摘要:
Objective: To explore the relationships between pathogenesis, prognosis and perinatal factors of neonatal hypoxicischemic encephalopathy (HIE). Methods: Clinical data of 187 cases of HIE admitted to neonatal intensive care unit in our hospital from July 2012 to June 2017 was retrospectively analyzed. Results: During the 5 years, the detection rate of HIE born in our obstetrics was 1. 12%, the fatality rate of HIE was 19. 79%. According to clinical grading, none of 62 mild HIE cases was dead, 3 of 43 moderate HIE cases were dead, 34 of 82 severe HIE cases were dead, and the fatality rate of severe HIE was41. 46%. As to perinatal factors, 3 of 29 cases of maternal factors were dead, 3 of 24 cases of placental factors were dead, 22 of70 cases of umbilical cord factors were dead, 7 of 46 cases dystocia factors were dead, and 2 of 18 cases of neonatal factors were dead. The fatality rate of umbilical cord factor was 31. 43% (22/70), which was the highest. Conclusion: The fatality rate of HIE is high. Umbilical cord is the most common and serious perinatal factor. The pregnant and lying-in women with high perinatal risk factors should be monitored and effective measures should be taken to prevent neonatal asphyxia.%目的:探讨新生儿缺氧缺血性脑病(HIE)的发病、预后与各种围产因素的关系.方法:对我院新生儿重症监护病房2012年7月至2017年6月收治的187例HIE临床资料进行回顾性分析.结果:5年间我院产科出生新生儿HIE检出率1.12%,HIE病死率19.79%.62例轻度HIE无死亡,43例中度HIE死亡3例,82例重度HIE死亡34例,重度HIE病死率41.46%.围产因素中孕母因素29例死亡3例,胎盘因素24例死亡3例,脐带因素70例死亡22例,难产因素46例死亡7例,新生儿因素18例死亡2例,以脐带因素的病死率31.43%(22/70)为最高.结论:HIE病死率高,其发病的围产因素中以脐带因素为多见和严重,对存在围产高危因素的孕产妇要加强监护,针对防止新生儿窒息采取有效措施.