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Y迷宫的相关文献在1986年到2023年内共计3955篇,主要集中在神经病学与精神病学、基础医学、药学 等领域,其中期刊论文63篇、会议论文1篇、专利文献3891篇;相关期刊48种,包括吉林体育学院学报、辽宁师范大学学报(自然科学版)、动物学研究等; 相关会议1种,包括第二次全国中西医结合诊断学术研讨会等;Y迷宫的相关文献由7778位作者贡献,包括邓伦胜、崔建伟、邵利平等。

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期刊论文>

论文:63 占比:1.59%

会议论文>

论文:1 占比:0.03%

专利文献>

论文:3891 占比:98.38%

总计:3955篇

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Y迷宫

-研究学者

  • 邓伦胜
  • 崔建伟
  • 邵利平
  • 童春国
  • 刘欣
  • 杨小龙
  • 陈波
  • 孙学雁
  • 吕穗军
  • 王坤
  • 期刊论文
  • 会议论文
  • 专利文献

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    • 李艳丽; 杨小荣; 张策; 郭军红
    • 摘要: 目的探讨广谱抗生素处理后,大鼠肠道菌群的改变、恢复及其对认知行为是否产生影响。方法实验大鼠随机分为抗生素处理(AT)组和对照(Control)组;AT组用氨苄青霉素、万古霉素、甲硝唑和亚胺培南4种抗生素混合液灌胃3 d,Control组用等量的生理盐水灌胃。在第4天(距最后一次抗生素处理24 h)及2个月时收集粪便进行16s rRNA基因测序检测肠道菌群的改变;在2个月时通过基于操作条件反射的延迟匹配样本任务(DMTP)和Y迷宫检测两组大鼠认知行为。结果第4天AT组大鼠肠道菌群减少,包括菌群多样性减少(P<0.0001);优势菌拟杆菌门数量减少(P<0.0001),厚壁菌门数量减少(P=0.0001);而变形菌门相对丰度增加(P<0.0001)。停用抗生素后肠道菌群恢复,在2个月时与Control组比较差异无统计学意义;且AT组大鼠的认知行为与Control组比较差异亦无统计学意义。结论广谱抗生素处理会引起大鼠肠道菌群减少,但这种减少是暂时的,在停用抗生素后会恢复正常,并且不会影响大鼠的工作记忆和空间记忆。
    • 张芯悦; 梁坤; 沈国晴; 冯清源; 李光建; 傅丹敏; 胡安冉; 汪萌芽; 黄宏平
    • 摘要: 目的:观察越鞠丸对慢性不可预见性应激(CUS)导致抑郁样行为模型大鼠空间学习记忆能力的影响。方法:28只雄性SD大鼠(160~190 g)分成正常组(n=9)、抑郁组(n=10)和越鞠丸组(n=9)。其中正常组大鼠不予任何处理,对其余两组进行3周的CUS刺激。通过比较正常组与抑郁组、越鞠丸组旷场和糖水偏爱实验的行为学指标差异检测模型是否制备成功,采用Y迷宫和Morris水迷宫检测大鼠的空间学习记忆能力,对越鞠丸组大鼠给药后,观察行为学指标和迷宫实验的指标差异。结果:①抑郁组与越鞠丸组体质量、糖水偏爱率、旷场实验得分均低于正常组(P<0.05)。在Y迷宫实验中,抑郁组与越鞠丸组自主交替率较正常组降低,新异臂停留时间缩短、新异臂潜伏期延长(P<0.01)。②给药21 d后,越鞠丸组的旷场实验得分较抑郁组提高(P<0.05)。在Y迷宫实验中,越鞠丸组较抑郁组自主交替率、起始臂进入次数和总进臂次数均增加(P<0.05)。③Morris水迷宫实验中,在空间探索阶段,越鞠丸组较抑郁组穿越虚拟平台次数增加(P<0.01),目标象限停留时间延长(P<0.05)。结论:越鞠丸在缓解CUS模型大鼠抑郁样行为的同时,能改善大鼠因应激导致的空间学习记忆障碍。
    • 梁嘉莹; 李佳男; 陈旭; 罗梦女; 吴梦露; 高宇; 李毅彤; 周游
    • 摘要: 目的 验证自行设计的热刺激联合Y迷宫实验用于观察糖尿病(DM)小鼠认知功能的可行性.方法 腹腔注射链尿佐菌素130 mg/kg构建小鼠DM模型(DM组,12只),取14只小鼠为空白对照(BC组).两组均进行自行设计的热刺激联合Y迷宫实验,比较两组建模后第6、8周热刺激联合Y迷宫实验的训练次数和错误次数、第7周Morris水迷宫实验逃避潜伏期及第9周空腹血糖和糖化血清蛋白水平.结果 建模后DM组饮水量和进食量均大于BC组(P<0.01或P<0.05).建模后第8周DM组错误次数多于BC组(P<0.01).DM组第9、10次Morris水迷宫逃避潜伏期延长(P<0.05).DM组糖化血清蛋白与 BC 组相仿[(5.14±3.48)mmol/L vs.(3.92±2.23)mmol/L](P>0.05).DM 组空腹血糖高于 BC 组[(17.23±9.61)mmol/Lvs.(6.18±1.16)mmol/L](P<0.05).结论 自主设计热刺激联合Y迷宫实验用于观察DM小鼠认知功能具有可行性.
    • 朴弋戈; 刘杨; 唐业忠; 陈勤
    • 摘要: 操作性条件反射训练是研究动物认知行为的重要方法,目前这一方法在经典模式动物中的应用较成熟,但在蛇类等爬行动物上鲜有报道.蝮亚科Crotalinae蛇类特有的红外感知觉系统受到了动物学、神经生物学和仿生学研究的关注,有效的操作性条件反射训练是揭示生物红外成像机制的关键方法.本实验以短尾蝮Gloydius brevicaudus为被试动物,采用Y迷宫考察了操作性条件反射训练的3种惩罚刺激方案.训练结果表明,水、高温、敲击刺激均不能使短尾蝮学会将Y迷宫路径选择与目标信号进行稳定关联.研究证明,基于现有惩罚刺激的训练方案对短尾蝮的条件反射习得效果弱于既有研究的其他实验动物.
    • 张建楠; 周红梅; 蔡靓羽; 蒋晨浩
    • 摘要: 目的 探究中药单体黄芩苷对脾切除老年大鼠术后认知障碍的改善作用及机制.方法?60只SD(Sprague Dawley)大鼠随机分为脾切除手术组(OP)、假手术组(Sham)、黄芩苷低剂量组(Baicalin A)、黄芩苷中剂量组(Baicalin B)、黄芩苷高剂量组(Baicalin C),每组12只.脾切除造模并按相应浓度给药或生理盐水.通过Y迷宫行为学实验、ELISA实验、荧光定量PCR实验检测TNF-α、IL-6、IL-1β以及NR2B表达的变化.检测黄芩苷对模型大鼠认知功能、学习记忆能力的影响.结果 中、高浓度的黄芩苷给药处理组别的老年大鼠,其在各个臂中的停留时间或穿梭次数占总探索时间或总穿梭次数的百分比相对于OP组有所提升,并且血清三种细胞因子水平和NR2B水平均恢复,这些指标均恢复至Sham组大鼠正常范围内.结论 黄芩苷可能通过降低术后炎症因子如TNF-α,IL-6,IL-1β的表达,并提高NR2B转录及翻译合成水平,从而改善POCD模型大鼠的术后认知功能障碍.
    • 黄明珠; 黄华品; 林婉挥; 陈圣根
    • 摘要: 目的 观察5-羟色胺6受体拮抗剂SB-271046对匹罗卡品致痫大鼠空间学习记忆的作用效应.方法 成年雄性SD大鼠分为两组:空白对照组(Vehicle组,n=10),氯化锂-匹罗卡品组(Lithium chloride-Pilocarpine,LiCl-PILO组,n=40).首先根据注射LiCl-PILO后是否出现癫痫持续状态(Status Epilepticus,SE),出现SE者纳入实验,未出现SE和死亡者则剔除;然后再随机分为3组:模型组即侧脑室注射羟丙基-β-环糊精(Hydroxypropyl-β-cyclodextrine,HP-β-CD),4μl;药物组按不同剂量分为2组,即侧脑室注射N-[4-Methoxy-3-(4-methyl-1-piperazinyl)-phenyl]-5-chloro-3-methylbenzo-thiophene-2-yl-sulphonamide monohydrochloride(SB-271047)剂量为10μg,4μl和侧脑室注射SB-271046剂量为20μg,4μl.结果 在Y迷宫自主交替行为实验中,模型组自主交替率显著下降(P0.05).在Morris水迷宫定位航行实验中,模型组平均潜伏期延长显著延长(P0.05).结论 SB-271046可以改善癫痫大鼠的空间学习记忆,主要作用于记忆获得巩固阶段,20μg剂量作用明显.%Objective Our primary objective is to investigate the effects of 5-HT6 receptor antagonist SB-271046 on spatial learning-memory in pilocarpine-induced epileptic rats. Methods 50 male adult Sprague-Dawley rats were divided into 2 groups,vehicle control group (n=10) and pilocarpine(PILO) treated group (n=50). Status epilepticus (SE) of rats was induced by intraperitoneal ( i. p. ) injection of LiCl-pilocarpine. According to Racine classify,seizures up to IV and last more than 30mins are supposed to be SE. Rats with successful SE were then divided into 3groups:mode control group (HP-CD,lateral ventricle (LV)injection with HP-β-CD,4 μl),10 μg-SB271046 group(10 μg-SB,LV injection with SB-271046,4μl),20μg-SB271046 group(20μg-SB,LV injection with SB-271046,4μl). Unsuccessful SE rats and died rats were both excluded from our experiment. Spatial learning-memory was evaluated to all groups by Y-maze and Morris water maze after 6 weeks. Results In Y-maze spontaneous alternation behavior test(SAB),We found significant decreasing of alternation rate in HP-CD group(P<0. 01). Besides,we saw reversion of alternation rate in the rats in SB-271046 injected groups,especially 20 μg-SB271046 group(P<0. 05). In Y-maze novel object discrimination 4h ITI test(NOD),new arm percentage of HP-CD also decreased significantly(P<0. 01),but SB-271046 didn't reverse this defect. In Morris water maze acquisition stage,the latency of different groups were gradually shorten from day 1 to day 5;meanwhile,the mean la-tency of the rats in HP-CD was prolonged significantly(P<0. 01),the most obvious improvement also was found in 20 μg-SB271046 group(P<0. 05). In retention stage,the results of 3 items: means latency,numbers of crossing target and per-centage of performance time in target zone indicated the memory of rats in HP-CD group were damaged,SB-271046 didn' t reverse the defects. Conclusion 5-HT6 receptor antagonist SB-271046 can reverse epileptic rats' spatial learning-memory defect,especially in acquisition stage,and maybe have dose-effect relationship.
    • 韩引秀; 陈征; 崔珍; 燕怡青; 刘婉玉; 王凌; 葛金芳
    • 摘要: 目的 观察不同月龄对雌性SD大鼠焦虑、绝望及学习记忆能力的影响,并探讨其可能的神经生物学机制.方法 2月龄和6月龄雌性SD大鼠各9只,适应性饲养1周后进行行为学实验,包括旷场实验、高架十字迷宫实验、Morris水迷宫实验、Y迷宫实验和强迫游泳实验.Western blot方法检测两组大鼠海马髓样细胞触发受体2(TREM2)的蛋白表达.结果 两组大鼠在旷场实验和强迫游泳实验中的表现差异无统计学意义.与2月龄SD雌鼠比较,6月龄SD雌鼠在高架十字迷宫实验中开臂的停留时间和移动距离增加;在Morris水迷宫定位航行实验中的逃避潜伏期显著缩短(P<0. 05),而在空间搜索实验中目标象限停留时间显著延长(P<0.05);在Y迷宫中的新臂优先指数显著增加(P< 0. 05). Western blot结果显示,6月龄SD雌鼠海马TREM2表达较2月龄组显著降低.Pearson相关性检验结果表明,海马TREM2的表达与大鼠在Morris水迷宫空间搜索实验中的目标象限游泳距离呈负相关性(r=-0. 724,P=0. 042).结论 与2月龄SD雌鼠相比,6月龄SD雌鼠的探究行为增多、学习记忆能力增强,其机制可能与海马TREM2表达降低有关.%Objective To investigate the difference in the anxious, despair-like, and learning and memory behavior tasks between female SD rats aging 2 month and 6 month and explore the possible mechanisms. Methods After one week;s adapt breeding, 18 female SD rats aging 2 month or 6 month were given the behavior tests including the open field test, the elevated plus maze, Morris water maze, Y maze, and the forced swimming test. The hippocampus were collected and the protein expression of triggering receptors expressed on myeloid cells 2 (TREM2) was detected via Western blot. Results There was no statistically significant difference between the two groups as regard to the moving distance, the duration in the center, and the frequencies of rearing and grooming in the open field test and the immobility in the forced swimming test. However, the sucrose preference index in the sucrose preference test, the duration in the target quadrant in the test phase of the Morris water maze (P <0. 05), and the preference index of the novel arm in the Y maze were increased in the 6 month group as compared with the 2 month group (P < 0. 05 ), while the escaping latency in the Morris water maze was decreased (P < 0. 05). The hippocampal protein expression of TREM2 in the 6 month group was less intensive than that in the 2 month group. Moreover, result of Pearson test showed that the hippocampal protein expression of TREM2 was negatively correlated with the duration in the target quadrant in the test phase of the Morris water maze (r =-0. 724, P =0. 042). Conclusion These results indicated that the female SD rats aging 6 month have more exploring activity and better learning and memory ability than 2 month group, the mechanism of which might be associated with the decreased expression of TREM2 in the hippocampus.
    • 李悦; 马丽娟; 肖辉; 田恬; 袁玉娟; 袁芳
    • 摘要: Objective To investigate the effect of polysaccharides extracted from vitis vinifera L.(VTP) on learning and memory abilities and oxidative stress in Alzheimer's disease(AD) rats.Methods Sixty male SD rats were randomly divided into 6 groups (n =10):normal control group,model control group,positive control group(polyphenidazole 0.5 mg/kg),low dose VTP(50 mg/kg) group,middle dose VTP(150 mg/kg) group and high dose VTP(300 mg/kg) group.Rats in model control group,positive control group,low,middle and high dose VTP groups were made AD models by hippocampal injection of amyloid-β (Aβ).The model control group had distilled water gavage and other groups had drug gavage for 15 d.Cognitive function was evaluated by the Y-maze test.Indicators of oxidative stress in serum and hippocampus were detected,including superoxide dismutase (SOD),glutathione peroxidase(GSH-Px),catalase(CAT) and malondialdehyde(MDA).Results Number of Y-maze test errors in model control group was significantly more,total reaction time was significantly longer and number of tests before meeting the standard was significantly more than those in normal control group [(6.2 ± 1.5) times vs (1.8 ± 0.8) times,(158 ± 19) s vs (86 ± 16) s,(92 ± 8) times vs (57 ± 8) times] (P < 0.05).Number of test errors in positive control group,middle and high dose VTP groups [(2.2 ± 0.8),(2.7 ± 1.2),(1.8 ±0.8)times] was significantly less,total reaction time[(87 ± 15),(89 ± 14),(83 ± 16) s] was significantly shorter and number of tests before meeting the standard[(60 ± 9),(75 ± 8),(63 ± 10)times] was significantly less than those in model control group(P < 0.05).Levels of SOD,GSH-Px and CAT in serum and hippocampus in model control group were significantly lower and MDA was significantly higher than those in normal control group (P < 0.05).Levels of SOD,GSH-Px and CAT in serum and hippocampus in positive control group,middle and high dose VTP groups were significantly higher and MDA was significantly lower than those in model control group (P <0.05).Levels of SOD,GSH-Px and CAT in hippocampus in low dose VTP group were significantly higher and MDA was significantly lower than those in model control group (P < 0.05).Conclusion VTP can antagonize the neurotoxicity of Aβ by affecting oxidative stress response to improve learning and memory abilities of AD rats.%目的 探讨琐琐葡萄多糖(VTP)对阿尔茨海默病(AD)大鼠学习记忆能力和氧化应激的影响以及可能的保护作用机制.方法 将60只雄性SD大鼠随机分为6组(n=10):正常对照组、模型对照组、阳性对照组(多耐哌齐0.5 mg/kg)、VTP低(50 mg/kg)、中(150 mg/kg)、高(300 mg/kg)剂量组.除正常对照组外,余各组大鼠正常喂养1周后,通过在海马区注射β淀粉样蛋白(Aβ) 25-35的方法建立AD模型,随后模型对照组大鼠给予蒸馏水灌胃,余各组给予相应药物灌胃15 d.通过Y迷宫实验进行认知功能评价;检测血清和海马组织中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)活性和丙二醛含量.结果 与正常对照组比较,模型对照组Y迷宫测试错误次数明显增多,总反应时间明显延长,达到标准所需次数明显增多[(6.2±1.5)次比(1.8±0.8)次、(158±19)s比(86±16)s、(92±8)次比(57±8)次],差异均有统计学意义(均P< 0.05);与模型对照组比较,阳性对照组、VTP多糖中、高剂量组测试错误次数明显减少[(2.2±0.8)、(2.7±1.2)、(1.8±0.8)次],总反应时间明显缩短[(87±15)、(89±14)、(83±16)s],达到标准所需次数明显减少[(60±9)、(75±8)、(63±10)次],差异均有统计学意义(均P <0.05).与正常对照组比较,模型对照组血清和海马组织中SOD、GSH-Px、CAT活性明显降低,丙二醛含量明显升高,差异均有统计学意义(均P<0.05).与模型对照组比较,阳性对照组、VTP中、高剂量组血清和海马组织中SOD、GSH-Px、CAT活性明显升高,丙二醛含量明显降低,差异均有统计学意义(均P<0.05);VTP低剂量组海马组织中SOD、GSH-Px、CAT活性明显升高,丙二醛含量明显降低,差异均有统计学意义(均P <0.05).结论 VTP能够改善AD大鼠的学习记忆能力,可能通过影响氧化应激反应来拮抗Aβ的神经毒性而起作用.
    • 黄忠兴; 何宏星; 王亚新; 邢作超; 周常文; 林炤华
    • 摘要: 目的 探讨成年小鼠大脑神经细胞特异性ADAM10基因缺失后对小鼠行为的影响.方法 通过Y迷宫、高架十字迷宫以及旷场实验,了解ADAM10基因敲除后,对小鼠的自主活动能力、探究学习能力的影响.结果 行为学实验结果显示ADAM10基因敲除小鼠的自主活动能力较对照组小鼠有所下降,其在新环境中探索的次数、时间和路程较对照组明显减少.说明了脑内神经细胞ADAM10基因的缺失对成年小鼠的自主活动能力和探究学习能力都产生了一定的影响.
    • 赵燕星; 苏殿三; 陈杰; 王祥瑞
    • 摘要: Objective To study the influences of Isoflurane on learning and memory of APPswe/PS1AE9 double transgenic mice of Alzheimer disease (AD). Methods Transgenic mice were divided into Tg-iso group and Tg-con group, wild-type mice were divided into Wt-iso group and Wt-con group. At the age of seven months, the Tg-iso group and the Wt-iso group were exposed to 1.1%Isoflurane for 2 hours per day for 5 days. Meanwhile, the mice in the Tg-con group and the Wt-con group inhaled oxygenitrogen (FiO2=30%). Learning and memory abilities were tested 48 hours and 5 months after Isoflurane exposure using the Morris Water Maze and Y maze, respectively. Results At the age of seven months, mean latency in the Wt-iso group decreased in a place navigation test compared to the Wt-con group ( P= 0.013); compared to the Tg-con group, the mean latency decreased in the Tg-iso group (P =0.043);there was no significant statistical difference in the target quadrant time or distance percentage in probe trials among the groups (P = 0.392). At the age of twelve months, compared to the Tg-con group, the discrimination errors of the Wt-con and Tg-iso groups decreased ( P= 0.044 and 0.020). Conclusions Repeated low-dose Isoflurane anaesthesia does not increase the dysfunction of learning and memory of APPswe/PS1AE9 double transgenic mice and wild type mice, to some extent, can even decrease dysfunction of learning and memory in APPswe/PS1AE9 double transgenic mice and wild type mice.%目的 研究异氟醚对阿尔茨海默病APPswe/PS1dE9双转基因型小鼠学习记忆能力的影响.方法 将转基因小鼠分为转基因异氟醚组(Tg-iso组)及转基因空白对照组(Tg-con组),野生型分为野生异氟醚组(Wt-iso组)及野生空白对照组(Wt-con组).Tg-iso组及Wt-iso组于7个月龄行异氟醚麻醉,吸入1.1%异氟醚2 h,连续5 d.同时Tg-con及Wt-con组吸入30%氧气与70%氮气的混合气体.麻醉后48 h各组行水迷宫实验,麻醉后5个月各组行Y迷宫实验.结果 7个月龄时:与Wt-con组比较,Wt-iso组的潜伏期缩短(P=0.013);与Tg-con组比较,Tg-iso组的潜伏期缩短(P=0.043);各组间空间探索实验目标象限时间和路程百分比的差异无统计学意义(P=0.392和P=0.300).12个月龄时:与Tg-con组比较,Wt-con组和Tg-iso组辨别错误次数明显减少(P=0.044和P=0.020).结论 短时间重复吸入低浓度的异氟醚不增加阿尔茨海默病APPswe/PS1dE9双转基因型小鼠及野生对照型小鼠近期及远期学习记忆能力障碍的风险,反而在一定程度上有减轻的作用.
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