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中华老年口腔医学杂志

中华老年口腔医学杂志

CSTPCD

Chinese Journal of Geriatric Dentistry
本刊为老年口腔医学专业学术期刊,季刊,面向国内外公开发行。杂志涵盖老年口腔医学及相关学科的内容,包括:老年口腔解剖生理、老年人踊病、老年人牙髓及根尖周病、老年人非龋性牙体硬组织病、老年牙周疾病、老年口腔黏膜病、老年人口腔修复、老年人种植修复、老年人额下领关节病、老年口腔颌面感染、老年口腔颌面创伤、老年口腔颁面肿瘤、老年人口腔用药、老年口腔病的预防、老年口腔病的护理等.辟有临床与基础研究论著、专题报告、述评、文献综述、讲座、短篇报道、个案报道、学术交流、会议总结、论文摘要、国内外学术动态、国际国内会议报道等栏目.欢迎广大作者踊跃投稿。
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  • 发文量：1914
  • 被引量：752
  • H指数：1
  • 开始收录时间：2003,1(1)
  • CNKI综合因子：0.601
  • 维普期刊影响因子： 1.23
  • 万方期刊影响因子：1.35
  • 创刊时间：2002
  • 国内刊号/CN：11-5010/R
    国际刊号/ISSN：1672-2973
  • 发行周期：双月刊
    邮发代号：82-633
  • 主管单位：解放军总医院
    主办单位：解放军总医院 口腔医学教研室
中华老年口腔医学杂志-联系信息
  • 主编：刘洪臣
  • 电话：010-66936254
  • 邮箱：cjgd301@163.com
  • 地址：北京复兴路28号解放军总医院
  • 邮编：100853
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中华老年口腔医学杂志 >2023年第4期

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  • 摘要：目的:研究雌激素缺乏大鼠根尖周炎病变区H MGB1的表达.方法:将40只雌性SD大鼠随机分为:OVX组及SHAM组,暴露两组大鼠下颌第一磨牙髓腔,分别于开髓后0、7、14、21d时处死大鼠.采用HE染色、酶组织化学染色、免疫组织化学法观测根尖周病变组织的骨破坏程度,破骨细胞数、HMGB1的表达.结果:较SHAM组而言,OVX组大鼠根尖周炎病变区骨吸收范同增大,破骨细胞数目增多,HMGB1的表达增强.结论:雌激素缺乏可增强大鼠根尖周炎病变区HMGB1的表达.%Objective:To study the effects of estrogen deficiency on the expression of HMGB1 in Periapical lesions of rats.Methods:Forty SD female rats were randomly divided into two groups:OVX group and SHAM group.All the rats were submitted to expose the pulp cavity of mandibular first molars.The rats were sacrificed on day 0,7,14,21 after the pulp cavity exposure.HE staining,enzyme histochemical staining and immunohistochemical staining were used to observe the bone destruction,the number of osteoclasts and the expression of HMGB1.Results:The alveolar bone loss area and the number of losteoclasts,HMGB1 positive cells in OVX group were higher than those in SHAM group.Conclusion:Estrogen deficiency increased the expression of HMGB 1 in rat's periapical lesions.
  • 摘要：Objective:The aim of this study was to find a more precise and safe way to implant radioactive particles into the maxilary and skull base regions using the three dimensional printing navigation system.Methods:Eight patients with invasive adenoid cystic carcinoma of the cranial base and maxilary and without any history of surgery were selected.A preoperative computed tomography scan was performed and three dimensional printing template was designed to aid the surgery.Results:No intracranial injury or visual impairment occurred,and the response rate was 100％.Conclusion:This study indicates that the implantation of radioactive particles using the three dimensional printing template was an effective and safe method for treating tumors in the skull base and maxilary,and should be considered for clinical use.%目的:将三维打印系统与放疗设计系统相结合,指导放射性粒子内照射治疗上颌、颅底腺样囊性癌,探索更高精度植入125Ⅰ放射粒子的方法,从而更加安全有效地控制已累及颅底及眶尖周的口腔颌面部恶性肿瘤.方法:肿瘤侵及颅底、上颌的腺样囊性癌患者8例,术前进行增强CT检查,进行放疗设计并制作三维打印模板.术中在模板引导下进行手术.结果:术中避免了颅脑及眶内组织损伤.实现了放射粒子组织内均匀分布,定位准确,无一例出现颅脑损伤及视力影响,术中出血少,治疗有效率(response rate,RR)达100％,疗效确切.结论:三维打印模板辅助下进行颅底眶尖周放射粒子植入是精确、安全的,有条件的情况下可考虑采用.
  • 摘要：恶性肿瘤在世界范围内均为严重威胁人类生命健康的重大疾病,病死率极高.手术、化疗、放疗以及联合治疗在临床上仍然是恶性肿瘤的一线治疗方案,然而传统治疗手段尚存在一定的局限性和毒副反应.光动力治疗作为新型的抗肿瘤手段,凭借其靶向特异性高、创伤较小、全身毒副作用较低以及可重复治疗等优势,成为浅表及腔体肿瘤的有效治疗策略.近年来,化疗与光动力联合治疗恶性肿瘤逐渐应用于临床,并取得了较好的治疗效果.一方面,光动力治疗可辅助化疗,增强靶向特异性,并通过改变血管通透性介导药物更好的在肿瘤区富集;另一方面,化疗可辅助光动力治疗,清除残余肿瘤细胞并抑制损伤血管的再生.二者联合治疗,可增强抗肿瘤疗效并减少全身毒副作用.笔者以阿霉素为化疗药物代表,对阿霉素-光动力联合治疗恶性肿瘤进行综述和展望.%Malignant tumors are serious diseases threatening human health and life worldwide with high fatality rate.Surgery,chemotherapy,radiotherapy and combined therapies are still the first-line treatments for malignant tumors.However,there are some limitations and side effects in these conventional treatments.Photodynamic therapy (PDT),as a new anti-tumor method,has become an effective strategy for superficial tumors,depending on its high specificity,minimal invasion,low systemic toxicity and repeatability.Recent years,chemotherapy combined with photodynamic therapy has been applied to the treatment of malignant tumors gradually and has obtained better effects.Photodynamic therapy can help chemotherapy target specifically and boost the deposition of nanoparticle drugs in tumors by enhanced vascular permeability.Meanwhile,chemotherapy can enhance the efficacy of PDT by targeting surviving cancer cells or by inhibiting regrowth of damaged tumor blood vessels.The combination of phototherapy and chemotherapy (chemophototherapy,CPT) can improve the anti-tumor effects and decrease the systemic toxic and side effects.Taking doxorubicin as a representative of chemotherapeutic agents,this article summarizes the applications of doxorubicin-photodynamic combined therapy in malignant tumors and looks forward to its development prospects.
  • 摘要：Objective:To study the effect of molecular biological behavior of Zirconia on mouse periodontal ligament cells.Methods:PDLCs were cultured in vitro.Extracting solution ofZirconia,Pd-Ag alloy porcelain,and Ni-Cr alloy porcelain were prepared and used to process PDLCs,and then cell viability,percentages of cell cycle and expression levels of Caspase-3,Caspase-8,Caspase-9 were detected.Results:There was no significant difference in group of DMEM,group of Zirconia and group of Pd-Ag alloy porcelain in cell viability when co-cultured 24h,48h,72h later(P＞0.05).Cell viability of group of Ni-Cr alloy porcelain was lowest in all groups(P＜0.05).There was difference in group of Zirconia,group of Ni-Cr alloy porcelain and group of Pd-Ag alloy porcelain in early phase rate of apoptosis,late phase rate of apoptosis and totle rate of apoptosis(P＜ 0.05).There was difference between Zirconia and Pd-Ag alloy porcelain in index of Prl(P＜ 0.05).But there was no difference between Pd-Ag alloy porcelain and Ni-Cr alloy porcelain in index of Prl (P＞0.05).There were no difference in the value of 2-△△CT about Caspase-3 and Caspase-9 in group of Zirconia,group of Pd-Ag and group of DMEM (P＞0.05).The value of 2-△△T about Caspase-3 and Caspase-9 of Ni-Cr alloy porcelain was higher than that of DMEM (P＜ 0.05).There were no difference in the value of 2-△△CT about Caspase-8 in Zirconia andPd-Ag alloy porcelain(P＞ 0.05),and both lower than that of DMEM(P＜ 0.05).The value of 2-△△CT about Caspase-8 of Ni-Cr alloy porcelain was higher than that of Zirconia and Pd-Ag alloy porcelain(P＜0.05).Conclusion:Zirconia is superior to Pd-Ag alloy porcelain and Ni-Cr alloy porcelain in cell viability and anti-apoptosis.It has good histocompatibility and will not affect cell viability,cell cycle and expression of cell apoptosisralated genes.%目的:评价二氧化锆对大鼠牙周膜细胞分子生物学行为的影响.方法:培养大鼠牙周膜细胞.制作二氧化锆、钯银合金、镍铬合金试件及其浸提液.将各组浸提液作用于细胞,检测24h、48h、72h的各组浸提液对细胞活性的影响;检测细胞早期凋亡率、晚期凋亡率、总凋亡率及各组细胞周期比例;检测不同浸提液组处理对大鼠牙周膜细胞Caspase-3,Caspase-8,Caspase-9的mRNA相对表达量.结果:24h、48h、72h时,二氧化锆组、钯银合金组、DMEM组OD值间均无统计学差异(P＞0.05),而镍铬合金组OD值明显高于其余各组(P＜0.05).细胞凋亡结果发现,早期凋亡率、晚期凋亡率、总凋亡率,二氧化锆组、钯银合金组、镍铬合金组间均有统计学差异(P＜0.05).细胞周期结果发现,Prl指数钯银合金组与二氧化锆组相比有统计学差异(P＜0.05),钯银合金组与镍铬合金组之间的Prl指数无统计学差异(P＞0.05).各组Caspase-3、Caspase-9的2-△△CT值,二氧化锆组、钯银合金组、DMEM组间差异无统计学意义(P＞0.05),镍铬合金组高于DMEM组(P＜0.05).Caspase-8的2-△△CT值,二氧化锆组、钯银合金组与DMEM组差异有统计学意义(P＜0.05),二氧化锆组与钯银合金组之间差异无统计学差异(P＞0.05),镍铬合金组高于二氧化锆组、钯银合金组,差异有统计学意义(P＜0.05).结论:二氧化锆在提高细胞增殖活力,抑制细胞凋亡方面优于钯银合金及镍铬合金材料,其良好的生物相容性不会影响牙周膜细胞的细胞活力、细胞周期、细胞凋亡以及相关基因的表达.
  • 摘要：Objective:To study effects of oral fibroblast growth factor FGF-1 on PCNA protein and submandibular gland degeneration in diabetic patients.Method:Twenty male db/db mice were randomly divided into two groups:experimental group and model group,and 10 8-week-old male db/m mice were selected as control group.The weight of the mice was measured at 0 weeks,4 weeks,8 weeks,12 weeks and 16 weeks respectively.The blood glucose meter was used to measure blood glucose in mice.Saliva flow rate was used to measure saliva flow in mice.Using the HE staining method to observe the distribution of submandibular gland vesicular cells and the functional cavity.Immunohistochemistry was used to observe the distribution of submandibular gland vesicles and catheters.Result:The blood glucose and weight of mice in the experimental group decreased significantly in the test of 0-4 weeks (P＜0.05).and gradually stabilized in the later stage.But the model group had no significant change (P＞0.05).The saliva flow rate of the experimental group showed an increasing trend,with the highest flow rate reaching 308± 34.0mg · min-1 · kg-1.It was significantly higher than that of the control group (P＜0.05).HE staining results show clear submandibular tissue structure in the experimental group.Severe adenovesicles and catheter atrophy were seen in the model group.Immunohistochemical results showed that the positive rate of PCNA cells in the experimental group was significantly higher than that in the model group (P＜0.05),but still significantly lower than the blank control group (P＜0.05).Conclusions:PGF-1 factor can significantly increase the positive rate of PCNA cells in submandibular gland of mice,balance the blood sugar and body weight of diabetic mice,and have a positive significance in reversing the degeneration of submandibular gland function.%目的:研究口腔成纤维细胞生长因子FGF-1因子对糖尿病患者颌下腺功能相关增殖细胞核抗原PCNA蛋白表达的影响.方法:将20只雄性db/db小鼠随机分为2组,实验组和模型组,另选10只8周龄的雄性db/m小鼠作为对照组.实验组小鼠以腹腔给药的方式注射FGF-1,连续给药12周.分别在给药后0、4、8、12、16周电子天平测量小鼠体重,血糖仪测定小鼠血糖,采用唾液流率测定法测定小鼠唾液流量,采用HE染色法观察颌下腺腺泡细胞和管腔分布情况,采用免疫组化法观察颌下腺腺泡和导管的分布.结果:实验组小鼠血糖和体重在0-4周检测中均显著下降(P＜0.05),后期逐渐趋于稳定,而模型组变化不显著(P＞0.05).实验组小鼠唾液流率检测结果成递增趋势,最高流率达到(308±34.0)mg·min-1·kg-1,显著高于同期对照组检测结果(P＜0.05).HE染色结果实验组可见清晰的颌下腺组织结构,模型组可见严重的腺泡和导管萎缩.免疫组织化学结果显示,实验组PCNA细胞阳性率显著高于模型组(P＜0.05),但与空白对照组相比仍显著较低(P＜0.05).结论:FGF-1因子可显著升高小鼠颌下腺PCNA细胞阳性率,平衡糖尿病小鼠血糖、体重水平,对逆转颌下腺功能退化具有积极意义.
  • 摘要：1.病例资料患者,女性,61岁,因诊治其它牙齿过程中需要拍上下颌锥形束CT（CBCT）,读片时发现双侧上颌第一前磨牙均为3根管,包括两个颊根、一个腭根,14两颊根自根上2/3分叉（图1）,24两颊根自根上1/2分叉（图2）。颊根形态扁圆形,腭根圆形（图3-图5）。三个牙根未见钙化影像、长度约为16.21mm。2.讨论CBCT由于其能够三维显示细微解剖结构,具有较高的分辨率、较低的辐射剂量等优点,
  • 摘要：目的:探讨冷热循环对不同粘接系统在不同桩道深度中粘接强度的影响.方法:选取32颗下颌第一前磨牙,常规根管充填并桩道预备后,选用全酸蚀+树脂粘接水门汀(A组)和自酸蚀+树脂粘接水门汀(B组)分别完成纤维桩粘接;每组又分为2个亚组(n=8),分别进行人工唾液存储24h(A0组、B0组),5℃-55℃冷热循环处理5000次(A1组、B1组);采用万能试验机分别测量各组在根上、根中和根尖部的粘接强度,扫描电镜观察粘接界面.结果:在根上部,A1组粘接强度(10.02±1.07MPa)大于B1组(8.62±1.12MPa)(P＜0.05);根中部和根下部,粘接强度B1组(7.98±0.47MPa,9.13±1.12MPa)大于A1组(2.98±0.76MPa,2.14±0.36MPa)(P＜ 0.05).冷热循环处理后,无论根上、根中和根下组,A0组大于A1组(P＜0.05);B0组大于B1组(P＜0.05).扫描电镜显示,A、B组粘接界面均可见树脂突和混合层结构,且B组混合层形态更加连续、致密.结论:桩道深度的增加会降低全酸蚀组的粘接强度,冷热循环会降低两种系统的粘接强度,但自酸蚀粘接系统相对全酸蚀粘接系统更可靠.%Objective:To discuss the effect of thermal cycle on the bond strength of glass fiber posts after different resin adhesive of different regions of root canal dentin.Methods:Thirty-two fresh human mandibular premolars were collected.After Conventional root canal filling and post-preparation.the fiber piles were bonded with total acid etching resin (group A) and self-etching resin bonded cement (group B) respectively.Each group is divided into 2 subgroups:Group A0 and group B0).They were treated with artificial saliva for 24h,respectively.The hot and cold cycles of 5℃-55℃ were performed 5000 times (group A1 and group B1).The universal testing machine was used to measure the bonding strength of fiber postsfor the upper,middle and apical parts of the root.And the bonding interface was observed by scanning electron microscope.Results:In the upper portion of the root,the bond strength in group A1 (10.02± 1.07MPa) was greater than that in group B1 (8.62± 1.12 MPa) (P＜0.05).For middle and lower portion of the root,the bond strength in group B1 and group B1 was (7.98±0.47MPa,9.13± 1.12MPa) was larger than that of group A1 (2.98±0.76MPa,2.14±0.36MPa) (P＜0.05).After hot and cold cycles,the groupA0 was greater than the A1 group (P＜0.05),while the B0 group was greater than the B1 group (P＜0.05) Scanning electron microscopy showed that resin bumps and mixed layer structures were observed at bonding interface of group A and group B.Conclusions:Thermal cycling could decrease the bond strengths of total-etch system and self-etch system.The self-etch system can show better bond strength than total-etch system.
  • 摘要：Objective:To construct the competency-oriented standardized resident training scale for resident in Stomatology,and evaluate its reliability and validity.Methods:According to literature investigation and expert interview,the competency of general resident in stomatology was defined in detail,the scale was compiled and filled out by resident in general stomatology.The reliability of the scale was analyzed by SPSS 11.0 software.Results:Expels authenticated the scales one with high validity.Its Chronbach's α is 0.861.The split-half reliability coefficient is 0.819.Factor analysis shows all five factors' variance contribution accumulates to 71.504％.Conclusions:The scale has good internal consistency reliability,half reliability and structural validity.It can be used to evaluate the post competence of the resident in general stomatology.In order to adapt to the resident standardized training pay attention to formative evaluation of the new model.%目的:构建以胜任力为导向的口腔全科住院医师规范化培训住院医师自评初量表,并评价其信度及效度.方法:根据文献调查和专家访谈,对口腔全科住院医师应具备的胜任特征进行详细定义,编写量表,并由口腔全科住院医师填写,采用SPSS 11.0软件分析量表的信度.结果:量表总体的克朗巴赫α系数为0.861,折半信度系数为0.819.因子分析显示本量表5个领域的方差累积贡献率为71.504％.通过专家法评估,本量表具有良好的内容效度.结论:本量表具有良好的内部一致性信度、折半信度及结构效度,可用于口腔全科住院医师对岗位胜任力的自我评估,以适应住院医师规范化培训中注重形成性评价的新模式.
  • 摘要：目的:研究增龄条件下骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)的增龄性改变及Wnt/β-catenin信号通路在增龄过程中的变化.方法:选用3月龄及18月龄的SD大鼠,双能X线检测股骨密度;分离培养BMSCs,SA-β-Gal染色分析3月龄组及18月龄组细胞衰老情况;实时定量PCR技术检测端粒酶(telomerase reverse transcriptase,TERT)mRNA表达;采用免疫酶联吸附试验检测肿瘤坏死因子(TNF-α)及白介素6(IL-6)的分泌情况;Western Blot法检测Wnt信号通路核心蛋白β-catenin在细胞浆及细胞核中的表达;实时定量PCR检测Wnt通路关键基因LEF-1、TCF-4的表达.结果:18月龄组大鼠股骨密度显著低于3月龄组;SA-β-Gal阳性表达细胞随年龄增加而增加,TERT表达水平随年龄增加而显著降低;18月龄组BMSCs TNF-α及IL-6的分泌量显著高于3月龄BMSCs;18月龄组BMSCs细胞核及细胞浆中β-catenin表达量较3月龄BMSCs均呈增高趋势;18月龄组BMSCs LEF-1的基因表达水平较3月龄BMSCs上升1.6倍,TCF-4的基因表达水平也上升3.12倍.结论:随着年龄的增加BMSCs分泌的炎症因子含量增加,导致Wnt/β-catenin信号通路活化进而影响干细胞的生物学功能.%Objective:To investigate the changes of bone marrow mesenchymal stem cells (BMSCs) and the changes of Wnt/β-catenin signaling pathway under aging condtion.Methods:3-month-old and 18-month-old were used in our study,the femur density were detect by dual energy X-ray.We isolated BMSCs from bone marrow and then the SA-β-Gal expression was analyzed to assess the cell senescence.The expression of telomerase reverse transcriptase (TERT) mRNA was detected by real-time quantitative PCR.The secretion of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) was detected by immuno-enzyme-linked immunosorbent assay.Western blot was used to detect the expression of β-catenin in the cytoplasm and nucleus.Real-time quantitative PCR was used to detect the expression of LEF-1 and TCF-4.Results:The femur density in the 18-month-old group was significantly lower than that in the 3-month-old group.The expression of SA-β-Gal positive cells increased in BMSCs (18-month-old group) compared with 3-month-old group,however,the expression of TERT was significantly decreased in BMSCs (18-month-old group).The secretion of TNF-α and IL-6 in BMSCs was significantly increased in 18-month-old group than in 3-month-old group.The expression of β-catenin in the nucleus and cytoplasm of BMSCs in 18-month-old group was higher than that in 3-month-old BMSCs group.The expression level of group LEF-1 in the 18-month-old group was 1.6 times higher than that of the 3-month-old group,and the gene expression level of TCF-4 also increased 3.12 times than that of the 3-month-old group.Conclusion:With the increase of age,the content of inflammatory cytokines secreted by BMSCs were increased,which led to the activation of Wnt/β-catenin signaling pathway and then affect the biological function of BMSCs.
  • 摘要：Objective:To observe the short-term and long-term curative effects of Duraphat combined with desensitized paste in the treatment of dentin hypersensitivity second to severe odontotripsis.Methods:79 patients with dentin hypersensitivity caused by severe odontotripsis (96 teeth) were selected and randomly divided into group A (n=30),B (n=32) and C (n=34),respectively.Duraphat,Duraphat combined with desensitized paste and desensitized paste were used for desensitization therapy of the diseased teeth,and three groups were compared for curative effects immediately,1,3,6 and 12 months after treatment.Results:Pair-wise comparison immediately after treatment showed both group A and group B were better than group C (P=0.003 and P=0.022),and there was no significant difference in curative effect between group A and group B.After 1 month,the pair-wise comparison showed that group B was better than group C (P=0.001),while there was no significant different efficacy between group A and group B,and between group A and group C.After 3 months,there was no statistically significant different efficacy among the three groups.After 6 months,the pair-wise comparison showed that group B was better than group A (P=0.010),group B was also better than group C (P=0.026),and there was no difference between group A and group C.After 12 months,the group B was better than group A (P=0.001),group B was also better than group C (P=0.038),and there was no difference between group A and group C.Conclusion:Duraphat combined with desensitized paste has remarkable efficacy in the treatment of dentine hypersensitivity,which is superior to any of them used alone.%目的:观察多乐氟联合脱敏糊剂治疗骀面磨损继发牙本质过敏症的临床效果.方法:选取因重度磨损致牙本质过敏症患者79例96颗牙齿,随机分为A组30颗、B组32颗和C组34颗牙齿,分别采用多乐氟、多乐氟联合糊剂和脱敏糊剂对患牙进行脱敏治疗,对比三组即刻、1、3、6、12个月临床治疗效果.结果:治疗后即刻两两比较A组及B组均优于C组(P=0.003和P=0.022),而A组和B组疗效差异无统计学意义.1个月后两两比较显示B组优于C组(P=0.001),而A组和B组,A组和C组间疗效差异无统计学意义.3个月后三组间疗效差异无统计学意义.6个月后两两比较显示B组优于A组(P=0.010),B组亦优于C组(P=0.026),A组和C组无差异.治疗12月后B组优于A组(P=0.001),B组亦优于C组(P=0.038),A组和C组无差异.结论:多乐氟联合脱敏糊剂治疗牙本质过敏症疗效显著,优于两者单独使用.
  • 摘要：目的:比较4种粘接剂对牙本质的剪切强度,以期为临床上粘接剂的选择提供参考.方法:选取48颗健康第三磨牙,随机分为4组,分别用A(Single bond 2)、B(Clearfil SE Bond)、C(Xeno Ⅲ)、D(Easy one)制备试件,万能材料试验机测定剪切强度,扫描电镜下判断断裂模式.结果:4种粘接剂对牙本质剪切强度的总体比较有显著性差异(P＜0.05).组间两两比较B与C组之间无显著性差异(P＞0.05),两者的剪切强度均低于A组,均高于D组.扫描电镜下显示绝大部分样本发生混合断裂,差异无统计学意义(P＞0.05).结论:Single bond 2粘接强度优于Clearfil SE Bond和Xeno Ⅲ,Easy one对牙本质的粘接强度最低.%Objective:To compare the shear bond strength and failure modes of four dentin adhesives,in order to provide reference for clinical application.Methods:Forty-eight normal third molars were randomly distributed into four groups.A (Single bond 2),B(Clearfil SE Bond),C(Xeno Ⅲ) and D(Easy one) were used to build up resin-dentin interfaces.The shear strength was examined and the failure modes were observed by scanning electron microscope(SEM).Results:The mean shear strength of group A showed the best result.There was no significant difference between group B and group C.The shear strength of group D was lowest.Most of the failure modes were mixed fractures and there was no significant difference between each group.Conclusion:The bonding strength of Single bond 2 was better than that of Clearfil SE Bond and Xeno Ⅲ easy one.Easy one had the lowest adhesive strength.
  • 摘要：Dental caries detector is used to stain the infected dentin layer in the dentin caries,that is,after the removal of discolored caries,the visual and tactile cannot directly determine the infected dentin,which is a method to assist in the diagnosis of infected dentin.By staining the collagen fibers in dentin,the caries needs to be removed,visually,efficiently and accurately,so as to avoid excessive removal of non infected dentin.At present,domestic and international experiments and clinical display have shown its good effect Therefore,a thorough understanding of the mechanism and clinical application of dental caries indicators will have a profound impact on the development of caries and tooth diseases.%龋齿指示剂是指用来染色牙本质龋中感染牙本质层,即去除变色龋损后,视觉、触觉无法直接判断的感染牙本质,属于一种辅助诊断感染牙本质的方法.通过染色脱矿牙本质中的胶原纤维,直观、高效、准确指出需要去除的龋损,避免过度去除非感染层牙本质.日前国内外实验和临床显示出了其良好的效果.所以,深入了解龋齿指示剂的机制和临床应用,对丁阻断龋病和牙体疾病的进一步发展有深远的影响.
  • 摘要：老年患者牙齿缺失后常因牙槽骨吸收造成传统义齿固位困难,种植修复可有效解决该问题,但口腔局部解剖结构的改变使老年人的人工种植牙表现出其独有的特点.就上颌而言,一方面上颌牙槽突、上颌结节、牙槽骨壁等部位随着牙齿缺失及其他局部或全身因素的影响会发生不同程度的萎缩和吸收,种植体与牙槽突长轴、鼻腔、上颌窦的位置关系变得更加复杂,加大了种植治疗的难度;而另一方面尖牙支柱、颧骨区等特殊结构或部位的骨质虽然也发生了萎缩和吸收,但这些结构的解剖特点决定了其可以作为种植体的植入位点,从而使牙槽骨严重萎缩老年患者的种植修复成为可能.充分认识老年人失牙后口腔颌面解剖结构的变化特点,不仅可以最大限度的避免种植并发症的发生,还可以扩大牙槽骨严重萎缩老年无牙颌患者的种植适应证,造福广大老年患者.本文针对我们在临床应用上颌牙槽突、上前牙牙长轴、牙槽骨壁、鼻腔、上颌窦、尖牙支柱、颧骨及上颌结节的解剖特点及增龄性变化完成不同类型人工种植修复的实际情况,结合文献,对这些解剖结构变化与种植的关系进行论述,探讨其作为老年患者种植基础的条件及可行性,供同行参考.%After tooth loss in elderly patients,traditional denture retention is difficult due to the absorption of alveolar bone.And dental implant is an effective method to solve this problem.However,the changes of local oral anatomy make the dental implants of elderly patients show its unique characteristics.In the maxilla,alveolar process,maxillary tuberosity and alveolar bone wall are atrophic and absorbed in varying degrees due to the loss of teeth and other local or systemic factors.The position relationship between the implant and the long axis of alveolar process,the nasal cavity and the maxillary sinus is more complicated.All of these increased the difficulty of planting treatment.On the other hand,the bone of some special anatomical structures such as canine buttress and zygomatic areas have also been atrophied and absorbed.However,the anatomical characteristics of these sites determine that they can be used as implantation sites for implants.And it is possible to restore the dental implant in elderly patients with severe alveolar bone atrophy.It is fully recognized that the changes of oral and maxillofacial anatomical structure of old people after tooth loss not only can avoid the occurrence of complications in maximum,but also expand the implant indications of elderly patients with edentulous jaws.And it is a gospel for elderly patients with severe alveolar bone atrophy.In this paper,we summarized the relationship between the anatomical characteristics and age-related changes of maxillary alveolar process,upper anterior teeth axis,alveolar bone wall,nasal cavity,maxillary sinus,canine buttress,zygomatic bone,maxillary tuberosity and the dental implant based on the actual situation of different types of artificial implant prosthesis,which we have completed in clinical practice and relevant literature in recent years to explore the condition and feasibility of elderly patients' dental implant basis,for peer reference.
  • 摘要：There is a correlation between general health and oral disease.Stroke,as one of the causes of disability,can lead to dysfunction and cognitive dysfunction.Affected arms can not effectively clean teeth,with the effect of decline of cognitive function,which weaken patients' oral self cleaning ability.Intention-to-treat and visit rates decrease.Poor oral health attitude,the lack of a unified standard of oral care program,and multiple medication lead to a decrease in saliva flow.Above factors lead to poor oral hygiene,and increase incidence of dental caries than peers.Streptococcus mutans,the main pathogen of dental caries,associated with hemorrhagic stroke.Number of remaining teeth and masticatory function has the effect on cognitive function.This article discusses the characteristics of stroke patients and the relationship between the caries and stroke.%全身健康与口腔疾病存在相关关系的观点已经被广泛接受.很多老年患者口腔健康意识差,缺乏统一口腔护理规范,多重用药也会导致唾液流量减少.作为致残原因之一的脑卒中,可导致认知功能以及运动功能障碍,表现为患者无法有效清洁牙齿.在认知功能下降介导作用下,患者口腔护理能力减弱,就诊意愿就诊率相应下降.因而脑卒中患者卫生状况较差,龋齿发病率也高于同龄老年人.另外众多文献显示,出血性脑卒中与龋病主要致病菌变异链球菌具有相关性;余留牙数与咀嚼功能同样对认知功能有所影响.本文就此人群龋病特点及脑卒中与龋病之间的相关关系加以论述.
  • 摘要：目的:探讨新型矿化胶原膜(the mineralized collagen membrane)对人成骨肉瘤细胞株Saos-2生物学行为的影响.方法:将人成骨肉瘤细胞Saos-2接种于矿化胶原膜表面,光镜观察细胞形态;制备胶原膜的浸提液,以正常培养基为阴性对照,Bio-gide的浸提液为阳性对照,检测三组细胞的增殖和碱性磷酸酶(ALP)的活性.采用SPSS17.0软件对数据进行统计学分析.结果:矿化胶原膜和Saos-2细胞共培养时,细胞伸展良好;随着培养时间的延长,对照组和浸提液组细胞数量不断增加,1、4、7d时三组OD值之间无显著性差异,10d时阴性对照组OD值明显高于Bio-gide组和矿化胶原膜组,但Bio-gide组和矿化胶原膜组之间无显著性差异;7d时阴性对照组ALP活性最低,Bio-gide膜组较高,矿化胶原膜组表达最高,三者间差异有统计学意义.结论:矿化胶原膜具有良好的细胞相容性.%Objective:To investigate the biological effects of a new mineralized collagen membrane on Saos-2 cells in vitro.Methods:The Saos-2 cells were cultured on the mineralized collagen membrane and the morphology was observed by the light microscope.The extract liquid from mineralized collagen membrane and Bio-gide membrane was made.There were three groups:the blank control group,Bio-gide group and mineralized collagen membrane group.The cell proliferation and ALP activity of three groups were studied.The data were analyzed by SPSS 17.0 software.Results:Saos-2 cells on the mineralized collagen membrane readily attached to it and exhibited an elongated appearance.The MTT assay showed that the proliferation proceeded in three groups.There was no significant difference after 1,4,7 days culture among three groups in statistics.But the OD value of Saos-2 in control group were the higher than the other two groups after 10 days.The ALP activities after 7 days culture were different in the three groups.The ALP activity of mineralized collagen membrane group was the highest,and that of the blank control group was the lowest.The difference in expression of ALP among three groups was statistically significant.Conclusions:Studies in vitro revealed that the mineralized collagen membrane has good cell biocompatibility.
  • 摘要：目的:总结分析伴有糖尿病的口腔颌面部感染的老年患者临床特征和治疗经验.方法:对2016年内就诊的20例严重口腔颌面部感染合并糖尿病老年患者的一般资料、病因、实验室检查指标、治疗方法和治疗结果进行分析.结果:老年糖尿病口腔颌面部感染患者的治疗在严格控制血糖的情况下,用药剂量大,疗程长,预防并发症.结论:老年人口腔颌面部感染伴有糖尿病患者应加强宣教,与专科合作控制血糖水平,规范化用药.%Objective:To summarize the experience of clinical features and treatment in elderly patients with oral and maxillofacial infections with diabetes mellitus.Methods:The general information,etiology,laboratory results,treatment and outcome of 20 elderly patients with oral and maxillofacial space infection in our hospital in 2016 were analyzed.Results:In the case of strict control of blood glucose,oral maxillofacial infections in elderly patients with diabetes had in a large dose drugs,the longer course of treatment,more complications under strict control of blood glucose.Conclusions:Propaganda and education,cooperation with specialist to control blood sugar level and standardization medication should be closed attention for the elderly patients with oral and maxillofacial infections and diabetes mellitus.
  • 摘要：目的:探究高糖高脂对成骨细胞增殖和凋亡的影响.方法:以完全培养基为对照组培养基,以含20.0mM葡萄糖(D-glucose)、0.4mM棕榈酸(Palmitic acid,PA)及0.5％牛血清白蛋白(Bovine serum albumin,BSA)的完全培养基为实验组模拟高糖高脂环境,分别处理成骨细胞0-48h后,显微镜下观察细胞形态,采用CCK-8检测细胞增殖活性,Annexin Ⅴ/PI双染流式检测细胞凋亡率,Western blotting检测caspase-3及cleaved caspase-3蛋白水平.结果:成骨细胞在高糖高脂环境下培养24h时观察到细胞皱缩变圆,胞间间隙增宽;CCK-8检测提示高糖高脂培养成骨细胞24h时与同时刻对照组相比出现增殖抑制(F24h=24.489,P=0.001),48h后增殖活性(0.027±0.022)较同时刻对照组差异有统计学意义(F48h=272.440,P＜0.001);Annexin Ⅴ/PI双染流式检测显示,24h时高糖高脂组细胞凋亡率为9.68％±3.33％,36h时细胞凋亡率上升至12.89％±3.40％,可达对照组(1.96±1.32)约6.6倍;Western blotting检测发现健康成骨细胞极少表达cleaved caspase-3,高糖高脂可时间依赖性上调cleaved caspase-3蛋白水平,24h时cleaved caspase-3相对蛋白表达量(0.349±0.068)约为对照组(0.146±0.033)2.4倍,36h时(0.468±0.136)达对照组3.2倍(F=9.603,P=0.001).结论:高糖高脂可时间依赖性抑制成骨细胞增殖,促进凋亡.%Objective:To investigate the effect of the combination of high glucose and free fatty acid on apoptosis and proliferation in osteoblast.Methods:Osteoblasts were treated with high glucose and free fatty acid (D-glucose 20.0mM,PA 0.4mM,BSA 0.5％) for 0-48h.Phase-contrast microscope was used to observe morphologic alteration of cells.Proliferation was detected by CCK-8.Apoptosis was analysed by Annexin Ⅴ/PI double dye staining followed by flow cytometry analysis.Western blotting was applied to examine protein expression of caspase-3 and cleaved caspase-3.Results:Combination of high glucose and free fatty acid caused cell shrinkage,rounding as well as detachment after 24h.CCK-8 data showed that high glucose and free fatty acid inhibited cell proliferation in a time dependent manner compared to control group (F24h=24.489,P=0.001;F48h=272.440,P＜0.001).Flow cytometry results revealed that in the present of high glucose and free fatty acid,the apoptotic rate was 9.68％±3.33％ after 24h and increased to 12.89％±3.40％ after 36h compared to control group (1.96％±1.32％).Western Blotting indicated that healthy osteoblasts rarely expressed cleaved caspase-3.High glucose and free fatty acid increased cleaved caspase-3 protein expression by 2.4 times (0.349±0.068,F=9.603,P=0.016) and 3.2 times (0.468±0.136,F=9.603,P=0.001) after 24h and 36h respectively compared to control group (0.146±0.033).Conclusion:High glucose and free fatty acid time-dependently inhibit proliferation and increase apoptosis in osteoblast.
  • 摘要：Objective:To investigate the anodontia and prosthodontics condition of elderly people in xi'an,and explore the oral health-related quality of life.Methods:The elderly aged more than 65 years in endowment institutions ofxi'an was selected to do oral examination according to the Third National Oral Health Investigation Criteria and Geriatric Oral Health Assessment Index was applied to evaluate the oral health-related quality of life.SPSS 18.0 software package was used for statistical analysis.Results:12.50％ of the subjects in the survey with complete dentition,20.29％ of the subjects in the survey were edentulous,the mean tooth loss was 11.42.Mean GOHAI score of the sample was 49.46,the score about physiological function is 15.20,pain and discomfort is 12.69,and psychological and social function is 21.58.When to analyse negative effects of each item,the item "biting or chewing difficulties" is the most common problem,about 46.20％ of the elderly experienced the trouble.The GOHAI score of complete dentition,dentition defect and edentulism is reduced in turn.Conclusion:The elderly in endowment institutions has a high tooth loss rate and the rate of prosthetic restorations is low,oral health-related quality of life and oral health are relatively poor,whether the dentitions is complete is an important factor that affect oral health-related quality of life.%目的:了解西安市养老机构老年人牙齿缺失及修复状况,进行口腔健康相关生命质量分析.方法:根据第三次全国口腔健康流行病学调查方法,对陕西省西安市16家养老机构中老年人牙齿缺失及义齿修复状况进行调查;采用老年口腔健康评价指数(Geriatric Oral Health Assessment Index,GOHAI)评价其口腔健康相关生命质量.数据采用SPSS18.0软件进行统计分析.结果:牙列完整者12.50％,牙列缺失者20.29％;失牙均数11.42.210名接受GOHAI量表调查者平均得分49.46,其中生理功能方面15.20,疼痛不适方面12.69,心理社会功能方面21.58;在各条目负面影响的分析中,“咬或咀嚼食物时有困难”最常给老年人带来困扰,达46.20％.牙列完整、牙列缺损、牙列缺失老年人GOHAI得分依次降低.结论:西安市养老机构失牙老年人占较大比例,义齿修复率偏低,口腔健康状况及相关生命质量较差,牙列是否完整是口腔健康相关生命质量的重要影响因素.
  • 摘要：Objective:The first case of transoral robotic surgery orthorax was performed in our hospital,which provided experience for the application of maxillofacial surgery robot in the future.Methods:First case of TORS was applied to a patient suffered from soft palate tumor with the Da Vinci robotic operation system in the Department of Stomatology of the General Hospital of the PLA,and the experience was summarized.Results:The operation was successfully completed.The operation area was exposed within 30 minutes,the operation time was 20 minutes,and the patient was discharged from the hospital in 2 days after the operation.Conclusion:Da Vinci robotic surgery system can independently complete the deep tumor of the mouth and has great potential for clinical application in oral and maxillofacial surgery.%目的:施行我院第一例经口入路机器人手术(transoral robotic surgery TORS),为将来颌面外科机器人的应用提供经验.方法:解放军总医院口腔科应用达芬奇机器人手术系统对1例软腭肿瘤患者行TORS,总结手术体会.结果:患者顺利完成手术,术区暴露用时30min,手术时间20min,患者术后2d顺利出院.结论:达芬奇机器人手术系统可以独立完成口腔深部肿瘤,在口腔颌面外科领域有较大的临床应用潜力.
  • 摘要：Objective:To compare the therapeutic effect of three different material onlays on the restoration of the massive defect of the posterior teeth.Method:Seventy-six patients were treated with 100 onlays for the restoration of massive defect of the posterior teeth.Primary root canal treatment was performed and onlays were fabricated with IPS e.max.CAD ceramics,composite resin and gold alloy alternatively.All restorations were evaluated at one year,two years,three years after placement.The clinical effects of three groups were compared according to the modified USPHS.Result:The three groups had no difference in marginal adaption,interproximal relations,periodontal reaction as well as marginal discoloration.In restoration integrity and the abrasion of opposite teeth,composite resin onlays and gold alloy onlays were better than IPS e.max.CAD ceramic onlays while composite resin onlays and IPS e.max.CAD ceramic onlays are obviously better than gold alloy onlays in color match.Conclusion:Good marginal adaptation as well as interproximal relations could be reached by the three different material onlays on the restoration of the masssive defect of the posterior teeth,which decreased the occurrence of periodontal disease and secondary caries.Thanking to their excellent fracture resistance and good apperance,onlay restorations fabricated with composite resin can be a good option for the restoration of the massive defect of the posterior teeth.However,the long-term reaction ofresoration was left to be studied in the future.%目的:比较三种材料的高嵌体修复大面积缺损后牙的效果.方法:选取行根管治疗后的76名患者的100颗后牙,分别用IPS e.max.CAD瓷块、复合树脂、金合金进行高嵌体修复,在修复后1年、2年、3年后短期随防,根据改良后的USPHS标准评价其修复效果.结果:三组不同材料高嵌体在继发龋、边缘染色、牙周反应的差异无统计学差异.而金合金和瓷嵌体的完整性好于树脂嵌体,树脂嵌体对对颌牙的磨损程度低于瓷嵌体与金合金嵌体.结论:三种材质的高嵌体用于修复大面积缺损的后牙时,均能够减少牙周反应和防止继发龋的发生.其中瓷嵌体和金合金嵌体在边缘密闭性、邻接关系及修复体完整性方面,优于树脂嵌体,而瓷嵌体的美观性明显优于金合金嵌体,可满足临床美学修复的要求,但其强度高,易磨耗对颌牙.
  • 摘要：目的:应用锥形束CT(CBCT)研究下颌前牙的牙根数目和根管形态,为下颌前牙的根管治疗提供依据.方法:选取2017年1月至2017年6月期间就诊于解放军总医院口腔科的247位患者(男136,女111)的1455颗下颌前牙的CBCT图像,对牙根数目及根管形态进行研究.结果:下颌中切牙和侧切牙均为单根牙,1.65％的下颌尖牙为双根牙,具有多根管的中切牙有93颗(19.14％),侧切牙有161颗(33.20％),尖牙有60颗(12.37％).51-60岁之间下颌切牙的双根管率最高,30岁以后年龄越大,下颌尖牙的多根管率越高.下颌前牙根管形态双侧对称率高,尤以侧切牙最高,为91.67％(66/72).结论:下颌前牙多根管常有发生,侧切牙的多根管率最高,且双侧对称率最高,下颌前牙的多根管分型以Ⅰ型(vertucci分型)多见.%Objective:The root number and root canal morphology of mandibular anterior teeth were studied by CBCT in order to provide evidence for root canal therapy of mandibular anterior teeth.Method:1455 CBCT images of mandibular anterior teeth were obtained from 247 patients (136 men and 111 women) who had treatment at the People's Liberation Army Stomatological Hospital between January 2017 and June 2017.We analyze the number of roots and root canal morphologies.Results:All the mandibular central incisors and lateral incisors were single root,and 1.65％ of canines had two roots.19.14％ of mandibular central incisors,33.20％ of lateral incisors,12.37％ of canines had multiple root canals.The rate of double root canals of mandibular incisors between 51 and 60 years old was the highest.The higher the age after 30 years old,the higher the rate of multi-rooted canals of mandibular incisors.The highest frequency of symmetry of root canals was in mandibular lateral incisors(91.67％).Conclusion:Multiple root canals often occur in mandibular anterior teeth.The rate of multiple root canals in lateral incisors is the highest,and the bilateral symmetry rate is the highest.Vertucci type Ⅰ canal morphology is most common in mandibular anterior teeth.
  • 摘要：Objective:The purpose of this study was to investigate the Effect of saliva contamination on microleakage at the gingival margin after universal adhesive curing in class Ⅴ restorations.Methods:A total of 50 fresh orthodontically extracted human premolars were included in this study.Class Ⅴ cavities were prepared with a cylindrical diamond bur on the facial surfaces of each tooth.Teeth were divided into five groups (10 in each group).A universal adhesive (Single Bond Universal,3M) was used.The adhesive was applied according to the instructions of manufacture under self-etch mode.In group A,Single Bond Universal was applied onto the surfaces directly as the control group.In other four groups,the surface of tooth was treated with the following methods after contaminated with artificial saliva for 10s.Group B,drying;Group C,water spraying and drying;Group D,water spraying,drying and reapplication of adhesive;Group E,water spraying,drying and re-etching and reapplication of adhesive.The cavities were restored with composite resin (FilteK Z350XT) after the adhesive system treatment.After cold and hot circulation and methylene blue solution dyeing for 24h.All teeth were cut in buccal-lingual direction and the degree of dye penetration was observed under stereomicroscope for the microleakage.Results:The present study revealed that the micro-leakage at the gingival margin in Group B and Group C were more than A group(P＜0.05).The micro-leakage at the gingival margin is no difference between A,D and E groups.(P＞0.05) Conclusion:Saliva contamination after universal adhesive curing could significantly increase the micro-leakage at the gingival margin in class Ⅴ restorations.When salivary contamination occurs,decontamination with rinsing,drying and reapplication of adhesive may reduce the micro-leakage at the gingival margin in class Ⅴ restorations.%目的:探讨通用型粘接剂固化后唾液污染及再处理对Ⅴ类洞充填体边缘微渗漏的影响.方法:选取50颗离体前磨牙,于釉牙骨质界处预备楔状缺损洞型,随机分为5组,每组10颗牙齿.A组:直接涂布Single Bond Universal通用粘接剂,吹干光照;B-E组:涂布Single Bond Universal通用粘接剂,吹干光照.新鲜唾液污染牙面10s后分别采用干燥;冲洗后干燥;冲洗后干燥再涂布粘接剂;及冲洗后干燥,再酸蚀再涂布粘接剂四种处理方式.所有试件均用FilteK Z350XT树脂进行充填.经冷热循环和亚甲基兰溶液染色后,从颊舌方向平行于牙体长轴正中将充填体纵向剖开,体视显微镜观测各组充填体龈壁边缘微渗漏程度.结果:通用粘接剂固化后唾液污染牙面仅干燥B组和冲洗后干燥C组其边缘微渗漏均高于未污染A组、差异具有统计学意义.冲洗干燥再涂布粘接剂D组和冲洗干燥、再酸蚀再涂布粘接剂E组与未污染A组龈壁边缘微渗漏无统计学差别.结论:Single Bond Universal通用粘接剂固化后唾液污染可导致充填体边缘微渗漏的增加.在临床操作中应避免唾液污染,一旦受到唾液污染后,应立即冲洗,干燥及再次应用粘接剂可减少树脂边缘微渗漏.
  • 摘要：目的:了解老年颞下颌关节紊乱病患者口腔健康相关生活质量与疲劳状况,并探讨其生活质量与疲劳状况的相关性.方法:使用口腔健康影响程度量表(OHIP)-14中文版及疲劳量表FS-14对颞下颌关节科就诊的211例老年颞下颌关节紊乱病患者及就诊于修复科的200例患者家属作为健康对照组进行问卷调查,并采用SPSS22.0软件对数据进行统计学分析.结果:老年颞下颌关节紊乱病患者(OHIP)-14总分(15.47±9.28)明显高于健康对照组(4.23±1.65);躯体疲劳、脑力疲劳及疲劳总分均明显高于健康对照组[躯体:(5.03±2.02)分vs (2.28±1.19)分,脑力:(2.06±1.78)分vs(1.11±1.09)分,总分:(7.09±3.17)分vs(3.06±1.66)分];老年颞下颌关节紊乱病患者生活质量总分与躯体疲劳及脑力疲劳得分均呈显著正相关,相关系数为分别为0.602、0.576.结论:老年颞下颌关节紊乱病患者的疲劳程度较健康对照组高,患病时间越长躯体疲劳程度越高,且生活质量水平随着疲劳程度的增加而呈下降趋势.在临床工作中应加强颞下颌关节紊乱病知识的宣教,引导患者及时及早就医,从而减轻疲劳程度提高生活质量.%Objective:To investigate the quality of life (QOL) and fatigue status in elderly patients with temporomandibular disorders (TMJ).Methods:OHIP-14 Chinese version and FS-14 were used to investigate 211 elderly patients with temporomandibular joint disorder and 200 relatives of patients in repair department as healthy control group.The statistical analysis of the data was carried out with SPSS22.0 software.Results:There were significant differences in (OHIP)-14 and FS-14 scale between two groups.(OHIP)-14 score (15.47±9.28) vs (4.23±1.65);physical fatigue score(5.03±2.02) vs (2.28±1.19) mental fatigue score (2.06±1.78) vs(1.11±1.09),total score of fatigue (7.09± 3.17) vs(3.06±1.66).There were a positive and significant relationship between quality of life and physical fatigue and mental fatigue,correlation coefficient were 0.602、0.576.Conclusions:The fatigue of elderly patients with temporomandibular joint disorders is higher than those of the healthy control group,and the degree of physical fatigue is affected by the time of illness,the quality of life decreased with the increase of fatigue.The knowledge of temporomandibular joint disorders should be strengthened in clinical work,in order to reduce the degree of fatigue and improve the quality of life.
  • 摘要：The finite element method is an important tool for mechanical research.Compared with the experimental stress analysis,the finite element method has many advantages.It is widely used in oral biomechanical research.The finite element method is used to not only study the influence of different implant bone binding sites on the stress analysis of bone interface under functional loads,but also simulate the mechanical loading of real chewing actions under the defined mechanical parameters and loading conditions of the oral tissues.This article summarizes the current situation and progress of the application of finite element method in dental implants.%有限元法是一种重要的力学研究工具,与实验应力分析相比,具有许多优点,因此被广泛应用于口腔生物力学的研究中.有限元法不仅可以研究功能负荷下不同种植体骨结合部位对骨界面应力分析的影响;而且可以规定口腔组织的力学参数和加载条件,进行模拟真实咀嚼动作的力学加载.本文对有限元法在口腔种植领域中的研究现状及进展做一综述.
  • 摘要：目的:应用锥形束CT(CBCT)观察下颌第二前磨牙根管系统解剖形态的增龄性变化,为临床治疗提供一定的参考.方法:依照纳入排除标准,筛选自2015年11月-2017年11月于解放军总医院口腔科就诊的患者,并搜集328颗下颌第二前磨牙,按照年龄依次分为6组:21-30岁,31-40岁,41-50岁,51-60岁,61-70岁,＞70岁.分别获取六组年龄人群的口腔颌面部锥形束CT影像资料.观察并统计如下指标:根管类型比例(Vertucci分类法),以及颊侧髓角与颊侧釉牙骨质界交角和颊舌侧釉牙骨质界(ECJ)连线的交角(BB-BL).六组之间采用卡方检验进行两两比较,并采用GraphPad Prism进行柱状图(平均值及标准差)分析.结果:各年龄组根管类型分布结果显示,Ⅰ型根管类型最为多见,比例高达96.6％ (317/328),组间比较差异无统计学差异(P＞0.05);另有约3.6％(11/328)的牙齿出现Ⅴ型根管,年龄组比较无统计学差异(P＞0.05).颊髓角(Buccal pulp angle)与颊侧釉牙骨质界连线(Buccal enamelo-cemental junction)和颊舌侧釉牙骨质界(Buccal-Lingual enamelo-cemental junction)连线的交角(BB-BL)显示,50岁之前该牙齿交角平均在36.1°左右,且无明显增龄性改变,进入50岁以后的交角降低为28.9°,而70岁以后的交角则明显变小为23.9°,且差异具有统计学意义(P＜0.05).结论:CBCT的应用使得根管系统研究变得简单而精确,增龄性改变对下颌第二前磨牙根管类型无明显影响,但该因素引起根管的钙化将使得根管髓腔缩窄,颊侧髓角降低,BB-BL角降低,从而增加了根管系统的复杂性.%Objective:Observing the age-related changes of root canal system of mandibular second premolars by using cone beam CT (CBCT),so as to provide some references for clinical treatment.Methods:According to inclusion and exclusion criteria,a total of 328 mandibular second premolars were selected from the Department of Stomatology of PLA General Hospital in November 2015-2017 November.They were divided into 6 groups in the light of their age:21-30,31-40,41-50,51-60,61-70 years old,＞ 70 years old,and obtain the CBCT images of the six groups.Observe and statistics the following indicators:root canal type proportion (Vertucci theory),and connection angle of buccal pulp horns and buccal&lingual enamel junction (ECJ).The six groups were compared with the chi square test,and the GraphPad Prism was used to analyze the histogram (average and standard deviation).Results:The results showed that type Ⅰ root canal type was the most common,the proportion is as high as 96.6％ (317/328),which accounts for the highest proportion in all age groups,and the difference was not statistically significant (P＞0.05);and about 3.6％ teeth (11/328) type Ⅴ root canal were found,and there was no significant difference in age group (P＞0.05).The connection angle of BB-BL displayed,before the age of 50,the average angle was about 36.1 degrees,and there is no obvious age-related changes,but the angle reduced to 28.9 degrees after 50 years of age,while the angle is significantly smaller for 23.9 degrees after the age of 70,and the difference wasstatistically significant (P＜0.05).Conclusion:The application of CBCT makes the study of the root canal system becomesimple and accurate,the age has no effects on the root canal type,but the calcification of root canal because of aging factorswill make the root medullary cavity narrow,BB-BL angle decreased,which increases the complexity of root canal system.
  • 摘要：目的:研究上颌后牙缺失患者上颌窦底壁骨分嵴的发生率及形态特征.方法:收集2016年1月至2016年12月就诊于首都医科大学附属北京口腔医院种植中心的上颌后牙缺失患者,在其CBCT影像上检测上颌窦底壁骨分嵴的发生率、分布、方向及高度,并对结果进行统计分析.结果:入选的患者共172例,其中男性93例,女性79例,上颌窦共计210个.骨分嵴的检出率约为21.9％,其中上颌窦中部占62.5％(30/48),上颌窦前部占20.8％(10/48),上颌窦后部占16.7％(8/48),骨分嵴的平均高度为(5.44±2.39)mm.骨分嵴的发生率与性别、年龄因素无明显相关性.骨分嵴方向为颊腭向42个(87.5％),近远中向6个(12.5％).结论:通过CBCT检查能观察上颌窦底骨分嵴的位置,方向,高度等,有利于减少手术并发症,提高种植的成功率.%Objective:To study the incidence and anatomical features of maxillary sinus septa in the patients with missing maxillary posterior teeth.Methods:CBCT images of maxilla in the patients who underwent posterior teeth implant therapy from January 2016 to December 2016.The incidence,location,direction and height of the maxillary sinus septa were analyzed.Data were presented using descriptive statistics.Results:There were a total of 172 patients (male 93,female 79) with 210 sinus,the prevalence of maxillary sinus segments with septa was 21.9％.63.0％ (29/46) of the septa were located in the middle region,21.7％ (7/46) in the posterior region,15.2％ (10/47) in the anterior region.The mean height of septa was (5.44±2.39)mm,and no statistically significant differences were observed with regard to gender or age.The distribution of septa in buccal-palate (87.23％) was far more than that in mesial-distal direction(12.77％).Conclusion:CBCT can observe the position,direction and height of maxillary sinus bone,which can reduce the complications of operation and improve the success rate of implantation.
  • 摘要：Objective:To compare the clinical effect of two methods of repair of Kennedy class Ⅲ Dentition defect.Methods:98 patients with Kennedy Class Ⅲ Dentition defect were divided into flexible denture group and traditional removable denture group according to different repair methods.The clinical effect and patient satisfaction were compared.Results:The flexible denture repair is superior to the traditional RPD group in stability,comfort index,beauty and food impaction.They were no significant differences in soft tissue compression and chewing efficiency.However,traditional RPD group gradually better than the flexible denture in the part of retention with the extension of time.They gradually appear discolour and aging phenomenon after wearing the flexible denture for half a year.The two groups were statistically significant (P＜0.05).Conclusion:The flexible denture has unique advantages in denture restoration of Kennedy class Ⅲ Dentition defect,it can be widely used in clinic,but long-term effects need to be observed.%目的:对临床中肯氏Ⅲ类磨牙缺损采用弹性义齿与传统可摘义齿两种修复方式的临床疗效进行比较.方法:选取肯氏Ⅲ类磨牙缺损的患者98例,按修复方式不同将其分为弹性义齿组和传统可摘义齿组,对两种修复方式下的临床效果和患者满意度进行比较.结果:对于肯氏Ⅲ类磨牙缺损的患者,弹性义齿组在稳定性、舒适度、美观性,食物嵌塞等方面优于传统可摘义齿组,在对软组织压迫、咀嚼效率等方面两组义齿修复并未出现明显差异,但随着佩戴时间的延长,传统可摘义齿固位性逐渐优于弹性义齿,弹性义齿佩戴半年后基托材料逐渐出现变色与老化的现象,两组比较均有统计学差异(P＜0.05).结论:弹性义齿在肯氏Ⅲ类磨牙缺损的义齿修复中有其独特的优势,在临床上可以根据其特性在适合患者中推广使用,远期效果仍需要继续观察.
  • 摘要：Objective:To investigate the effect of denture adhesives on Oral Health-Related Quality of Life (OHRQoL) of elderly edentulous patients with complete dentures.Methods:Divided 60 elderly edentulous patients (treated in Jan 2016-Jun 2017) into the test group and the control group randomly,30 persons per group.The Chinese version of the Oral Health Impact Profile-14 (OHIP-14) was used to evaluate OHRQoL.They were invited to fill the questionnaire of OHIP-14 after complete denture prostheses replacement.Patients of the test group used denture adhesives according to the manufacture's suggestions.Three months later of complete denture prosthesis replacement,patients of two groups were invited to fill the questionnaire again.SPSS 22.0 software package was used for data analysis.Results:The total OHIP-14 scores of patients of the test group (17.13±3.937) and the control group (15.43±4.032) were not statistically different after treatment.Three months later of complete denture prosthesis replacement,the total OHIP-14 scores of patients of the test group(8.20±2.511) were lower significantly than controls (13.30±3.789),including functional limitation domain、physical pain domain、physical disability domain and psychological disability domain.Conclusion:Denture adhesives can be used to improve OHRQoL of elderly edentulous patients with complete dentures.%目的:探讨使用义齿稳固剂对老年全口义齿佩戴者口腔健康相关生活质量(Oral Health-Related Quality of Life,OHRQoL)的影响.方法:选取2016年1月-2017年6月收治的老年牙列缺失患者60例,将其随机分成对照组和试验组,各30例.采用口腔健康影响程度量表中文版(Oral Health Impact Profile,OHIP-14)来评价生活质量.全口义齿初戴时由患者本人填写OHIP-14量表.对照组给予常规治疗和护理,试验组在对照组基础上使用义齿稳固剂,修复3个月后再次填写OHIP-14量表.采用SPSS22.0软件包对相关数据进行统计学分析.结果:全口义齿初戴时试验组的OHIP-14量表总分为(17.13±3.937),对照组OHIP-14量表总分为(15.43±4.032),两组无统计学差异;修复3个月后试验组的OHIP-14量表总分为(8.20±2.511)分,显著低于对照组(13.30±3.789)分,差异主要体现在口腔功能上的限制、生理性疼痛、生理障碍、心理障碍四个方面.结论:使用义齿稳固剂可提高老年全口义齿佩戴者口腔健康相关的生活质量.
  • 摘要：Nanomaterial,with one dimension in the range of 1 to 100 nm at least,possesses unique properties and functions of nanoscale.And nanoparticles are three-dimensional nanoscale materials.Nanoparticles have a broad application prospect because of their unique physical and chemical properties and special effects.Meanwhile,the biological safety ofnanoparticles has attracted more and more attention.Nanoparticles can affect organisms in multiple levels,such as animals,cells,subcells,proteins,genes and so on.The effect of nanoparticles on organisms is an extremely complex biological process,and the current research is mostly focused on the level of cells.Nanotechnology has promoted the improvement of traditional dental materials and made great progress in the clinical treatment of oral diseases.With the increasing application of nanomaterials in the field of stomatology,the chances of exposure to nanoparticles in patients with oral diseases are greatly increased.Studies have shown that a variety of dental nanomaterials are potentially toxic to the central nervous system,and the biological effects of different nanoparticles on osteoblasts,dental pulp cells and periodontal ligament cells will become the focus of future research.The study of the biological effects of nanoparticles on cells is beneficial to the safe application of nanoparticles in the field of life sciences.In this review,we summarized the biological effects,possible mechanisms and influencing factors of nanoparticles on cells.%纳米材料是指至少有一个维度的直径范围在1-100nm之间且具有纳米尺度独特性质和功能的物质,而三维均在纳米尺度的纳米材料被称为纳米颗粒.纳米颗粒以其特有的理化性质和特殊效应展现出广阔的应用前景,与此同时其生物安全性也越来越多的引起人们的关注.纳米颗粒可以在动物、细胞和亚细胞、蛋白和基因等多水平对生物体产生作用,纳米颗粒对生物体作用的方式、途径和机制是一个极其复杂的生物学过程,目前的研究多集中于细胞水平.纳米技术推动了传统口腔材料的改良,使口腔临床治疗取得了巨大进步.随着纳米材料在口腔医学领域的应用日益增多,口腔患者接触到纳米颗粒的机会大大增加.研究表明,多种口腔纳米材料对中枢神经系统具有潜在毒性,而不同纳米颗粒对成骨细胞、牙髓细胞及牙周膜细胞等的生物学效应将成为未来研究的重点.开展纳米颗粒对细胞生物学效应的研究,有利于纳米颗粒材料在生命科学领域中的安全应用.本文结合相关文献就纳米颗粒对细胞的生物学效应、可能机制及影响因素做一论述.

    中华老年口腔医学杂志的期刊信息

    • 创刊时间：2002
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    • 语言：中文
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    • 期刊栏目：牙体牙髓病；口腔外科；牙周黏膜病；口腔修复；口腔病调查；综述；口腔医学讯息
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