Therapeutic Insights From a Novel Breast Tumor Suppressor Pathway.

摘要

Epigenetic gene silencing is a common element of breast cancers. The specific genes targeted and the mechanisms of silencing, and how these relate to disease progression and outcome, are not well understood. This research project has 1) identified a new breast tumor suppressor gene (RIN1) that is silenced in the majority of breast tumor cell lines and most tumor tissue samples tested; 2) begun to describe a breast tumor suppressor locus with three genes (B3GNT6; BRMS1, RIN1) that appear to be coordinately silenced in breast cancer; 3) uncovered multiple mechanisms of gene silencing operating at this locus and 4) demonstrated the development of specific tumorigenic phenotypes resulting from loss of RIN1 expression.