摘要：
目的 探讨红花黄色素在心脏瓣膜置换术前辅助治疗中的应用效果及安全性.方法 将因二尖瓣或主动脉瓣病变拟行心脏瓣膜置换术的100例患者随机分为研究组和对照组各50例.术前研究组、对照组分别给予注射用红花黄色素、生理盐水静脉滴注至手术前1 d.比较用药后两组患者左室射血分数(LVEF)、血清N末端脑利钠肽原(NT-proBNP)水平,以及术前调整时间、心脏复跳方式、呼吸机辅助时间、ICU停留时间、总住院时间及围术期正性肌力药物使用时间;比较用药前后两组的血常规、肝肾功、凝血功能、术中出血量及术后第1、2、3天引流量.结果 与对照组比较,用药后研究组LVEF较高,NT-proBNP较低,术前调整时间、呼吸机辅助呼吸时间、围术期正性肌力药物辅助治疗时间均较短(均P0.05).给药前后,两组患者肝肾功能、凝血功能及血常规指标比较,差异均无统计学意义(P>0.05);各组内给药前后肝肾功能、凝血功能及血常规指标比较,差异亦无统计学意义(P>0.05).结论 心脏瓣膜置换术术前应用注射用红花黄色素能有效改善心瓣膜病患者的心功能,用药安全性高.%Objective To investigate the efficacy and safety of carthamin yellow applied to the adjunctive treatment before heart valve replacement. Methods A hundred patients planned to undergo heart valve replacement due to bicuspid valve or aortic valve disease were randomly divided into study group and control group,with 50 cases in each group. The study group and the control group were intravenously administered carthamin yellow and normal saline until the day before surgery respectively. The left ventricular ejection fraction(LVEF), serum N-terminal pro-brain natriuretic peptide(NT-proBNP) level,duration of preoperative adjustment,type of cardiac resuscitation,duration of ventilator assistance,ICU stay,total hospital stay,and duration for using perioperative positive inotropic drugs were compared between the two groups. The complete blood count,liver function,renal function,coagulation function,intraoperative blood loss,and volumes of drainage on the 1st, 2nd and 3rd day after operation were also compared between the two groups before and after administration. Results After administration,LVEF was higher,NT-proBNP level was lower,durations of preoperative adjustment,ventilator assistance and for using perioperative positive inotropic drugs were shorter in the study group compared to the control group(all P>0. 05). There were no significant differences in the rate of autonomous cardiac resuscitation ,postoperative ICU stay,total hospital stay,intraoperative blood loss,volume of drainage on the 1st,2nd or 3rd day after operation between the two groups(all P>0. 05). Before and after administration,no significant differences were observed in the liver function,renal function,coagulation function or indices of complete blood count between the two groups(P>0. 05). And in each group,the liver function,renal function,coagulation function or indices of complete blood count before administration did not differ from the indices after administration(P>0. 05). Conclusion Administration of carthamin yellow before heart valve replacement can effectively improve the cardiac function of patients with valve disease,and it achieves a high safety.
