首页> 外文期刊>Clinical journal of sport medicine: official journal of the Canadian Academy of Sport Medicine >Muscle strength and body size and later cerebrovascular and coronary heart disease.
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Muscle strength and body size and later cerebrovascular and coronary heart disease.

机译:肌肉力量和体型以及后来的脑血管和冠心病。

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摘要

OBJECTIVE: To investigate the associations between muscle strength, relative weight, and stature in young adulthood with later coronary heart disease (CHD) and stroke incidence. DESIGN: Cohort study. SETTING: Baseline data were drawn from the Swedish Military Service Conscription Register from the records of 1969 to 1994. PARTICIPANTS: At baseline, male Swedish citizens born between 1951 and 1976 (median age, 18.2 y) attended a mandatory conscription examination from which the only grounds for exemption were a severe handicap or a chronic disease. Full data sets with blood pressure in the acceptable range [diastolic (DBP), 40-100 mm Hg and systolic (SBP), 100-180 mm Hg] were available for 1 145 467 men (99%). ASSESSMENT OF RISK FACTORS: The conscription examination included measurements of elbow flexion, hand grip, and knee extension strength; DBP and SBP, and height and weight for calculation of body mass index (BMI). Data on education and socioeconomic status were derived from censuses conducted every decade. MAIN OUTCOME MEASURES: The main outcome measures were fatal and nonfatal CHD events and hemorrhagic and ischemic strokes in relation to strength, BMI, and height. Follow-up data were collected from 1969 to 2006 from the Swedish Cause of Death Register, Swedish Hospital Discharge Register, and Statistics Sweden's Emigration Register. Follow-up time was counted from conscription examination to death or hospitalization (median follow-up time, 24.4 y). Standardized hazard ratios (HR) were calculated for a 1-SD increase in the exposure variables. MAIN RESULTS: During the follow-up period 12 323 CHD and 8865 stroke cases occurred. After adjustment for other risk factors, strength indicators were inversely associated with CHD and all strokes (HR for CHD: elbow flexion strength, 0.95; 95% confidence interval [CI], 0.93-0.97; grip strength, 0.89; 95% CI, 0.88-0.91; knee extension strength, 0.92; 95% CI, 0.90-0.94; and HR for stroke: elbow flexion strength, 0.96; 95% CI, 0.94-0.99; grip strength, 0.95; 95% CI, 0.93-0.97; knee extension strength, 0.93; 95% CI, 0.90-0.95). Greater grip strength predicted a lower risk of intracerebral infarction (HR, 0.91; 95% CI, 0.88-0.95) and greater knee extension strength predicted a lower risk of intracerebral and subarachnoid hemorrhagic stroke (HR, 0.88; 95% CI, 0.82-0.93 and HR, 0.92, 95% CI, 0.86-0.99, respectively). Risk of CHD and intracerebral infarction increased progressively with increasing BMI, whereas both very low BMI and overweight were associated with intracerebral and subarachnoid hemorrhagic stroke. Tallness was positively associated with lower rates of CHD and stroke. CONCLUSIONS: Muscle strength was inversely associated with risk of fatal and nonfatal coronary heart disease and stroke, independently of associations of BMI and stature with mortality and morbidity, during 24 years of follow-up of men on Swedish conscription rolls.
机译:目的:探讨青年期成年后合并冠心病(CHD)和中风发生率的肌力,相对体重和身高之间的关系。设计:队列研究。地点:基线数据是从1969年至1994年的瑞典兵役征兵登记簿中提取的。参与者:基线时,出生于1951年至1976年(平均年龄为18.2岁)的瑞典男性男性参加了强制性征兵检查,唯一的一项是豁免的依据是严重的障碍或慢性疾病。可以得到1145467名男性(99%)的血压在可接受范围内的完整数据集[舒张压(DBP),40-100 mm Hg和收缩压(SBP),100-180 mm Hg]。危险因素的评估:征兵检查包括测量肘部弯曲,手抓握和膝盖伸展的力量。 DBP和SBP,以及身高和体重,用于计算体重指数(BMI)。有关教育和社会经济地位的数据来自每十年进行的一次普查。主要观察指标:主要结局指标为致命和非致命冠心病事件以及出血,缺血性卒中的强度,BMI和身高。 1969年至2006年的随访数据来自瑞典死亡原因登记册,瑞典医院出院登记册和瑞典统计局的移民登记册。随访时间从征兵检查到死亡或住院计算(中位随访时间24.4年)。对于暴露变量的1-SD增长,计算标准危险比(HR)。主要结果:在随访期间发生了12323例CHD和8865例中风病例。在调整了其他危险因素后,强度指标与冠心病和所有卒中呈负相关(冠心病的HR:肘屈肌强度为0.95; 95%置信区间[CI]为0.93-0.97;握力为0.89; 95%CI为0.88 -0.91;膝盖伸展强度,0.92; 95%CI,0.90-0.94;中风HR:肘部弯曲强度,0.96; 95%CI,0.94-0.99;握力,0.95; 95%CI,0.93-0.97;膝盖延伸强度为0.93; 95%CI为0.90-0.95)。较高的抓地力预示着较低的脑梗死风险(HR,0.91; 95%CI,0.88-0.95),较高的膝盖伸展强度预示着较低的大脑内和蛛网膜下腔出血性中风的风险(HR,0.88; 95%CI,0.82-0.93和HR,分别为0.92、95%CI,0.86-0.99)。随着BMI的增加,冠心病和脑梗死的风险逐渐增加,而BMI极低和超重均与脑和蛛网膜下腔出血性中风有关。高大与冠心病和中风发生率降低呈正相关。结论:在瑞典征募名单中,对男性进行了24年的随访,肌肉力量与致命和非致命性冠心病和中风的风险成反比,而与BMI和身材与死亡率和发病率的关系无关。

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