摘要：
目的 应用血氧水平依赖的功能性磁共振成像研究帕金森病(Parkinson's disease,PD)静息状态下功能连接的改变.材料与方法 对35例符合PD诊断标准的患者及20名健康者行静息态脑功能性磁共振成像,选双侧纹状体(striaum, STR)为感兴趣区,采用双样本t检验分别比较左侧STR (L-STR)、右侧STR (R-STR)在两组间的脑功能连接的差异.结果 (1)以L-STR为种子点时,PD组右侧前额叶背外侧部、双侧后扣带回皮质、左侧中央前后回、顶下小叶、左侧楔前叶、左侧缘上回等脑区的正连接较正常组减弱(P<0.05,AlphaSim校正),额下回、海马旁回、左侧海马、左侧岛叶正连接增强(P<0.05,AlphaSim校正).(2)以R-STR为种子点时,PD组右侧前额叶背外侧部、双侧后扣带回皮质等脑区正连接较正常组减弱(P<0.05,AlphaSim校正),右侧舌回、岛叶、海马旁回、双侧海马、左侧丘脑等脑区正连接增强(P<0.05,AlphaSim校正).结论 静息状态下PD患者的脑功能连接网络存在异常.%Objective: To explore the functional connectivity changes in patients with Parkinson's disease (PD) by blood-oxygen-level dependent functional magnetic resonance imaging (BOLD-fMRI). Materials and Methods: Twenty normal control (NC) and thirty-five PD patients, who were examined with resting state fMRI. Selecting the bilateral striatum areas as the seed voxels. Two sample t test was used to compare the differences of L-STR and R-STR between PD group and NC group. Results: (1)L-STR: Compared to NC group, the positive functional connectivity of bilateral posterior cingulate cortex, right dorsolateral prefrontal cortex, left, posterior central gyrus, inferior parietal lobule, left precuneus, were decreased and the inferior frontal gyrus, parahippocampal gyrus, left hippocampus, left insula were increased in the PD group(P<0.05,AlphaSim corrected).(2)R-STR:Compared to NC group, the positive functional connectivity of bilateral posterior cingulate cortex, dorsolateral prefrontal cortex were decreased and the right lingual gyrus, insular lobe, parahippocampal gyrus, bilateral hippocampus, left thalamus, were increased in PD group(P<0.05,AlphaSim corrected).Conclusions:PD patients have abnormal brain functional connectivity network in resting state.
