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摘要： 【教学设计】指导思想与理论依据:《义务教育英语课程标准》课程总目标三级要求学生能够:能与教师或同学就熟悉的话题(如学校、家庭生活)交换信息;能用短语或句子描述系列图片。语言技能分级目标中说的技能三级要求学生:能在课堂活动中用简短的英语进行交际;能就熟悉的话题进行简单的交流;能提供有关个人情况和个人经历的信息;能在上述口语活动中做到语音、语调基本正确。

摘要： 甲状腺呈胸腺样分化癌(carcinoma showing thymus like element,CASTLE)是一种发生于甲状腺及其周围颈部软组织的低度恶性肿瘤。文献报道CASTLE多位于甲状腺中下极,亦可发生于腮腺、梨状窝、侧颈部颌下区等。CASTLE应与恶性程度高,预后差的癌相鉴别,以免过诊过治。CASTLE属全球罕见病例,鲜有合并其他恶性肿瘤报道,本例为CASTLE合并甲状腺乳头状癌。1病例资料患者,男性,38岁。因发现右颈部肿物4个月入院。

摘要： AIM: To investigate whether a glucagon-like peptide-1(GLP-1) analogue inhibits nonalcoholic steatohepatitis(NASH), which is being increasingly recognized in Asia, in non-obese mice. METHODS: A methionine-choline-deficient diet(MCD) along with exendin-4(20 μg/kg per day, ip), a GLP-1 analogue, or saline was administered to male db/db mice(non-obese NASH model). Four or eight weeks after commencement of the diet, the mice were sacrificed and their livers were excised. The excised livers were examined by histochemistry for evidence of hepatic steatosis and inflammation. Hepatic triglyceride(TG) and free fatty acid(FFA) content was measured, and the expression of hepatic fat metabolism- and inflammation-related genes was evaluated. Oxidative stress-related parameters and macrophage recruitment were also examined using immunohistochemistry.RESULTS: Four weeks of MCD feeding induced hepatic steatosis and inflammation and increased the hepatic TG and FFA content. The expression of fattyacid transport protein 4(FATP4), a hepatic FFA influxrelated gene; macrophage recruitment; and the level of malondialdehyde(MDA), an oxidative stress marker, were significantly augmented by a 4-wk MCD. The levels of hepatic sterol regulatory element-binding protein-1c(SREBP-1c) m RNA(lipogenesis-related gene) and acyl-coenzyme A oxidase 1(ACOX1) m RNA(β-oxidation-related gene) had decreased at 4 wk and further decreased at 8 wk. However, the level of microsomal triglyceride transfer protein m RNA(a lipid excretion-related gene) remained unchanged. The administration of exendin-4 significantly attenuated the MCD-induced increase in hepatic steatosis, hepatic TG and FFA content, and FATP4 expression as well as the MCD-induced augmentation of hepatic inflammation, macrophage recruitment, and MDA levels. Additionally, it further decreased the hepatic SREBP-1c level and alleviated the MCD-mediated inhibition of the ACOX1 m RNA level. CONCLUSION: These results suggest that GLP-1 inhibits hepatic steatosis and inflammation through the inhibition of hepatic FFA influx and oxidative stress in a non-obese NASH model.

摘要： AIM: To investigate the role of mi R-125 b in regulating monocyte immune responses induced by hepatitis C virus(HCV) core protein.METHODS: Monocytic THP-1 cells were treated with various concentrations of recombinant HCV core protein, and cytokines and mi R-125 b expression in these cells were analyzed. The requirement of Tolllike receptor 2(TLR2) or My D88 gene for HCV core protein-induced immune responses was determined by the transfection of THP-1 cells with gene knockdown vectors expressing either TLR2 si RNA or My D88 si RNA. The effect of mi R-125 b overexpression on TLR2/My D88 signaling was examined by transfecting THP-1 cells with mi R-125 b mimic RNA oligos.RESULTS: In response to HCV core protein stimulation, cytokine production was up-regulated and mi R-125 b expression was down-regulated in THP-1 cells. The modulatory effect of HCV core protein on cellular events was dose-dependent and required functional TLR2 or My D88 gene. Forced mi R-125 b expression abolished the HCV core protein-induced enhancement of tumor necrosis factor-α, interleukin(IL)-6, and IL-10 expression by 66%, 54%, and 66%, respectively(P < 0.001), by inhibiting My D88-mediated signaling, including phosphorylation of NF-k Bp65, ERK, and P38.CONCLUSION: The inverse correlation between mi R-125 b and cytokine expression after HCV core challenge suggests that mi R-125 b may negatively regulate HCVinduced immune responses by targeting TLR2/My D88 signaling in monocytes.

摘要： 研究运用了变异社会语言学理论和历史比较语言学方法论,以引述语be like的分布特征和变异模式为切入点,旨在揭示加拿大英语和其他英语变体在引述语使用上表现出来的共性和差异。提取了加拿大渥太华英语语料库中27个受访者的口语语料,其中引述结构在必要语境下共出现1193次。研究发现,引述语be like的使用频率出现了显著增长,已成为年轻人群中的主流引述手段。而say、go think等传统引述语的使用频率渐次降低。多变量分析结果进一步证实了引述语be like变异受到了语言因素和非语言因素的共同制约。同时,共时变异特征也为be like的语法化进程提供了证据。

摘要： Gene editing has recently emerged as a promising technology to engineer genetic modifications precisely in the genome to achieve long-term relief from corneal disorders.Recent advances in the molecular biology leading to the development of clustered regularly interspaced short palindromic repeats(CRISPRs) and CRISPR-associated systems,zinc finger nucleases and transcription activator like effector nucleases have ushered in a new era for high throughput in vitro and in vivo genome engineering.Genome editing can be successfully used to decipher complex molecular mechanisms underlying disease pathophysiology,develop innovative next generation gene therapy,stem cell-based regenerative therapy,and personalized medicine for corneal and other ocular diseases.In this review we describe latest developments in the field of genome editing,current challenges,and future prospects for the development of personalized genebased medicine for corneal diseases.The gene editing approach is expected to revolutionize current diagnostic and treatment practices for curing blindness.

摘要： Hepatocyte transplantation is an alternative to liver transplantation in certain disorders such as inheritedliver diseases and liver failure.It is a relatively less complicated surgical procedure,and has the advantage that it can be repeated several times if unsuccessful.Another advantage is that hepatocytes can be isolated from partly damaged livers which are not suitable for liver transplantation.Despite these advantages hepatocyte transplantation is less popular.Important issues are poor engraftment of the transplanted cells and the scarcity of donor hepatocytes.Generation of "hepatocyte like cells"/i Heps from embryonic stem cells(ES) and induced pluripotent stem cells(iP SCs) by directed differentiation is an emerging solution to the latter issue.Direct conversation or trans-differentiation of fibroblasts to "hepatocyte like cells" is another way which is,being explored.However this method has several inherent and technical disadvantages compared to the directed differentiation from ES or i PSC.There are several methods claiming to be "highly efficient" for generating "highly functional" "hepatocyte like cells".Currently different groups are working independently and coming up with differentiation protocols and each group claiming an advantage for their protocol.Directed differentiation protocols need to be designed,compared,analyzed and tweaked systematically and logically than empirically.There is a need for a wellcoordinated global initiative comparable to the Human Genome Project to achieve this goal in the near future.

摘要： Complicated migraine encompasses several individual clinical syndromes of migraine. Such a syndrome in children frequently presents with various neurological symptoms in the Emergency Department. An acute presentation in the absence of headache presents a diagnostic challenge. A delay in diagnosis and treatment may have medicolegal implication. To date, there are no reports of a common clinical profile proposed in making a clinical diagnosis for the complicated migraine. In this clinical review, we propose and describe:(1) A common clinical profile in aid to clinical diagnosis for spectrum of complicated migraine;(2) How it can be used in differentiating complicated migraine from migraine without aura, migraine with aura, and seizure;(3) We discuss the status of complicated migraine in the International Headache Society classification 2013; and(4) In addition, a common treatment strategy for the spectrum of migraine has been described. To diagnose complicated migraine clinically, it is imperative to adhere with the proposed profile. This will optimize the use of investigation and will also avoid a legal implication of delay in their management. The proposed common clinical profile is incongruent with the International Headache Society 2013. Future classification should minimize the dissociation from clinically encountered syndromes and coin a single word to address collectively this subtype of migraine with an acute presentation of a common clinical profile.

摘要： 本发明涉及气垫船运动控制领域，具体涉及的是一种基于纵向速度规划的气垫船高速回转控制方法。本发明采用基于侧滑角约束的航速规划方法解决了气垫船采用传统非线性反馈控制在高速回转时的失速问题，能够保证气垫船在回转的同时实现精确的航速跟踪，提高了气垫船的机动性和作业能力，本发明在保证气垫船在高速回转过程中准确跟踪期望艏向的同时避免回转率过大导致的甩尾现象，提高了气垫船在高速回转时的可靠性和安全性。

摘要： 本发明适用于材料技术领域，提供了一种低光泽度聚氯乙烯材料及其制备方法、应用，其中，所述低光泽度聚氯乙烯材料包括以下重量份数的原料：聚氯乙烯树脂80～100份、稳定剂1～10份、增塑剂4～15份、加工助剂0.8～5份、改质剂4～15份、消光剂0～5.5份以及润滑剂0.5～5份。本发明通过稳定剂、增塑剂、加工助剂、改质剂、消光剂以及润滑剂各原料的合理配比，配合特定种类的聚氯乙烯树脂，所得到的低光泽度聚氯乙烯材料，不仅易于加工成型、且具有较为优异力学性能，且低光泽度，耐温以及成本低；另外，通过消光剂的加入可进一步降低材料光泽度的同时，进一步提高本发明聚氯乙烯材料机械力学性能，具有很好的经济效益。

摘要： 本发明涉及光纤耦合技术领域，尤其涉及一种高效率的叠阵型半导体激光器，包括激光源、光束整形组件、会聚透镜、鲍威尔棱镜组件和光纤；所述激光源发出的光束经过光束整形组件进行整形；整形后的光束经会聚透镜会聚，会聚后光束经过鲍威尔棱镜组件进行光束整形可以耦合进光纤的光束。本发明系统结构简单,便于操作,减少了操作步骤,光纤耦合效率达到84.3％。

摘要： 本申请公开了一种变频空调控制方法、装置、电子设备和介质。其中方法包括：获取空调的设置温度值，获取当前室内温度值；根据所述设置温度值、所述当前室内温度值和预设偏差阈值，确定所述变频空调的系统负荷率；获取当前室外温度值，获取所述变频空调的目标器件的信息；依据所述当前室外温度值、所述目标器件的信息以及所述系统负荷率，确认总传热温差；以达到所述总传热温差为目标，对所述变频空调的制冷系统进行控制，可以控制空调系统在不同负荷率下、不同室外温度值下运行在比较高的能效，实现空调系统节能运行。

摘要： 本发明涉及兽医生物技术领域，尤其涉及一种猪轮状病毒重组蛋白以及表达该蛋白的重组腺病毒和应用。所述所述重组蛋白由猪轮状病毒5型VP7蛋白和猪轮状病毒9型VP8蛋白连接组成，具体包括如SEQ ID NO:1所示的氨基酸序列。本发明将猪轮状病毒5型VP7蛋白和猪轮状病毒9型VP8蛋白的编码基因的基因序列构建至腺病毒表达载体中，并进行密码子优化，制备得到针对猪轮状病毒的重组腺病毒，该重组腺病毒表达的目的蛋白的结构和功能与天然状态完全一致，具有较高的安全性和免疫原性。

摘要： 本发明公开了一种改性TPEE电缆料及其制备方法，所述改性TPEE电缆料，按重量份数计，其组分包含改性TPEE100份，阻燃剂50‑100份，阻燃协效剂2‑10份，润滑剂1‑5份，抗氧剂1‑5份，助剂5‑10份。本发明提供的改性TPEE电缆料通过对TPEE接枝功能化石墨烯，以及对阻燃剂氢氧化镁进行改性，使其兼具优异的阻燃性能，力学性能，热老化性能以及加工性能，并且可回收利用，环境友好。

摘要： 本发明公开了一种路线规划方法，包括：获取N个订单的物流信息，所述物流信息包括订单地址，所述订单地址包括第一地址以及第二地址，其中，所述第一地址为目的地在直送范围内的地址，所述第二地址为目的地在直送范围外的地址，N为正整数；筛选出所述订单地址为所述第一地址的M个订单，确定配送M个订单的第一初始路线，对所述第一初始路线进行优化，得到第一优化路线，M为小于等于N的正整数；筛选出所述订单地址为所述第二地址的N‑M个订单，确定配送所述N‑M个订单的第二初始路线，对所述第二初始路线进行优化，得到第二优化路线。

摘要： 本发明公开了一种芳砜纶/四氧化三铁磁性长丝的制备方法，包括如下步骤：四氧化三铁磁性纳米颗粒制备、芳砜纶/四氧化三铁共混纺丝液制备、湿法纺丝，得到具有不同截面形状的磁性长丝。本发明可以实现芳砜纶的连续化湿法纺丝，制备过程温和可控；本发明将四氧化三铁磁性颗粒结合到芳砜纶纤维中，可以实现芳砜纶纤维的功能化，使得芳砜纶纤维具备磁性；本发明采用蛋白模板调控法制备四氧化三铁磁性颗粒，实现四氧化三铁磁性颗粒形貌及尺寸调控，同时使得纳米颗粒在纺丝液中分散均匀性；本发明制备的芳砜纶/四氧化三铁磁性长丝可用于保健、过滤、智能纺织品等领域。

摘要： 本发明属于污水处理技术领域，尤其是涉及一种污水水质预处理快速检测装置，包括检测水箱，检测水箱内壁上固定连接有第一竖板和第二竖板，第一竖板和第二竖板将检测水箱分隔成处理腔室、检测腔室和储存腔室，处理腔室内底壁上固定连接有向下延伸的梯形凸起，且梯形凸起内形成沉淀腔室，梯形凸起的下端固定连接有两根竖直的排污管，检测水箱的侧壁上固定连接有与处理腔室连通的污水进水管。优点在于：本发明可以对不同分层的污水进行水质检测，且多层之间的检测过程均为独立过程，不会出现相互之间的影响，能够对污水进行实时的检测，有助于后续的数据统计，另外采用分级式的检测方式，能够有效的对污水进行全面的检测，提高检测的质量。

摘要： 本发明公开了一种软硬件联合验证系统及方法。该系统包括：驱动软件、基于systemc模拟的存储器和异构集群；驱动软件嵌入在systemc框架中；驱动软件根据预设验证需求向异构集群发送驱动指令；存储器加载并保存待验证数据；异构集群根据驱动指令从存储器中提取待验证数据，计算得到输出数据，发送至驱动软件；驱动软件根据输出数据进行软硬件的联合验证。通过systemc模拟异构集群，驱动软件嵌入systemc框架，为驱动软件提供与硬件功能相等的模型，实现驱动软件对硬件的控制流程，协助软件前期的开发与调试，为硬件提供标准数据。解决了现有技术中软件与硬件在大多数的系统开发中分开进行，导致开发周期长的技术问题。