摘要:Objective To assess the early changes in left ventricular systolic synchrony and cardiac function by real-time three-dimensional echocardiography ( RT3DE )in patients with coronary heart disease after percutaneous coronary intervention ( PCI ). Methods Thirty-five subjects were selected and underwent RT3DE and two-dimensional echocardiography( 2DE )l day before treatment,3 days and one month after treatment. We measured left ventricular ejection fraction( LVEF ), left ventricular end-diastolic internal diameter( LVIDd ), left ventricular end-systolic inlernal diameter ( LVIDs ),peak early( E )and late( A ) trans-mitral Doppler velocities,and E/A ratio. The left ventricular volume-time curves ( VTC ), the left ventricular end-diastolic volume( EDV ), end-systolic volume( ESV ), left ventricular ejection fraction( LVEF ), peak ejection rate( PER ), peak early filling rate( PFR ), PERt = PER/EDV, PFRt = PFR/EDV,the time to minimal systolic volume of 16-segmental standard deviation and the maximum difference as a ratio of R-R interval ( Tmsvl6-SD% and Tmsv 16-Dif% ) of RT3DE were obtained. Results RT3DE parameters: EDV of patients pre-treatment, 3 days and one month after PCI were( 115. 74 ±22. 27 )mL,( 110. 51 ±20.44 )mL and ( 110. 26 ±27. 55 )mL respectively. The difference among the three groups was not statistically significant F =0.59,P >0. 05 );ESV were( 53. 57 ±22. 63 )mL,( 44. 28 ± 14. 34 )mL and( 44. 00 ± 15. 08 )mL, LVEF were( 56. 48 ± 10. 12 )% ,( 60. 45 ± 7. 91 )% and( 61. 77 ± 6. 63 )% ,PERt were 3. 10 ± 0. 80,3. 37 ± 0. 47 and 3. 43 ± 0.52 ,PFRt were 2.01 ± 0.51,2.16 ± 0.39 and 2.34 ± 0.44 ,Tmsvl6-SD% were 2. 33 ±2.32,1.61 ±0.83 and 1. 22 ± 0. 87, Tmsvl6-Dif% were 9.84 ±3.20,6.34 ±3.49 and 4. 07 ± 2. 62. The differences were all statistically significant F -2. 63,3. 80, 2. 80,4. 55 ,4. 88,5. 95,P < 0. 05 ); LVEF, PERt , PFRt of 3 days after PCI treatment were larger than those before PCI, but the differences were not statistically significant ( P > 0. 05 ); ESV, Tmsvl6-SD% , Tmsvl6-Dif% of 3 days after PCI treatment were lower than those before treatment. The differences were all statistically significant t = 1. 98,2. 00,1. 98, P < 0. 05 ). ESV, Tmsvl6-SD% , Tmsvl6-Dif% of one month after PCI treatment were significantly lower than those before treatment t = 2.02,3.08,3.44, P <0.05 ),LVEF,PER! ,PFRt of one month after PCI treatment were significantly larger than those before treatment t = -2. 65, -2.21, - 3. 02 ,P <0.05 ). 2DE parameters: LVIDd of patients pre-treatment, 3 days and one month after PCI treatment were (51.28 ±4.46)mm,(50. 60±5.40)mm and( 49. 82 ±3. 69 )mm respectively,E were ( 51.28 ±4.46 )cm/s,( 50.60 ±5.40 )cm/s,and( 49. 82 ±3. 69 )cm/s, A were( 0. 72 ± 0. 18)cm/s,(0. 76 ±0. 17 )cm/s and( 0. 73 ±0.23 )cm/s,E/A were 1.06 ±0.47, 1.03 ±0.41 and 1.21 ±0.47. The differences were all statistically significant F =0. 89,1.31,0.36,1. 61,P>0. 05);LVIDs were( 35. 02 ±4. 89 )mm,( 32. 51 ±5.40) mm and( 32. 54 ± 4. 28 )mm, LVEF were( 59. 37 ± 8. 67 )% ,( 62. 60 ± 8. 07 )% and ( 65. 29 ± 6. 86 )% . The differences were statistically significant F = 3. 06,5. 35 ,P < 0.05 );LVIDs of 3 days and one month after PCI treatment were significantly lower than that before treatment t = 2.16,2.13 ,P <0.05 ). LVEF of 3 days after PCI treatment was larger than that before treatment. The difference was not statistically significant P > 0. 05 );LVEF of one month after PCI treatment was significantly larger than that before PCI( t = -3.19,P <0.05 ). Conclusions Left ventricular systolic synchrony and systolic and diastolic function were significantly improved after PCI. RT3DE is a promising approach to evaluate the changes in left ventricular systolic synchrony and cardiac function in the patients with coronary heart disease after PCI.%目的 应用实时三维超声心动图评价冠心病患者经皮冠状动脉介入(PCI)治疗后左心室收缩同步性及心功能的早期改变.方法 对35例行PCI治疗的冠心病患者于术前及术后3 d、1个月进行经胸二维和实时三维超声心动图检查,二维超声获得左心室射血分数(LVEF)、左心室舒张末内径(LVIDd)、左心室收缩末内径(LVIDs)、二尖瓣口舒张早期峰值流速(E)和舒张晚期峰值流速(A)及其比值(E/A);三维超声获得左心室容积时间曲线,计算或采集左心室舒张末容积(EDV)、左心室收缩末容积(ESV)、左心室射血分数(LVEF)、峰值射血率(PER)和峰值充盈率(PFR)及其容积校正值PER1和PFR1、校正的16节段不同步指数Tmsv16-SD%和Tmsv16-Dif%.结果 三维超声参数:冠心病患者术前、术后3 d、1个月EDV分别为(115.74±22.27)、(110.51±20.44)、(110.26±27.55)mL,组间比较差异无统计学意义(F=0.59,P>0.05);ESV分别为(53.57±22.63)、(44.28±14.34)、(44.00±15.08)mL,LVEF分别为(56.48±10.12)%、(60.45±7.91)%、(61.77±6.63)%,PER1分别为(3.10±0.80)、(3.37±0.47)、(3.43±0.52),PFR1分别为(2.01±0.51)、(2.16±0.39)、(2.34±0.44),Tmsv16-SD%分别为(2.33±2.32)、(1.61±0.83)、(1.22±0.87),Tmsv16-Dif%分别为 (9.84±3.20)、(6.34±3.49)、(4.07±2.62),组间比较差异均有统计学意义(F=2.63、3.80、2.80、4.55、4.88、5.95,P均<0.05);冠心病患者术后3 d LVEF、PER1、PFR1较术前均升高,但差异均无统计学意义(P均>0.05);冠心病患者术后3 d ESV、Tmsv16-SD%、Tmsv16-Dif%较术前均降低,差异均有统计学意义 (t=1.98、2.00、1.98,P均<0.05);冠心病患者术后1个月ESV、Tmsv16-SD%、Tmsv16-Dif%较术前均降低,LVEF、PER1、PFR1较术前均升高,差异均有统计学意义(t=2.02、3.08、3.44、-2.65、-2.21、-3.02,P均<0.05).二维超声参数:冠心病患者术前、术后3 d、1个月LVIDd分别为(51.28±4.46)、(50.60±5.40)、(49.82±3.69)mm,E分别为(51.28±4.46)、(50.60±5.40)、(49.82±3.69)cm/s,A分别为(0.72±0.18)、(0.76±0.17)、(0.73±0.23)cm/s,E/A分别为(1.06±0.47)、(1.03±0.41)、(1.21±0.47),组间比较差异均无统计学意义(F=0.89、1.31、0.36、1.61,P均>0.05);LVIDs分别为(35.02±4.89)、(32.51±5.40)、(32.54±4.28)mm,LVEF分别为(59.37±8.67)%、(62.60±8.07)%、(65.29±6.86)%,组间比较差异均有统计学意义(F=3.06、5.35,P均<0.05);冠心病患者术后3 d、术后1个月LVIDs均较术前降低,差异均有统计学意义(t=2.16、2.13,P均<0.05).冠心病患者术后3 d LVEF较术前升高,差异无统计学意义(P>0.05);术后1个月LVEF较术前也升高,但差异有统计学意义(t=-3.19,P<0.05).结论 PCI术后早期,患者左心室收缩同步性及收缩和舒张功能均得到明显改善,实时三维超声心动图可较客观的评价PCI术后左心室壁收缩同步性及心功能的早期变化.