Preferential Binding of βS Globin Chains Associated with Stroma in Sickle Cell Disorders

摘要

Sickle cell anemia (SS) is associated with abnormalities of the red cell membrane and decreased red cell deformability. The present study assesses globin chain binding to stroma in SS, sickle cell trait (AS), and nonsickling (AA) cells. The results indicate that there is preferential binding of newly synthesized β^S globin to red cell stroma in SS cells and preferential binding of β^S to stroma compared to β^A in AS cells. These studies show that β^S globin binding to stroma accompanies the membrane abnormalities in SS and AS patients.