摘要：Objective To identify the differences of 5-methylcytosine (5-MC) level between primary prostatecancer tissues (PCTs), prostate cancer-adjacent benign tissues (PCABTs), low-grade prostaticintraepithelial neoplasia (LGPIN), and high-grade prostatic intraepithelial neoplasia (HGPIN), andfurther analysis the 5-MC alterations in prostate cancer with pathologic grade and clinicalprognosis.Materials and methods Immunohistochemistry method with a 5-MC monoclonal antibody wasused to identify the 5-methylcytosine (5-MC) levels in PCTs, PCABTs, LGPIN, and HGPINspecimens in the present study. Statistical analysis with SPSS software (SPSS Inc.,Chicago, IL)was used to compare differences of 5-MC levels in the four groups and evaluate the 5-MCalterations in prostate cancer with pathologic grade and clinical prognosis.
