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中国药业

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China Pharmaceuticals
本刊立足药品监督管理政策，传递医药发展信息，传播医药科技知识，交流药品科研、生产、流通、使用各方面的管理经验和药学成果。
  • 发文量：30363
  • 被引量：9658
  • H指数：1
  • 开始收录时间：1995(3)
  • CNKI综合因子：0.689
  • 维普期刊影响因子： 1.53
  • 万方期刊影响因子：1.7
  • 创刊时间：1992
  • 国内刊号/CN：50-1054/R
    国际刊号/ISSN：1006-4931
  • 发行周期：半月刊
    邮发代号：78-130
  • 主管单位：国家食品药品监督管理局
    主办单位：重庆市食品药品监督管理局
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  • 主编：刘斌
  • 电话：023-86592565
  • 邮箱：zgyaoye@vip.tom.com
  • 地址：重庆市渝中区长江一路61号地产大厦1号楼19层
  • 邮编：400014
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  • 摘要：Flos Campsis is the traditional Chinese medicine. Its mainly chemical constituents are fatty alcohols,aliphatic ketones,fatty acids,phenolic acids,cyclohexylethanoids,pentacyclic triterpenoids,flavonoids and anthocyanins,iridoids and iridoid glycosides,phenyl-propanoid glycosides and volatile oils. The mainly common adulterants are Flos Paulownia tomentosa,Flos Paulownia fortunei,Flos Datura metel,Flos Rhododendron molle and Flos Hibiscus syriacus. This paper reviewed the research advances in chemical constituents of Flos Campsis and morphological identification,microscopic identification,physicochemical identification of its adulterants,and to provide reference for rational use of Flos Campsis.%凌霄花为我国传统中药，主要化学成分为脂肪醇、脂肪酮、脂肪酸、酚酸、cyclohexylethanoids、五环三萜、黄酮及花色素、环烯醚萜及其苷、苯丙素苷、挥发油等，常见伪品主要有泡桐花、洋金花、闹羊花、木槿花等。该文综述了凌霄花化学成分及与其伪品性状鉴别、显微鉴别、理化鉴别的研究进展，为中药凌霄花的合理使用提供参考。
  • 摘要：Objective To investigate the clinical efficacy of Butylphthalide Injection in treating acute cerebral infarction patients and its influence on high sensitive C reactive protein(hs-CRP). Methods 90 cases of acute cerebral infarction patients from October 2012 to November 2014 were divided into two groups according to treatment methods,45 cases in the control group were given citicoline treatment,and 45 cases in the experimental group were given Butylphthalide Injection. Results The total effective rate of the experi-mental group was 93. 33%,which was significantly higher than 73. 33% of the control group ( P < 0. 05);after treatment,the NIHSS score after 14 d of treatment of the experiment group was (6. 82 ± 1. 22) points,which was significantly lower than (13. 32 ± 3. 29) points before treatment and the control group′s(9. 97 ± 1. 70)points after 14 d treatment;the hs-CRP level of the experiment group was(2. 72 ± 2. 92)mg/L,which was significantly lower than(6. 73+3. 97)mg/L before treatment and the (4. 61 ± 3. 51)mg/L of the control group after treatment( P < 0. 05). Conclusion Butylphthalide Injection in treating acute cerebral infarction has significant efficacy,can effectively improve the clinical symptoms of the patients,the inflammatory reaction is suppressed,promote nerve cell function recovery of patients,which is worthy of clinical promotion.%目的：观察丁苯酞注射液治疗急性脑梗死的临床疗效及对超敏C反应蛋白（hs－CRP）的影响。方法选取2012年10月至2014年11月医院收治的急性脑梗死患者90例，按治疗方法不同分为对照组和试验组，各45例。对照组患者给予胞磷胆碱治疗，试验组患者给予丁苯酞注射液治疗。结果试验组患者总有效率为93.33%，明显高于对照组的73.33%（ P<0.05）；治疗后，试验组治疗14 d后的神经功能缺损评分（NIHSS）评分为（6.82±1.22）分，明显低于本组治疗前的（13.32±3.29）分及对照组治疗后14 d的（9.97±1.70）分（ P <0.05）；试验组 hs－CRP 水平为（2.72±2.92）mg/L，明显低于本组治疗前的（6.73±3.97）mg/L 及对照组治疗后的（4.61±3.51）mg/L（ P<0.05）。结论丁苯酞注射液治疗急性脑梗死疗效明显，可有效改善临床症状，抑制炎性反应，促进神经细胞功能的恢复，值得临床推广。
  • 摘要：Objective To strengthen and innovate the construction of drug safety administration information in a city. Methods To in-vestigate the construction situation of the drug safety administration in one food and drug administration,and to analyze the current situ-ation and deficiency of the drug safety administration system. Results and Conclusion The countermeasure and suggestion of the con-struction of the drug safety administration were put forward on the basis of big data:to establish the big data thinking,innovative drug regulatory mode;build big data centers,perfect the drug safety administration model divined by information,construct the 3 big basic da-ta bases of pharmaceutical information,pharmaceutical enterprise subject information,pharmaceutical enterprise behavior,and consolidate the basis of information interconnection and intercommunication.%目的：促进药品安全监管信息化建设的加强和创新。方法对某地食品药品监管部门药品安全监管信息化建设情况进行调研，对其药品安全监管信息系统的运行现状及存在的不足进行分析。结果与结论基于大数据思维提出了药品安全监管信息化建设的对策与建议，即建立“大数据思维”，创新药品安全监管模式；构建大数据中心，完善信息驱动下的药品安全监管模式；建设药品信息、医药企业主体信息、医药企业行为三大基础数据库，夯实信息互联互通基础。
  • 摘要：目的：分析医药上市公司的创新能力，促进医药行业整体竞争力的提升。方法采用SPSS因子分析法比较93家国有和33家私营医药上市公司的技术创新能力、管理创新能力、制度创新能力、市场营销创新能力。结果与结论私营医药上市公司这4个方面的创新能力得分相对高于国有医药上市公司，导致私营医药上市公司的综合创新能力得分也高于国有医药上市公司，表明企业创新能力的提升是这4个方面综合作用的结果。%Objective The innovation capability of pharmaceutical Listing Corporation that helped to increase the overall performance of pharmaceutical Industry was analyzed. Methods The SPSS factor analysis was used to make comparisons for the state owned 93 com-panies and privately owned 33 listed companies from 4 perspectives of technical innovation ability,management innovation ability,regula-tion innovation ability and marketing innovation ability. Results and Conclusion The 4 perspectives of innovation ability scores in the privately owned listed pharmaceutical companies′were better than state owned companies,and these lead to the conclusion that the com-prehensive innovation scores of the privately owned listed pharmaceutical companies were also higher than the state owned pharmaceuti-cal companies. The improvement of enterprise innovation ability couldn′t do without the comprehensive roles of the 4 perspectives.
  • 摘要：目的：系统分析在中国申请的三氧化二砷应用于医药领域的专利信息。方法利用国家知识产权局专利检索与服务系统和Soopat专利搜索引擎，检索在我国申请并公开的三氧化二砷在医药领域中应用的发明专利，并从其专利申请数量、区域分布数量、主要申请人、法律状态、技术动向等方面进行定量分析和定性分析。结果三氧化二砷在医药领域的专利申请量总体上呈增长趋势，2001年后增长趋势显著；国内专利申请人所在区域主要集中在北方及浙江沿海一带；国内申请量远高于国外在中国的申请量，国外申请量仅为4.44%，但国内专利申请主要集中在中药和药物制剂，国外则均为化合物；职务专利占申请总量的43.70%，申请人主要为大学（研究所）、公司、医院。结论我国在三氧化二砷的医药应用研究已有一定基础，但专利的维护和成果转化率不高；三氧化二砷对多种疾病的治疗具有应用价值，尤其具有广泛的抗瘤谱，故三氧化二砷在医药领域的专利申请仍具有较大上升空间。%Objective To systematical analyzes the patent information of arsenic trioxide ( As2O3 ) applied in Chinese medicine. Methods The State Intellectual Property Office patent search and service systems and Soopat patent search engine were used to search the patent application of As2O3 in the medical field in China,and its number of patent applications,the number of regional distribution,the princi-pal applicant,legal status,technology trends were analyzed in quantitative and qualitative way. Results As2O3 patent applications in the field of medicine enjoyed an overall growth,with a significant growth trend after 2001;the domestic patent applicants were mainly con-centrated in the northern area and the coastal areas of Zhejiang;the domestic applications were much more than international applica-tions(only 4. 44%),but the domestic patent applications mainly concentrated in traditional Chinese medicine and pharmaceutical formu-lations,while the international applications were mostly compounds;duties patents accounted for 43. 70% of total applications,and the applicants mainly worked in universities(institutes),companies and hospitals. Conclusion The study of As2O3 application in medicine has already achieved a rather solid foundation,but the patent maintenance and conversion rate are not high enough;As2O3 has applica-tion value for the treatment of various diseases,especially with a broad spectrum anti-tumor,therefore,the patent application of As2O3 in medicine will have greater room for growth.
  • 摘要：Objective To observe the clinical efficacy of Xingpi Yang′er Granules combined with exercise of abdomen muscles in the treatment of nocturnal enuresis. Methods 96 patients hospitalized in the hospital diagnosed as nocturnal enuresis were randomly divided into the treatment group and the control group,48 cases in each group. The control group was treated with desmopressin Acetate Tablets,and the treatment group was treated with Xingpi Yang′er Granules combined with exercise of abdomen muscles. 2 weeks was 1 course of treatment,and the two groups were treated for 3 courses. Results After treatment,the urinary incontinence symptom integral of enuresis children in the treatment group was decreased compared with before treatment ( P < 0. 01),and the treatment group de-creased obviously more compared with control group ( P < 0. 05);the clinical efficacy of the treatment group was significantly better than the control group( P<0. 05);the ADH level and urine osmolality were significantly increased compared with before treatment( P<0. 01), and the increases in the treatment group were more than the control group( P < 0. 05);both groups had no significant adverse reac-tions. Conclusion Xingpi Yang′er Granules combined with exercise of abdomen muscles has obvious effects to the number of urinary incontinence,decrease the quantity of urinary incontinence,improve the sleep depth degree,and enhance the level of ADH and Urine os-molality in the blood,with obvious clinical efficacy and few adverse reactions.%目的：观察醒脾养儿颗粒联合腹肌锻炼治疗小儿遗尿的疗效。方法将96例遗尿患儿随机分为对照组和治疗组，各48例。对照组患儿给予醋酸去氨加压素片治疗，治疗组患儿给予醒脾养儿颗粒联合腹肌锻炼治疗。2周为1个疗程，治疗3个疗程。结果治疗后，治疗组小儿遗尿症状评分较治疗前明显降低（ P <0.01），且较对照组降低幅度更大（ P <0.05）；治疗组临床疗效显著优于对照组（ P<0.05）；血浆渗透压、血清抗利尿激素水平较治疗前明显增高（ P<0.01），且较对照组增高幅度更大( P<0.05)；两组均未见明显不良反应。结论醒脾养儿颗粒联合腹肌锻炼能有效改善遗尿患儿遗尿次数，减少遗尿量，改善睡眠深浅程度，并提高患儿血浆渗透压和血清抗利尿激素水平，临床疗效显著，不良反应少。
  • 摘要：目的：建立测定胃乐胶囊中硫酸阿托品含量的高效液相色谱（HPLC）法。方法色谱柱为Kromasil C18柱（250 mm ×4.6 mm，5μm），流动相为0.05 mol/L磷酸二氢钠溶液（用磷酸调节pH至2.8）－乙腈（90：10），柱温为30℃，流速为1.0 mL/min，检测波长为210 nm。结果硫酸阿托品质量浓度在10.0~100.0μg/mL范围内与峰面积呈良好线性关系，平均回收率为98.88%，RSD为0.50%( n=6)。结论该方法准确、灵敏、重复性好，可作为胃乐胶囊的质量控制方法。%Objective To establish an HPLC method for the determination of atropine sulfate in Weile Capsules. Methods The chro-matographic column was the Kromasil C18 column(250 mm × 4. 6 mm,5 μm)at the temperature of 30 ℃,with 0. 05 mol/L sodium di-hydrogen phosphate solution(adjusting pH to 2. 8 with phosphoric acid)-acetonitrile(90 :10) as the mobile phase and detected with UV 210 nm and the flow rate of 1. 0 mL/min. Results The Atropine Sulfate in the range of 10. 0-100. 0 μg/mL showed good lin-ear relatiomship with the peak area,the average recovery rate was 98. 88%,RSD=0. 50% ( n=6 ) . Conclusion This method is accurate,sensitice and reproducible,which can be used for the determination of atropine sulfate in Weile Capsules.
  • 摘要：Objective To establish the quality standards of Baibai Granules. Methods The atractylodes macrocephala,codonopsis pilosu-la,poria cocos,astragalus membranaceus were indentified by TLC,and the content of glycyrrhizic acid was determined by HPLC. Results The characteristic identification by TLC was distinct and highly specific. Glycyrrhizic acid showed a good liner relationship at the range of 6-60 μg/mL ( r=0. 999 9 ) ,and the average recovery rate was 98. 89% with RSD of 0. 66%( n=6). Conclusion The method is reliable,accurate and specific,which can be used for the quality control of the preparation.%目的：建立白柏颗粒质量标准。方法采用薄层色谱法对处方中的白术、党参、茯苓、黄芪进行定性鉴别；采用高效液相色谱法对样品中的甘草酸进行含量测定。结果薄层鉴别的分离度好，专属性强，阴性对照无干扰；含量测定甘草酸质量浓度（以甘草酸单铵盐计）在6~60μg/mL范围内与峰面积线性关系良好（ r=0.9999），平均回收率为98.89%（ n=6），RSD为0.66%。结论所建立的方法准确、可靠、专属性强，可用于该制剂的质量控制。
  • 摘要：目的：分析临床路径管理用于肺炎患儿的临床疗效评价。方法选择医院2014年1月至2015年10月诊断为细菌性肺炎的患儿120例，随机分为观察组与对照组，各60例。对照组患儿依据常规诊疗措施给予经验性综合处理，观察组患儿进入医院自行设计小儿肺炎诊疗临床路径。结果治疗后，观察组患儿抗生素使用时间、抗生素使用费用、药物总费用、检查费用、检验费用、住院时间、住院费用、非预期再住院率、并发症发生率、患者满意度均较对照组明显降低（ P<0.05）；两组患儿病死率（1.67%比1.67%，χ2=0.935）比较，差异无统计学意义（ P>0.05）。结论对肺炎患儿实施临床路径管理可有效降低临床医疗费用，缩短住院时间，提高患儿家属满意度，降低临床并发症发生率，显著提高医疗质量。
  • 摘要：目的：观察醒脑静治疗急性酒精中毒急诊的临床疗效和安全性。方法将医院收治的100例急性酒精中毒患者按治疗方法分为对照组和治疗组，各50例。对照组患者采用纳洛酮治疗，观察组患者在对照组基础上加用醒脑静治疗。结果治疗后，观察组急性酒精中毒患者平均清醒时间为（3.75±0.99）h，明显少于对照组的（6.89±1.78）h（ P<0.05）；观察组患者嗜睡、恶心呕吐、面红、瘙痒等不良反应发生率为2.00%，明显低于对照组的28.00%（ P<0.05）。结论在常规纳洛酮静脉滴注基础上联合应用醒脑静静脉滴注治疗急性酒精中毒疗效更佳，患者清醒时间明显缩短，可有效降低不良反应的发生率，安全性高，值得临床推广。%Objective To investigate the clinical efficacy and safety of Xingnaojing Injection in the treatment of acute alco-holism. Methods 100 patients with acute alcoholism in the hospital were divided into control group and the observation group according to the therapeutic method,50 cases in each group. The control group was treated with naloxone,on this basis,the observation group was added with Xingnaojing. Results After treatment,the average consciousness time of the observation group was(3. 75 ± 0. 99) h,which was significantly less than(6. 89 ± 1. 78)h of the control group( P < 0. 05);the incidence rate of adverse drug reactions,such as drowsiness,nausea and vomiting,itching,flushing,of the observation group was 2. 00%,which was significantly lower than 28. 00% of the control group( P < 0. 05). Conclusion On the basis of the conventional treatment of naloxone intravenous,the combination of Xing-naojing Injection intravenous infusion in the treatment of acute alcoholism has better effect,and can shorten the consciousness time,re-duce the incidence rate of adverse reaction,it is safe and worthy of clinical promotion.
  • 摘要：目的：建立柿叶提取物中总黄酮的质量研究方法。方法用薄层色谱法对总黄酮中的芦丁、槲皮素、山柰酚进行定性鉴别；以芦丁为标准品，用分光光度法测定总黄酮的含量；用高效液相色谱法对总黄酮的水解苷元槲皮素、山柰酚进行含量测定。结果薄层鉴别的色谱斑点清晰。供试品溶液最大吸收波长为410 nm。槲皮素质量浓度在9.6~57.6μg/mL 范围内与峰面积呈良好线性关系（ r=0.9998），平均回收率为99.09%，RSD为0.47%（ n=6）。山柰酚质量浓度在9.28~55.68μg/mL范围内与峰面积呈良好线性关系（ r=0.9998），平均回收率为99.03%，RSD为0.55%（ n=6）。结论该方法简便、快速，重复性及稳定性均较好，可用于柿叶提取物中总黄酮的初步质量控制。%Objective To establish the quality standard of persimmon leaf flavonoids. Methods To qualitatively identify the rutin, kaempferol and quercetin in the total flavonoid by TLC method;the total flavonoid was determined by spectrophotometry with rutin as standard material. The content of quercetin and kaempferol was determined by HPLC. Results The characteristic identification by TLC was distinct and highly specific. The absorbance of total flavonoid was measured at 410 nm. The quercetin showed a good linear in the range of 9. 6-57. 6 μg/mL( r=0. 999 8),the average recovery was 99. 09%,and RSD was 0. 47%( n=6). The kaempferol showed a good linear relationship with the peak area in the range of 9. 28 -55. 68 μg/mL( r=0. 999 8 ),the average recovery was 99. 03%,and RSD was 0. 55%( n=6 ). Conclusion The method is simple and rapid,and the reproducibility and stability are good,it is suitable for the quality control of persimmon leaf flavonoids.
  • 摘要：目的：观察养血清脑颗粒治疗慢性脑供血不足的临床疗效。方法将60例慢性脑供血不足患者随机分为治疗组与对照组，各30例。对照组患者在常规治疗基础上给予尼莫地平片20 mg，每日3次；治疗组患者在对照组基础上加用养血清脑颗粒，每次4 g，每日3次。两组患者均行中医护理干预。结果治疗2个月后，与对照组比较，治疗组症状及客观检查指标均有明显改善，治疗总有效率明显高于对照组（ P <0.05）。结论养血清脑颗粒治疗慢性脑供血不足患者临床疗效显著，有利于改善患者脑血流状况，降低血黏度，值得临床推广。%Objective To investigate the influence of Yangxue Qinnao Granules on blood rheology in patients with chronic cerebral cir-culation insufficiency. Methods 60 cases of patients with chronic cerebral circulation insufficiency were randomly divided into treatment group and control group,30 cases in each group. Patients in both groups were given the same basic treatment,at the same time given nimodipine 20 mg,3 times a day. The treatment group was provided extra oral administration of Yangxue Qinnao Granule 4 g,3 times a day. Results After 2 months of treatment,symptoms and objective examination showed more significant improvement in the treatment group than that of the control group( P < 0. 05). Conclusion Yangxue Qinnao Granules for the treatment of chronic cerebral circula-tion insufficiency is safe and effective,and can improve cerebral blood flow,reduce blood viscosity.
  • 摘要：目的：建立测定山黄祛痛喷雾剂中秋水仙碱含量的高效液相色谱（HPLC）法。方法色谱柱为Phenomenex Luna C18柱（150 mm ×4.6 mm，5μm），流动相为甲醇－水（45：55），检测波长为245 nm，柱温为30℃，进样量为10μL。结果秋水仙碱质量浓度在2.0~50.1μg/mL范围内与峰面积呈良好线性关系，回归方程为 A=35181.93 C＋8.72( r=0.9999)，平均加样回收率为100.31%，RSD为2.23%（ n=9）。结论该方法分离效率高、分析速度快、灵敏度高、易于实现自动化，为后期产品的质量控制和评价提供了科学依据。
  • 摘要：目的：建立测定青果丸中没食子酸含量的高效液相色谱法。方法色谱柱采用Inertsil C18柱（150 mm ×4.6 mm，5μm），以甲醇－0.1%磷酸溶液（5：95）为流动相，检测波长为273 nm，流速为1.0 mL/min。结果没食子酸质量浓度在10.536~36.876μg/mL范围内与峰面积线性关系良好，平均回收率为99.95%，RSD为0.24%（ n=6）。结论该方法简便、灵敏、稳定、准确，无其他成分干扰，可作为青果丸质量控制的有效方法。%Objective To establish an HPLC method for the content determination of gallic acid in Qingguo Pills. Methods The HPLC method was adopted and the Inertsil C18 column(150 mm × 4. 6 mm,5 μm)was used. The mobile phase was methanol-0. 1%phosphoric acid (5 :95). The detection wavelength was at 273 nm and the flow rate was 1. 0 mL/min. Results The linear range of gallic acid was 10. 536-36. 876 μg/mL. The average recovery rate was 99. 95%,RSD was 0. 24%( n=6). Conclusion The method is simple, sensitive,stable and accurate,which can be used for the quality control of Qingguo Pills.
  • 摘要：Objective To study the effect of safety management on the prevention of clinical drug delivery errors. Methods The ratio of drug use error occurred in the hospital after the implementation of safety management in 2014,and the data collected in 2013 were compared. Results In 2014,error of 119 429 patients with drug use occurred 489 times,accounting for 0. 41%;in 2013,error of 95 198 patients with drug use occurred 599 times,accounting for 0. 63%,which was statistically significant( P < 0. 05). Conclusion Through a series of safety management measures,it can improve the safety of drug use,the effect is remarkable,which is worthy of clinical promotion.%目的：研究安全管理对策预防临床给药错误的效果。方法比较医院2013年（实施安全管理前）及2014年（实施安全管理后）患者出现用药错误的比率。结果2014年119429人次患者中发生用药错误489人次（0.41%），显著低于2013年的95198人次中发生用药错误599人次（0.63%），P<0.05。结论实施安全管理措施可提高用药安全性，效果显著，值得推广。
  • 摘要：目的：评价单剂量口服药品自动摆药机（简称摆药机）应用于住院药房的工作模式、效益及不足，为国内医院引进自动口服药品摆药机提供思路和建议。方法系统总结医院使用摆药机的工作流程，汇总摆药中遇到的摆药机问题、药品问题、人员问题、药品准备工作中的问题及临床使用存在的问题。结果与结论摆药机可提高摆药的速度和准确性，改善卫生状况，减少药品污染，适合医院药房使用，有助于提高医院的综合药学服务水平，但对于临床工作中存在的实际问题仍需进一步探讨。%Objective To evaluate the dispensing mode and analyze cost-benefit and shortage after the use of automatic oral drug dis-pensing devices in inpatient dispensary,to offer suggestions for domestic hospitals in the introduction of automatic oral drug dispensing devices. Methods The gradual improved workflow of drug dispensing mechanism was summarized in the hospital. All problems and res-olution related to machine,drug,person,drug preparation and the problems existed in its clinical use were systematically summa-rized. Results and Conclusion The automatic oral drug dispensing system could enhance the speed and accuracy of drug dispensing, improve health condition and decrease medicine pollution. The automatic oral drug dispensing system is suitable for drug dispensing in hospitals and conducive to the enhancing of pharmaceutical care level. However,the problems existed in its clinical use still remain to be further studied.
  • 摘要：目的：观察蒲地蓝口服液联合克拉霉素颗粒治疗儿童慢性鼻－鼻窦炎的疗效。方法选取2014年6月至2015年6月医院收治的慢性鼻－鼻窦炎患儿102例，随机分为对照组50例和观察组52例。对照组给予克拉霉素颗粒治疗，观察组给予蒲地蓝口服液联合克拉霉素颗粒治疗。评估两组临床疗效，比较治疗前后病情严重程度视觉模拟量表( VAS )评分和不良反应。结果观察组总有效率为96.15%，明显高于对照组的54.00%（ P<0.05）；治疗后，观察组的鼻塞、鼻漏、嗅觉障碍、头面部疼痛改善情况均明显优于对照组（ P<0.05）；两组均无严重不良反应发生。结论蒲地蓝口服液联合克拉霉素颗粒治疗儿童慢性鼻－鼻窦炎的疗效显著，能明显改善患儿的临床症状，且无严重不良反应发生，值得临床推广。
  • 摘要：Objective To investigate the clinical efficacy and safety of allicin combined with ilaprazole in the treatment of patients with duodenal ulcer. Methods 220 cases of patients with duodenal ulce and Helicobacter pylori(HP)infection were randomly divided into 2 groups. The observation group( n=110):in the first week,allicin + ilaprazole + bismuth potassium citrate + clarithromycin + tinidazole orally;in 2-4 weeks,allicin capsule + ilaprazole orally. The control group( n=110):in first week,lansoprazole + bismuth potassium citrate+clarithromycin + tinidazole orally;in 2-4 weeks,lansoprazole orally. After stopping taking medicine,the recovery of ulcer was rechecked by endoscope,and the improvement of symptoms,adverse reactions,and eradication rates of HP were recorded. Results The HP eradication rate in the observation group was 94. 54% ,which was significantly higher than 85. 45% of the control group ( P < 0. 05). The cure rate of ulcer in the observation group was 96. 36%,which was significantly higher than 86. 36% of the control group( P < 0. 05). The disappearing time of pain in the observation group was (1. 52 ± 0. 50) d,which was significantly shorter than (2. 20 ± 1. 20) d of the control group( P < 0. 05). The rate of symptom disappearance and adverse reactions between the two groups had no statistical difference( P > 0. 05). Conclusion Allicin combined with ilaprazole-based five-medicine therapy in treating Heli-cobacter pylori is safe,has a higher eradication rate and high cure rate of duodenal ulce,the pain disappearance time after treatment in patients is short,which is worthy of clinical promotion.%目的：探讨大蒜素联合艾普拉唑治疗十二指肠溃疡的临床疗效。方法选择幽门螺杆菌阳性的十二指肠溃疡患者220例，随机分为观察组和对照组，各110例。对照组患者第1周口服兰索拉唑＋枸橼酸铋钾＋替硝唑＋克拉霉素片，第2~4周口服兰索拉唑片。观察组患者第1周口服大蒜素胶囊＋艾普拉唑＋枸橼酸铋钾＋替硝唑＋克拉霉素片，第2~4周口服大蒜素胶囊＋艾普拉唑肠溶片。停药后复查内镜并检测幽门螺杆菌，观察溃疡愈合、幽门螺杆菌根除、症状改善及不良反应发生情况。结果观察组幽门螺杆菌根除率为94.54%，显著高于对照组的85.45%（ P<0.05）；观察组痊愈率为96.36%，显著高于对照组的86.36%（ P<0.05）；观察组的疼痛消失时间为（1.52±0.50）d，显著短于对照组的（2.20±1.20）d（ P<0.05）；两组的症状消失率、不良反应发生率比较，差异均无统计学意义（ P>0.05）。结论大蒜素联合艾普拉唑的五联疗法对幽门螺杆菌有较高的根除率，对十二指肠溃疡的治愈率较高，用药后患者腹痛消失时间较短，安全性高，值得临床推广。
  • 摘要：目的：观察银杏酮酯滴丸治疗不稳定心绞痛的临床疗效。方法回顾性分析医院2013年6月至2014年12月收治的80例不稳定心绞痛患者的临床资料，随机分为治疗组和对照组，各40例。治疗组患者给予银杏酮酯滴丸，对照组患者给予复方丹参滴丸。结果用药1个疗程后，治疗组硝酸甘油用量及心绞痛发作次数明显少于本组治疗前及同期对照组（ P<0.05）；治疗组总有效率为95.00%，明显高于对照组的77.50%（ P<0.05）。结论银杏酮酯滴丸治疗不稳定心绞痛疗效确切，不良反应少，值得临床推广。%Objective To observe the clinical effect of Ginkgo Ketone Ester Drop Pills in the treatment of unstable angina pec-toris. Methods 80 patients with unstable angina were randomly divided into the treatment group and the control group,40 cases in each group. The treatment group was treated with Ginkgo Ketone Ester Drop Pills,while the control group was treated with Compound Danshen Drop Pills. Results After 1 course of treatment,the frequency of angina pectoris and the dosage of nitroglycerin in the treat-ment group was significantly reduced than before treatment and the control group at the same time( P < 0. 05);the total effective rate was 95. 00% in the treatment group,which was significantly higher than 77. 50% of the control group( P < 0. 05). Conclusion The Ginkgo Ketone Ester Drop Pills has good effect for treating unstable angina pectoris,it has less adverse reactions and worthy of clinical promotion.
  • 摘要：目的：提高药剂学专业研究生的课题研究能力。方法结合近年来高等药学教育教学工作经历和体会，对医院药学部药剂学专业研究生的课题研究能力的培养及提高进行浅析及探讨。结果药剂学专业研究生课题研究能力的提高需高校、导师及学生自身三方面的协同努力，更需要与企业的高效联合。结论提高高校药剂学专业研究生的课题研究能力对高等药学教育教学的进一步深化改革具有重要意义。
  • 摘要：Objective To study the preparation technology of Fufangjinpu Dispersible Tablets. Methods The disintegration ratio rate was taken as index,the different ratio of cCMC-Na,PVP,LS-HPC,cross-linked carboxymethyl cellulose sodium was examined,and the orthogonal design was used to optimize the formulation of Fufangjinpu Dispersible Tablets. Results The dispersible tablets could be disaggregated in 120 seconds,and the dispersible uniformity test proved that it could pass through No. 2 sieve. The dissolution rate of the Fufangjinpu Dispersible Tablets was much better than that of the normal tablets. Conclusion The optimized technology of Fu-fangjinpu Dispersible Tablets is reasonable and feasible.%目的：研究复方金蒲分散片的处方工艺。方法以崩解时限和溶出度为考察指标，采用正交设计试验，对交联羧甲基纤维素钠、聚乙烯吡咯烷酮、低取代羟丙纤维素不同配比进行优选处方，制备复方金蒲分散片。结果分散片在120 s内完全崩解，分散均匀度测定能通过2号筛网，体外溶出度优于普通片。结论优选的复方金蒲分散片处方工艺合理、可行。
  • 摘要：目的：比较中晚期非小细胞肺癌肺叶切除术后2种化疗方案的疗效。方法选取2011年1月到2013年6月在医院行肺叶切除术的非小细胞肺癌患者365例，随机分为GP联合组182例与TP联合组183例。GP联合组采用艾迪＋顺铂＋吉西他滨，TP联合组采用艾迪＋顺铂＋多西他赛。两组均以21 d为1个疗程，3个疗程结束后评估不良反应，随访2年间的生存率、复发及转移率、生活质量情况。结果 GP联合组血小板减少率和脱发率显著高于TP联合组（ P<0.05），TP联合组的周围神经炎率显著高于GP组（ P<0.05），其他不良反应如白细胞减少、肝肾功能异常等均无显著差异（ P>0.05）。两组卡氏生活质量（KPS）评分最高分出现在化疗后半年，然后逐渐降低，直至1.5年时仍显著高于化疗前（ P<0.05），在2年时接近化疗前的水平（ P>0.05），整个过程中同时段组间无显著性差异（ P>0.05）。两组的生存率与死亡率在同时段无显著性差异（ P>0.05），0.5年生存率两组均为100.00%，2年生存率均在70.00%左右。结论两组联合方式远期疗效无显著差异，但不良反应不同，具体应用中可根据个体差异选择。
  • 摘要：目的：建立测定山茱萸中马钱苷含量的高效液相色谱（HPLC）法，修订并提高六味地黄胶囊的质量标准，增加熟地黄的薄层色谱鉴别方法。方法色谱柱为 Agilent Zorbax SB－C18柱（250 mm ×4.6 mm，5μm），流动相为乙腈－0.05%磷酸溶液（9：91），流速为1.0 mL/min，检测波长为236 nm。结果薄层色谱斑点清晰，阴性无干扰，马钱苷进样量在0.099~1.324μg范围内与峰面积线性关系良好（ r=0.9999），平均回收率为99.13%，RSD为1.43%（ n=6）。结论该法操作简便、专属性强，能更好地控制六味地黄胶囊的质量。%Objective To establish an HPLC method for the content determination of loganin in Fructus Corni ,and to modify and improve the quality standard for Liuweidihuang Capsules,to add the TLC method of Radix Renntanniae. Methods Agilent Zorbax SB-C18 column(250 mm × 4. 6 mm,5 μm) was used with the mobile phase consisted of acetonitrile-0. 05% phosphoric acid (9 :91),at the flow rate of 1. 0 mL/min,the detection wavelength was 236 nm. Results The TLC spots were clear and there were no interferences on the negative controls. The liner range of loganin was 0. 099-1. 324 μg( r=0. 999 9). The average recovery was 99. 13%,RSD was 1. 43%( n=6). Conclusion This method is simple,specialty and suitable to control the quality of Liuweidihuang Capsules.
  • 摘要：Objective To establish an HPLC method for the determination of salidroside in Rhodiola Capsules. Methods The Waters Symmetry -C18 column(150 mm × 4. 6 mm,5 μm) was used with methanol-water(10 :90)as the mobile phase at the flow rate of 1. 0 mL/min,the detection wavelength was 215 nm,the column temperature was 30 ℃. Result The injection volume of salidroside showed good linear relationship with the peak area in the range of 0. 266 92-6. 673 μg ( r=0. 999 9,n=5). The recovery rate was 103. 63%,RSD was 1. 19%( n=9). Conclusion The method is simple,sensitive and effective,it can be used for the content determi-nation and quality control of Rhodiola capsule.%目的：建立测定红景天胶囊中红景天苷含量的高效液相色谱（HPLC）法。方法色谱柱为Waters Symmetry－C18柱（150 mm ×4.6 mm，5μm），流动相为甲醇－水(10：90)，流速为1.0 mL/min，检测波长为215 nm，柱温为30℃。结果红景天苷进样量在0.26692~6.673μg范围内与峰面积呈良好线性关系( r=0.9999，n=5），平均加样回收率为103.63%，RSD为1.19%（ n=9）。结论该方法简便、灵敏、有效，可用于红景天胶囊中红景天苷的含量测定及质量控制。
  • 摘要：目的：总结医院药品零库存管理经验，为基层医院改变传统的药品库房管理模式提供新思路。方法分析医院药库零库存实施情况，探讨现阶段基层医院推行药品零库存管理的必要性、可行性及存在的问题。结果目前所有基层医院实现药品零库存有一定难度，既需医院内部药品管理和控制机制的改革，还需医院外部药品配送机制加以配套，但随着国家基本药物制度的不断完善和《药品经营质量管理规范》( GSP )供应链的日趋成熟，药品零库存管理是基层医院药库管理的发展趋势。结论基层医院实施零库存管理可行且有益。%Objective To summarize the experience of Drug Zero Inventory Management in the hospital,to provide new ideas in changing the traditional pharmaceutical management model in basic hospitals. Methods Based on the implementation of Drugs Zero Inventory Management in the hospital,to discuss the need,feasibility and the existing problems in promoting it at this stage. Results Currently,all basic hospital had some difficulties to achieve Drug Zero Inventory Management. It needed not only the reform of hospital management in the internal drug control mechanisms,but also the support of drug distribution mechanism outside the hospital. However,with the con-tinuous improvement of the National Essential Drug System and the maturing of the GSP supply chain,Drug Zero Inventory Management was the development trend of the inventory management in basic hospitals. Conclusion Drug Zero Inventory Management is feasible and useful in basic hospitals.
  • 摘要：Objective To provide references for identifying drug fever with infectious disease and rational use of drugs. Methods The process data of clinical pharmacists involving in analysis of medical consultation and treatment for drug fever were analyzed. Results Drug fever disappeared after the drug fever was identified with infectious disease and withdrawing related drugs. Conclusion Clinical pharmacist participating in medical consultation can promote clinical rational drug use and ensure safety usage.%目的：为临床鉴别药物热和感染性疾病及促进临床合理用药提供参考。方法对临床药师参与药物热会诊的资料进行分析。结果临床药师将药物热和感染性疾病进行鉴别后，停用相关药物，药物热消失。结论临床药师参与临床会诊可促进临床合理用药，保证患者用药安全。
  • 摘要：目的：为疾病预防控制中心开展药学服务提供参考。方法总结疾病预防控制中心开展药学服务的具体形式和内容。结果与结论通过明确疾病预防控制中心药学人员职责，加强教育培训，完善管理，使其开展药学服务，可促进疾病预防控制中心医疗、预防与药学的健康发展。
  • 摘要：目的：分析肿瘤患者发生药品不良反应（ADR）的规律及特点，为临床安全、合理用药提供参考。方法对医院报告的173例肿瘤患者发生ADR的病历进行汇总、归纳、统计和分析。结果 ADR患者女性远多于男性；50~59岁患者占比最大；给药途径主要为静脉给药；涉及抗肿瘤药、中药注射剂和抗生素等，多西他赛、顺铂等抗肿瘤药位居首位；临床表现以胃肠系统和血液系统损害最常见。结论医院应重视化学治疗药物的合理、规范使用，以降低肿瘤患者的用药风险，减少ADR发生。
  • 摘要：Objective To compare the consistency of package inserts of same composition but from different manufacturers. Methods A total of 26 groups of injections′ package inserts with same composition but from different manufacturers were collected and investigated from the hospital. Results 18 groups of package inserts were basicly similar,4 groups differed from usage and dosage,3 groups were different under adverse reactions and precautions,and the rest 4 groups were different in storage items. Conclusion There are differ-ences between the same composition injections′ package inserts of different manufacturers. It is easy for medical institutions and medical staffs to ignore the situation,which thus remain to be improved further.%目的：比较相同成分不同厂家注射剂药品说明书内容的一致性。方法收集并调查分析医院药房相同成分不同厂家的注射剂药品说明书26组。结果18组说明书内容基本相似，4组用法用量项有差异，3组不良反应与注意事项项下有差异，4组贮存项有差异。结论相同成分不同厂家的注射剂药品说明书间有差异，医疗机构及广大医务人员易忽视，应引起重视并加以管理和规范。
  • 摘要：目的：评价丹七片治疗冠状动脉粥样硬化性心脏病（简称冠心病）的临床疗效及对凝血纤溶系统的影响。方法选择2014年3月至12月医院收治的冠心病患者56例，随机分为治疗组和对照组，各28例。两组患者均给予抗血小板凝聚、血管紧张素转换酶抑制剂/血管紧张素转换酶受体抑制剂（ACEI/ ARB）等常规性心脏病治疗药物，治疗组患者加用丹七片，口服。治疗28 d后，评价两组的临床疗效及治疗前后血浆血管内皮素－1（ET－1）值，血清一氧化氮（NO）值，人组织纤溶酶原激活物（t－PA）、人纤溶酶原激活剂抑制物－1（PAI－1），观察并记录两组患者服药后的不良反应。结果治疗后，治疗组总有效率为89.29%，高于对照组的71.43%（ P<0.05）；治疗组和对照组的t－PA水平均上升，治疗组PAI－1表达水平下调，较治疗前均有统计学差异（ P<0.05），且治疗组t－PA的上调水平与PAI－1的下调水平均高于对照组，差异有统计学意义（ P<0.05）；与治疗前比较，两组NO水平上升、ET－1水平下降均显著改善（ P<0.05），治疗组NO上升水平、ET－1下降水平均高于对照组，差异有统计学意义（ P<0.05）；治疗组患者瘀斑、皮疹、恶心和呕吐的发生率与对照组相比差异无统计学意义（ P>0.05）。结论在常规治疗基础上加用丹七片能治疗冠心病显著提高临床疗效，促进纤溶系统的平衡，且能提高血管内皮的功能，临床效果好，安全性较好，值得临床推广。

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