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The Journal of Clinical Investigation

【机译】：该临床研究杂志

ISSN：-
出版周期：Monthly, 2005-
语言：English, English

起始发布年份：1924
出版者：New Haven [etc.] American Society for Clinical Investigation.
出版地：United States

NLM刊名缩写：J Clin Invest

数据库引入：PubMed: v1,1924-, OLDMEDLINE, PMC

MeSH词表主题词：Medicine*

备注：Issues for 1925-74 include abstracts of the 17th-66th annual meeting of the展开▼

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1.HIV-1 replicates and persists in vaginal epithelial dendritic cells

机译：HIV-1在阴道上皮树突状细胞中复制并持续存在
- 作者：Victor Pena-Cruz;Luis M. Agosto;Hisashi Akiyama;Alex Olson;Yvetane Moreau;Jean-Robert Larrieux;Andrew Henderson;Suryaram Gummuluru;Manish Sagar
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第8期
- AIDS/HIV Infectious disease;
2.JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation

机译：JAK2-V617F通过β1/β2整合素激活促进静脉血栓形成
- 作者：Bärbel Edelmann;Nibedita Gupta;Tina M. Schnoeder;Anja M. Oelschlegel;Khurrum Shahzad;Jürgen Goldschmidt;Lars Philipsen;Soenke Weinert;Aniket Ghosh;Felix C. Saalfeld;Subbaiah Chary Nimmagadda;Peter Müller;Rüdiger Braun-Dullaeus;Juliane Mohr;Denise Wolleschak;Stefanie Kliche;Holger Amthauer;Florian H. Heidel;Burkhart Schraven;Berend Isermann;Andreas J. Müller;Thomas Fischer
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Hematology;
3.CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease

机译：CaMK4在自身免疫性和非自身免疫性肾脏疾病中损害足细胞功能
- 作者：Kayaho Maeda;Kotaro Otomo;Nobuya Yoshida;Mones S. Abu-Asab;Kunihiro Ichinose;Tomoya Nishino;Michihito Kono;Andrew Ferretti;Rhea Bhargava;Shoichi Maruyama;Sean Bickerton;Tarek M. Fahmy;Maria G. Tsokos;George C. Tsokos
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第8期
- Autoimmunity Nephrology;
4.Neonatal Fc receptor antagonist efgartigimod safely and sustainably reduces IgGs in humans

机译：新生儿Fc受体拮抗剂efgartigimod安全可持续地降低人类IgG
- 作者：Peter Ulrichts;Antonio Guglietta;Torsten Dreier;Tonke van Bragt;Valérie Hanssens;Erik Hofman;Bernhardt Vankerckhoven;Peter Verheesen;Nicolas Ongenae;Valentina Lykhopiy;F. Javier Enriquez;JunHaeng Cho;Raimund J. Ober;E. Sally Ward;Hans de Haard;Nicolas Leupin
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Autoimmunity Therapeutics;
5.Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes

机译：自身反应性T效应器记忆分化反映1型糖尿病的β细胞功能
- 作者：Lorraine Yeo;Alyssa Woodwyk;Sanjana Sood;Anna Lorenc;Martin Eichmann;Irma Pujol-Autonell;Rosella Melchiotti;Ania Skowera;Efthymios Fidanis;Garry M. Dolton;Katie Tungatt;Andrew K. Sewell;Susanne Heck;Alka Saxena;Craig A. Beam;Mark Peakman
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第8期
- Autoimmunity Immunology;
6.The BRG1/SOX9 axis is critical for acinar cell–derived pancreatic tumorigenesis

机译：BRG1 / SOX9轴对于腺泡源性胰腺肿瘤的发生至关重要
- 作者：Motoyuki Tsuda;Akihisa Fukuda;Nilotpal Roy;Yukiko Hiramatsu;Laura Leonhardt;Nobuyuki Kakiuchi;Kaja Hoyer;Satoshi Ogawa;Norihiro Goto;Kozo Ikuta;Yoshito Kimura;Yoshihide Matsumoto;Yutaka Takada;Takuto Yoshioka;Takahisa Maruno;Yuichi Yamaga;Grace E. Kim;Haruhiko Akiyama;Seishi Ogawa;Christopher V. Wright;Dieter Saur;Kyoichi Takaori;Shinji Uemoto;Matthias Hebrok;Tsutomu Chiba;Hiroshi Seno
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第8期
- Gastroenterology Oncology;
7.TLR3 agonist and CD40-targeting vaccination induces immune responses and reduces HIV-1 reservoirs

机译：TLR3激动剂和靶向CD40的疫苗接种可诱导免疫反应并减少HIV-1储库
- 作者：Liang Cheng;Qi Wang;Guangming Li;Riddhima Banga;Jianping Ma;Haisheng Yu;Fumihiko Yasui;Zheng Zhang;Giuseppe Pantaleo;Matthieu Perreau;Sandra Zurawski;Gerard Zurawski;Yves Levy;Lishan Su
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- AIDS/HIV Vaccines;
8.P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes

机译：P2X7R突变会破坏NLRP3介导的Th程序并预测同种异体心脏移植结果不良
- 作者：Francesca D’Addio;Andrea Vergani;Luciano Potena;Anna Maestroni;Vera Usuelli;Moufida Ben Nasr;Roberto Bassi;Sara Tezza;Sergio Dellepiane;Basset El Essawy;Maria Iascone;Attilio Iacovoni;Laura Borgese;Kaifeng Liu;Gary Visner;Sirano Dhe-Paganon;Domenico Corradi;Reza Abdi;Randall C. Starling;Franco Folli;Gian Vincenzo Zuccotti;Mohamed H. Sayegh;Peter S. Heeger;Anil Chandraker;Francesco Grigioni;Paolo Fiorina
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第8期
- Immunology Transplantation;
9.Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth

机译：特异性共价抑制MALT1半胱天冬酶抑制B细胞淋巴瘤生长
- 作者：Lorena Fontán;Qi Qiao;John M. Hatcher;Gabriella Casalena;Ilkay Us;Matt Teater;Matt Durant;Guangyan Du;Min Xia;Natalia Bilchuk;Spandan Chennamadhavuni;Giuseppe Palladino;Giorgio Inghirami;Ulrike Philippar;Hao Wu;David A. Scott;Nathanael S. Gray;Ari Melnick
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Oncology Therapeutics;
10.Metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy

机译：Metreleptin介导的胰岛素敏感性改善与脂肪营养不良的人的食物摄入无关
- 作者：Rebecca J. Brown;Areli Valencia;Megan Startzell;Elaine Cochran;Peter J. Walter;H. Martin Garraffo;Hongyi Cai;Ahmed M. Gharib;Ronald Ouwerkerk;Amber B. Courville;Shanna Bernstein;Robert J. Brychta;Kong Y. Chen;Mary Walter;Sungyoung Auh;Phillip Gorden
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第8期
- Endocrinology Metabolism;
11.Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer

机译：抑癌药Par-4的表观遗传沉默促进复发性乳腺癌的化学耐药性
- 作者：Nathaniel W. Mabe;Douglas B. Fox;Ryan Lupo;Amy E. Decker;Stephanie N. Phelps;J. Will Thompson;James V. Alvarez
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Oncology;
12.Mosaic-variegated aneuploidy syndrome mutation or haploinsufficiency in Cep57 impairs tumor suppression

机译：Cep57中的马赛克杂色非整倍性综合征突变或单倍体不足会削弱肿瘤抑制能力
- 作者：Khaled Aziz;Cynthia J. Sieben;Karthik B. Jeganathan;Masakazu Hamada;Brian A. Davies;Raul O. Fierro Velasco;Nazneen Rahman;David J. Katzmann;Jan M. van Deursen
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第8期
- Cell Biology Oncology;
13.Antibiotic treatment–induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia

机译：抗生素治疗引起的继发性IgA缺乏症增强了对铜绿假单胞菌肺炎的易感性
- 作者：Oliver H. Robak;Markus M. Heimesaat;Andrey A. Kruglov;Sandra Prepens;Justus Ninnemann;Birgitt Gutbier;Katrin Reppe;Hubertus Hochrein;Mark Suter;Carsten J. Kirschning;Veena Marathe;Jan Buer;Mathias W. Hornef;Markus Schnare;Pascal Schneider;Martin Witzenrath;Stefan Bereswill;Ulrich Steinhoff;Norbert Suttorp;Leif E. Sander;Catherine Chaput;Bastian Opitz
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第8期
- Infectious disease;
14.Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer

机译：免疫基因组学分析将免疫学改变与前列腺癌的错配修复缺陷相关联
- 作者：Daniel Nava Rodrigues;Pasquale Rescigno;David Liu;Wei Yuan;Suzanne Carreira;Maryou B. Lambros;George Seed;Joaquin Mateo;Ruth Riisnaes;Stephanie Mullane;Claire Margolis;Diana Miao;Susana Miranda;David Dolling;Matthew Clarke;Claudia Bertan;Mateus Crespo;Gunther Boysen;Ana Ferreira;Adam Sharp;Ines Figueiredo;Daniel Keliher;Saud Aldubayan;Kelly P. Burke;Semini Sumanasuriya;Mariane Sousa Fontes;Diletta Bianchini;Zafeiris Zafeiriou;Larissa Sena Teixeira Mendes;Kent Mouw;Michael T. Schweizer;Colin C. Pritchard;Stephen Salipante;Mary-Ellen Taplin;Himisha Beltran;Mark A. Rubin;Marcin Cieslik;Dan Robinson;Elizabeth Heath;Nikolaus Schultz;Joshua Armenia;Wassim Abida;Howard Scher;Christopher Lord;Alan D’Andrea;Charles L. Sawyers;Arul M. Chinnaiyan;Andrea Alimonti;Peter S. Nelson;Charles G. Drake;Eliezer M. Van Allen;Johann S. de Bono
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Genetics Oncology;
15.Optimal bone fracture repair requires 24R25-dihydroxyvitamin D3 and its effector molecule FAM57B2

机译：最佳的骨折修复需要24R25-二羟基维生素D3及其效应分子FAM57B2
- 作者：Corine Martineau;Roy Pascal Naja;Abdallah Husseini;Bachar Hamade;Martin Kaufmann;Omar Akhouayri;Alice Arabian;Glenville Jones;René St-Arnaud
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第8期
- Bone Biology Endocrinology;
16.REVERBa couples the circadian clock to hepatic glucocorticoid action

机译：REVERBa将昼夜节律与肝糖皮质激素作用相结合
- 作者：Giorgio Caratti;Mudassar Iqbal;Louise Hunter;Donghwan Kim;Ping Wang;Ryan M. Vonslow;Nicola Begley;Abigail J. Tetley;Joanna L. Woodburn;Marie Pariollaud;Robert Maidstone;Ian J. Donaldson;Zhenguang Zhang;Louise M. Ince;Gareth Kitchen;Matthew Baxter;Toryn M. Poolman;Dion A. Daniels;David R. Stirling;Chad Brocker;Frank Gonzalez;Andrew S.I. Loudon;David A. Bechtold;Magnus Rattray;Laura C. Matthews;David W. Ray
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Endocrinology Metabolism;
17.Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models

机译：反义寡核苷酸可延长ALS模型中肌肉的存活时间并逆向递减
- 作者：Alex McCampbell;Tracy Cole;Amy J. Wegener;Giulio S. Tomassy;Amy Setnicka;Brandon J. Farley;Kathleen M. Schoch;Mariah L. Hoye;Mark Shabsovich;Linhong Sun;Yi Luo;Mingdi Zhang;Nicole Comfort;Bin Wang;Jessica Amacker;Sai Thankamony;David W. Salzman;Merit Cudkowicz;Danielle L. Graham;C. Frank Bennett;Holly B. Kordasiewicz;Eric E. Swayze;Timothy M. Miller
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第8期
- Neuroscience Therapeutics;
18.Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming

机译：基质表观遗传改变驱动代谢和神经内分泌前列腺癌重编程
- 作者：Rajeev Mishra;Subhash Haldar;Veronica Placencio;Anisha Madhav;Krizia Rohena-Rivera;Priyanka Agarwal;Frank Duong;Bryan Angara;Manisha Tripathi;Zhenqiu Liu;Roberta A. Gottlieb;Shawn Wagner;Edwin M. Posadas;Neil A. Bhowmick
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Cell Biology Metabolism;
19.GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain

机译：GPR37调节巨噬细胞吞噬作用和炎症性疼痛的缓解
- 作者：Sangsu Bang;Ya-Kai Xie;Zhi-Jun Zhang;Zilong Wang;Zhen-Zhong Xu;Ru-Rong Ji
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第8期
- Inflammation Neuroscience;
20.ASK1 contributes to fibrosis and dysfunction in models of kidney disease

机译：ASK1导致肾脏疾病模型中的纤维化和功能障碍
- 作者：John T. Liles;Britton K. Corkey;Gregory T. Notte;Grant R. Budas;Eric B. Lansdon;Ford Hinojosa-Kirschenbaum;Shawn S. Badal;Michael Lee;Brian E. Schultz;Sarah Wise;Swetha Pendem;Michael Graupe;Laurie Castonguay;Keith A. Koch;Melanie H. Wong;Giuseppe A. Papalia;Dorothy M. French;Theodore Sullivan;Erik G. Huntzicker;Frank Y. Ma;David J. Nikolic-Paterson;Tareq Altuhaifi;Haichun Yang;Agnes B. Fogo;David G. Breckenridge
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Nephrology Therapeutics;
21.Purinergic P2X4 receptors and mitochondrial ATP production regulate T cell migration

机译：嘌呤能P2X4受体和线粒体ATP产生调节T细胞迁移
- 作者：Carola Ledderose;Kaifeng Liu;Yutaka Kondo;Christian J. Slubowski;Thomas Dertnig;Sara Denicoló;Mona Arbab;Johannes Hubner;Kirstin Konrad;Mahtab Fakhari;James A. Lederer;Simon C. Robson;Gary A. Visner;Wolfgang G. Junger
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第8期
- Cell Biology Transplantation;
22.No recovery of replication-competent HIV-1 from human liver macrophages

机译：无法从人肝巨噬细胞中回收具有复制能力的HIV-1
- 作者：Abraham J. Kandathil;Sho Sugawara;Ashish Goyal;Christine M. Durand;Jeffrey Quinn;Jaiprasath Sachithanandham;Andrew M. Cameron;Justin R. Bailey;Alan S. Perelson;Ashwin Balagopal
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- AIDS/HIV Infectious disease;
23.TNF overproduction impairs epithelial staphylococcal response in hyper IgE syndrome

机译：高IgE综合征中的TNF过量生产损害上皮葡萄球菌反应
- 作者：Ian A. Myles;Erik D. Anderson;Noah J. Earland;Kol A. Zarember;Inka Sastalla;Kelli W. Williams;Portia Gough;Ian N. Moore;Sundar Ganesan;Cedar J. Fowler;Arian Laurence;Mary Garofalo;Douglas B. Kuhns;Mark D. Kieh;Arhum Saleem;Pamela A. Welch;Dirk A. Darnell;John I. Gallin;Alexandra F. Freeman;Steven M. Holland;Sandip K. Datta
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第8期
- Immunology Infectious disease;
24.Long noncoding RNA LERFS negatively regulates rheumatoid synovial aggression and proliferation

机译：长非编码RNA LERFS负调控类风湿性滑膜的侵略和增殖
- 作者：Yaoyao Zou;Siqi Xu;Youjun Xiao;Qian Qiu;Maohua Shi;Jingnan Wang;Liuqin Liang;Zhongping Zhan;Xiuyan Yang;Nancy Olsen;Song Guo Zheng;Hanshi Xu
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Immunology;
25.Hijacking a key chromatin modulator creates epigenetic vulnerability for MYC-driven cancer

机译：劫持关键的染色质调节剂会为MYC驱动的癌症带来表观遗传易感性
- 作者：Zhenhua Yang;Kushani Shah;Theodore Busby;Keith Giles;Alireza Khodadadi-Jamayran;Wei Li;Hao Jiang
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第8期
- Hematology Oncology;
26.Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis

机译：泛素连接酶RNF8抑制Notch信号调节乳腺发育和肿瘤发生
- 作者：Li Li;Kiran Kumar Naidu Guturi;Brandon Gautreau;Parasvi S. Patel;Amine Saad;Mayako Morii;Francesca Mateo;Luis Palomero;Haithem Barbour;Antonio Gomez;Deborah Ng;Max Kotlyar;Chiara Pastrello;Hartland W. Jackson;Rama Khokha;Igor Jurisica;El Bachir Affar;Brian Raught;Otto Sanchez;Moulay Alaoui-Jamali;Miguel A. Pujana;Anne Hakem;Razq Hakem
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Cell Biology Oncology;
27.Trefoil factor 1 inhibits epithelial-mesenchymal transition of pancreatic intraepithelial neoplasm

机译：三叶因子1抑制胰腺上皮内肿瘤的上皮-间质转化
- 作者：Junpei Yamaguchi;Yukihiro Yokoyama;Toshio Kokuryo;Tomoki Ebata;Atsushi Enomoto;Masato Nagino
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第8期
- Gastroenterology Oncology;
28.Endothelial pyruvate kinase M2 maintains vascular integrity

机译：内皮丙酮酸激酶M2维持血管完整性
- 作者：Boa Kim;Cholsoon Jang;Harita Dharaneeswaran;Jian Li;Mohit Bhide;Steven Yang;Kristina Li;Zolt Arany
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Metabolism Vascular Biology;
29.Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction

机译：雄激素受体聚谷氨酰胺的扩展驱动年龄相关的质量控制缺陷和肌肉功能障碍
- 作者：Samir R. Nath;Zhigang Yu;Theresa A. Gipson;Gregory B. Marsh;Eriko Yoshidome;Diane M. Robins;Sokol V. Todi;David E. Housman;Andrew P. Lieberman
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第8期
- Muscle Biology Neuroscience;
30.CD122 signaling in CD8+ memory T cells drives costimulation-independent rejection

机译：CD8 +记忆T细胞中的CD122信号传导与刺激无关的排斥反应
- 作者：David V. Mathews;Ying Dong;Laura B. Higginbotham;Steven C. Kim;Cynthia P. Breeden;Elizabeth A. Stobert;Joseph Jenkins;J. Yun Tso;Christian P. Larsen;Andrew B. Adams
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Immunology Transplantation;
31.Eupatilin rescues ciliary transition zone defects to ameliorate ciliopathy-related phenotypes

机译：依帕替林挽救睫状过渡带缺陷改善与睫状体病相关的表型
- 作者：Yong Joon Kim;Sungsoo Kim;Yooju Jung;Eunji Jung;Ho Jeong Kwon;Joon Kim
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第8期
- Development Ophthalmology;
32.PD-1 blockade partially recovers dysfunctional virus–specific B cells in chronic hepatitis B infection

机译：PD-1阻滞剂可部分恢复慢性乙型肝炎感染中功能异常的病毒特异性B细胞
- 作者：Loghman Salimzadeh;Nina Le Bert;Charles-A. Dutertre;Upkar S. Gill;Evan W. Newell;Christian Frey;Magdeleine Hung;Nikolai Novikov;Simon Fletcher;Patrick T.F. Kennedy;Antonio Bertoletti
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Hepatology Infectious disease;
33.Circulating and intrahepatic antiviral B cells are defective in hepatitis B

机译：乙型肝炎中循环和肝内抗病毒B细胞存在缺陷
- 作者：Alice R. Burton;Laura J. Pallett;Laura E. McCoy;Kornelija Suveizdyte;Oliver E. Amin;Leo Swadling;Elena Alberts;Brian R. Davidson;Patrick T.F. Kennedy;Upkar S. Gill;Claudia Mauri;Paul A. Blair;Nadege Pelletier;Mala K. Maini
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Immunology Infectious disease;
34.The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease

机译：波形蛋白中间丝网络抑制移植物抗宿主病的调节性T细胞抑制
- 作者：Cameron McDonald-Hyman;James T. Muller;Michael Loschi;Govindarajan Thangavelu;Asim Saha;Sudha Kumari;Dawn K. Reichenbach;Michelle J. Smith;Guoan Zhang;Brent H. Koehn;Jiqiang Lin;Jason S. Mitchell;Brian T. Fife;Angela Panoskaltsis-Mortari;Colby J. Feser;Andrew Kemal Kirchmeier;Mark J. Osborn;Keli L. Hippen;Ameeta Kelekar;Jonathan S. Serody;Laurence A. Turka;David H. Munn;Hongbo Chi;Thomas A. Neubert;Michael L. Dustin;Bruce R. Blazar
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Immunology Transplantation;
35.Use of contraceptive depot medroxyprogesterone acetate is associated with impaired cervicovaginal mucosal integrity

机译：避孕药甲羟孕酮的使用与宫颈阴道粘膜完整性受损有关
- 作者：Irina A. Zalenskaya;Neelima Chandra;Nazita Yousefieh;Xi Fang;Oluwatosin E. Adedipe;Suzanne S. Jackson;Sharon M. Anderson;Christine K. Mauck;Jill L. Schwartz;Andrea R. Thurman;Gustavo F. Doncel
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- AIDS/HIV Reproductive Biology;
36.Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium

机译：铜绿假单胞菌利用宿主多不饱和磷脂酰乙醇胺引发支气管上皮的盗窃-肥大病
- 作者：Haider H. Dar;Yulia Y. Tyurina;Karolina Mikulska-Ruminska;Indira Shrivastava;Hsiu-Chi Ting;Vladimir A. Tyurin;James Krieger;Claudette M. St. Croix;Simon Watkins;Erkan Bayir;Gaowei Mao;Catherine R. Armbruster;Alexandr Kapralov;Hong Wang;Matthew R. Parsek;Tamil S. Anthonymuthu;Abiola F. Ogunsola;Becca A. Flitter;Cody J. Freedman;Jordan R. Gaston;Theodore R. Holman;Joseph M. Pilewski;Joel S. Greenberger;Rama K. Mallampalli;Yohei Doi;Janet S. Lee;Ivet Bahar;Jennifer M. Bomberger;Hülya Bayır;Valerian E. Kagan
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Cell Biology Infectious disease;
37.Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade

机译：NK细胞对PD-1 / PD-L1阻断介导的免疫治疗的贡献
- 作者：Joy Hsu;Jonathan J. Hodgins;Malvika Marathe;Chris J. Nicolai;Marie-Claude Bourgeois-Daigneault;Troy N. Trevino;Camillia S. Azimi;Amit K. Scheer;Haley E. Randolph;Thornton W. Thompson;Lily Zhang;Alexandre Iannello;Nikhita Mathur;Karen E. Jardine;Georgia A. Kirn;John C. Bell;Michael W. McBurney;David H. Raulet;Michele Ardolino
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Immunology;
38.PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation

机译：PD-1 + CD8 + T细胞是人类慢性炎症中的克隆扩展效应子
- 作者：Alessandra Petrelli;Gerdien Mijnheer;David P. Hoytema van Konijnenburg;Maria M. van der Wal;Barbara Giovannone;Enric Mocholi;Nadia Vazirpanah;Jasper C. Broen;Dirkjan Hijnen;Bas Oldenburg;Paul J. Coffer;Sebastian J. Vastert;Berent J. Prakken;Eric Spierings;Aridaman Pandit;Michal Mokry;Femke van Wijk
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Immunology;
39.Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma

机译：芳基烃受体/多胺生物合成轴的抑制抑制多发性骨髓瘤
- 作者：Anna Bianchi-Smiraglia;Archis Bagati;Emily E. Fink;Hayley C. Affronti;Brittany C. Lipchick;Sudha Moparthy;Mark D. Long;Spencer R. Rosario;Shivana M. Lightman;Kalyana Moparthy;David W. Wolff;Dong Hyun Yun;Zhannan Han;Anthony Polechetti;Matthew V. Roll;Ilya I. Gitlin;Katerina I. Leonova;Aryn M. Rowsam;Eugene S. Kandel;Andrei V. Gudkov;P. Leif Bergsagel;Kelvin P. Lee;Dominic J. Smiraglia;Mikhail A. Nikiforov
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Cell Biology Oncology;
40.Zika virus infects human testicular tissue and germ cells

机译：寨卡病毒感染人类睾丸组织和生殖细胞
- 作者：Giulia Matusali;Laurent Houzet;Anne-Pascale Satie;Dominique Mahé;Florence Aubry;Thérèse Couderc;Julie Frouard;Salomé Bourgeau;Karim Bensalah;Sylvain Lavoué;Guillaume Joguet;Louis Bujan;André Cabié;Gleide Avelar;Marc Lecuit;Anna Le Tortorec;Nathalie Dejucq-Rainsford
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Virology;
41.Inhibition of neogenin fosters resolution of inflammation and tissue regeneration

机译：抑制新生成素促进炎症和组织再生的消退
- 作者：Martin Schlegel;Andreas Körner;Torsten Kaussen;Urs Knausberg;Carmen Gerber;Georg Hansmann;Hulda Soffia Jónasdóttir;Martin Giera;Valbona Mirakaj
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Immunology Inflammation;
42.Schwann cell–derived periostin promotes autoimmune peripheral polyneuropathy via macrophage recruitment

机译：雪旺细胞衍生的骨膜素通过巨噬细胞募集促进自身免疫性外周多发性神经病
- 作者：Denise E. Allard;Yan Wang;Jian Joel Li;Bridget Conley;Erin W. Xu;David Sailer;Caellaigh Kimpston;Rebecca Notini;Collin-Jamal Smith;Emel Koseoglu;Joshua Starmer;Xiaopei L. Zeng;James F. Howard Jr.;Ahmet Hoke;Steven S. Scherer;Maureen A. Su
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
- Autoimmunity Neuroscience;
43.Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation

机译：颗粒状变应原通过持续的IgE介导的肥大细胞活化增强小鼠的过敏性哮喘
- 作者：Cong Jin;Christopher P. Shelburne;Guojie Li;Erin N. Potts;Kristina J. Riebe;Gregory D. Sempowski;W. Michael Foster;Soman N. Abraham
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
44.JAK2/IDH-mutant–driven myeloproliferative neoplasm is sensitive to combined targeted inhibition

机译：JAK2 / IDH突变驱动的骨髓增生性肿瘤对联合靶向抑制敏感
- 作者：Anna Sophia McKenney;Allison N. Lau;Amritha Varshini Hanasoge Somasundara;Barbara Spitzer;Andrew M. Intlekofer;Jihae Ahn;Kaitlyn Shank;Franck T. Rapaport;Minal A. Patel;Efthymia Papalexi;Alan H. Shih;April Chiu;Elizaveta Freinkman;Esra A. Akbay;Mya Steadman;Raj Nagaraja;Katharine Yen;Julie Teruya-Feldstein;Kwok-Kin Wong;Raajit Rampal;Matthew G. Vander Heiden;Craig B. Thompson;Ross L. Levine
- 期刊名称：《The Journal of Clinical Investigation》 | 2018年第10期
45.A conversation with Eric Olson

机译：与埃里克·奥尔森的对话
- 作者：Ushma S. Neill
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
46.Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis

机译：线粒体是衰老和特发性肺纤维化的焦点
- 作者：Ana L. Mora;Marta Bueno;Mauricio Rojas
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
47.Overcoming therapeutic resistance in glioblastoma: the way forward

机译：克服胶质母细胞瘤的治疗耐药性：前进的方向
- 作者：Satoru Osuka;Erwin G. Van Meir
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
48.Redirecting cardiac growth mechanisms for therapeutic regeneration

机译：重定向心脏生长机制以进行治疗性再生
- 作者：Ravi Karra;Kenneth D. Poss
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
49.The aging clock: circadian rhythms and later life

机译：老化时钟：昼夜节律和晚年生活
- 作者：Suzanne Hood;Shimon Amir
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
50.Seeing how we smell

机译：看到我们的气味
- 作者：Helene Benveniste;Yuri Lazebnik;Nora D. Volkow
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
51.How does leptin restore euglycemia in insulin-deficient diabetes?

机译：瘦素如何恢复胰岛素缺乏型糖尿病的正常血糖？
- 作者：Douglas Oberlin;Christoph Buettner
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
52.Out of the frying pan: dietary saturated fat influences nonalcoholic fatty liver disease

机译：走出平底锅：饮食中的饱和脂肪会影响非酒精性脂肪肝
- 作者：Elizabeth Parks;Hannele Yki-Järvinen;Meredith Hawkins
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
53.Carbohydrate-binding protein CLEC14A regulates VEGFR-2– and VEGFR-3–dependent signals during angiogenesis and lymphangiogenesis

机译：碳水化合物结合蛋白CLEC14A在血管生成和淋巴管生成过程中调节VEGFR-2和VEGFR-3依赖性信号
- 作者：Sungwoon Lee;Seung-Sik Rho;Hyojin Park;Jeong Ae Park;Jihye Kim;In-Kyu Lee;Gou Young Koh;Naoki Mochizuki;Young-Myeong Kim;Young-Guen Kwon
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
54.Fluorescent aminoglycosides reveal intracellular trafficking routes in mechanosensory hair cells

机译：荧光氨基糖苷揭示了机械感觉毛细胞的细胞内运输途径
- 作者：Dale W. Hailey;Robert Esterberg;Tor H. Linbo;Edwin W. Rubel;David W. Raible
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
55.M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss

机译：M1毒蕈碱别构调节剂可延缓病毒神经变性并恢复记忆丧失
- 作者：Sophie J. Bradley;Julie-Myrtille Bourgognon;Helen E. Sanger;Nicholas Verity;Adrian J. Mogg;David J. White;Adrian J. Butcher;Julie A. Moreno;Colin Molloy;Timothy Macedo-Hatch;Jennifer M. Edwards;Jurgen Wess;Robert Pawlak;David J. Read;Patrick M. Sexton;Lisa M. Broad;Joern R. Steinert;Giovanna R. Mallucci;Arthur Christopoulos;Christian C. Felder;Andrew B. Tobin
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
56.Gsα deficiency in the dorsomedial hypothalamus underlies obesity associated with Gsα mutations

机译：下丘脑下丘脑中的Gsα缺乏症是与Gsα突变相关的肥胖症的基础
- 作者：Min Chen;Yogendra B. Shrestha;Brandon Podyma;Zhenzhong Cui;Benedetta Naglieri;Hui Sun;Thuy Ho;Eric A. Wilson;Yong-Qi Li;Oksana Gavrilova;Lee S. Weinstein
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
57.Astrocytic calcium release mediates peri-infarct depolarizations in a rodent stroke model

机译：啮齿动物中风模型中星形胶质钙的释放介导梗死周围的去极化
- 作者：Cordula Rakers;Gabor C. Petzold
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
58.Selective graft-versus-leukemia depends on magnitude and diversity of the alloreactive T cell response

机译：选择性移植物抗白血病取决于异反应性T细胞反应的大小和多样性
- 作者：Cornelis A.M. van Bergen;Simone A.P. van Luxemburg-Heijs;Liesbeth C. de Wreede;Matthijs Eefting;Peter A. von dem Borne;Peter van Balen;Mirjam H.M. Heemskerk;Arend Mulder;Fransiscus H.J. Claas;Marcelo A. Navarrete;Wilhelmina M. Honders;Caroline E. Rutten;Hendrik Veelken;Inge Jedema;Constantijn J.M. Halkes;Marieke Griffioen;J.H. Frederik Falkenburg
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
59.Excessive expression of miR-27 impairs Treg-mediated immunological tolerance

机译：miR-27的过度表达会损害Treg介导的免疫耐受
- 作者：Leilani O. Cruz;Somaye Sadat Hashemifar;Cheng-Jang Wu;Sunglim Cho;Duc T. Nguyen;Ling-Li Lin;Aly Azeem Khan;Li-Fan Lu
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
60.Versatile humanized niche model enables study of normal and malignant human hematopoiesis

机译：多功能人性化利基模型可研究正常和恶性人类造血功能
- 作者：Ander Abarrategi;Katie Foster;Ashley Hamilton;Syed A. Mian;Diana Passaro;John Gribben;Ghulam Mufti;Dominique Bonnet
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
61.Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I

机译：靶向失调的AMPK / mTORC1途径可改善I型肌强直性营养不良的肌肉功能
- 作者：Marielle Brockhoff;Nathalie Rion;Kathrin Chojnowska;Tatiana Wiktorowicz;Christopher Eickhorst;Beat Erne;Stephan Frank;Corrado Angelini;Denis Furling;Markus A. Rüegg;Michael Sinnreich;Perrine Castets
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
62.MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis

机译：MerTK受体的裂解促进动脉粥样硬化中的斑块坏死和分辨率降低
- 作者：Bishuang Cai;Edward B. Thorp;Amanda C. Doran;Brian E. Sansbury;Mat J.A.P. Daemen;Bernhard Dorweiler;Matthew Spite;Gabrielle Fredman;Ira Tabas
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
63.Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation

机译：衔接蛋白NUMB和NUMBL通过靶向ERBB2降解来促进细胞周期退出
- 作者：Maretoshi Hirai;Yoh Arita;C. Jane McGlade;Kuo-Fen Lee;Ju Chen;Sylvia M. Evans
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
64.Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease

机译：核受体LRH-1的SUMOylation受损会促进非酒精性脂肪肝疾病
- 作者：Sokrates Stein;Vera Lemos;Pan Xu;Hadrien Demagny;Xu Wang;Dongryeol Ryu;Veronica Jimenez;Fatima Bosch;Thomas F. Lüscher;Maaike H. Oosterveer;Kristina Schoonjans
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
65.Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation

机译：孤儿Gpr182抑制再生和腺瘤形成过程中ERK介导的肠道增殖
- 作者：Daniel O. Kechele;R. Eric Blue;Bailey Zwarycz;Scott T. Espenschied;Amanda T. Mah;Marni B. Siegel;Charles M. Perou;Shengli Ding;Scott T. Magness;P. Kay Lund;Kathleen M. Caron
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
66.Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy

机译：毒蕈碱受体的选择性拮抗作用在周围神经病变中具有神经保护作用
- 作者：Nigel A. Calcutt;Darrell R. Smith;Katie Frizzi;Mohammad Golam Sabbir;Subir K. Roy Chowdhury;Teresa Mixcoatl-Zecuatl;Ali Saleh;Nabeel Muttalib;Randy Van der Ploeg;Joseline Ochoa;Allison Gopaul;Lori Tessler;Jürgen Wess;Corinne G. Jolivalt;Paul Fernyhough
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
67.Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis

机译：脂蛋白三磷酸酶介导的EpCAM的切割破坏了claudins的稳定性并失调了肠上皮稳态。
- 作者：Chuan-Jin Wu;Xu Feng;Michael Lu;Sohshi Morimura;Mark C. Udey
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
68.BCL-W has a fundamental role in B cell survival and lymphomagenesis

机译：BCL-W在B细胞存活和淋巴瘤发生中具有基本作用
- 作者：Clare M. Adams;Annette S. Kim;Ramkrishna Mitra;John K. Choi;Jerald Z. Gong;Christine M. Eischen
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
69.Rapamycin-mediated mTOR inhibition uncouples HIV-1 latency reversal from cytokine-associated toxicity

机译：雷帕霉素介导的mTOR抑制使HIV-1潜伏期逆转与细胞因子相关毒性无关
- 作者：Alyssa R. Martin;Ross A. Pollack;Adam Capoferri;Richard F. Ambinder;Christine M. Durand;Robert F. Siliciano
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
70.Mechanism for leptin’s acute insulin-independent effect to reverse diabetic ketoacidosis

机译：瘦素的急性胰岛素非依赖性作用逆转糖尿病酮症酸中毒的机制
- 作者：Rachel J. Perry;Liang Peng;Abudukadier Abulizi;Lynn Kennedy;Gary W. Cline;Gerald I. Shulman
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
71.Blood pressure–associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding

机译：血压相关多态性通过血清反应因子DNA结合控制ARHGAP42表达
- 作者：Xue Bai;Kevin D. Mangum;Rachel A. Dee;George A. Stouffer;Craig R. Lee;Akinyemi Oni-Orisan;Cam Patterson;Jonathan C. Schisler;Anthony J. Viera;Joan M. Taylor;Christopher P. Mack
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
72.Nasal neuron PET imaging quantifies neuron generation and degeneration

机译：鼻神经元PET成像可量化神经元的生成和变性
- 作者：Genevieve C. Van de Bittner;Misha M. Riley;Luxiang Cao;Janina Ehses;Scott P. Herrick;Emily L. Ricq;Hsiao-Ying Wey;Michael J. O’Neill;Zeshan Ahmed;Tracey K. Murray;Jaclyn E. Smith;Changning Wang;Frederick A. Schroeder;Mark W. Albers;Jacob M. Hooker
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
73.Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance

机译：急性饮食中的脂肪摄入会引发能量代谢和胰岛素抵抗的改变
- 作者：Elisa Álvarez Hernández;Sabine Kahl;Anett Seelig;Paul Begovatz;Martin Irmler;Yuliya Kupriyanova;Bettina Nowotny;Peter Nowotny;Christian Herder;Cristina Barosa;Filipa Carvalho;Jan Rozman;Susanne Neschen;John G. Jones;Johannes Beckers;Martin Hrabě de Angelis;Michael Roden
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
74.Kisspeptin modulates sexual and emotional brain processing in humans

机译：Kisspeptin调节人类的性和情感性大脑加工
- 作者：Alexander N. Comninos;Matthew B. Wall;Lysia Demetriou;Amar J. Shah;Sophie A. Clarke;Shakunthala Narayanaswamy;Alexander Nesbitt;Chioma Izzi-Engbeaya;Julia K. Prague;Ali Abbara;Risheka Ratnasabapathy;Victoria Salem;Gurjinder M. Nijher;Channa N. Jayasena;Mark Tanner;Paul Bassett;Amrish Mehta;Eugenii A. Rabiner;Christoph Hönigsperger;Meire Ribeiro Silva;Ole Kristian Brandtzaeg;Elsa Lundanes;Steven Ray Wilson;Rachel C. Brown;Sarah A. Thomas;Stephen R. Bloom;Waljit S. Dhillo
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
75.Chemogenetic stimulation of striatal projection neurons modulates responses to Parkinson’s disease therapy

机译：纹状体投射神经元的化学生成刺激调节对帕金森氏病治疗的反应
- 作者：Cristina Alcacer;Laura Andreoli;Irene Sebastianutto;Johan Jakobsson;Tim Fieblinger;Maria Angela Cenci
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第2期
76.Autoreactive T cells in type 1 diabetes

机译：1型糖尿病的自身反应性T细胞
- 作者：Alberto Pugliese
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
77.The relationship between cardiac endothelium and fibroblasts: it’s complicated

机译：心脏内皮细胞与成纤维细胞之间的关系：这很复杂
- 作者：Ravi Karra;Agoston O. Walter;Sean M. Wu
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
78.Leukotrienes and sex: strange bedfellows?

机译：白细胞与性别：奇怪的床友？
- 作者：Lewis J. Smith
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
79.Astrocytes to the rescue! Glia limitans astrocytic endfeet control CNS inflammation

机译：拯救星形胶质细胞！胶质限脂细胞星形胶质细胞尾足控制中枢神经系统炎症
- 作者：Francisco J. Quintana
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
80.BAG3 plays a central role in proteostasis in the heart

机译：BAG3在心脏蛋白稳定中起核心作用
- 作者：Wataru Mizushima;Junichi Sadoshima
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
81.Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression

机译：炎性Ly6Chi单核细胞及其向M2巨噬细胞的转化驱动动脉粥样硬化的消退
- 作者：Karishma Rahman;Yuliya Vengrenyuk;Stephen A. Ramsey;Noemi Rotllan Vila;Natasha M. Girgis;Jianhua Liu;Viktoria Gusarova;Jesper Gromada;Ada Weinstock;Kathryn J. Moore;P’ng Loke;Edward A. Fisher
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
- Cardiology Vascular Biology;
82.ILC2-modulated T cell–to-MDSC balance is associated with bladder cancer recurrence

机译：ILC2调节的T细胞至MDSC平衡与膀胱癌复发相关
- 作者：Mathieu F. Chevalier;Sara Trabanelli;Julien Racle;Bérengère Salomé;Valérie Cesson;Dalila Gharbi;Perrine Bohner;Sonia Domingos-Pereira;Florence Dartiguenave;Anne-Sophie Fritschi;Daniel E. Speiser;Cyrill A. Rentsch;David Gfeller;Patrice Jichlinski;Denise Nardelli-Haefliger;Camilla Jandus;Laurent Derré
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
- Immunology Oncology;
83.IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

机译：IFN-γ相关的mRNA谱预测对PD-1阻断的临床反应
- 作者：Mark Ayers;Jared Lunceford;Michael Nebozhyn;Erin Murphy;Andrey Loboda;David R. Kaufman;Andrew Albright;Jonathan D. Cheng;S. Peter Kang;Veena Shankaran;Sarina A. Piha-Paul;Jennifer Yearley;Tanguy Y. Seiwert;Antoni Ribas;Terrill K. McClanahan
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
- Immunology Oncology;
84.Hepatic β-arrestin 2 is essential for maintaining euglycemia

机译：肝β-抑制蛋白2对维持正常血糖至关重要
- 作者：Lu Zhu;Mario Rossi;Yinghong Cui;Regina J. Lee;Wataru Sakamoto;Nicole A. Perry;Nikhil M. Urs;Marc G. Caron;Vsevolod V. Gurevich;Grzegorz Godlewski;George Kunos;Minyong Chen;Wei Chen;Jürgen Wess
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
- Endocrinology Metabolism;
85.Two rheumatoid arthritis–specific autoantigens correlate microbial immunity with autoimmune responses in joints

机译：两种类风湿关节炎特有的自身抗原将微生物免疫与关节自身免疫反应联系起来
- 作者：Annalisa Pianta;Sheila L. Arvikar;Klemen Strle;Elise E. Drouin;Qi Wang;Catherine E. Costello;Allen C. Steere
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
- Autoimmunity;
86.Anthrax toxin receptor 1 is the cellular receptor for Seneca Valley virus

机译：炭疽毒素受体1是塞内卡山谷病毒的细胞受体
- 作者：Linde A. Miles;Laura N. Burga;Eric E. Gardner;Mihnea Bostina;John T. Poirier;Charles M. Rudin
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
- Virology;
87.Preexisting endothelial cells mediate cardiac neovascularization after injury

机译：损伤后已有的内皮细胞介导心脏新血管形成
- 作者：Lingjuan He;Xiuzhen Huang;Onur Kanisicak;Yi Li;Yue Wang;Yan Li;Wenjuan Pu;Qiaozhen Liu;Hui Zhang;Xueying Tian;Huan Zhao;Xiuxiu Liu;Shaohua Zhang;Yu Nie;Shengshou Hu;Xiang Miao;Qing-Dong Wang;Fengchao Wang;Ting Chen;Qingbo Xu;Kathy O. Lui;Jeffery D. Molkentin;Bin Zhou
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
- Angiogenesis Vascular Biology;
88.Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment

机译：抑癌药PML的泛素化调节转移和免疫抑制的肿瘤微环境
- 作者：Ya-Ting Wang;Jocelyn Chen;Chou-Wei Chang;Jayu Jen;Tzu-Yu Huang;Chun-Ming Chen;Roger Shen;Suh-Yuen Liang;I-Cheng Cheng;Shuenn-Chen Yang;Wu-Wei Lai;Kuang-Hung Cheng;Tao-Shih Hsieh;Ming-Zong Lai;Hung-Chi Cheng;Yi-Ching Wang;Ruey-Hwa Chen
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
- Oncology;
89.Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis

机译：5-甲基胞嘧啶氧化酶TET2和RhoA的突变合作破坏T细胞稳态。
- 作者：Shengbing Zang;Jia Li;Haiyan Yang;Hongxiang Zeng;Wei Han;Jixiang Zhang;Minjung Lee;Margie Moczygemba;Sevinj Isgandarova;Yaling Yang;Yubin Zhou;Anjana Rao;M. James You;Deqiang Sun;Yun Huang
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
- Hematology Immunology;
90.Biallelic mutations in the ubiquitin ligase RFWD3 cause Fanconi anemia

机译：泛素连接酶RFWD3中的双等位基因突变引起范可尼贫血
- 作者：Kerstin Knies;Shojiro Inano;María J. Ramírez;Masamichi Ishiai;Jordi Surrallés;Minoru Takata;Detlev Schindler
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
- Genetics;
91.Gentamicin induces functional type VII collagen in recessive dystrophic epidermolysis bullosa patients

机译：庆大霉素在大隐性营养不良性表皮松解症患者中诱导功能性VII型胶原
- 作者：David T. Woodley;Jon Cogan;Yingping Hou;Chao Lyu;M. Peter Marinkovich;Douglas Keene;Mei Chen
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
- Dermatology;
92.Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy

机译：Ly6Clo单核细胞可驱动免疫抑制并赋予抗VEGFR2癌症治疗的抗性
- 作者：Keehoon Jung;Takahiro Heishi;Omar F. Khan;Piotr S. Kowalski;Joao Incio;Nuh N. Rahbari;Euiheon Chung;Jeffrey W. Clark;Christopher G. Willett;Andrew D. Luster;Seok Hyun Yun;Robert Langer;Daniel G. Anderson;Timothy P. Padera;Rakesh K. Jain;Dai Fukumura
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
- Oncology;
93.Ibrutinib treatment improves T cell number and function in CLL patients

机译：依鲁替尼治疗可改善CLL患者的T细胞数量和功能
- 作者：Meixiao Long;Kyle Beckwith;Priscilla Do;Bethany L. Mundy;Amber Gordon;Amy M. Lehman;Kami J. Maddocks;Carolyn Cheney;Jeffrey A. Jones;Joseph M. Flynn;Leslie A. Andritsos;Farrukh Awan;Joseph A. Fraietta;Carl H. June;Marcela V. Maus;Jennifer A. Woyach;Michael A. Caligiuri;Amy J. Johnson;Natarajan Muthusamy;John C. Byrd
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
- Hematology;
94.An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility

机译：红细胞特异性ATP2B4增强剂介导红细胞水合作用和疟疾易感性
- 作者：Samuel Lessard;Emily Stern Gatof;Mélissa Beaudoin;Patrick G. Schupp;Falak Sher;Adnan Ali;Sukhpal Prehar;Ryo Kurita;Yukio Nakamura;Esther Baena;Jonathan Ledoux;Delvac Oceandy;Daniel E. Bauer;Guillaume Lettre
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
- Genetics Hematology;
95.Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2

机译：靶向NEK2通过使组蛋白甲基转移酶EZH2不稳定来减弱胶质母细胞瘤的生长和放射抵抗
- 作者：Jia Wang;Peng Cheng;Marat S. Pavlyukov;Hai Yu;Zhuo Zhang;Sung-Hak Kim;Mutsuko Minata;Ahmed Mohyeldin;Wanfu Xie;Dongquan Chen;Violaine Goidts;Brendan Frett;Wenhao Hu;Hongyu Li;Yong Jae Shin;Yeri Lee;Do-Hyun Nam;Harley I. Kornblum;Maode Wang;Ichiro Nakano
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
- Oncology Stem cells;
96.DNA methylation–based immune response signature improves patient diagnosis in multiple cancers

机译：基于DNA甲基化的免疫反应特征可改善多种癌症的患者诊断
- 作者：Jana Jeschke;Martin Bizet;Christine Desmedt;Emilie Calonne;Sarah Dedeurwaerder;Soizic Garaud;Alexander Koch;Denis Larsimont;Roberto Salgado;Gert Van den Eynden;Karen Willard Gallo;Gianluca Bontempi;Matthieu Defrance;Christos Sotiriou;François Fuks
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
- Development Immunology;
97.A leptin-regulated circuit controls glucose mobilization during noxious stimuli

机译：瘦素调节回路控制有害刺激过程中的葡萄糖动员。
- 作者：Jonathan N. Flak;Deanna Arble;Warren Pan;Christa Patterson;Thomas Lanigan;Paulette B. Goforth;Jamie Sacksner;Maja Joosten;Donald A. Morgan;Margaret B. Allison;John Hayes;Eva Feldman;Randy J. Seeley;David P. Olson;Kamal Rahmouni;Martin G. Myers Jr.
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
- Endocrinology Neuroscience;
98.Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury

机译：创伤性脑损伤后增强的星形细胞d-丝氨酸成为突触损伤的基础
- 作者：Enmanuel J. Perez;Stephen A. Tapanes;Zachary B. Loris;Darrick T. Balu;Thomas J. Sick;Joseph T. Coyle;Daniel J. Liebl
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
- Neuroscience;
99.Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency

机译：与HDAC抑制剂伏立诺他间隔给药可有效逆转HIV潜伏期
- 作者：Nancie M. Archin;Jennifer L. Kirchherr;Julia A.M. Sung;Genevieve Clutton;Katherine Sholtis;Yinyan Xu;Brigitte Allard;Erin Stuelke;Angela D. Kashuba;Joann D. Kuruc;Joseph Eron;Cynthia L. Gay;Nilu Goonetilleke;David M. Margolis
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
- AIDS/HIV Clinical Trials;
100.Astrocytic tight junctions control inflammatory CNS lesion pathogenesis

机译：星形细胞紧密连接控制炎症性中枢神经系统病变的发病机理
- 作者：Sam Horng;Anthony Therattil;Sarah Moyon;Alexandra Gordon;Karla Kim;Azeb Tadesse Argaw;Yuko Hara;John N. Mariani;Setsu Sawai;Per Flodby;Edward D. Crandall;Zea Borok;Michael V. Sofroniew;Candice Chapouly;Gareth R. John
- 期刊名称：《The Journal of Clinical Investigation》 | 2017年第8期
- Immunology Neuroscience;