Severe vitamin D deficiency is associated with non-tuberculous mycobacterial lung disease: A case-control study.

摘要

Previous studies have found evidence of an association between tuberculosis and vitamin D deficiency (VDD). However, the association between VDD and infection caused by non-tuberculous mycobacteria (NTM) has never been studied. This study evaluated the prevalence and severity of VDD in NTM lung disease and attempted to identify predictive factors.Age- and sex-matched case-control study was conducted to assess the prevalence and severity of VDD in patients with NTM lung disease.After adjusting for potential confounding factors, the adjusted mean serum level of 25-hydroxyvitamin D (25(OH)D) levels was lower in 104 patients with NTM lung disease (10.7?ng/mL, 95% confidence interval (CI) 4.5-16.8?ng/mL) than that of 312 controls (13.7?ng/mL, 95% CI 7.4-19.5?ng/mL) (P?=?0.012). Although the prevalence of VDD defined as serum 25(OH)D level <20?ng/mL was not different, severe VDD defined as serum 25(OH)D level <10?ng/mL was more prevalent in patients (P?