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Comparison of high-dose intravenous methylprednisolone with low-dose oral prednisolone in acute renal allograft rejection in children.

机译:小剂量静脉用强的松龙与小剂量口服泼尼松龙在儿童急性肾移植排斥反应中的比较。

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摘要

Two corticosteroid regimens were compared in a randomised, prospective study of 48 consecutive acute rejection episodes occurring at least one month after transplantation in 22 children who had received renal allografts. The higher dose schedule (intravenous methylprednisolone 600 mg/m2 daily for three days) was no more effective than the lower (oral prednisolone 3 mg/kg daily for three days) in reversing rejection, being successful in 70% as opposed to 72% of episodes. Few major side effects were seen with either treatment, but unpleasant sensations were reported much more frequently in the group given intravenous methylprednisolone; this regimen was much more disruptive of the patient's life. Oral prednisolone in the dosage described is as effective as about 10 times that dose of intravenous methylprednisolone; it is much cheaper and is viewed as less unpleasant by patients.
机译:在一项随机,前瞻性研究中比较了两种皮质类固醇方案,该研究对接受肾脏同种异体移植的22名儿童在移植后至少一个月连续发生48次连续急性排斥反应。较高的剂量方案(静脉每天泼尼松龙600 mg / m2,连续三天)在逆转排斥反应中没有比较低的剂量方案(口服泼尼松龙,每天3 mg / kg,连续三天)更有效,成功率为70%,而不是72%情节。两种疗法均未见主要副作用,但静脉给予甲基强的松龙组的不适感更常见。该方案对患者的生活更具破坏性。所述剂量的泼尼松龙口服液的有效性是静脉注射甲基泼尼松龙剂量的10倍左右。它便宜得多,并且被患者认为不那么令人不快。

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