首页> 外文期刊>European Journal of Radiology >Diffusion-weighted MRI versus transient elastography in quantification of liver fibrosis in patients with chronic cholestatic liver diseases
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Diffusion-weighted MRI versus transient elastography in quantification of liver fibrosis in patients with chronic cholestatic liver diseases

机译:弥散加权MRI与瞬时弹性成像定量分析慢性胆汁淤积性肝病患者肝纤维化

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Purpose: To evaluate the diagnostic value of diffusion-weighted magnetic resonance imaging (DWMRI) and transient elastography (TE) in quantification of liver fibrosis in patients with chronic cholestatic liver diseases. Materials and methods: Forty-five patients underwent DWMRI, TE, and liver biopsy for staging of liver fibrosis. Apparent diffusion coefficient (ADC) was calculated for six locations in the liver for combination of five diffusion sensitivity values b = 0, 50, 200, 400 and 800 s/mm 2. A receiver operating characteristic (ROC) analysis was performed to determine the diagnostic performance of DWMRI and TE. Segmental ADC variations were evaluated by means of coefficient of variation. Results: The mean ADCs (×10 -3 mm 2/s; b = 0-800 s/mm 2) were significantly different at stage F1 versus F ≥ 2 (p 0.05) and F2 versus F4. However, no significant difference was found between F2 and F3. For prediction of F ≥ 2 and F ≥ 3 areas under the ROC curves were 0.868 and 0.906 for DWMRI, and 0.966 and 0.960 for TE, respectively. The sensitivity and specificity were 90.9% and 89.3% for F ≥ 2 (ADC ≤ 1.65), and 92.3% and 92.1% for F ≥ 3 (ADC ≤ 1.63). Segmental ADC variation was lowest for F4 (CV = 9.54 ± 6.3%). Conclusion: DWMRI and TE could be used for assessment of liver fibrosis with TE having higher diagnostic accuracy and DWMRI providing insight into liver fibrosis distribution.
机译:目的:评价弥散加权磁共振成像(DWMRI)和瞬时弹性成像(TE)对慢性胆汁淤积性肝病患者肝纤维化定量的诊断价值。材料和方法:45例患者接受了DWMRI,TE和肝活检以进行肝纤维化分期。针对五个扩散敏感性值b = 0、50、200、400和800 s / mm 2的组合,计算了肝脏中六个位置的表观扩散系数(ADC)。执行了接收器工作特性(ROC)分析以确定DWMRI和TE的诊断性能。通过变化系数评估分段ADC的变化。结果:在阶段F1与F≥2(p <0.05)和阶段F2与F4之间,平均ADC(×10 -3 mm 2 / s; b = 0-800 s / mm 2)显着不同。但是,F2和F3之间没有发现显着差异。为了预测F≥2和F≥3,ROC曲线下的DWMRI区域分别为0.868和0.906,TE区域分别为0.966和0.960。 F≥2(ADC≤1.65)的敏感性和特异性分别为90.9%和89.3%,F≥3(ADC≤1.63)的敏感性和特异性为92.3%和92.1%。对于F4,分段ADC的变化最低(CV = 9.54±6.3%)。结论:DWMRI和TE可用于肝纤维化的评估,TE具有较高的诊断准确性,DWMRI可提供对肝纤维化分布的认识。

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