转化生长因子β1对软骨组织代谢影响的研究进展*★

摘要

BACKGROUND:Transforming growth factor beta 1 can mediate cartilage synthesis and inhibit decomposition of col agen and protein polysaccharide, which has a most important effect on induction of cartilage differentiation in vitro and maintenance of cartilage phenotype, realizing the functional repair of cartilage defects. OBJECTIVE:Based on the biological characteristics, applications in biotechnology, gene polymorphism, signaling pathways and microRNA, to introduce research progress of transforming growth factor beta 1 influence on cartilage tissue metabolism. METHODS:The first author searched CNKI and SPRINGERLINK databases (2007/2012) to retrieve articles related to transforming growth factor beta 1 influence on cartilage tissue metabolism using the key words of“transforming growth factor beta 1, cartilage differentiation, cartilage matrix”in Chinese and English, respectively. A total of 130 articles were retrieved, and final y 54 were included. RESULTS AND CONCLUSION:Transforming growth factor beta 1 can induce chondrogenic differentiation of mesenchymal stem cel s, promote cartilage-specific matrix synthesis, protect the cartilage matrix against proteolysis, enhance self-renew ability of cartilage tissues, and realize repair of cartilage injury. In the field of cartilage repair, transforming growth factor beta 1 demonstrates a great potential value.%　　背景：转化生长因子β1可以介导软骨合成、抑制胶原和蛋白多糖分解，在诱导软骨分化和维持软骨表型上起着重要作用，实现软骨缺损的功能性修复。　　目的：从生物学特性、在生物工程中的应用、基因多态性、信号通路及微小 RNA等方面综述转化生长因子β1对软骨组织代谢影响的研究进展。　　方法：以“transforming growth factor-β1，Cartilage Differentiation，cartilage matrix”为英文检索词，以“转化生长因子β1，软骨分化，软骨基质”为中文检索词。经第一作者检索2007/2012CNKI数据库及SPRINGERLINK数据库有关转化生长因子β1对软骨组织代谢影响的研究进展方面的文献130篇，根据纳入排除标准保留54篇进行总结。　　结果与结论：转化生长因子β1可诱导间充质细胞向软骨细胞分化，促进软骨特异性基质的合成，保护软骨基质不被各种蛋白酶水解破坏，能够增强软骨组织自身再生能力，实现使软骨的损伤逆转，在软骨修复领域展现了巨大的潜在应用价值。