MLL2 not MLL1 Plays a Major Role in Sustaining MLL-rearranged Acute Myeloid Leukemia

摘要

Chen et al. report that wild-type MLL1 is dispensable for MLL fusion leukemia, but instead loss of MLL2 reduces the survival of leukemia cells from human patients and in a mouse model of MLL-AF9 AML. Combined loss of MLL1 and MLL2 further reduces leukemia cell viability.