聚乙二醇干扰素α-2a治疗核苷(酸)类似物经治者初探

摘要

Nowadays, management of nucleos(t)ide analogue (NA)-experienced patients with chronic hepatitis B becomes one of the focuses and difficult issues. Several domestic and international pilot studies have revealed that the addition of pegylated interferon α-2a to NA therapy is associated with a high sustained post-treatment response. For NA-experienced patients, treatment strategies that can achieve a higher sustained immune control rate with pegylated interferon α-2a are worthy of being explored.%核苷(酸)类似物经治慢性乙型肝炎患者的处理是目前临床的热点与难点问题之一.国内外小规模的研究结果显示,聚乙二醇干扰素α-2a治疗核苷(酸)类似物经治患者有助提高停药后持久应答,对于各类核苷(酸)类似物经治患者,如何采用更有效的聚乙二醇干扰素α-2a治疗方案,实现更高持久免疫控制,值得探讨.