• 主题
高级搜索  >
历史搜索 清空历史
您现在的位置：首页> 中文期刊>医药卫生>预防医学与卫生学>中国妇幼健康研究

中国妇幼健康研究

中国妇幼健康研究

CSTPCD

Chinese Journal of Woman and Child Health Research
本刊从妇女儿童出发，主要报道国外有关妇幼卫生保健的新理论、新进展、新成就、新技术、新动向，为妇幼卫生教学、科研、临床提供国外信息。
  • 发文量：6627
  • 被引量：6068
  • H指数：1
  • 开始收录时间：1993(3)
  • CNKI综合因子：1.027
  • 维普期刊影响因子： 1.9
  • 万方期刊影响因子：3.55
  • 创刊时间：1990
  • 国内刊号/CN：61-1448/R
    国际刊号/ISSN：1673-5293
  • 发行周期：双月刊
    邮发代号：52-135
  • 主管单位：中华人民共和国教育部
    主办单位：西安交通大学；中国疾病控制中心妇幼保健中心
中国妇幼健康研究-联系信息
  • 主编：李旭
  • 电话：029-82655049
  • 邮箱：bjbllm@mail.xjtu.edu.cn
  • 地址：西安市雁塔西路76号西安交通大学医学院009信箱
  • 邮编：710061
中国妇幼健康研究-获奖情况
  • • 2007年已被评为中国科技核心期刊（中国科技论文统计源期刊），已取得《中国期刊网》和《中国学术期刊（光盘版）》全文收录，并作为“中国学术期刊综合评价数据库”、“中国科学引文数据库”来源期刊。同时被《中文医学科学核心期刊要目总览》、《中国生物医学文献光盘数据库》（CBMdisc）、《中文生物医学期刊目次数据库》（CMCC）、《中国科技期刊片名数据库》及两种书本式检索刊《中国科技资料目录》（医药卫生）、《中国医药文献》进行目次、文摘或全文收录。2009年以来曾2次获全国高校科技期刊质量奖、2016年高校科技期刊优秀奖和2015年省科协“学会创新和服务能力提升”项目优秀科技期刊奖。
  • 收录汇总
  • 刊内文献检索
  • 投稿信息

刊期浏览

相关中文期刊

相关外文期刊

相关外文会议

最新期刊

热门期刊

中国妇幼健康研究 >2023年第11期

学科

年度

全选（0）
排序：
共4384条结果
  • 摘要：睡眠障碍在中年女性中很常见；带有血管舒缩症状的围绝经期／绝经后女性睡眠障碍的发生率增加。2014年8月，发表在《Menopause》的研究对帕罗西汀改善睡眠障碍的效果进行前瞻性评估。结果表明，在接受更年期血管舒缩症状治疗的绝经后妇女中，帕罗西汀7．5mg能够显著性降低因血管舒缩症状而导致的夜间觉醒次数，并且增加睡眠持续时间，但不会差异影响睡眠潜伏期或镇静。
  • 摘要：Lead and manganese have been used for more than half a century as gasoline additives, which cause serious damage to human health when the vehicle emissions get into atmosphere.Both of two heavy metals have significant neurotoxicity, especially for children who have immature blood brain barrier.Nowadays environmental pollution is very serious, and more attention is paid to the joint exposures of heavy metals.This paper reviewed the toxicology of lead and manganese on nerves and further elaborated their joint toxic effects.%铅和锰相继作为汽油添加剂，已使用大半个世纪，随汽车尾气排放到大气中，严重危害人类的健康。这两种重金属都有明显的神经毒性，尤其对于血脑屏障发育不完善的儿童来说，铅、锰更容易在脑内蓄积。现环境污染十分严重，重金属之间的联合暴露越来越得到人们的重视，该文对铅与锰的神经毒理及其联合毒性进行综述。
  • 摘要：Objective To master health status of preschool children in Wuxi City and to provide scientific basis for management of common diseases in preschool children for administrative department of public health.Methods Statistical statements of health care work reported by nurseries in Wuxi City from 2011 to 2013 were collected, sorted and analyzed.Results In these three years the prevalence of obesity, malnutrition, dental caries and poor vision was significantly rising year by year (χ2 value was 68.851,99.600, 14.774 and 100.218, respectively, all P<0.05).The differences in common diseases of children living in different regions and different nurseries were significant.The prevalence of anemia was higher in rural areas (χ2 =1 494.64, P<0.001), in nurseries set up by local people and in provincial excellent nurseries than in urban areas, in state-run nurseries, and in city excellent or qualified nurseries (χ2 value was 1 494.640, 15.847 and 35.542, respectively, all P<0.001).The prevalence of obesity was higher in urban areas, in nurseries set up by local people and in provincial excellent nurseries than in rural areas, in state-run nurseries, and in city excellent or qualified nurseries (χ2 value was 1 525.640,19.082 and 120.063, respectively, all P<0.05).Compared with rural areas, nurseries set up by local people and qualified nurseries, the prevalence of malnutrition was lower in urban areas, state-run nurseries, provincial excellent nurseries and city excellent nurseries (χ2 value was 4.820, 186.998 and 123.046, respectively, all P<0.05).The prevalence of dental caries was higher in urban areas than in rural areas (χ2 =7.220, P<0.05), in nurseries set up by local people than in state-run nurseries (χ2 =106.106, P<0.001), in qualified nurseries than in provincial excellent nurseries and city excellent nurseries (χ2 =76.578, P<0.001).The prevalence of poor vision in urban areas, in state-run nurseries and in provincial excellent nurseries was higher than in rural areas (χ2 =12.188, P<0.05), in nurseries set up by local people (χ2 =82.549, P<0.001) and in city excellent nurseries and qualified nurseries (χ2 =163.709, P<0.001).Conclusion Poor vision, dental caries and obesity are major health problems of children in nurseries in Wuxi City.Intervention of common diseases in preschool children should be strengthened in the future to ensure the physical and mental health of children.%目的：掌握无锡市学龄前儿童健康状况及变化趋势，为卫生行政部门制定学龄前儿童常见病管理方案提供科学依据。方法收集、整理、分析2011至2013年无锡市托幼机构卫生保健工作统计年报表。结果3年间肥胖、营养不良、龋齿和视力不良患病率均有逐年上升趋势，均有统计学意义（χ2值分别为68．851、99．600、14．774和100．218，均P＜0．05）。儿童的常见病患病情况在不同地区、不同性质和不同类别的托幼机构均有统计学意义，贫血患病率：农村高于城市（χ2＝1494．640，P＜0．001），民办园高于公办园（χ2＝15．847，P＜0．05），省优质园高于市优质园和合格园（χ2＝35．542，P＜0．001）；肥胖患病率：城市高于农村（χ2＝1525．640，P＜0．001），民办园高于公办园（χ2＝19．082，P＜0．05），省优质园高于市优质园和合格园（χ2＝120．063，P＜0．001）；营养不良患病率：农村高于城市（χ2＝4．820，P＜0．05），民办园高于公办园（χ2＝186．998，P＜0．001），合格园高于省优质园和市优质园（χ2＝123．046，P＜0．001）；龋患率：城市高于农村（χ2＝7．220，P＜0．05），民办园高于公办园（χ2＝106．106，P＜0．001），合格园高于省优质园和市优质园（χ2＝76．578，P＜0．001）；视力不良率：城市高于农村（χ2＝12．188，P＜0．05），公办园高于民办园（χ2＝82．549，P＜0．001），省优质园高于市优质园和合格园（χ2＝163．709，P＜0．001）。结论视力不良、龋齿和肥胖是无锡市托幼机构儿童的主要健康问题，今后要进一步加强对学龄前儿童常见病的干预，保障儿童的身心健康。
  • 摘要：Objective To provide basis for reinforcement of oral health care among pregnant women by investigating their oral health care awareness and behavior.Methods Investigation was made on oral health care awareness and behavior pattern of pregnant women living in Harbin, Changsha and Shanghai, and analysis and comparison were also made among them.Results Pregnant women in these three areas had moderate knowledge of oral health care.As for questionnaires involving dental caries and relevant questions on periodontal disease, 50.17%and 46.79%respondents could correctly answer more than half of the questions, respectively.However, their oral health care behavior remained to be improved.The investigation found that only 3.78%pregnant women brushed teeth 3 times a day, 13.29%ones used dental floss more than once each day, and 27.3%had the habit of using mouthwash.There were significant differences in knowledge about periodontal diseases, brush teeth, dental floss use and mouthwash use among three areas (χ2 value was 12.010, 18.311, 9.975 and 9.828, respectively, all P<0.05).Conclusion Oral health care for pregnant women is of vital importance.Improvement can be made on oral health of pregnant women by strengthening education on oral health care, relieving burdens on dental medical treatment and intensifying oral health care among pregnant women.%目的：探讨妊娠期女性口腔保健意识及行为，为加强妊娠期女性口腔保健工作提供依据。方法调研哈尔滨、长沙、上海三地妊娠期女性口腔保健意识及行为方式，并对调查结果进行分析。结果三地妊娠期女性口腔保健相关知识掌握情况尚可，对于龋病及牙周病相关问题的调研中，能够答对半数及以上的受访者分别占50．17％及46．79％。而三地妊娠期女性口腔保健行为习惯有待提高：仅有3．78％的妊娠期女性达到每日3次刷牙，13．29％的妊娠期女性每日使用1次以上的牙线，27．34％的妊娠期女性有漱口水使用习惯。三地牙周病相关知识掌握、刷牙、牙线使用和漱口水使用情况均有显著性差异（χ2值分别为12．010、18．311、9．975、9．828，均P＜0．05）。结论妊娠期女性口腔保健工作至关重要，需要加强孕妇口腔教育，减轻口腔医疗负担，强化孕期女性口腔保健，提升女性妊娠期口腔健康情况。
  • 摘要：目的：探讨社会因素以及性激素水平与围绝经期抑郁症高发的关系。方法采用汉密尔顿抑郁量表（ HAMD-17）及国际疾病分类（ ICD-10）中“抑郁发作”的诊断标准筛查入选研究对象。收集79名围绝经期抑郁症和58名围绝经期非抑郁症研究对象的一般资料和外周血标本。采用电化学发光法检测血清中的雌二醇（ E2）、睾酮（ T）、孕酮（ P）、黄体生成素（ LH）和卵泡刺激素（ FSH）水平。结果围绝经期抑郁症组睡眠障碍和慢性病发生率高于非抑郁症组（χ2＝4．700，P＝0．030；χ2＝4．866，P＝0．027）。围绝经期抑郁症组E2、T、P水平均低于非抑郁症组（ z＝-3．175，P＝0．001；z＝-3．726，P＜0．000；z＝-2．868，P＝0．004）。 HAMD评分与E2、T、P均存在负相关关系（ r＝-0．284，P＝0．001；r＝-0．389，P＝0．000；r＝-0．352，P＝0．000）。Logistic回归分析显示E2、T、P水平高是抑郁症发生的保护因素[OR（95％CI）分别为：3．851（1．347～11．785），P＝0．014；4．580（1．298～14．132），P＝0．012；1．864（0．984～3．942），P＝0．049）]。结论睡眠障碍、慢性病、E2、T、P水平与围绝经期抑郁症的发生相关，E2、T、P水平高是围绝经期抑郁症发生的保护因素。%[ Abatract] Objective To explore the relationship among social factors, sex hormone levels and the high incidence of perimenopausal depressive disorder.Methods Subjects were recruited with the diagnosis criteria for depressive onset in HAMD-17 and international classification of disease-10 (ICD-10).The general data and peripheral blood samples of 79 patients with depressive disorder and those of 58 women without depressive disorder were collected to detect the levels of estrogen ( E2 ) , testosterone ( T) , progesterone ( P) , luteinizing hormone ( LH) and follicle-stimulating hormone ( FSH) with electrochemiluminescence assay.Results The incidence of sleep disorder and chronic disease in perimenopausal women with depressive disorder was higher than that in women without depressive disorder (χ2 =4.700, P=0.030;χ2 =4.866, P=0.027).The levels of E2, T, and P in the depressive disorder group were lower than those in the group without depressive disorder (z=-3.175,P=0.001;z=-3.726,P<0.000;z=-2.868, P=0.004).HAMD scores were negatively correlated with E2, T, and P levels (r=-0.284,P=0.001;r=-0.389, P=0.000; r=-0.352, P=0.000).Logistic regression analysis indicated that E2, T, and P were protective factors for the development and progression of perimenopausal depression [OR(95%CI):3.851(1.347-11.785),P=0.014;4.580(1.298-14.132),P=0.012;1.864(0.984-3.942), P=0.049].Conclusion Sleep disorder, chronic diseases and the levels of E2 , T and P are correlated with the incidence of perimenopausal depressive disorder in women. E2 , T, and P are protective factors for the development and progression of perimenopausal depression.
  • 摘要：Objective To observe the expressions of matrix metalloproteinase 2 (MMP-2) and vascular endothelial growth factor (VEGF) in epithelial ovarian tumors, and explore their clinical significance.Methods The expressions of MMP-2 and VEGF protein in tissues of 60 cases with epithelial ovarian tumors and in tissues of 20 cases with normal ovarian were detected by immunohistochemical technology, and their relationship with clinical pathology were analyzed.Results The positive expressions of MMP-2 and VEGF protein in epithelial ovarian carcinomas were 65.0%and 75.0%, respectively, which were significantly higher than in normal ovarian tissues (χ2 value was 9.697 and 4.252, respectively, both P<0.05).There were differences in epithelial ovarian tumors with high differentiation, middle differentiation and low differentiation between MMP-2 and VEGF (χ2 value was 1.959 and 2.104, respectively, both P >0.05 ) without statistical significance.With the reduction of tissue differentiation, the positive expression rate of MMP-2 and VEGF increased.There was significant positive correlation between MMP-2 and VEGF in patients with epithelial ovarian carcinoma (r=0.464, P<0.05).Conclusion MMP-2 and VEGF have reference significance for the diagnosis of epithelial ovarian tumor, and they play an important role in invasion and metastasis of epithelial ovarian tumor.%目的：观察基质金属蛋白酶-2（ MMP-2）及血管内皮生长因子（ VEGF）蛋白在卵巢上皮性肿瘤中的表达，并探讨其临床意义。方法采用免疫组织化学检测技术，检测60例卵巢上皮性肿瘤组织及20例正常卵巢组织中MMP-2及VEGF蛋白的表达，并分析其表达与临床病理之间的关系。结果 MMP-2和 VEGF 在上皮性卵巢癌症中的阳性表达率分别为65．0％和75．0％，显著高于正常卵巢组织（χ2值分别为9．697、4．252，均P＜0．05）。 MMP-2和VEGF在高分化、中分化及低分化卵巢上皮性肿瘤中的阳性表达率均存在差异，但无统计学意义（χ2值分别为1．959、2．104，均P＞0．05），即随着组织分化级别的降低，MMP-2和VEGF的阳性表达率在升高。上皮性卵巢癌患者中MMP-2和VEGF蛋白表达呈显著正相关（r＝0．464，P＜0．05）。结论MMP-2及VEGF对卵巢上皮性肿瘤的诊断有参考意义，并且在卵巢上皮性肿瘤的浸润转移中可能发挥重要作用。
  • 摘要：Objective To explore the significance of fiberoptic bronchoscopy on the diagnosis and treatment of pediatric recurrent asthmatic disease.Methods From October 2012 to April 2013 211 cases of children with recurrent asthmatic disease treated in Children’ s Hospital of Xi’ an were divided into 3 groups by age, <1 year old group, 1-3 years old group and >3-12 years old group.They underwent fiberoptic bronchoscopy, and the results were analyzed.Results In 211 cases of children with recurrent wheeze, the results of bronchoscopy in the order of frequency were airway malformation, tracheal intima inflammation, and tracheal foreign body.There were 100 cases of airway malformation (47.4%) , including 43 cases of tracheal and bronchial stenosis (20.4%) , 40 cases of throat, trachea and bronchial softening (20.0%), 7 cases of tracheoesophageal fistula (3.3%), 6 cases of epiglottis cyst (2.8%), and 4 cases of bronchial and pulmonary dysplasia (1.9%).There were 69 cases of tracheal and bronchial intima inflammation (32.7%),including 10 cases of bronchial intima tuberculosis (4.7%).And there were 42 cases of bronchial foreign body (19.9%).The airway factors leading to wheeze were significantly different among different groups (χ2 =55.304,P<0.001) .The primary cause leading to wheeze in >3-12 years old group and 1-3 years old group was endotracheal factor, but the extratracheal factors and the factor of bronchial wall, especially the latter one, was the main cause of asthma in the <1 year old group.Significant differences were found in the results of fiberoptic bronchoscopy among 3 groups (χ2 =72.064, P<0.001).In the <1 year old group, the frequency of airway malformation was high, in >3-12 years old group the frequency of tracheal intima inflammation was high, and in 1-3 years old group the frequencies of bronchial foreign bodies and tracheal intima inflammation were high.Conclusion Fiberoptic bronchoscopy plays an important role in etiology diagnosis and treatment for asthmatic children.%目的：探讨纤维支气管镜（纤支镜）术对儿科反复喘息性疾病的诊断及治疗意义。方法回顾2012年10月至2013年4月西安市儿童医院收治反复喘息的患儿211例，按年龄分为＜1岁组、1～3岁组和＞3～12岁，采用纤维支气管镜检查，对检查结果进行分析总结。结果在211例反复喘息患儿中，镜检结果按发生频率依次为：气道发育畸形、气管支气管内膜炎症、气管支气管异物。其中气道畸形100例（47．4％），包括气管支气管狭窄43例（20．4％），喉气管支气管软化40例（20．0％），气管食管瘘7例（3．3％），会厌囊肿6例（2．8％），支气管肺发育不良4例（1．9％）；气管支气管内膜炎症69例（32．7％），包括支气管内膜结核10例（4．7％）；支气管异物42例（19．9％）。不同年龄组导致喘息的气道因素有显著差异（χ2＝55．304，P＜0．001）。＞3～12岁及1～3岁组气管内因素为喘息主要病因，而在＜1岁组，气管外因素及气管壁因素，尤其后者是导致喘息的主要病因。不同年龄组喘息患儿的镜检结果也有显著差异（χ2＝72．064，P＜0．001）。在＜1岁组，气道畸形检出率高，而＞3～12岁气管内膜炎症检出率高，1～3岁组支气管异物及气管内膜炎症检出率高。结论纤支镜对喘息性患儿的病因诊断和治疗有重要作用。
  • 摘要：目的：探讨不同程度妊娠期高血压综合征疾病（ PIH）对妊娠结局的影响。方法将南京市妇幼保健院2008年12月至2013年1月期间收治的256例妊娠期高血压综合征孕妇作为观察组，并选取同期住院的正常妊娠孕妇256例作为对照组，分别就观察组和对照组、不同程度观察组的妊娠结局进行回顾性分析研究。结果在256例观察组产妇中，妊娠期高血压、轻度子痫前期、重度子痫前期分别占49．61％、28．13％、22．27％。观察组产妇早产、剖宫产、胎盘早剥、产后出血、胎儿窘迫、新生儿窒息、围产儿死亡及低体重出生儿的发生率显著高于对照组（χ2值分别为13．20、88．44、6．07、8．15、9．31、33．12、4．03、12．60，均P＜0．05）。子痫前期组孕妇早产、剖宫产、胎盘早剥、产后出血、胎儿出现窘迫、新生儿发生窒息、围产儿死亡及低体重出生儿的发生率明显高于妊娠期高血压组，经比较差异有统计学意义（χ2值分别为22．03、49．37、13．63、55．06、20．89、66．25，7．25，19．52，均P＜0．05）。结论妊娠期高血压综合征疾病对母婴健康有严重影响，而且程度越重，对妊娠结局影响越大。大力普及孕期保健知识，早发现、早诊断、早治疗，及早控制病情，可有效改善母婴预后。%Objective To analyze the influence of different severity of pregnancy-induced hypertension ( PIH) on pregnancy outcomes. Methods A retrospective study was carried out on the pregnancy outcomes of 256 cases with PIH admitted in Nanjing Maternal and Child Health Hospital from December 2008 to January 2013 as observation group and 256 pregnant women selected at the same hospital and period as the control group.The pregnancy outcomes of different groups were analyzed.Results Among the observation group, gestational hypertension, mild preeclampsia and severe preeclampsia occupied 49.61%, 28.13%and 22.27%, respectively.The observation group had higher incidence of prematurity, cesarean section, placental abruption, postpartum hemorrhage, fetal distress, neonatal asphyxia, perinatal mortality and low birth weight than the control group (χ2 value was 13.20, 88.44, 6.07, 8.15, 9.31, 33.12, 4.03 and 12.60, respectively, all P<0.05).Compared with PIH group, the incidence of prematurity, cesarean section, placental abruption, postpartum hemorrhage, fetal distress, neonatal asphyxia, perinatal mortality and low birth weight was significantly higher in preeclampsia group (χ2 value was 22.03, 49.37, 13.63, 55.06, 20.89, 66.25, 7.25 and 19.52, respectively, all P<0.05).Conclusion PIH causes great harm to pregnant women and infants, and the influence on pregnancy outcomes is increasing with the severity of disease.Vigorous popularizing health care knowledge at pregnancy period and early detection, diagnosis, treatment and control can effectively improve the maternal and neonatal prognosis.
  • 摘要：目的：探讨剖宫产围手术期短疗程预防感染使用抗生素的临床疗效。方法选择南京医科大学附属无锡市人民医院产科2012年6月到2014年3月行选择性剖宫产手术的孕妇100例，按照随机数字表法分试验组和对照组，每组各50例，试验组在术前30min给予头孢噻肟钠，术后断脐后24h内维持给药，对照组术后仅仅断脐后24h给予头孢噻肟钠，一直持续到患者出院，观察两组应用抗生素的效果。结果对照组术后最高体温、术后退烧时间明显的高于试验组，在两组之间的差异具有统计学意义（ t值分别为5．344、6．571，均P＜0．05）；试验组的术后发病率、手术感染率以及子宫内膜炎发生率明显的低于对照组（χ2值分别为4．332、4．891、6．658，均P＜0．05）。试验组和对照组发生消化发生道反应、药物性皮疹等不良反应间差异无统计学意义（χ2值分别为1．042、1．010，均P＞0．05），术后白细胞数和中性粒细胞数在两组间的差异无统计学意义（t值分别为2．552、1．132，均P＞0．05）。结论剖宫产围手术期短疗程使用抗生素可以明显降低体温，缩短退烧时间，同时有效预防产后的感染。%Objective To investigate the clinical efficacy of short course of antibiotics on perioperative cesarean section.Methods One hundred pregnant women undergoing selective cesarean section during the period of June 2012 to March 2014 were selected from obstetrics department of People’ s Hospital of Wuxi Affiliated Nanjing Medical University.They were divided into experimental group and control group with 50 cases in each according to random number.Cefotaxime sodium was given to the experimental group 30min before operation and maintenance dose was provided within 24h after clamping umbilical cord.The control group was provided with cefotaxime sodium 24h after clamping umbilical cord till hospital discharge.The effect of two antibiotics therapy was observed.Results In the control group the highest temperature after surgery was higher and time to remove fever was longer, and the differences were significant ( t value was 5.344 and 6.571, respectively, both P <0.05).Compared with the control group, the postoperative morbidity, surgical infection rate and incidence of endometritis were significantly lower in the experimental group (χ2 value was 4.332, 4.891 and 6.658, respectively, all P<0.05).There were no significant differences in gastrointestinal reactions and drug rash between two groups (χ2 value was 1.042 and 1.010, respectively, both P>0.05).The differences in postoperative leukocyte count and neutrophil count were not significant between two groups (t value was 2.552 and 1.132, respectively, both P>0.05).Conclusion Short course of antibiotics for perioperative cesarean section can significantly reduce body temperature and shorten fever time.Meanwhile, it can prevent postpartum infection effectively.
  • 摘要：Objective To observe the clinical effect of different doses of mifepristone on the treatment of uterine fibroid.Methods Totally 105 patients with uterine fibroids were treated at Qixian Town’s Community Health Service of Shaoxing during the period of February 15, 2012 to November 15, 2012.They were divided into three equal groups with 35 cases: group A, group B and group C.Normal dose (25mg/d) was given to group A, small dose (12.5mg/d) was given to group B, and minimum dose (5mg/d) was given to group C.All patients started to take mifepristone at the third day of menstruation, and 12 continuous weeks was considered as a treatment course.The changes of patients’ uterine volume, hysteromyoma volume and hormone levels ( including FSH, LH, E2 and P) were measured.Their adverse reactions were analyzed as well.Results B-ultrasound examination indicated that all patients’ uterus and uterine fibroid volume diminished in different degree after one treatment course.The volume reduction ratio of uterus and uterine fibroids was significantly different among three groups (F value was 613.106 and 548.191, respectively, both P<0.001).The reduction ratio of group B was great.The reduction ratio of uterine fibroid was 65.2%, and that of uterus was 61.9%.The reduction ratio of uterine fibroid and uterus of group A was 36.4%and 33.1%, respectively, and that of group C was 34.6%and 31.3%, respectively.All patients’ hormone levels (including FSH, LH, E2 and P) reduced.Compared with the levels before treatment, the levels of E2 and P decreased significantly ( F value was 16.713 and 20.968, respectively, both P<0.001).There was no obvious adverse reaction in three groups.Conclusion Small dose of mifepristone has good clinical effect on the treatment of uterine fibroid.%目的：观察不同剂量的米非司酮治疗子宫肌瘤的临床效果。方法绍兴市柯桥区齐贤医院2012年2月15日至11月15日共接收患有子宫肌瘤的患者105例，将其平均分为A、B、C组，每组35例。 A组给予正常剂量米非司酮25mg/d，B组给予小剂量米非司酮12．5mg/d，C组给予最小剂量5mg/d。所有病患须在月经开始第3天服用米非司酮，连续服用12周为1个疗程，比较3组患者服药前后子宫体积、子宫肌瘤体积、各项激素水平，包括血清卵泡刺激素（ FSH），黄体生成素（ LH），雌激素（ E2），孕酮（ P）等指标的变化及不良反应。结果接受1个疗程治疗后，全部患者经过B超检查其子宫和子宫肌瘤的体积均有不同程度变小，3组患者间子宫和子宫肌瘤体积缩小率组间有显著性差异（F值分别为613．106和548．191，均P＜0．001），其中小剂量B组缩小体积较为显著，子宫肌瘤体积治疗前后缩小率为65．2％，子宫体积缩小率为61．9％；正常剂量A组缩小率分别为36．4％和33．1％；最小剂量C组缩小率分别为34．6％和31．3％。3组激素水平（FSH、LH、E2、P）指标均有降低，与治疗前相比，治疗后E2、P水平显著降低（F值分别为16．713和20．968，均P＜0．001）。3组患者的不良反应均不明显。结论小剂量米非司酮连续使用12周治疗子宫肌瘤临床效果较佳。
  • 摘要：目的：探讨超声介入在妇科恶性肿瘤手术后盆腔淋巴囊肿治疗的效果。方法选择妇科恶性肿瘤60例术后出现的98个盆腔淋巴囊肿患者为研究对象，根据囊肿大小及临床症状分为正常组56例和感染组42例，两组均进行超声介入无水乙醇硬化剂治疗。结果术后随访1周～3个月，正常组治愈率为100．00％，感染组治愈率85．71％，正常组治愈率明显高于感染组，差异有统计学意义（χ2＝8．522，P＝0．004）。正常组治疗后经1周～12周随访无1例出现不良症状，感染组入组前均表现为不同程度的不良反应，但介入治疗后，症状均逐渐缓解，3个月后不良反应发生率为7．14％，明显高于正常组（χ2＝3．415，P＝0．033）。结论超声介入治疗妇科恶性肿瘤手术后盆腔淋巴囊肿是一种安全、有效的方法，值得临床广泛推广和应用。%Objective To explore the clinical effects of ultrasound-guided percutaneous tube drainage therapy for postoperative pelvic lymphocele in malignant cancer of gynecology.Methods The cases with 98 postoperative pelvic lymphoceles in malignant cancer were selected and divided into normal group (n=56) and infection group (n=42) according to cyst size and clinical symptoms.They were treated with ultrasound-guided percutaneous tube drainage combined with absolute alcohol sclero therapy.Results Patients were followed up for 1 week to 3 months.For the infection group and the normal group, the effective rate was 85.71% and 100.00%, respectively, and there was statistical significance (χ2 =8.522,P=0.004).Normal group was followed up for 1 to 12 weeks, and no case was found with adverse symptoms.The infection group had varying degrees of adverse reaction before grouping, but the symptoms were gradually relieved after interventional therapy.The incidence of adverse reactions was 7.14%, which was significantly higher than the normal group (χ2 =3.415, P =0.033).Conclusion Ultrasound-guided interventional therapy is a safe and effective treatment for postoperative pelvic lymphocele in gynecologic malignancy, and it is worthy of wide promotion and application.
  • 摘要：发表于《儿科学》（ Pediatrics）杂志的最新研究表明，无论是多动症（ ADHD），还是用来治疗该病的刺激药物，都不会影响儿童的生长和他们成年后的身高。以前的研究对于多动症，兴奋剂和儿童生长之间的关系很不清楚。为了更好地了解多动症和多动症药物对儿童成长的影响，波士顿儿童医院的研究人员对明尼苏达州罗彻斯特市所有41所学校的学生资料进行了调查分析。资料中1976年1月1日到1982年12月31日之间出生的儿童有5718个，其中243人患有多动症。分析显示，多动症儿童与同年龄对照儿童最终的成年身高无统计学显著差异。对男性来说，平均差异为-0．4厘米。对女性来说，平均差异为-1．1厘米。而多动症儿童中服用刺激药物治疗和未治疗对成年后的身高也没有影响，男性之间的高度差为0．6厘米，女性之间的差异为0．2厘米。研究结果表明，多动症本身及刺激药物治疗多动症都不会对成年后的身高造成显著变化差异。
  • 摘要：目的：分析流行性腮腺炎的流行病学分布，探讨流行性腮腺炎的各项防控措施，对防控效果进行初步评价，为下一步的防控工作提供科学依据。方法收集2011年10月至12月西安市某小学流行性腮腺炎病例资料，进行流行病学调查，制定控制措施。结果全校2450例学生中197例发病，发病率为8．05％。发病率从高至低依次为三年级14．94％、二年级10．38％、一年级7．88％、五年级6．56％、六年级5．45％、四年级3．65％。2007例接种了腮腺炎疫苗的66例学生本次发病，占发病人数的33．5％，发病率为3．28％；443例未接种腮腺炎疫苗的131例学生本次发病，占发病人数的66．5％，发病率为29．8％，发病率显著高于已接种疫苗的学生（χ2＝339．00，P＜0．05）。在采取了消毒、隔离、接种疫苗等措施后再无新增病例，197例患者痊愈，疫情得到有效控制。结论制定合理及时有效的防控措施非常重要。%Objective To analyze the epidemiology of mumps, explore the measures and assess the results of control and prevention, so as to provide scientific evidence for further work.Methods The cases of mumps were collected in a primary school from October to December in 2011, and their epidemiologic features were studied to make measures for control and prevention.Results Among 2 450 students, 197 pupils were found with mumps, and the incidence was 8.05%.The incidence was 14.94%, 10.38%, 7.88%, 6.56%, 5.45% and 3.65%, respectively in grade 3, 2, 1, 5, 6, 4.There were 66 ( 33.5%) infected pupils in 2 007 ones who had inoculated mumps vaccine, and the incidence was 3.28%.Among the students not receiving mumps vaccine, 131 ( 66.5%) were infected, and the incidence was 29.8%, which was significantly higher than that in vaccinated students (χ2 =339.00, P<0.05).No new patient was found after taking measures of disinfection, isolation and vaccination.All of 197 patients recovered, and the epidemic situation was controlled.Conclusion It is very important to make effective measures in time.
  • 摘要：目的：探讨剖宫产术后子宫瘢痕憩室阴式手术治疗的临床疗效。方法对北京市顺义区中医院2009年1月至2012年6月采用阴式子宫瘢痕憩室切除术治疗的7例剖宫产子宫瘢痕憩室的病例进行回顾性分析。结果7例患者术中和术后均无并发症，术后均随访6～18个月，患者经期延长、不规则阴道出血较术前明显好转（χ2值分别为10．50、4．95，均P＜0．05），而下腹隐痛无明显变化（χ2＝1．08，P＝0．30）。术后超声显示切口处楔形暗区消失，肌层连续，宫腔线完整可见。结论剖宫产术后子宫瘢痕憩室患者，经阴道手术治疗是安全、简单、有效的一种治疗方法。%Objective To explore the clinical effect of transvaginal operation on uterine scar diverticulum after cesarean section.Methods Retrospective analysis was conducted on 7 cases with cesarean section scar diverticulum treated by operation from January 2009 to June 2013 in Shunyi Hospital of Traditional Chinese Medicine.Results There was no intraoperative and post-operative complication in 7 patients.All patients were followed up for 6-18 months after surgery.The menostaxis and abnormal vaginal bleeding were significantly improved after surgery (χ2 value was 10.50 and 4.95, respectively, both P <0.05), but the lower abdomen ache had no significant change (χ2 =1.08, P=0.30).Postoperative ultrasonography showed that diverticulum disappeared, muscular layer was continuous and uterine cavity line was complete.Conclusion Transvaginal operation is a safe, simple and effective treatment for patients with cesarean section scar diverticulum.
  • 摘要：目的：探讨米氮平联合坤泰胶囊对更年期抑郁症的疗效。方法将54例符合更年期首发抑郁障碍的患者随机分成米氮平联合坤泰胶囊治疗组（观察组）和单用米氮平治疗组（对照组），疗程8周。采用汉密尔顿抑郁量表（ HAMD）评定疗效。结果治疗2、4、6、8周后观察组的HAMD评分显著低于对照组，两组HAMD评分比较均有显著性差异（ t值分别为2．46、4．78、4．98、6．22，均P＜0．05）。两组躯体化症状在治疗后1、2、4、6、8周比较均有显著性差异（t值分别为1．11、2．79、2．86、3．01、3．11，均P＜0．01）。结论米氮平联合坤泰胶囊治疗更年期抑郁症起效快、效果好。%Objective To explore the curative effect of mirtazapine combined with kuntai capsule on menopausal depression.Methods Fifty-four patients with menopausal depression were recruited in the study, and they were randomly divided into two groups: mirtazapine combined with kuntai capsule group ( observation group) and single mirtazapine group ( control group) .The treatment course was 8 weeks. The efficacy was assessed with Hamilton depression scale (HAMD).Results HAMD scores of the observation group were significantly lower than those of the control group after treatment for 2, 4, 6 and 8 weeks (t value was 2.46, 4.78, 4.98 and 6.22, respectively, all P<0.05).The differences in somatization symptoms were significant between two groups after treatment for 1, 2, 4, 6 and 8 weeks (t value was 1.11, 2.79, 2.86, 3.01 and 3.11, respectively, all P<0.01).Conclusion In the treatment of menopausal depression, mirtazapine combined with kuntai capsule is effective with fast action.
  • 摘要：目的：探讨正电子发射计算机断层显像（ PET/CT）与核磁共振成像（ MRI）在妇科恶性肿瘤中的诊断价值及意义。方法选取2010年2月至2013年2月在武警浙江省总队医院应用PET/CT 与MRI检查的妇科恶性肿瘤患者40例，比较分析两种检查对妇科恶性肿瘤的诊断价值。结果 PET/CT与MRI检查对原发病灶的检出率分别为87．50％和60．00％，差异无统计学意义（χ2＝0．27，P＞0．05）；40例患者中PET/CT对淋巴结转移病例诊断敏感性、准确率均高于MRI，差异具有统计学意（χ2值分别为4．59、8．66，均P＜0．05）；PET/CT与MRI共同检出转移的淋巴结共98个，与手术证实淋巴结数目107个相比，联合检出率为91．58％；经比较PET/CT检出率高于MRI，差异具有统计学意义（χ2＝43．19，P＜0．01）。结论 PET/CT检查是一种安全、有效、准确率、敏感性高的诊断方法，并且能准确的检出妇科恶性肿瘤转移的淋巴结数目，对临床妇科恶性肿瘤的诊治具有重要的应用价值。%Objective To explore the significance of PET/CT and MRI in diagnosing gynecologic malignant tumors.Methods Forty patients with gynecological malignant tumors accepting PET/CT or MRI examination in Armed Police Corps Hospital of Zhejiang Province were selected from February 2010 to February 2013, and the diagnostic value of two methods on malignant tumors was compared.Results The detection rate of PET/CT and MRI for primary lesion was 87.50%and 60.00%, respectively, and there was no significant difference (χ2 =0.27, P>0.05).The sensitivity and accuracy of PET/CT in diagnosing lymph node metastasis cases were higher than those of MRI, and the differences were significant (χ2 value was 4.59 and 8.66, respectively, both P<0.05).Totally 98 metastatic lymph nodes were detected by the combination of PET/CT and MRI methods, and there were 107 confirmed by surgery.The detection rate of combined examination was 91.58%, which was higher than that of MRI with significant difference (χ2 =43.19, P<0.01).Conclusion PET/CT examination for gynecologic malignant tumors is safe, effective, accurate and sensitive.It can detect the accurate number of metastatic lymph nodes, which is very important to the diagnosis and treatment of gynecological malignant tumors in clinics.
  • 摘要：Calcium ( Ca) , iron ( Fe) , zinc ( Zn) , magnesium ( Mg) and copper ( Cu) are the most common trace elements in blood test for child health assessment in China.Whole blood test of these trace elements has been applied in clinical examination and scientific research for its simple operation and little blood sample needed, and it can be used to evaluate level in the body.It is valuable to build reference intervals for Ca, Fe, Zn, Mg and Cu for Chinese children.This article reviewed the studies of reference intervals for these trace elements in children’ s whole blood in the past decade, and the following suggestions were provided.Reference intervals for Chinese children should be set and more standard management should be taken since the standards for quality control in laboratories of the studies are not unified.Reference intervals are used for clinical diagnosis and prevalence survey, thus defining reference intervals of laboratories provides evidence only and more work is needed to confirm.More population and feasible sampling methods are needed to apply the reference intervals.Furthermore, more studies should be conducted in young children and in rural areas.%钙、铁、锌、镁、铜是我国儿童保健领域检测较多的矿物质，全血检测操作简单、采血量少，且可以用于检验人体水平，因此，被临床检验和科学研究领域接受。建立儿童全血钙、铁、锌、镁、铜参考值是有意义的。该文综述中国10年来的多地区和单个地区的儿童全血中钙、铁、锌、镁、铜参考值的研究，提出：①各研究中制定参考值的实验室都有质量控制相关操作，但标准不统一，建议建立中国儿童群体自己参考区间，并进行更加规范化的管理；②确定参考区间供临床和科研调查使用，因此，确定了实验室参考区间，只是提供了依据，需要进一步论证；③确定参考区间如果要推广到其他区域，就需要更多的人群参与检测，或使用能反应目标人群的更合理的抽样方法；④争取纳入更多小年龄儿童和农村地区的儿童。
  • 摘要：众所周知，母乳可以提高新生儿的免疫力，帮助其预防感染，而最新的一项美国研究提示，这种保护持续的时间可能更长。在上千名自出生时就开始随访的6岁儿童中，婴儿时接受母乳喂养的孩子在其儿童期发生耳、鼻窦和咽喉感染的人数少于非母乳喂养的孩子。并且在1周岁以内母乳喂养的时间越长，在6岁时发生感染的风险就越低。美国疾控中心（ CDC）流行病学家Ruowei Li博士及其同事利用了最初进入一项大型婴儿喂养实践研究中的数据，该研究是由美国FDA和CDC在2005至2007年间组织的。研究者于2012年在孩子大约6岁的时候联系了1281位母亲，询问在过去12个月她们的孩子常见感染的次数和类型，以及需要就诊的次数。研究发现，66％的孩子在过去1年有过感冒或上呼吸道感染，25％有耳部感染，24％有咽喉部感染，而16％有鼻窦感染。肺部和尿路感染则不常见。对比发现，15％母乳喂养的孩子发生过鼻窦炎症，而非母乳喂养的孩子为22％。根据《儿科学》（ Pediatrics）杂志上报告的结果，大约24％母乳喂养的孩子曾发生咽喉部炎症，而非母乳喂养的孩子则为30％。发生耳部感染在母乳喂养的孩子中占25％，而非母乳喂养的孩子中占28％。在患感冒、上呼吸道感染、肺炎或其他肺部感染的数量上两组没有差异。但是对于耳部、咽喉和鼻窦感染，研究者发现母乳喂养的时间越长，儿童患这些感染的风险就越低。在婴儿期母乳喂养至少9个月的孩子发生上述感染的病例数为母乳养0～3个月孩子的1／3至1／2。
  • 摘要：Objective To study the influence of different feeding patterns on bone mineral density of preterm small for gestational age (SGA) infants.Methods Totally 215 preterm SGA infants were divided into 5 groups:group A fed with formula for preterm infants after discharge, group B fed with breast milk , group C fed with formula for full-term infants, group D fed with breast milk and formula for preterm infants after discharge , and group E fed with breast milk formula for full-term infants.The bone mineral density of different groups was compared at 6 and 12 month of age .Results The bone mineral density of SGA infants was highest in group D , followed by group B , group A, group E and group C in order .The difference was significant (6 month of age:Fmale =2.845,Ffemale =2.570;12 month of age:Fmale =2.737, Ffemale =7.461, all P<0.05).Conclusion Breastfeeding or strengthened breastfeeding can improve the bone density of preterm SGA infants .This feeding pattern is more applicable for preterm SGA infants .%目的：研究不同喂养方式对早产小于胎龄儿（ SGA）骨密度的影响。方法将215例小于胎龄儿按照喂养方式分为5组：早产儿出院后配方奶喂养组、母乳喂养组、足月儿配方奶喂养组、母乳＋早产儿出院后配方奶喂养组、母乳＋足月儿配方奶喂养组，比较各组在生后第6月、12月骨密度值。结果5组小于胎龄儿的骨密度数值从高到低依次为：母乳＋早产儿出院后配方奶喂养组、母乳喂养组、早产儿出院后配方奶喂养组、母乳＋足月儿配方奶组、足月儿配方奶喂养组，差异具有统计学意义（6月龄时：F男＝2．845，F女＝2．570；12月龄时：F男＝2．737，F女＝7．461，均P＜0．05）。结论对早产小于胎龄儿童进行母乳喂养或强化母乳喂养能改善其骨密度情况，适用于早产儿。
  • 摘要：Objective To investigate the changes of CD4 +CD25 +regular T cells (Treg) and Th17 cells in peripheral blood in children with Kawasaki disease ( KD) before and after treatment , and to guide clinical treatment and evaluate prognosis .Methods A total of 32 KD children (KD group) and 28 healthy children (control group) were recruited.Morning peripheral vein bloods were collected from two groups before treated by immunoglobulin and aspirin and three days after defervescence by treatment .ELISA was used to detect the levels of serum IL-15, IL-17 and IL-23.Flow cytometry was used to detect proportions of Treg cells and Th 17 cells in peripheral blood .Results Compared with the control group , the levels of serum IL-15, IL-17 and IL-23 in KD group were significantly increased before treatment (t value was -4.35, -3.98 and -4.11, respectively, all P<0.05), but after treatment the levels of them were significantly decreased (t value was 3.74, 2.94 and 3.06, respectively, all P<0.05).Proportion of Treg cells in KD group was remarkably lower than in the control group.After treatment, it could rise to control group ’ s level, and it was significantly different from that before treatment ( t=-2.13,P<0.05).Proportion of Th17 cells in KD group was markedly higher (t=-1.87,P<0.05), which was significantly decreased after treatment (t=2.71,P<0.05).Conclusion Unbalance of Treg cells and Th17 cells may have an important role in the development of Kawasaki disease , and the proportion changes of them are valuable in guiding clinical medicine use and evaluating patient ’ s condition and prognosis.%目的：探讨川崎病（ KD）患儿治疗前后外周血中CD4＋CD25＋调节性T细胞（ Treg）与Th17细胞比例的变化，以指导临床治疗及评估预后。方法选择KD患儿32例（ KD组）及健康幼儿28例（对照组）；抽取对照组幼儿和KD组患儿使用免疫球蛋白＋阿司匹林治疗前及治疗后热退3天时清晨空腹静脉血，采用ELISA双抗体夹心法检测血清中白细胞介素－15（ IL-15）、白细胞介素－17（IL-17）和白细胞介素－23（IL-23）水平；采用流式细胞术检测外周血中Treg细胞和Th17细胞比例。结果与对照组相比，KD组患儿治疗前血清中IL-15、IL-17和IL-23水平均显著增高（t值分别为－4．35、－3．98和－4．11，P＜0．05）；经治疗后，血清中IL-15、IL-17和IL-23水平均有显著降低（t值分别为3．74、2．94和3．06，P＜0．05）。 KD组患儿外周血中Treg细胞比例明显降低（t＝2．54，P＜0．05），经治疗后可基本回升至对照组水平，与治疗前相比差异有显著性（t＝－2．13，P＜0．05）；Th17细胞比例明显升高（t＝－1．87，P＜0．05），治疗后与治疗前相比有明显降低（t＝2．71，P＜0．05）。结论 Treg细胞与Th17细胞之间的失衡可能在川崎病的发病中起重要作用，其比例的变化对指导临床用药及评估病情和预后具有一定的意义。
  • 摘要：目的：研究孕期体操运动对不良症状的改善作用，为开展孕期体操提供理论依据。方法选择北京市5个孕妇学校的孕25～34周孕妇为研究对象，采用专家研发的孕期体操，观察孕期不良症状的改善效果。结果孕妇通过体操干预，便秘症状改善率为81．2％，失眠改善率为82．8％，腿抽筋症状改善率为89．3％，浮肿症状改善率为53．3％，腰背疼痛感改善率为72．5％，血糖控制改善率为50％，髋关节打开程度改善率为90．6％。结论孕期体操运动能够有效改善孕期便秘、失眠、腿抽筋、浮肿、腰背疼痛等不良症状，孕妇养生保健体操是安全有效，值得进一步研究和推广的。%Objective To study the effect of pregnancy gymnastic exercises on improving adverse symptoms during pregnancy , so as to provide theoretical basis for research and development of pregnancy gymnastic exercises .Methods Pregnant women with gestational age of 25-34 weeks in 5 pregnant schools in Beijing were selected for the study , and pregnancy gymnastic exercises developed by experts were adopted to observe the improving effect on adverse symptoms .Results Through the intervention of gymnastic exercises , the improving rate of constipation symptoms, insomnia, leg cramps, swelling, lower back pain, blood sugar control and hip joint open degree was 81.2%, 82.8%, 89.3%, 53.3%, 72.5%, 50% and 90.6%, respectively.Conclusion The pregnancy gymnastic exercises can effectively improve pregnancy constipation , insomnia, leg cramps, swelling, back pain and other adverse symptoms .They deserve further study and spread because of safety and effect .
  • 摘要：目的：探究子痫前期高龄产妇胎盘低氧诱导因子－1α（ HIF-1α）蛋白水平与外周血血管性假血友病性因子（ vWF ）浓度的相关性，为及时有效预防子痫的发生提供实验室依据。方法对30例正常分娩高龄产妇（ A组）、35例子痫前期轻度高龄产妇（ B组）、41例子痫前期重度高龄产妇（ C组）的HIF-1α蛋白水平与外周血vWF浓度进行测定，并分析HIF-1α蛋白水平与vWF浓度的相关性。结果 B组、C组的HIF-1α蛋白水平、vWF浓度显著高于A组，（ B组：t1＝13．194，P1＝0．000；t2＝4．856， P2＝0．000。 C组：t1＝17．441，P1＝0．000；t2＝9．156，P2＝0．000）；C组的HIF-1α蛋白水平、vWF浓度显著高于B组，差异均有统计学意义（t1＝9．681，P1＝0．000；t2＝4．899，P2＝0．000）。 Spearman 相关性分析显示，vWF 浓度与子痫前期的病情程度（r＝0．288，P＝0．000）、HIF-1α蛋白水平（r＝0．410，P＝0．000）均呈显著正相关关系。结论子痫前期高龄产妇的胎盘HIF-1α蛋白水平与外周血vWF浓度明显升高，二者可能共同参与子痫前期的发生和发展。%Objective To investigate the correlation between hypoxia induced factor-1α( HIF-1α) protein level in the placenta and concentration of von Willbrand Factor ( vWF) in peripheral blood of aged puerpera in pre-eclampsia, so as to provide laboratory basis for preventing the happening of eclampsia timely and effectively .Methods The HIF-1αprotein level and concentration of vWF of peripheral blood in 30 cases of aged normal delivery (group A), 35 cases of aged puerpera with mild pre-eclampsia (group B) and 41 cases of aged puerpera with severe pre-eclampsia (group C) were measureed, and the correlation between HIF-1αprotein level and the concentration of vWF was analyzed .Results The HIF-1αprotein level and the concentration of vWF of group B and group C were significantly higher than those of group A(group B:t1 =13.194,P1 =0.000;t2 =4.856,P2 =0.000.group C:t1 =17.441,P1 =0.000;t2 =9.156,P2 =0.000). The HIF-1αprotein level and the concentration of vWF of group C were significantly higher than those of group B (t1 =9.681,P1 =0.000;t2 =4.899,P2 =0.000).Spearman correlation analysis showed that the concentration of vWF was positively correlated with the illness severity of pre-eclampsia (r=0.288,P=0.000) and HIF-1αprotein level (r=0.410,P=0.000).Conclusion The HIF-1αprotein level and the concentration of vWF of aged puerpera in pre-eclampsia increase significantly , and they may act synergistically in development and progression of pre-eclampsia.
  • 摘要：目的：研究血管内皮生长因子（VEGF）及其受体血管内皮生长因子受体1（VEGFR1）、血管内皮生长因子受体2（VEGFR2）在上皮性卵巢癌中表达及临床预后意义。方法采用SP免疫组化法检测139例不同卵巢组织VEGF及其受体VEGFR1、VEGFR2的表达及在上皮性卵巢癌组织中的共表达情况，并结合临床资料进行统计分析。结果 VEGF及其受体VEGFR1、VEGFR2在上皮性卵巢癌组织中的染色强度明显高于良性卵巢肿瘤及正常卵巢组织；并且VEGF及其受体在上皮性卵巢癌组织中的表达与临床分期、腹水量的差异均具有统计学意义（χ2＝4．207，P＝0．034；χ2＝7．432，P＝0．007）；在相关分析中高表达的VEGF与VEGFR2（r＝0．316，P＜0．05）、VEGFR1与VEGFR2（r＝0．415，P＜0．05）均存在相关性；VEGF及其受体三者共高表达较非共高表达患者的5年生存率差异具有统计学意义（χ2＝4．043，P＝0．044）。结论高表达和共表达VEGF及其受体VEGFR1和VEGFR2的患者可能存在较差预后，并且三者共表达及高表达可作为一项指导临床应用抗肿瘤血管生成药物（ Bev）靶向治疗的疗效预测分子。%Objective To evaluate the expression and prognostic significance of vascular endothelial growth factor (VEGF) and its receptor vascular endothelial growth factor receptor 1( VEGFR1) and vascular endothelial growth factor receptor 2 ( VEGFR2) in epithelial ovarian cancer ( EOC) .Methods The expression and co-expression of VEGF and its receptors ( VEGFR1 and VEGFR2 ) were detected with immunohistochemistry methods in 139 different ovarian tissues and epithelial ovarian cancer .They were analyzed combining with clinical data .Results The staining intensities of VEGF and its receptor VEGFR 1 and VEGFR2 in EOC tissue were significantly higher than those in benign ovarian tumors and normal ovary .In the correlation analysis, VEGF and VEGFR2 (r=0.316,P<0.05), VEGFR1 and VEGFR2 (r=0.415,P<0.05) were highly associated.High co-expression of VEGF and its receptors was statistically different from high non-co-expression of them in 5-year survival rate (χ2 =4.043,P=0.044).Conclusion High and co-expression of VEGF, VEGFR1 and VEGFR2 may indicate poor prognosis , and the co-expression and high expression of the three can be used as a guide to choose clinical targeted therapy of anti-angiogenesis drug ( Bev) and to predict curative effect .
  • 摘要：Objective To investigate the influence of elderly primipara on pregnancy outcomes and delivery mode .Methods From June 2009 to September 2010 442 cases of elderly primiparas (≥35 years old ) were selected from Beijing Ditan Hospital in experimental group to analyze the incidence of pregnant complications , delivery mode and pregnant outcomes .At the same period 450 normal primiparas were randomly selected in control group to conduct statistical analysis .Results The proportion of cases complicated with preeclampsia , uterine fibroids, oligohydramnios, fetal macrosomia, breech presentation, gestational diabetes, or impaired glucose tolerance was significantly higher in the experimental group than in the control group (χ2 value was 7.470, 35.212, 8.811, 10.874, 4.747, 12.844 and 26.159, respectively, all P<0.05).In the control group the incidence of fetus distress and premature rupture of membrane was significantly higher (χ2 value was 4.874 and 6.689, respectively, both P<0.05).The cesarean section rate of elderly primiparas (68.3%) was remarkably higher than that of the normal primiparas (33.6%).Conclusion The incidence of pregnant complications among elderly primiparas is obviously higher than that among young primiparas , so elderly pregnancy should be avoided .For elderly pregnancy perinatal care should be strengthened , pregnancy complications should be prevented and the indications of cesarean section should be controlled reasonably to ensure maternal and fetal safety and health .%目的：探讨高龄初产对妊娠及分娩发生合并症和并发症及分娩方式的影响。方法选取在北京地坛医院2009年6月至2010年9月分娩的高龄初产妇（≥35岁）442例为观察组进行临床分析研究妊娠合并症和妊娠并发症的发生、分娩方式及妊娠结局，随机选取同期非高龄初产妇（＜35岁）450例为对照组，并进行统计学分析。结果观察组妊娠合并子痫前期、子宫肌瘤、羊水少、巨大儿、臀位、糖尿病和糖耐量受损的比例显著高于对照组（χ2值分别为7．470、35．212、8．811、10．874、4．747、12．844、26．159，均P＜0．05）；对照组合并胎儿窘迫、胎膜早破的发生率显著高于观察组（χ2值分别为4．874、6．689，均P＜0．05）。高龄初产妇的剖宫产率为68．3％，明显高于对照组的33．6％。结论高龄初产妇妊娠合并症和并发症的发生明显高于年轻初产妇，应避免高龄妊娠；对高龄妊娠应加强围产期保健，预防妊娠并发症，合理控制剖宫产手术指征，确保母婴安全与健康。
  • 摘要：Objective To explore the pregnancy outcomes of Rh negative pregnant women and the complication treatment and prevention measures.Methods Totally 50 pregnant women with Rh negative blood type after blood antibody test in hospital were selected in study group, and another 50 healthy pregnant women hospitalized at the same period were randomly selected in control group .Pregnant outcomes of two groups were analyzed .Results There were no significant differences in the rates of postpartum hemorrhage , amniotic fluid pollutionⅢdegree, neonatal asphyxia, low weight, transferring to NICU and fetal death between two groups (χ2 value was 0.00, 0.00, 0.00, 0.00, 1.60 and 1.01, respectively, all P>0.05), and the amount of postpartum bleeding volume was not significantly different between two groups (t=0.11,P>0.05).But the rates of cesarean section , preterm birth and neonatal hyperbilirubinemia in the study group were significantly higher than those in the control group (χ2 value was 4.03, 10.70 and 8.27, respectively, all P<0.05).Rh antibody positive rate was significantly higher than negative rate in ABO blood type (χ2 =4.05,P<0.05).Among 14 cases of maternal and fetal ABO blood group incompatibility, 11 cases suffered neonatal hemolysis (78.57%) and 2 died.The rest were survival.Conclusion Rh negative blood type has mild influence on pregnant women themselves , but it will easily lead to hemolysis .Some measures such as strengthening pregnancy care, giving proper treatment at pregnant period , providing comprehensive treatment including plasmapheresis and intrauterine transfusion if necessary for Rh negative women can reduce the incidence of neonatal and perinatal adverse events .%目的：探讨Rh阴性血型孕妇妊娠结局及相应并发症处理、预防措施。方法选择50例孕妇入院后经血型抗体检测显示为RH阴性为研究组，随机抽取同期住院健康孕妇50例定为对照组，分析两组孕妇妊娠结局。结果两组孕妇产后出血、羊水污染Ⅲ度、新生儿窒息、低体重儿、转NICU、胎儿死亡发生率比较无显著性差异（χ2值分别为0．00、0．00、0．00、0．00、1．60、1．01，均P＞0．05），且两组产后出血量比较无显著性差异（t＝0．11，P＞0．05）。而研究组剖宫产率、早产率及新生儿高胆红素血症发生率明显高于对照组（χ2值分别为4．03、10．70、8．27，均P＜0．05）。ABO血型不合中Rh抗体阳性发生率显著高于阴性发生率（χ2＝4．05，P＜0．05）。14例母儿ABO血型不合患者中，11例（78．57％）发生新生儿溶血，死亡2例，其余均存活。结论 Rh阴性血型孕妇对孕妇本身影响不大，易引发新生儿溶血。对Rh阴性妇女加强孕期监护，孕期给予合理治疗，必要时给予血浆置换、宫内输血等综合治疗，均可降低新生儿及围产儿不良事件发生率。
  • 摘要：Objective To explore the effect of music combined hypnosis therapy on blood pressure and pulse during childbirth , fetal heart rate and the amount of postpartum bleeding .Methods Meeting normal vaginal delivery conditions , 223 pregnant women were selected and they were divided into treatment group and control group .The treatment group accepted music combined hypnosis in childbirth , while the control group received routine nursing care .Breathing, pulse, mean arterial pressure and the amount of postpartum hemorrhage were compared between two groups .Results The natural birth rate in the treatment group was significantly higher than that in the control group (χ2 =6.49, P<0.05), and neonatal Apgar scores were significantly higher than those in the control group (χ2 value was 5.23, 4.26 and 5.17, respectively, all P<0.05).Neonatal asphyxia rate was significantly lower in the treatment group (χ2 =4.38,P<0.05).In the treatment group maternal total labor time , intrapartum and postpartum bleeding volume 2 hours after delivery were significantly lower than those in the control group (t value was 16.34 and 15.24, respectively, both P<0.05).Conclusion Application of music combined hypnosis for parturients with normal delivery can reduce the changes of respiratory , blood pressure and pulse , and it also reduces the amount of postpartum hemorrhage .%目的：探讨音乐联合催眠治疗对于产妇分娩期间血压、脉搏、胎心率和产后出血量的影响。方法选取符合正常阴道分娩条件的产妇223例，分为治疗组和对照组，治疗组在分娩期运用音乐联合催眠方法，对照组采用常规护理。比较两组孕妇产时呼吸、脉搏、平均动脉压和产后出血量。结果治疗组自然分娩率显著高于对照组（χ2＝6．49，P＜0．05），且新生儿阿氏评分显著高于对照组（χ2值分别为5．23、4．26、5．17，均P＜0．05），而产妇发生新生儿窒息率显著低于对照组（χ2＝4．38，P＜0．05）。治疗组产妇的总产程时间、产时及产后2小时出血量均显著低于对照组（ t值分别为16．34、15．24，均P＜0．05）。结论在正常分娩产妇中应用音乐联合催眠方法具有减少呼吸、血压、脉搏的波动，明显减少产后出血量的作用。
  • 摘要：目的：探讨并比较子宫颈扩张球囊与地诺前列酮栓用于足月羊水偏少引产的有效性及安全性。方法选择2012年6月至2013年1月嘉兴市妇幼保健院96例足月妊娠羊水偏少孕妇作为研究对象，随机分为两组，采用子宫颈扩张球囊引产为实验组，使用地诺前列酮栓药物引产为对照组，每组各48例。比较两组促宫颈成熟、产程进展、分娩方式、产妇及围产儿的一般情况。结果与地诺前列酮栓组相比，子宫颈扩张球囊引产在缩短第一产程（t＝3．682）、第二产程（t＝7．033）的促宫颈成熟有效率（χ2＝1．792）、降低剖宫产率（χ2＝4．381）方面疗效显著（均P＜0．05），但对造成胎儿窘迫发生率（χ2＝1．344）、新生儿窒息率（0例）及产后出血量（t＝0．505）方面，两组比较均无显著性（均P＞0．05）。结论子宫颈扩张球囊应用于羊水偏少足月妊娠产妇的引产具有显著的临床疗效，安全性高，值得临床应用。%Objective To investigate and compare the efficacy and safety of uterine cooker ballon and Dinoprostone for labor induction of term pregnancy with oligohydramnios .Methods From June 2012 to January 2013 96 cases of term pregnancy with oligohydramnios were selected and randomly divided into experimental group with uterine cooker ballon and control group with Dinoprostone .There were 48 cases in each group .Cervical ripening , general progress of labor , delivery mode and maternal and perinatal physical condition were compared between two groups .Results Compared with the control group , the first and second stage of labor could be cut down by uterine cooker ballon (t value was 3.682 and 7.033, respectively).Uterine cooker ballon had great effect on promoting cervical ripening and reducing cesarean section rate (χ2 value was 1.792 and 4.381, respectively, both P <0.05).But there was no significant difference in fetal distress (χ2 =1.344), neonatal asphyxia (0 case) and postpartum hemorrhage (t =0.505) between two groups (all P >0.05). Conclusion Uterine cooker ballon is effective and safe for labor induction of term pregnancy with oligohydramnios , and it is worthy of clinical application .
  • 摘要：目的：探讨腹腔镜下双侧卵巢巧克力囊肿剔除术对卵巢储备功能的影响，并分析其敏感指标。方法选择2010年1月至2012年1月期间来青岛市妇女儿童医院进行诊治的双侧卵巢巧克力囊肿且对生育有要求的患者94例为研究对象，所有患者均行腹腔镜下双侧卵巢巧克力囊肿剔除术。回顾性分析患者的临床资料，并根据其术后6个月的基础卵泡刺激素（ bFSH）水平分为卵巢储备功能下降组（bFSH≥10IU／L，18例）和卵巢储备功能正常组（bFSH＜10IU／L，76例）。术后分析敏感指标对各组卵巢储备功能的影响及妊娠结果。结果卵巢储备功能下降组的年龄及囊肿分型构成与卵巢储备功能正常组相比差异均有统计学意义（t＝6．877，χ2＝7．243，均P＜0．05）；卵巢储备功能下降组的术前癌抗原125（CA125），术后CA125，术前用药，囊肿直径，合并深部浸润型子宫内膜异位症（ DIE）、腹膜型子宫内膜异位症（ PEM）、子宫腺肌症（ AM）情况及妊娠率与卵巢储备功能正常组相比差异均无统计学意义（均P＞0．05）。结论腹腔镜下双侧卵巢巧克力囊肿剔除术对卵巢的储备功能有影响，年龄较大及多房囊肿患者术后卵巢储备功能下降的风险更高。%Objective To investigate the influence of laparoscopic bilateral ovarian chocolate cystectomy on ovarian reserve function and the sensitive indicators .Methods From January 2010 to January 2012 94 patients diagnosed with bilateral ovarian chocolate cyst in Qingdao Women and Children Hospital and having requirement on birth were chosen , and they performed laparoscopic bilateral ovarian chocolate cystectomy.The clinical data of them were analyzed , and the patients were divided into decreased ovarian reserve function group ( bFSH≥10IU/L, 18 cases) and normal ovarian reserve function group (bFSH <10IU/L, 76 cases).The influence of sensitive indicators on ovarian reserve function of both groups and the pregnancy outcomes were analyzed .Results The differences in cyst type and patients ’ age were significant between two groups (t=6.877, χ2 =7.243,P<0.05).There were no significant differences in CA125 before surgery, CA125 after surgery, premedication, cyst diameter, deeply infiltrating endometriosis ( DIE ), peritoneal endometriosis ( PEM ), adenomyosis (AM) and pregnancy rate between two groups (all P >0.05).Conclusion Laparoscopic bilateral ovarian chocolate cystectomy will affect ovarian reserve function .Old patients with multi-room cyst have higher risks of ovarian reserve function decreased .
  • 摘要：目的：调查四川地区孕产妇对新生儿遗传代谢病筛查相关知识的认知情况，为今后开展有效的新生儿疾病筛查健康教育提供依据。方法采用随机抽样法，用自制问卷调查四川地区6家医疗机构2014年5月10至20日期间住院的孕产妇，并进行分析。结果有79．4％的孕产妇通过不同医院宣传途径获知新生儿遗传代谢病筛查知识，仅有9．8％能够准确回答全部筛查内容，有93．9％认为进行新生儿遗传代谢病筛查是必要的，94．2％有意愿继续了解相关知识。经单因素分析显示，文化程度、职业、年均收入与答题正确率不同差异有统计学意义（χ2值分别为12．022、19．177、10．334，均P＜0．05）。不同职业和年均收入是新生儿遗传代谢病筛查认知水平的独立影响因素，差异均有统计学意义（χ2值分别为16．630、10．267，均P＜0．05）。结论孕产妇认知水平较低且主动获知意识差，但被动学习意愿强，因此，以医院为主开展多渠道、多样化的健康教育工作以提高新生儿遗传代谢病筛查认知水平是很有必要的。%Objective To survey the cognition of pregnant and parturient women on newborn genetic metabolic disease screening knowledge in the areas of Sichuan province , so as to provide scientific basis for health teaching related to the newborn genetic metabolic disease screening.Methods Random sampling strategy was employed to select maternal women admitted in 6 medical institutions in Sichuan province since May 10 to 20 in 2014 to complete home-made questionnaires .Results Among the investigated pregnant and parturient women, 79.4%could get the newborn genetic metabolic disease screening knowledge from hospitals , but only 9.8% could answer the question precisely.There were 93.9% of them thinking newborn genetic metabolic disease screening necessary , and 94.2% had the invention to get the screening knowledge .The single factor analysis showed that there was significant difference in cultural degree , occupation and annual income (χ2 value was 12.022, 19.177 and 10.334, respectively, all P<0.05).Occupation and annual income were independent influencing factors of basic knowledge of newborn genetic metabolic disease screening , and the differences were significant (χ2 value was 16.630 and 10.267, respectively, both P<0.05).Conclusion Maternal cognitive level is relatively low and their actively learn consciousness is poor , but the passive learning willingness is strong .Therefore , it is necessary for hospitals to carry out multi-channel and diversified health education to improve the cognition of knowledge of newborn genetic metabolic disease screening .
  • 摘要：目的：研究自拟镇痫丸联合抗癫痫西药治疗小儿癫痫的疗效。方法将2010年1月至2013年6月余姚市第二人民医院儿科收治的小儿癫痫患者70例随机分为观察组和对照组，分别给予自拟镇痫丸联合西药治疗组（观察组）和单纯西药治疗组（对照组）；治疗2个疗程后（3个月为1个疗程），观察其治疗效果。结果疗程结束后观察组的治愈率、显效率、总有效率、疗程内发作率和治疗依从性分别为48．6％、37．1％、94．3％、4．2％和94．3％，以及对照组为25．7％、20．0％、77．1％、6．5％和74．3％；两组比较，观察组总疗效优于对照组（χ2＝3．769，P＜0．05），疗程内发作次数少与对照组（t＝－5．91，P＜0．05）。结论自拟镇痫丸联合西药的治疗具有疗效佳、症状控制稳定、不良反应轻、依从性高等优点，值得临床推广和使用。%Objective To explore the curative effect of Zhenxian pill combined with western medicine in treatment of pediatric epilepsy . Methods Seventy pediatric epilepsy patients treated in Yuyao City Second People ’ s Hospital during the period of January 2010 and June 2013 were randomly divided into observation group and control group .The observation group was given Zhenxian pill combined with western medicine , while the control group was provided with western medicine only .The curative effect of two groups was observed after 2 courses of treatment (one course of treatment lasting 3 months).Results After treatment the cure rate, obvious effective rate, total effective rate, attack rate within treatment and treatment compliance in the observation group were 48.6%, 37.1%, 94.3%, 4.2% and 94.3%, respectively, while those of the control group were 25.7%, 20.0%, 77.1%, 6.5%and 74.3%, respectively.Comparison between two groups showed that the total effective rate was higher and the attack within treatment was less in the observation group (χ2 =3.769,t=-5.91, both P <0.05).Conclusion Zhenxian pill combined with western medicine in the treatment of pediatric epilepsy has the advantages of good curative effect , stable control of symptom , mild adverse reaction and high compliance , so it is valuable in clinic application .

    中国妇幼健康研究的期刊信息

    • 曾用名：国外医学：妇幼保健分册;国外医学:妇幼保健分册;国外医学(妇幼保健分册);国外医学.妇幼保健分册
    • 创刊时间：1990
    • 地区：CN
    • 语言：中文
    • 热门主题：西安交通大学;妇幼健康研究会
    • 学科分类：

    中国妇幼健康研究的获奖情况

    • • 2007年已被评为中国科技核心期刊（中国科技论文统计源期刊），已取得《中国期刊网》和《中国学术期刊（光盘版）》全文收录，并作为“中国学术期刊综合评价数据库”、“中国科学引文数据库”来源期刊。同时被《中文医学科学核心期刊要目总览》、《中国生物医学文献光盘数据库》（CBMdisc）、《中文生物医学期刊目次数据库》（CMCC）、《中国科技期刊片名数据库》及两种书本式检索刊《中国科技资料目录》（医药卫生）、《中国医药文献》进行目次、文摘或全文收录。2009年以来曾2次获全国高校科技期刊质量奖、2016年高校科技期刊优秀奖和2015年省科协“学会创新和服务能力提升”项目优秀科技期刊奖。

    中国妇幼健康研究的收录情况

    • • 中国科技核心期刊

    中国妇幼健康研究的投稿信息

    • 投稿方式：在线投稿
    • 投稿须知：点击查看
    • 期刊官方网站：点击前往
    • 通讯地址：西安市雁塔西路76号西安交通大学医学院009信箱
    • 邮编：710061
    • 联系电话：029-82655049
    • 邮箱：bjbllm@mail.xjtu.edu.cn
    • 期刊栏目：综述；介评；论坛；简介；信息；国外考察；继续教育；编译
    免费订阅本刊

    客服邮箱：kefu@zhangqiaokeyan.com

    京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有 出版物经营许可证

    • 客服微信

    • 服务号