药物溶血实验检测方法研究进展

摘要

A comparative research is conducted on the performance of various methods of hemolysis test for drugs nowadays.It is classificated by the destruction of erythrocyte or the release of erythrocyte cell content.It is found that the substitutions of a dry chemistry method for cyanmethemoglobin and 4-amino antipyrine method for o-methyl benzidine method can be more accuracy and higher performance for hemolysis test.This review will provide references for the biocompatibility of drugs.%对现阶段多种药物溶血实验方法进行了对比研究,并依据红细胞破坏量、红细胞内容物释放等进行分类,发现干化学法替代氰化高铁法、4-氨基安替比林法替代甲联苯胺法等进行溶血试验可提高结果的精确度,更加便利和高效.由此,为药物生物安全性评价提供参考方法和依据.