Objective To explore the teaching effect of"Organ-system-based curriculum" in-tegrated model on clinical graduation field work. Method 150 clinical medical undergraduates of Grade 2009 from Shenyang Medical College selected, were randomly divided into the experimental group (75 persons) and the control group (75 persons). The experimental group adopted the means of the "Organ-system-based curriculum" integrated model, namely practicing according to human organ-system and the control group accepted the traditional pattern of "discipline centered" practice during the clinical graduation internship. The two groups of students carried out questionnaire survey and comprehend examinations when the practice ended, and then statistics analysis (the chi square test, t test) was done by the SPSS 19.0 software between the two groups in order to explore the teaching effect. Result The students' satisfaction degree from six aspects of the questionnaire survey showed in the experimental group was significantly higher than that in the control group (the degree of recognition of practicing pattern: χ2=11.437, P=0.003; the architectonic integrality: χ2=9.881, P=0.007; the im-provement of the autonomic learning ability χ2=9.643, P=0.008; the teaching method and means: χ2=11.006, P=0.004; motivating learning interest: χ2=13.550, P=0.001; increasing the ability of clinical thinking: χ2=13.309, P=0.001), and the average test scores of students from three parts of examination results showed by comprehend examinations (speculative knowledge examination: t=2.768, P=0.006;technical skill examination: t=2.212, P=0.029; clinical capability examination: t=5.015, P=0.000) in the experimental group was obviously higher than that in the control group and the difference was sig-nificant. Conclusion "Organ-system-based curriculum" integrated model on clinical graduation in-ternship is generally approved by the students, which has significantly improved the students' clinical thinking ability, and the quality of graduation internship teaching.%目的：分析“以器官系统为基础”的临床毕业实习整合模式的教学效果。方法选取沈阳医学院2009级临床医学专业本科生150人，随机分为实验组75人，对照组75人。实验组接受“以器官系统为基础”的整合模式实习，即按照人体器官系统实习；对照组按照“以学科为中心”的传统模式实习。实习结束对两组学生进行问卷调查和综合考试，对教学效果进行比较。数据统计利用SPSS 19.0软件，采用卡方检验和t检验进行分析。结果实验组学生在实习模式认可度（χ2=11.437，P=0.003）、知识体系的完整性（χ2=9.881，P=0.007）、提高自主学习能力（χ2=9.643，P=0.008）、教学方法和手段（χ2=11.006，P=0.004）、激发学习兴趣（χ2=13.550，P=0.001）、提高临床思维能力（χ2=13.309，P=0.001）六个方面满意度均高于对照组学生，差异均有统计学意义。综合考试成绩显示，实验组学生在理论知识考试（t=2.768，P=0.006）、技能操作考试（t=2.212，P=0.029）、临床能力考试（t=5.015，P=0.000）三部分成绩也明显高于对照组学生，差异有统计学意义。结论“以器官系统为基础”的临床毕业实习整合模式受到学生的普遍认可，明显提高了学生的临床思维能力以及毕业实习教学质量。
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