群体感应系统在乳酸菌产细菌素中的作用

摘要

Several lactic acid bacteria（LAB） produce peptides with antimicrobial activity usually referred to as bacteriocins.Bacteriocins are diverse in terms of structure,mode of action,antimicrobial spectrum,and potency.Both LAB and their bacteriocins are generally regarded as safe.Bacteriocins produced by LABs have demonstrated great potential as natural preservatives Intercellular communication has emerged as the key regulatory mechanism that controls the synthesis of bacteriocins via a regulatory strategy denominated quorum sensing,which allows population-wide synchronised production of antimicrobial peptides as a function of cell density.The intercellular communication phenomenon required for sensing of the cell density is mediated by secreted signaling molecules that accumulate in the environment as the cell density increase and activate signal transduction cascades,resulting in the production of bacteriocins.This review aims at describing the types of signal molecules,signal transduction mechanism and the regulation of quorum sensing in bacteriocins synthesis of LAB and understanding the regulation mechanism of quorum sensing involved in the production of two classes of bacteriocin in LAB.%许多乳酸菌能够产生抗菌活性肽——细菌素,细菌素具有不同的结构、作用方式、抑菌谱和效价,通常认为乳酸菌和其所产的细菌素都是安全的,乳酸菌所产细菌素作为天然食品防腐剂已显示了巨大的潜能。基于群体感应的细胞间交流已成为细菌素合成的关键调控机制,群体感应作为细胞密度函数,可使细菌素产生保持同步性。群体感应需通过信号分子介导感知菌体密度,信号分子随着菌体密度增加而增加,并激活信号转导级联使菌体产生细菌素。本文通过对乳酸菌群体感应信号分子种类、信号转导机制及群体感应系统对两类细菌素合成的调控进行综述,以初步了解群体感