LIPOPEPTIDE CONJUGATES AND THEIR SALTS, METHOD OF MANUFACTURE OF LIPOPEPTIDE CONJUGATES AND THEIR SALTS, PHARMACEUTICAL COMPOSITION COMPRISING A LIPOPEPTIDE CONJUGATE AND ITS SALTS FOR THE TREATMENT OF CHRONIC WOUNDS

摘要

Object of the invention ;The object of the invention is a method of obtaining lipopeptide conjugates especially rich in L-hydroxyproline residues described by the general formula Nα-acyl-(AK5-AK4-AK3-AK2-AK1)n-NH2 (I) or their pharmaceutically acceptable salts, wherein: AK1,AK2,AK3,AK4,AK5 denote amino acid residues or their lack; AK1 is a lysine residue of L or D configuration; AK2 is an amino acid residue selected from the group consisting of non-polar neutral amino acids: Phe, Ala, Gly, Ile, Leu, Met, Pro, Val, Trp or its lack; AK3 is an amino acid residue selected from Hyp, Phe, Ala, Gly, Ile, Leu, Met, Pro, Val, Trp; AK4 is an amino acid residue selected from Pro, Hyp or its lack; AK5 is the Gly residue; Nα-acyl group has the formula R1-C(=O), wherein R1 is a saturated carbon chain of length from C7 to C13; n denotes a number of repeat units from 1 to 2 of a general formula: AK5-AK4-AK3-AK2-AK1.;In addition, the invention concerns the use of a pharmaceutical composition containing at least one lipopeptide conjugate or its pharmaceutically acceptable salt or a preparation for the stimulation of proliferation and migration of fibroblasts and keratinocytes, containing the pharmaceutical composition as a basic component for the manufacture of a wound dressing in the form of an aqueous solution, a suspension, an emulsion, an aerosol, a cream, an ointment, a three-dimensional scaffold, a hydrogel in a tube, for the use in the treatment of deep full-thickness wounds, i.e. burn wounds (second and third degree), venous leg ulcers, bedsores or metabolic disorders i.e diabetic foot, being a complication of existing cardiovascular disease or diabetes mellitus.