目的：探讨产妇血清和新生儿脐带血中总IgE与儿童特应性皮炎（AD）的相关性及过敏原检测的临床意义。方法选取2009—2011年建立的出生队列中诊断为AD的儿童35例（AD组），随机抽取未患AD的35例儿童作为对照（对照组），ELISA法分别检测儿童出生前产妇血清和新生儿脐带血中的总IgE水平，定量免疫印迹法检测血清特异性IgE水平。结果 AD组中母亲血清和新生儿脐带血总IgE阳性率高于对照组(χ2分别为16.568和14.933，均P<0.01)。AD组中母亲血清过敏原中尘螨，屋尘，豚草花粉，蒿类花粉，杨、柳及榆树花粉，霉菌，虾，海洋鱼类特异性IgE阳性率高于对照组（均P<0.05）；AD组患儿脐带血过敏原中蒿类花粉，霉菌IgE阳性率高于对照组（均P<0.05）。结论母亲血清总IgE升高可能会对婴儿后期罹患AD起预测作用，母亲的过敏状态与婴儿的过敏状态无明显一致性。%Objective To explore the correlation of total IgE and childhood atopic dermatitis (AD) in maternal serum and newborn cord blood, as well as its clinical significance of allergen testing. Methods Thirty-five cases diagnosed as AD (AD group) were selected, and other 35 children who were not diagnosed as AD (control group) were randomly selected from a birth cohort established in 2009—2011. The total IgE levels were detected by ELISA in maternal serum and newborn cord blood. The serum specific IgE antibody level was detected by quantitative immunoblotting method. Results The serum total IgE level was significantly higher in mother and newborn cord blood in AD group than that in control group (χ2=16.568 and 14.933, P<0.01). Compared to control group, there was a significantly higher positive rate of mother serum allergen includ⁃ing dust mites, house dust, ragweed pollen, song kind of pollen, poplar, surname and elm pollen, mould, shrimp, marine fish, in AD group (P<0.05). There was a significantly higher positive rate of artemisia pollen and fungi IgE in newborn cord blood in AD group (P<0.05). Conclusion The increased total IgE in maternal serum may play a predictive effect on infants suf⁃fering from AD. There is no obvious consistency in allergic state between mothers and infants.
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