妄是否具有相关性,为临床及时诊治谵妄和进一步研究提供基础数据.方法 选取该院收入重症医学科后安置漂浮导管监测氧摄取率的患者,按照是否发生谵妄分成2组:对照组24例,患者未发生谵妄;观察组27例,患者发生谵妄.按观察组谵妄发生前(T1)、发生时(T2)、发生后(T3)时间段收集观察组数据,并于相应时间段收集对照组数据,包括血红蛋白(Hb)、动脉血氧饱和度(SaO2)、动脉血氧分压(PaO2)、混合静脉血氧饱和度(SvO2)、混合静脉血氧分压(PvO2)、心脏指数(CI),计算出动脉血氧水平(CaO2)、静脉血氧水平(CvO2)、氧输送(DO2)、氧消耗(VO2)、全身氧摄取率(O2 ER),观察2组患者氧摄取率变化与谵妄发生的相关性.结果 在T1、T2、T3时间段,观察组的实际监测指标CI、PvO2、Hb均值与对照组数值相近,PaO2、SvO2均值低于对照组,计算指标SaO2、DO2、VO2、O2 ER均值高于对照组,但差异无统计学意义(P>0.05).结论谵妄发生前后与氧摄取率变化无相关性.
    • 杜薇; 刁玉刚; 周锦; 曹惠鹃; 张铁铮; 李林
    • 摘要: 目的 评价低温环境暴露对失血性休克猪全麻期间血流动力学和氧代谢的影响.方法 清洁级巴马小型猪12头,雌雄不拘,体重20~24 kg,采用随机数字表法分为2组(n=6):常温环境组(RT组)和低温环境组(EH组).吸入2%异氟醚维持麻醉,RT组和EH组分别置于常温(20~22°C)和低温(-10°C)环境中,采用改良容控法(放血量30 ml/kg)制备失血性休克模型.于放血前(T1)、放血结束后即刻(T2)、休克1、2、3、4和5 h(T3~T7)时记录HR、MAP、平均肺动脉压(MPAP)、CI、全身血管阻力指数(SVRI);并经右侧股动脉及颈内静脉取血标本1 ml,行动脉及混和静脉血血气分析,记录乳酸浓度(Lac)、Hb、PaO2、SaO2、混合静脉血氧饱和度(SvO2),并计算氧供指数(DO2I)、氧耗指数(VO2I)和氧摄取率(O2ER).结果 与RT组比较,EH组T3~7时HR、T5~7时CI和DO2I、T1~7时VO2I、T2~6时O2ER、T5~7时Lac降低,T4,5时MAP、T4~7时MPAP、T3~7时SVRI、T2~6时S;O2升高(P<0.05).结论 低温环境暴露可抑制失血性休克猪全麻期间心脏代偿反应,增加外周血管阻力,并加剧氧代谢障碍.%Objective To evaluate the effect of environmental hypothermia exposure on hemodynamics and oxygen metabolism during general anesthesia in a pig model of hemorrhagic shock.Methods Twelve pathogen-free Bama miniature pigs of both sexes,weighing 20-24 kg,were divided into 2 groups (n=6 each) using a random number table:room temperature group (group RT) and environmental hypothermia group (group EH).The animals inhaled 2% isoflurane for maintenance of anesthesia.The pigs were placed at room temperature (20-22°C) and at low temperature (-10 °C) in group RT and group EH,respectively.Hemorrhagic shock was induced by withdrawing blood from the right femoral artery within 20 min (30 ml/kg).Before withdrawing blood (T1),immediately after the end of withdrawing blood (T2),and at 1,2,3,4 and 5 h of shock (T3-7),heart rate,mean arterial pressure,mean pulmonary artery pressure,cardiac index and systemic vascular resistance index were recorded.Blood samples were collected from the right femoral artery and internal jugular vein for blood gas analysis,and lactic acid concentrations,hemoglobin,arterial oxygen partial pressure,arterial oxygen saturation,and mixed venous oxygen saturation were recorded.Oxygen delivery index,oxygen consumption index and O2 extraction rate were calculated.Results Compared with group RT,heart rate at T3-7,cardiac index and oxygen delivery index at T5-7,oxygen consumption index at T1-7,O2 extraction rate at T2-6,and lactic acid concentrations at T5-7 were significantly decreased,and mean arterial pressure at T4,5,mean pulmonary artery pressure at T4-7,systemic vascular resistance index at T3-7,and mixed venous oxygen saturation at T2-6 were increased in group EH (P<0.05).Conclusion Environmental hypothermia exposure inhibits cardiac compensatory responses,increases the peripheral vascular resistance,and aggravates oxygen dysmetabolism during general anesthesia in a pig model of hemorrhagic shock.
    • 郭唯真; 陈梦媛; 高巨; 葛亚丽; 黄天丰; 周罗晶
    • 摘要: 目的 评价肺保护性通气对单肺通气老年患者脑氧代谢和术后认知功能的影响.方法 择期全麻下行胸腔镜食管癌根治术的患者60例,性别不限,年龄65~80岁,体重45 ~ 75 kg,ASA分级Ⅱ或Ⅲ级.采用随机数字表法,将其分为2组(n=30):容量控制通气组(VCV组)和保护性通气组(PV组).VCV组双肺通气期间VT10 ml/kg,单肺通气期间VT7 ml/kg;PV组双肺通气期间VT7ml/kg+ PEEP 5 cmH2O+肺复张术,单肺通气期间VT5 ml/kg+PEEP 5 cmH2O+肺复张术.肺复张术:维持吸气压15、20、25 cmH2O,PEEP 5 cmH2O,每个压力3次呼吸,5 s/次,45 min复张1次.于诱导前(T1)、双肺通气10 min(T2)、单肺通气30 min(T3)、再次改为双肺通气15 min(T4)时采集桡动脉和颈静脉球部血样行血气分析,记录pH值、PaO2、PaCO2、SaO2、颈静脉球部血氧饱和度(SjvO2);计算氧合指数(OI)、肺内分流率(Qs/Qt)、动脉-颈内静脉血氧含量差(Da-jvO2)和脑氧摄取率(CE-RO2).于术后7d、1个月时采用简易精神状态检查量表(MMSE)评估认知功能,记录术后认知功能障碍的发生情况.结果 与T1时比较,2组T2-4时PaO2、Da-jvO2、CERO2和Qs/Qt升高,SjvO2和OI降低(P<0.05);与T2时比较,2组T3时PaO2、SjvO2和OI降低,Qs/Qt和CERO2升高,T3-4时Da-jvO2升高(P<0.05);与VCV组比较,PV组T3时PaO2、PaCO2、SjvO2和OI升高,Qs/Qt、Da-jvO2和CERO2降低,术后7d时MMSE评分升高,术后认知功能障碍发生率降低(P<0.05).结论 肺保护性通气策略有助于改善单肺通气老年患者术后脑功能.%Objective To evaluate the effects of lung-protective ventilation on the cerebral oxygen metabolism and postoperative cognitive function in elderly patients requiring one-lung ventilation (OLV).Methods Sixty patients of both sexes,aged 65-80 yr,weighing 45-75 kg,of American Society of Anesthesiologists physical status Ⅱ or Ⅲ,scheduled for elective radical resection for esophageal cancer performed via video-assisted thoracoscope with general aneshesia,were divided into 2 groups (n =30 each)using a random number table:volume-controlled ventilation group (group VCV) and protective ventilation group (group PV).In group VCV,the tidal volume (VT) was set at 10 ml/kg during two-lung ventilation (TLV) and at 7 ml/kg during OLV.In group PV,the VT was set at 7 ml/kg during TLV and at 5 ml/kg during OLV with positive end-expiratory pressure of 5 cmH2O,and lung recruitment maneuver was performed every 45 min with inspiratory pressure at 15,20 and 25 cmH2O,PEEP 5 cmH2O,3 breaths per pressure,5 s/breath.Before induction of anesthesia (T1),at 10 min of TLV (T2),at 30 min of OLV (T3) and at 15 min after restoration of TLV (T4),blood samples were taken from the radial artery and jugular bulb for blood gas analysis,and pH value,arterial oxygen partial pressure (PaO2),arterial carbon dioxide partial pressure (PaCO2),arterial oxygen saturation (SaO2) and jugular venous oxygen saturation (SjvO2) were recorded.Oxygenation index (OI),intrapulmonary shunt (Qs/Qt),arteriovenous blood O2 content difference (Da-jvO2) and cerebral O2 extraction rate (CERO2) were calculated at the same time.Cognitive function was assessed using Mini-Mental State Examination at 7 days and 1 month after operation,and the development of postoperative cognitive dysfunction was recorded.Results PaO2,DajvO2,CERO2 and Qs/Qt were significantly higher and SjvO2 and OI were lower at T2-4 than at T1 in two groups (P<0.05).PaO2,SjvO2 and OI were significantly lower and Qs/Qt and CERO2 were higher at T3 than at T2,and Da-jvO2 was higher at T3-4 than at T2 in two groups (P<0.05).Compared with group VCV,PaO2,PaCO2,SjvO2 and OI were significantly increased and Qs/Qt,Da-jvO2 and CERO2 were decreased at T3,the Mini-Mental State Examination scores were increased on postoperative day 7,and the incidence of postoperative cognitive dysfunction was decreased in group PV (P<O.05).Conclusion Lungprotective ventilation is helpful in improving postoperative brain function of elderly patients requiring OLV.
    • 左友梅; 李珺; 程新琦; 刘学胜; 顾尔伟
    • 摘要: Objective To evaluate the effect of therapeutic hypercapnia on the balance between cer-ebral O2supply and demand in the patients undergoing arthroscopic shoulder surgery in the beach chair posi-tion(BCP). Methods Forty-eight patients of both sexes, aged 21-64 yr, weighing 45-80 kg, of Ameri-can Society of Anesthesiologists physical statusⅠorⅡ, scheduled for elective arthroscopic shoulder surgery in the beach chair position, were divided into 2 groups(n=24 each)using a random number table: control group(group C, end-tidal pressure of carbon dioxide 35-40 mmHg)and therapeutic hypercapnia group (group H, end-tidal pressure of carbon dioxide 45-50 mmHg). The regional cerebral oxygen saturation (rSO2)was recorded after induction and before BCP, immediately after BCP, at 3, 6, 9, 12, 15, 18, 21, 24, 27 and 30 min after BCP and at the end of surgery(T0-12). The occurrence of cerebral desaturation events, extubation time, duration of stay in postanesthesia care unit, development of nausea and vomiting and requirement for vasoactive drugs were recorded during surgery. Results Compared with the baseline at T0, the rSO2was significantly decreased at T1-12in group C and at T2-6in group H(P005). Conclusion Therapeutic hypercapnia can improve the balance between cerebral O2supply and demand in the patients undergoing arthroscopic shoulder surgery in the BCP.%目的 评价治疗性高碳酸血症对沙滩椅位(BCP)下肩关节镜手术患者脑氧供需平衡的影响.方法 择期拟行沙滩椅位肩关节镜手术患者48例,性别不限,年龄21~64岁,体重45~80 kg,ASA分级Ⅰ或Ⅱ级.采用随机数字表法分为2组(n=24):对照组C组)和治疗性高碳酸血症组(H组).于诱导后BCP前、BCP后即刻、3、6、9、12、15、18、21、24、27、30 min和术毕(T0-12)时记录脑氧饱和度(rSO2);记录脑去氧饱和度事件(CDE)的发生情况、拔除气管导管时间、PACU滞留时间、恶心、呕吐的发生情况和血管活性药物使用情况.结果 与T0时比较,C组T1-12时rSO2降低,H组T2-6时rSO2下降(P005).结论 治疗性高碳酸血症可改善BCP下肩关节镜手术患者的脑氧供需平衡.
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