目的 通过检测新生儿高胆红素血症患儿血清神经元特异性烯醇化酶(NSE)的变化,探讨NSE早期诊断新生儿胆红素脑病的意义.方法 36名健康新生儿和96名本院新生儿室收治的高胆红素血症患者生后3-7天静脉采血检测血清胆红素和γ-GGT、NSE水平,同时做脑干听觉诱发电位(BAEP)检测,分析统计不同胆红素水平下NSE和BAEP、γ-GGT的变化.结果 NSE水平在胆红素重度升高、中度升高、轻度升高组均增高,各组间及与对照组间差异有显著性,P<0.05.BAEP异常和γ-GGT升高在轻度升高组与对照组、重度升高组与中度升高组之间差异有显著性,但在轻度升高组与中度升高组之间差异无显著性.结论 血清NSE水平较BAEP及γ-GGT检测来判断新生儿胆红素脑病更早、更敏感,NSE可作为判断高胆红素血症新生儿发生脑病早期诊断指标之一.%Objective To investigate the significance of neuron specific enolase(NSE) for the diagnosis of neonatal bilirubin encephalopathy. Methods 36 healthy newborns and 96 patients with hyperbilirubinemia were detected by blood serum NSE level,while doing the brain stem auditory evoked potentials(BAEP) detection andy glutamyl transfer ase. Results There was significant difference in NSE level between severe hyperbilirubinemia group and moderate one. So was between moderate and mild,mild and control groups(P＜0. 05). BAEP became abnormal in babies with jaun dice, y GGT increased in those babies. There was significant difference between severe and moderate hyperbilirubinemia groups,mild and control groups. But serum y GGT level and BAEP were not different between mederate and mild groups. Conclusion NSE detect more early diagnosis of neonatal bilirubin encephalopathy.
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