呼吸功能不全/治疗

呼吸功能不全/治疗的相关文献在2002年到2017年内共计146篇,主要集中在内科学、临床医学、儿科学 等领域,其中期刊论文145篇、专利文献1380541篇;相关期刊14种,包括科学养生、中华实用中西医杂志、医学临床研究等; 呼吸功能不全/治疗的相关文献由362位作者贡献,包括万绍勇、付四毛、刘志光等。

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呼吸功能不全/治疗

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  • 万绍勇
  • 付四毛
  • 刘志光
  • 刘玉玲
  • 孙师元
  • 崔朝勃
  • 张卫东
  • 张巧莉
  • 张志培
  • 曾凡茂
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    • 王建宇; 付国强; 任彬; 王伯良
    • 摘要: Objective:To investigate the effect of noninvasive ventilation on PaCO2, SpO2 changes and adverse reactions of COPD with respiratory failure.Methods:122 patients with COPD and II respiratory failure were selected.All patients were randomly divided into observation group and control group, each group got 61 cases.The clinical efficacy, PaO2, PaCO2, SpO2, RR, HR before and after treatment, and adverse reactions after treatment of the two groups were compared.Results:The total effective rate of the observation group (80.3%) was significantly higher than that of the control group (63.9%)(P0.05).Conclusion:Noninvasive ventilator can effectively improve PaO2, PaCO2, SpO2 in patients with COPD accompanied with respiratory failure of II, relieve symptoms of dyspnea, less adverse reactions.%目的:探讨无创呼吸机对COPD并发呼吸衰竭PaCO2、SpO2的影响.方法:将122例COPD并发II型呼吸衰竭患者随机分为两组,在常规治疗基础上,观察组61例采用吸氧联合无创呼吸机治疗,对照组61例仅采用低流量吸氧治疗.比较两组患者的临床疗效及治疗前后PaO2、PaCO2、SpO2、RR、HR,治疗后不良反应发生情况.结果:观察组患者总有效率为80.3%,显著高于对照组的63.9%(P0.05).结论:无创呼吸机可有效改善COPD伴II型呼吸衰竭患者PaO2、PaCO2、SpO2指标,可迅速缓解患者的呼吸困难,不良反应少.
    • 李登媛; 周向东
    • 摘要: 目的:比较无创通气联合不同时机给予氧气雾化吸入治疗慢性阻塞性肺疾病急性加重期(AECOPD)合并Ⅱ型呼吸衰竭的疗效。方法将2015年1~12月重庆医科大学附属第二医院呼吸科收治的60例AECOPD合并Ⅱ型呼吸衰竭患者随机分为观察组和对照组,每组30例。观察组在无创通气治疗同时给予氧气雾化吸入,对照组于无创通气治疗间歇期给予氧气雾化吸入。观察两组患者临床疗效和相关指标改善情况。结果观察组总有效率[93.3%(28/30)]、pH 值(7.40±0.06)、动脉血氧分压[(82.93±12.36)mm Hg]、动脉血二氧化碳分压[(62.00±6.92)mm Hg]、心率[(92.50±5.40)次/分]、呼吸频率[(16.00±3.00)次/分]、用力1秒呼气量[(3.20±0.50)V/L]及6分钟步行试验[(260.00±30.00)m]明显优于对照组[分别为56.7%(17/30),7.38±0.14,(79.75±12.76)、(65.03±8.90)mm Hg,(95.60±7.70)、(20.00±4.00)次/分,(2.90±0.50)V/L,(240.00±25.00)m],差异均有统计学意义(P<0.05)。结论无创通气同时联合雾化吸入药液治疗AECOPD合并Ⅱ型呼吸衰竭具有显著疗效。%Objective To compare the effects of noninvasive ventilation combined with different timing for giving the oxygen atomizing inhalation in the treatment of the patients with acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) complicating type II respiratory failure. Methods Totally 60 patients with AECOPD complicating type Ⅱ respiratory failure admitted to the respiration department of the Second Affiliated Hospital of Chongqing Medical University from January to December 2015 were randomly divided into the observation group and control group ,30 cases in each group. The observation group was given the oxygen atomizing inhalation combined with noninvasive ventilation at the same time ,while the control group was given oxygen atomizing inhalation in the interval of noninvasive ventilation. The clinical efficacy and improvement of relevant indicators were observed in two groups. Results The total effective rate,pH value,arterial oxygen partial pressure,arterial car-bon dioxide partial pressure,heart rate,respiratory rate,forced expiratory volume in one second(FEV1) and 6 min walking test in the observation group were 93.3%(28/30),7.40 ±0.06, (82.93 ±12.36)mm Hg, (62.00 ±6.92)mm Hg, (92.50 ±5.40)beats/min, (16.00±3.00)times/min,(3.20±0.50)V/L and(260.00±30.00)m,which were significantly better than 56.7%(17/30),7.38±0.14, (79.75±12.76)mm Hg,(65.03±8.90)mm Hg,(95.60±7.70)beats/min,(20.00±4.00)times/min,(2.90±0.50)V/L and(240.00± 25.00)min the control group,the differences were statistically significant(P<0.05). Conclusion Noninvasive ventilation combine with drug atomizing inhalation has a significant effect for treating AECOPD complicating typeⅡrespiratory failure.
    • 王荣欣; 秦俭; 孙长怡
    • 摘要: 【目的】探讨呼吸衰竭患者急救时机与患者生存状况的关系。【方法】收集呼吸衰竭患者200例的临床资料,根据插管时机的选择分为对照组和观察组,统计两组患者的生存情况,分析插管时机与患者生存状况的相关性。【结果】观察组的病死率为25.40%,明显低于对照组55.41%,差异有统计学意义(P <0.05);观察组平均呼吸机使用时间(53.47±13.42)h,短于对照组(67.52±15.72)h,差异有统计学意义(P <0.05)。Logistic 回归多因素分析结果显示:急救时机、年龄、营养状况、pH、动脉二氧化碳分压(PaCO 2)、动脉氧分压(PaO 2)及血液中乳酸平均含量是影响急性呼吸衰竭患者生存的独立危险因素。【结论】急救时机与呼吸衰竭患者的病死率及平均呼吸机使用时间密切相关。%[Objective]To investigate the effect of emergency treatment timing on the survival situation of patients with respiratory failure.[Methods]200 clinic patients with respiratory failure were collected.upon the timing of intubation conditions,Patients were divided into the observation group and the control group,The rate of survival and the risk factors associated with survival were analyzed.[Results]The mortality rate in the observation group was 25.40%,significantly lower than the control group (55.41%),the difference was sta-tistically significant (P <0.05 );the average ventilator time of observation group was (53.47 ± 13.42 )h, which was shorter than the control group (67.52 ± 1 5.72)h,the difference was statistically significant (P <0.05 ).Logistic regression analysis showed that:time of intubation,age,nutritional status,averages pH, PaCO 2 values (mm Hg),PaO 2 values (mm Hg),and the average content of lactic acid in the blood (mmol/L)compose the risk factors associated with survival situation in patients with respiratory failure.[Conclusion]The timing of emergency and average time of ventilator.are closely related to the mortality in patients with re-spiratory failure.
    • 肖丽娟; 李再清
    • 摘要: [Objective] To explore the clinical efficacies of fiber bronchoscope‐guided nasotracheal intubation plus lung lavage in the treatment of acute respiratory failure (ARF) .[Methods]A total of 180 patients fulfilled the stand‐ard diagnostic criteria of ARF were divided into treatment and control groups ( n=90 each) .The treatment group underwent fiberoptic bronchoscope‐guided nasotracheal intubation and lung lavage .And the control group had laryn‐goscopic orotracheal intubation .And the clinical efficacies were compared for two groups .[Results] The intubation durations of treatment and control groups were 2 .2 ± 1 .2 and 3 .1 ± 2 .3 min ,mechanical ventilation time 105 .38 ± 45 .89 and 197 .32 ± 89 .13 hours and hospitalization time 9 .68 ± 2 .89 and 15 .88 ± 2 .12 days respectively .The treat‐ment group was shorter than the control group ( P<0 .05) .Intubation was all successful at one time for 90 cases in treatment group versus 74 cases in control group .The intubation success rate of treatment group was significantly higher than that of control group (100% vs 82 .22% ) .And the rescue success rate of treatment group was signifi‐cantly higher than that of control group (94 .44% vs 85 .56% ,P<0 .05) .[Conclusion]As compared with traditional laryngoscopic orotracheal intubation ,fiberoptic bronchoscope‐guided nasotracheal intubation plus lung lavage is more rapid ,safer and efficient for ARF patients .%【目的】探讨纤支镜引导下经鼻气管插管联合肺灌洗治疗急性呼吸衰竭的临床疗效。【方法】选择本院符合急性呼吸衰竭诊断标准的180例患者按插管方式不同分为两组,观察组90例行纤维支气管镜引导下经鼻气管插管及肺灌洗治疗,对照组90例予喉镜经口气管插管,比较两组患者的临床疗效。【结果】观察组和对照组气管插管时间分别为(2.2±1.2)min、(3.1±2.3)min ,机械通气时间分别为(105.38±45.89)h、(197.32±89.13)h ,住院时间分别为(9.68±2.89)d、(15.88±2.12)d ,观察组均明显短于对照组,且两组相比较差异有显著性( P <0.05);观察组90例全部一次插管成功,对照组74例一次插管成功,一次插管成功率观察组(100%)明显高于对照组(82.22%),观察组抢救成功率(94.44%)明显高于对照组(85.56%),且两组相比较差异有显著性( P <0.05)。【结论】纤支镜引导下经鼻气管插管联合肺灌洗治疗较传统喉镜经口气管插管能更快速、安全、高效地抢救急性重症呼吸衰竭患者。
    • 彭旭; 张智搏; 谭红; 唐璐; 张丹; 姜波涛
    • 摘要: 目的探讨无创机械通气在吉兰-巴雷综合征并呼吸衰竭患者中的临床应用价值。方法32例吉兰-巴雷综合征并呼吸衰竭患者,按随机数字表法分为对照组16例和观察组16例。对照组给予有创通气;观察组给予无创通气,如病情恶化给予有创通气。结果对照组机械通气时间[(9.6±1.8)d vs (6.5±1.3)d, P <0.05]、住神经科重症监护室(NICU)时间[(13.4±3.1)d vs (8.1±2.3)d, P <0.05]、抗生素使用时间[(15.2±3.7)d vs (10.5±3.5)d, P <0.05]明显长于观察组;对照组呼吸机相关性肺炎发生率明显高于观察组(37.5%vs 6.25%, P <0.05);两组病死率均为6.25%。结论与有创机械通气比较,无创机械通气可以降低吉兰-巴雷综合征并呼吸衰竭患者机械通气时间、住NICU时间、抗生素使用时间和呼吸机相关性肺炎发生率。
    • 牛新荣; 刘艳
    • 摘要: 目的 探讨有创-无创序贯机械通气治疗心脏术后所致急性呼吸衰竭(ARF)的效果.方法 选取因心脏术后收入ICU且并发呼吸衰竭40例患者入组,其中序贯通气组20例,对照组20例,当两组患者血流动力学趋于稳定,但尚未达到拔管指征时,机械通气治疗出现改变,序贯通气组予以逐步撤机,继而无创正压通气(NPPV)治疗,对照组继续有创正压通气(IPPV)治疗,达到拔管指征后可撤离机械通气与拔除气管插管.结果 序贯通气组给予NPPV治疗后,心率、呼吸、氧分压较对照组明显改善,而且序贯通气组在有创通气时间、总机械通气时间、住院时间、呼吸机相关肺炎和撤机失败等指标较对照组明显减少,差异有统计学意义(P<0.05).结论 有创-无创序贯通气对心脏术后并发急性呼吸衰竭的患者成功撤机具备一定作用.
    • 杨渭临; 张晓艳; 章琳; 孙师元
    • 摘要: 目的:探讨自动变流(Autoflow )在慢性阻塞性肺病急性发作(AECOPD)并发Ⅱ型呼吸衰竭患者机械通气中的临床应用价值。方法:54例A EC O PD并发Ⅱ型呼吸衰竭患者,经气管插管行机械通气治疗,给予同步间歇指令通气(SIM V )+压力支持通气(PSV ),病情稳定后随机分为SIM V-PSV组(对照组)和 SIM V-PSV + AutoFlow 组(治疗组)。继续治疗4~6h ,对两组心率(HR)、平均动脉血压(MAP)、动脉血气(ABG)、浅快呼吸指数(f/VT)、撤机时间、气道吸气峰压(PIP)、气道平均压(Pmean)、气道阻力(R)、胸肺顺应性(C)和分钟通气量(VE)等数据进行统计学分析。结果:治疗组f/V T、撤机时间、Pmean、R低于对照组( P<0.05);PIP低于对照组( P<0.01);C高于对照组(P<0.01)。结论:AECOPD并发Ⅱ型呼吸衰竭患者机械通气使用Autoflow 既可以保证分钟通气量、降低气道压、减少人-机对抗,在一定程度上还可改善胸肺顺应性、减少患者在IC U住院时间。%Objective :Investigating the clinical value of Autoflow in therapy of mechanically ventilated pa-tients with RFⅡ(type Ⅱ respiratory failure) caused by AECOPD .Methods :When got stable ,54 patients with RFⅡ caused by AECOPD ,who had received treatments of mechanically ventilation under SIMV + PSV mode though tracheal cannula ,were divided into two groups as SIMV-PSV group and SIMV-PSV+Alow group .Then ,after 4~6 hours of continuous treatment ,HR(heart rate) ,MAP(mean arterial pressure) ,ABG(arterial blood gases) ,f/VT (frequency/tidal volume ratio) ,weaning time ,PIP(peak inflation pressure) ,Pmean(mean airway pressure) ,R(air-way resistance) ,C(chest-lung compliance) and VE(minute ventilation) were recorded so that comparisons could be done .Results :Compared with SIMV-PSV group ,f/VT ,weaning time ,Pmean and R in SIMV-PSV+ Autoflow group were lower significantly (P<0 .05) ,PIP was lower significantly (P<0 .01) ,and C was higher significantly (P<0 .01) .Conclusions :Autoflow in mechanically ventilation treatments could ensure minute ventilation ,decrease airway pressure and improve man-machine counteraction ,and in part ,could also improve chest-lung compliance and decrease hospitalization time in ICU .
    • 赵飞; 刘志光
    • 摘要: [目的]探讨呼吸重症监护病房的慢性阻塞性肺病(COPD)急性加重期(AECOPD)合并高碳酸血症意识障碍疗效观察.[方法]回顾性分析对39例AECOPD合并呼吸衰竭高碳酸血症意识障碍患者8≤GCS评分<15在急性发作期入住呼吸重症监护病房,予无创正压通气治疗,观察机械通气前与机械通气后2h、d1、d2、d3的pH值、动脉二氧化碳分压(PaCO2)、碳酸氢根离子(HCO3-)、氧合指数指标的变化情况.根据无创通气治疗前GCS评分分为两组,A组为(10≤GCS评分<15),B组为(8分≤GCS评分<10分),对两组指标进行比较.[结果]无创呼吸治疗39例AECOPD意识障碍患者,平均住院时间为(17±10)d,住ICU的时间为(9±5)d,APACHE-Ⅱ评分平均(15.4±2.2)分.上呼吸机2h后GCS评分较机械通气前升高且有显著差异(P <0.01),动脉血气指标的PaCO2值明显低于机械通气前(P<0.01),治疗后pH高于机械通气前(P <0.05).对NIPPV治疗前GCS评分A组(10≤GCS评分<15)同B组(8≤GCS评分<10)相比,在APACHE-Ⅱ评分(P<0.05)、pH值(P<0.01)、PaCO2有显著差异(P<0.01).[结论]NIPPV对于AE-COPD合并呼吸衰竭高碳酸血症意识障碍有效,临床上能减少AECOPD及高碳酸血症呼吸衰竭患者的插管率及住院病死率.
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