摘要:
目的:了解常熟市第二人民医院(以下简称"我院")抗高血压药的使用情况,为临床合理用药及药品管理提供依据.方法:按照世界卫生组织推荐的限定日剂量法,对2014-2016年我院口服抗高血压药的销售金额、年增长率、构成比,用药频度(defined daily dose system,DDDs)及限定日费用(defined daily cost,DDC)等指标进行回顾性统计分析.结果:2014-2016年我院口服抗高血压药销售金额分别为1 562.44、1 593.24和1 617.60万元,西药销售金额分别为32 010.38、31 162.36、31 218.22万元,口服抗高血压药销售金额占西药销售金额的比例分别为4.88%、5.11%和5.18%;2015年我院口服抗高血压药销售金额较2014年增长了1.97%,2016年较2015年增长了1.53%;3年来,销售金额和DDDs排序均居第1、2位的抗高血压药类别分别为血管紧张素Ⅱ受体拮抗剂和钙通道阻滞剂.3年来,销售金额排序居前3位的单品种抗高血压药依次为缬沙坦胶囊(合资)、厄贝沙坦片(进口)和氨氯地平片(合资),销售金额排序居前15位药品的销售金额累计占口服抗高血压药销售金额的90.81%;3年来,DDDs排序居前3位的单品种抗高血压药依次为美托洛尔缓释片(进口)、氨氯地平片(国产)和左旋氨氯地平片(国产),DDDs排序居前15位药品的DDDs累计占口服抗高血压药DDDs的86.97%.结论:我院口服抗高血压药的使用与《中国高血压防治指南(2010年版)》的推荐基本一致,符合目前抗高血压药的使用规律和趋势.不足之处在于对复方抗高血压药的选择倾向于相对较低.%OBJECTIVE:To investigate the application of oral antihypertensive drugs in Changshu the Second People's Hospital(hereinafter referred to as "our hospital"), so as to provide references for the rational application and management of the drugs.METHODS: According to the defined daily dose recommended by the WHO, the application of oral antihypertensive drugs in our hospital during 2014-2016 was retrospectively analyzed in terms of consumption sum, annual growth rate, constituent ratio, defined daily dose system(DDDs)and defined daily cost (DDC), etc.RESULTS: The consumption sum of oral antihypertensive drugs during 2014 to 2016 were respectively 15.624 4 million yuan, 15.932 4 million yuan, 16.176 0 million yuan, and the consumption sum of western medicine were respectively 320.103 8 million yuan, 311.623 6 million yuan, 312.182 2 million yuan, which accounted for respectively 4.88%, 5.11% and 5.18% of the consumption sum of western medicine.The consumption sum of oral antihypertensive drugs in 2015 increased by 1.97% over in 2014, and that in 2016 increased by 1.53% over in 2015.Among the 3 years, the angiotensin Ⅱ receptor blocking agents (ARB) and calcium-channel blockers (CCB) ranked top 2 both in the consumption sum and the DDDs, and the top 3 single antihypertensive drugs ranked by consumption sum were respectively valsartan capsules (joint venture), irbesartan tablets (imported) and amlodipine tablets (joint venture), the consumption sum of top 15 drugs accounted for 90.81% of the total amout of oral antihypertensive drugs.The top 3 single antihypertensive drugs ranked by DDDs were respectively metoprolol sustained-release tablets(imported), amlodipine tablets(domestic)and levamlodipine tablets (domestic), the DDDs of top 15 drugs accounted for 86.97% of the total amount of oral antihypertensive drugs.CONCLUSIONS: The application of oral antihypertensive drugs in our hospital is basically consistent with the Guideline for Prevention and Control of Hypertension in China(2010), in accord with the application regularity and trend of oral antihypertensive drugs.However, the application of compound antihypertensive drugs was relatively low.