摘要:
Objective To analyze the therapeutic effect ofShengji-Yuhong ointment in the treatment of patients with pressure ulcer.Methods 86 patients of pressure ulcer were randomly divided into a control group and an observation group, with 43 cases in each. After debridement, the wound was covered with vaseline gauze in the control group, whileShengji-Yuhong ointment in the treatment group. 10 days constituted 1 course of treatment, and both groups were treated for 3 courses. The blood supply of the whole blood viscosity, plasma viscosity, erythrocyte aggregation index detection; white blood cell count (WBC), erythrocyte sedimentation rate (ESR), and C reactive protein (CRP) were observed in order to observe the control condition of the patients with wound infection.Results The total effective rate was 95.3% (41/43) and 74.4% (32/43) in the observation group and control group respectively, with significant difference between two groups (χ2=5.800,P=0.016). After treatment, the whole blood viscosity (high-shea) (4.06 ± 1.38 mPa•svs. 4.74 ± 1.62 mPa•s,t=2.095), the whole blood viscosity (medium-shea) (3.71 ± 1.22 mPa•svs. 4.34 ± 1.41 mPa•s,t =2.216), blood reduction viscosity (1.13 ± 0.22 mPa•svs.1.44 ± 0.51 mPa•s,t=3.660), the whole blood viscosity (medium-shea) (4.16 ± 0.48 mPa•svs. 4.51 ± 0.89 mPa•s,t=2.270) obviously compared with group before treatment decreased (P<0.05). The patients in the observation group in the whole blood viscosity (medium-shea) (3.71 ± 1.22 mPa•svs. 4.16 ± 0.48 mPa•s,t=2.251), and blood reduction viscosity (1.13 ± 0.22 mPa•svs. 1.32 + 0.31 mPa•s,t=3.278) in the observation group were obvious better than the control group (P<0.05). After the treatment the WBC, CRP, ESR in the observation group were decreased significantly than the control group (t=5.947, 7.198, 12.064,P<0.01).ConclusionShengji-Yuhong ointment can effectively control the PU infection in the wound, improve wound tissue under the blood circulation, and promote wound healing.%目的:评价生肌玉红膏治疗压力性溃疡(pressure ulcer, PU)的疗效。方法将符合纳入标准的PU患者按随机数字表法分为2组各43例。清创后,对照组于创面上覆盖凡士林油纱布,观察组外敷生肌玉红膏,10 d为1个疗程,3个疗程后评价临床疗效,检测全血黏度、血浆黏度、红细胞聚集指数以观察创面血供情况;检测白细胞计数(white blood cells, WBC)、红细胞沉降率(erythrocyte sedimentation rate, ESR)、C反应蛋白(C-reactive protein, CRP)水平以判定创面感染的控制情况。结果观察组和对照组的总有效率分别为95.3%(41/43)、74.4%(32/43),2组比较差异有统计学意义(χ2=5.800,P=0.016)。治疗后,观察组全血黏度高切[(4.06±1.38)mPa•s 比(4.74±1.62)mPa•s,t=2.095]、中切[(3.71±1.22)mPa•s 比(4.34±1.41)mPa•s,t=2.216],血浆黏度[(1.13±0.22)mPa•s比(1.44±0.51)mPa•s,t=3.660],对照组全血中切[(4.16±0.48)mPa•s比(4.51±0.89)mPa•s,t=2.270]均较同组治疗前明显降低(P<0.05)。观察组治疗后全血中切[(3.71±1.22)mPa•s 比(4.16±0.48)mPa•s,t=2.251]、血浆黏度[(1.13±0.22)mPa•s 比(1.32±0.31)mPa•s,t=3.278]降低情况较对照组更为明显(P<0.05)。治疗后,观察组WBC、CRP、ESR明显低于对照组(t值分别为5.947、7.198、12.064,P均<0.01)。结论生肌玉红膏可有效控制PU患者的创面感染,改善创面下组织的血液循环,促进创面愈合。