首页> 外国专利> IMMUNO-MODULATOR EXHIBITING ANTI-MICROBIAL AND ANTI-MYCOBACTERIAL ACTIVITIES, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL PREPARATION FOR TREATING MYCOBACTERIOSES AS WELL AS LUNG CHRONIC AND NON SPECIFIC CONDITIONS, SEXUALLY TRANSMITTED DISEASES AND THE RESULTING IMMUNO-DEFICIENCY

IMMUNO-MODULATOR EXHIBITING ANTI-MICROBIAL AND ANTI-MYCOBACTERIAL ACTIVITIES, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL PREPARATION FOR TREATING MYCOBACTERIOSES AS WELL AS LUNG CHRONIC AND NON SPECIFIC CONDITIONS, SEXUALLY TRANSMITTED DISEASES AND THE RESULTING IMMUNO-DEFICIENCY

机译:免疫调节剂,具有抗微生物和抗真菌活性,生产用于治疗真菌以及肺部慢性和非特定疾病的相同和药物制剂的方法,通常是疾病的传播和传播

摘要

The present invention pertains to the field of medicine and more precisely relates to a novel immuno-modulator of the following formula CHEM which exhibits anti-microbial and anti-mycobacterial activities. This modulator is produced by reacting equimolecular amount of 6-methyluracyl-5-sulphochloride and isoniazide in acetonitrile at a high temperature. The preparation is practically not toxic (LD50 in severe conditions exceeding 7000 mg/kg) and can be used according to a given clinical tests for expressing the immuno-modulating and anti-mycobacterial activity. This preparation can be used for correcting various immuno-deficiecies including in HIV-infected patients as well as for treating mycobacterioses such as leprosy, tuberculosis, etc. This preparation can be administrated internally or parenterally. The compound described in the present invention represents the active substance of this pharmaceutical preparation, wherein said preparation can be used against secondary various immuno-deficiecies or mycobacterioses.
机译:本发明涉及医学领域,更确切地涉及具有抗微生物和抗分枝杆菌活性的下式的新型免疫调节剂。该调节剂通过使等分子量的6-甲基尿嘧啶-5-磺酰氯和异烟肼在乙腈中在高温下反应而制得。该制剂实际上无毒(在超过7000 mg / kg的严酷条件下,LD50),可以根据给定的临床试验用于表达免疫调节和抗分枝杆菌活性。该制剂可用于纠正各种免疫缺陷,包括在HIV感染的患者中,以及用于治疗分枝杆菌,例如麻风,结核等。该制剂可以内部或肠胃外给药。本发明中描述的化合物代表该药物制剂的活性物质,其中所述制剂可用于抵抗继发的各种免疫缺陷或分枝杆菌。

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