Zinc

摘要： neuromuscular disease caused by the homozygous mutation or deletion of the survival motor neuron 1(SMN1)gene.A second copy,SMN2,is similar to SMN1,but produces only~10%SMN protein because of a single-point mutation(C>T)in coding exon 7 causing a splicing defect which leads to the exclusion of exon 7,resulting in a majority(~90%)of transcripts lacking exon 7 that translate into mutant SMN(SMNΔ7)protein.SMA is caused by chronic low levels of SMN and is characterized by the degeneration of the spinal cord motor neurons leading to symmetrical skeletal muscle atrophy,respiratory failure,and death(Ahmad et al.,2012).Chronic low levels of SMN cause the accumulation of pathogenic R-loops and double-stranded breaks(DSBs)in DNA,leading to genomic instability and neurodegeneration in SMA(Kannan et al.,2018).The severity of SMA disease correlates inversely with SMN levels.

摘要： Hepatic encephalopathy(HE)is a reversible syndrome of impaired brain function and represents one of the many complications of portal hypertension and decompensated liver disease.Although ammonia is clearly implicated in the pathogenesis of HE,the pathogenesis of HE is multifactorial with numerous mechanisms that results in functional impairment of neuronal cells.The initial management of HE focuses on supportive care and stabilization which includes providing appropriate nutritional support.Thereafter,focus should be on identifying and treating the precipitating factors.There are many therapeutic agents available for the management of HE,most of which are directed towards lowering the gut nitrogen load and thus the serum ammonia level.This review aims to provide an update on the conventional and emerging treatment options for HE.

摘要： Micronutrients deficiency is a major limiting factor for increasing yield and productivity of major crops in India. Recent findings of multiple micronutrients interactions have evidenced the indispensable role played by micronutrients in plant nutrition. Though they are needed in smaller quantities, however, their availability in the Right amount, at the Right time, and for the Right crop has been a major limiting factor for improving the productivity and yield of Sugarcane in northern Karnataka state of India. This study was conducted to assess the level of Boron (B), Copper (Cu), Iron (Fe), Manganese (Mn) and Zinc (Zn) deficiencies in Sugarcane growing Vertisols of six micro-watersheds in northern Karnataka. The six selected micro-watersheds were intensively traversed and six representative pedons of standard dimensions were dug and horizon-wise soil samples collected and analyzed for various micronutrients using standard analytical procedures. Based on the optimum critical levels of micronutrients, B, Fe and Zn were deficient, ranging from 0.15 - 0.64, 1.23 - 5.92 and 0.11 - 0.64 mg⋅kg?1 respectively while Cu and Mn were in excess, ranging from 1.54 - 7.62 and 1.22 - 7.03 mg⋅kg?1 respectively. The distribution of B, Fe and Zn were inversely proportional to soil depth whereas that of Cu and Mn were irregular, which is an indication of the influence of pedoturbation in these soils. With the current rate of agricultural intensification, unbalanced fertilizer application, depletion of nutrients and no replenishment by smallholders, the results reveal that the current deficiency levels may increase further if appropriate and timely actions are not taken. We therefore recommend the use of site-specific nutrient management, balanced fertilizer application and good agronomic practices. These can enhance nutrient use efficiency in the study area.

摘要： BACKGROUND At present,there is no ideal method to cure diabetes,and there are few reports on the treatment of diabetes with probiotics.AIM To propose a method for preparing a new type of chromium-and zinc-rich Acetobacter aceti(A.aceti)and explore its ability to enhance the hypoglycemic effects of probiotics in the treatment of diabetes.METHODS A.aceti was cultured in a liquid medium that contained chromium trichloride and zinc chloride,both at a concentration of 64 mg/mL,with the initial concentration of the bacterial solution 1×10^(4) CFU/mL.After the bacterial solution had been inducted for 48 h,the culture media was changed and the induction was repeated once.The levels of chromium and zinc in the bacteria were detected by inductively coupled plasma mass spectrometry,and the contents of NADH and glucose dehydrogenase were determined using an NAD/NADH kit and glucose dehydrogenase kit,respectively.Streptozotocin was used to establish a mouse model to evaluate the hypoglycemic effects of the proposed chromium-and zincrich A.aceti.Ten-times the therapeutic dose was administered to evaluate its biological safety.The effect on MIN6 islet cells was also assessed in vitro.RESULTS The levels of chromium metal,metallic zinc,NADH coenzyme,and glucose dehydrogenase in A.aceti prepared by this method were 28.58-34.34 mg/kg,5.35-7.52 mg/kg,5.13-7.26μM,and 446.812-567.138 U/g,respectively.The use of these bacteria resulted in a better hypoglycemic effect than metformin,promoting the repair of tissues and cells of pancreatic islets in vivo and facilitating the growth of MIN6 pancreatic islet cells and increasing insulin secretion in vitro.Ten-times the therapeutic dose of treatment was non-toxic to mice.CONCLUSION Chromium trichloride and zinc chloride can be employed to induce the preparation of chromiumand zinc-rich A.aceti,which can then promote the hypoglycemic effect found in normal A.aceti.The bacteria biotransforms the chromium and zinc in a way that could increase their safety as a treatment for diabetes.

摘要： The most common allergic dermatitis of the horse is associated with hypersensitivity to insect bites. A purely hereditary-based background to this allergic pruritus has not been shown, and so far, it is not fully understood why some horses are more susceptible than others. Although altered zinc levels have been detected in many inflammatory and allergic disorders, changes in various trace elements have not been widely investigated in horses with allergic dermatitis. Therefore, the purpose was to analyse trace element profiles in the sera of 8 affected and 8 matched healthy horses and to further assess whether the profiles change after therapy of the affected animals. Sera were collected both before and after therapy of the eczema horses. Samples were analysed by inductively coupled plasma mass spectrometry for their iron (Fe), copper (Cu), zinc (Zn), titanium (Ti), vanadium (V), chromium (Cr), manganese (Mn), cobalt (Co) and nickel (Ni) content. Concentrations of Zn and Ni were significantly lower in eczema than in healthy horses (p = 0.0089 and p = 0.0018, respectively). In addition, concentrations of Fe, Zn and Ni displayed significant inverse associations with the severity of clinical signs (p = 0.0075, p = 0.0397 and p = 0.0011, respectively). After a 4-week therapy, no significant differences were found between the groups. Concentrations of Ti were exceptionally stable both between the horses and over time. Horses with allergic dermatitis have alterations in their trace element profiles in comparison with healthy horses. Alterations seem to diminish when clinical signs are regressing.

摘要： It was shown that the concentration of heavy metal ions Fe3+, Cu2+, Cr3+ and Zn2+, which are contained in the fermentation medium, affects the process of biogas production. The aim of this paper was to establish the concentration of ions, which makes it possible to increase the yield of biogas and the methane content in it. The total yield of biogas per unit of dry organic matter, methane and the kinetics of changes in the yield of biogas during fermentation of cattle manure in the presence of different concentrations of metal ions in the anaerobic environment. It was established that the content of Fe3+, Cu2+ is up to 80 mg/dm3, Cr3+ and Zn2+ is up to 50 mg/dm3 in the medium lead to increased methane production by anaerobic association of microorganisms due to the effect on the activity of enzyme systems in comparison with the sample without the addition of metal ions. It was found that the rational concentrations to increase the methane yield in the biogas obtained by fermentation of cattle manure are: Fe3+-20 - 40 mg/dm3, Cu2+-40 - 60 mg/dm3, Cr3+-10 mg/dm3. The increase in the concentration of metal ions above rational values leads to a decrease in the methane content in biogas. It was shown that zinc ions have a positive effect on methane production, but reduce the total biogas yield and, accordingly, the degree of conversion of organic raw materials. Therefore, the rational concentration of Zn2+ in the fermentation medium is 10 mg/dm3.

摘要： To evaluate the zinc(Zn)remediation capacity of four alfalfa species,the effects of different concentrations of Zn on plant growth,Zn uptake and translocation as well as uptake of other nutrients were investigated.The results showed that the Zn tolerance index of Aohan was significantly higher than other species.Among the four species,Aohan had the highest concentration of Zn in roots,followed by Golden Empress,Sanditi and Longxi.Aohan had the highest bioconcentration factor(BCF)in leaves.Whereas,Sanditi and Longxi had the lowest BCF in stem and roots,respectively.The translocation factor of Golden Empress was significantly lower than other species.The Zn accumulation rate of Aohan was higher than other species regardless of the concentration of Zn.Longxi had the lowest allocation of Zn in leaves and Golden Empress had the lowest allocation of Zn in roots.The concentrations of other elements(Fe and Mg)in leaves were decreased with Zn additions,but the interactions between Zn and other elements in roots varied with species.These results indicated that suitable species of alfalfa could successfully be used for the phytoremediation of Zn-contaminated soils.

摘要： In recent years,heavy metal hazards in the soil have seriously affected agricultural production.This study aims to examine the effects of different levels of heavy metal Zn on the growth,photosynthesis and physiological characteristics of wheat,and provide a theoretical basis for the diagnosis and control of heavy metal pollution in agricultural production.The field test method was used to explore the changes of wheat agronomic traits,photosynthetic capacity,chlorophyll fluorescence parameters,spectral characteristic curve,active oxygen metabolism system,cell ultrastructure,and yield,under different Zn levels(0,250,500,750,and 1000 mg kg^(-1)).The results show that,low-level Zn treatments can effectively promote the synthesis of wheat chlorophyll,improve photosynthetic capacity,and increase yield.The yield of ZnL1(250 mg kg^(-1))was the highest in the two-year test,which increased by 20.4%in 2018 and 13.9%in 2019 compared with CK(0 mg kg^(-1)).However,a high Zn level had a significant stress effect on the photosystem of wheat.PIabs(reaction center performance index)and Fv/Fm(maximum photochemical efficiency)were significantly reduced,the active oxygen metabolism system was damaged,and the photosynthetic capacity was reduced,which in turn led to reduced yield.Among them,the yield of ZnL4(1000 mg kg^(-1))was the lowest in the two-year test,which was 28.1 and 16.4%lower than CK in 2018 and 2019,respectively.The green peak position of ZnL3 and ZnL4 had"red shift"to the long wave direction,while the red valley position of ZnL4 had"blue shift"to the short wave direction.Under ZnL4,some wheat leaf organelles began to decompose,vacuoles increased,cytoplasm decreased,cell walls thickened,chloroplast basal lamellae were disordered,and mitochondrial membranes disintegrated.Stepwise regression and Path analysis showed that Pn(net photosynthetic rate)played a leading role in the formation of yield.Redundancy(RDA)analysis showed that the optimal Zn level for wheat growth was about 250 mg kg^(-1),and wheat would be stressed when the soil Zn level exceeded 500 mg kg^(-1) in the test condition of this study.Findings of this study provide a theoretical basis for the diagnosis and prevention of heavy metal(Zn)pollution in the soil.

摘要： Alzheimer's disease(AD)is one of the most common age-related neurodegenerative disorders that have been studied for more than 100 years.Although an increased level of amyloid precursor protein is considered a key contributor to the development of AD,the exact pathogenic mechanism remains known.Multiple factors are related to AD,such as genetic factors,aging,lifestyle,and nutrients.Both epidemiological and clinical evidence has shown that the levels of micronutrients,such as copper,zinc,and iron,are closely related to the development of AD.In this review,we summarize the roles of eight micronutrients,including copper,zinc,iron,selenium,silicon,manganese,arsenic,and vitamin D in AD based on recently published studies.

摘要： Nanoscience is a development concept in the field of agriculture. Water scarcity is one of the most serious stresses that restrict growth of plant. This search was done to value the positive and negative influence of ZnO nanoparticles on wheat plant growth under drought stress. A green synthesis technique was used to produce pollutant-free nano structures. A field experiment was carried out during successive season (2019/2020). NP-Zn-O was applied either by seed-soaking, foliar spraying, or both together applications. The dose of ZnO NPs was 100 mg/l. Data showed that drought stress reduced the grain and shoot wheat yield. The use of different forms of ZnO improved the grain and shoot wheat yield, these increases reached 1.16-, 1.54-fold that control. In addition, one of the other effects of Zn-O-NPs is to increase the levels of chlorophyll and proline antioxidants in plant tissues, as it is a cofactor for enzymes such as superoxide dismutase and catalase. The data suggest that the role of ZnO NPs is not only to improve plant growth and physiological parameters, but also to improve nutrient uptake and plant nutrient levels. In this regard, the use of zinc in the form of ZnO NPs has a positive effect on reducing the adverse effects of drought conditions and improving the nutritional quality of plants.

摘要： The purified Co-Ni residue, in the process of zinc hydrometallurgy, is treated with the hydrometallurgical process. The flow sheet, which is researched by us, indicates that cobalt, nickel and cadmium can be recovered respectively, and zinc can be returned into zinc hydrometallurgy system. Sulphuric acid is used to leach the residue, and the optimized leaching conditions are that sulphuric acid quantity is 1.2-1.4 times to theoretical consumption, temperature is 60°C-80°C, leaching period is 60 min-80 -min., Leaching rates of zinc, cobalt, nickel and cadmium are up to 98% under the above condition.

摘要： Trace elements,especially heavy metals,are considered to be one of the main sources of pollution in the environment,Since they have a significant effect on i0ts ecological quailty.Human activities often mobilize and redistribute natural substances in the environment so much so that they can cause adverse effect environment so much so that they can causeintroduced into lake andadverse effect .a number of chemical,reservoir waters by riverine or atmosphericTrace heavy metalsinputs are involved inbiological and physical processes that control their concentrations inthe aqueous phase, and inspeciation of an element in environmentbioavailability , soil organic matter ingovernsenvironmentsites duereleasedill-defined substances, ediments. In general, the chemicalits biogeochemical behavior andpresents a large number of bindingbioorganisms. The largesubstances,.g，humic matter, or to different type of ligandsnumber of ionisable functional groups in humicsubstances,mainly carboxylic and phenolic groups, results in an appreciable ability to formstable complexes with heavy metal canons. In addition, different binding sites may presentdifferent degrees of lability, i.e., different dissociation rate constants. This depends notonly on the type of the metal ions and organic matter that are present in solution, but alsoon tnetr relative concentration .Due to the large number of complexmg sites withdifferent functional groups and different affinities for heavy metal canons (chemicalbydyheterogeneity), the complexation properties of humic substances are representedaverage stability parameters orequilibrium distribution functions. The complexation properties of humic andaim of this stuwas to study and compare theisolated from soils.fulvic substance.

摘要： 本发明属于高分子材料领域，具体涉及一种PBSeT/Zinc gluconate耐穿刺生物可降解材料及其制备方法；所述PBSeT/Zinc gluconate耐穿刺生物可降解材料由以下重量份配比的原料制备而成：PBSeT 90~100份，Zinc gluconate0~10份；制备方法包括将合成的PBSeT在鼓风干燥箱中干燥12h后，再将PBSeT和Zinc gluconate进行熔融共混，得到PBSeT/Zinc gluconate耐穿刺生物可降解材料；本发明提供的共混条件下制备的PBSeT/Zinc gluconate生物可降解材料耐穿刺性能比单一的PBSeT生物可降解材料耐穿刺性能提高25%以上。本发明的制备方法可改善PBSeT生物可降解材料的耐穿刺性能，具有一定的市场价值。

摘要： 本发明公开了ZINC62678696在制备抑制肝纤维化药物的用途。本发明提供了能够降低GPR65活性的物质——抑制剂ZINC62678696在制备能够治疗肝纤维化的产品中的应用。本发明通过研究肝纤维化过程中GPR65的作用及机制，发现抑制巨噬细胞中GPR65的活性能够减轻肝纤维化的病情进展。本发明对于肝纤维化的发病机制的研究以及未来治疗策略的选择具有重要参考意义。

摘要： 本发明以ZINC数据库中ZINC19909927为材料，采用CCK8法检测ZINC19909927对肺腺癌细胞的杀伤效果，实验证明，ZINC19909927对肺腺癌细胞的增殖具有明显的抑制作用，为新型抗肿瘤药物的开发提供依据。

摘要： 本发明属于高分子材料领域，具体涉及一种PBSeT/Zinc gluconate耐穿刺生物可降解材料及其制备方法；所述PBSeT/Zinc gluconate耐穿刺生物可降解材料由以下重量份配比的原料制备而成：PBSeT 90~100份，Zinc gluconate0~10份；制备方法包括将合成的PBSeT在鼓风干燥箱中干燥12h后，再将PBSeT和Zinc gluconate进行熔融共混，得到PBSeT/Zinc gluconate耐穿刺生物可降解材料；本发明提供的共混条件下制备的PBSeT/Zinc gluconate生物可降解材料耐穿刺性能比单一的PBSeT生物可降解材料耐穿刺性能提高25%以上。本发明的制备方法可改善PBSeT生物可降解材料的耐穿刺性能，具有一定的市场价值。

摘要： 本发明公开了ZINC62678696在制备抑制肝纤维化药物的用途。本发明提供了能够降低GPR65活性的物质——抑制剂ZINC62678696在制备能够治疗肝纤维化的产品中的应用。本发明通过研究肝纤维化过程中GPR65的作用及机制，发现抑制巨噬细胞中GPR65的活性能够减轻肝纤维化的病情进展。本发明对于肝纤维化的发病机制的研究以及未来治疗策略的选择具有重要参考意义。

摘要： 本发明提供一种包含至少一种榆绿木(Anogeissus)属提取物和在吡咯烷酮羧酸锌的局部组合物，以及一种用于治疗人类皮肤以得到改善的方法，所述方法包含向皮肤施加包含至少一种榆绿木属提取物吡咯烷酮羧酸锌的局部组合物。