Mechanistic Population PK/PD Modeling of a Bispecific Antibody in Nonhuman Primates: Impact of Immunogenicity

Campagne Olivia; Delmas Audrey; Fouliard Sylvain; Chenel Marylore; Chichili Gurunadh R.; Li Hua; Alderson Ralph; Scherrmann Jean-Michel; Mager Donald E.

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Mechanistic Population PK/PD Modeling of a Bispecific Antibody in Nonhuman Primates: Impact of Immunogenicity

机译：非人类原始植物中双特异性抗体的机械群体PK / PD建模：免疫原性的影响

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来源
《Journal of pharmacokinetics and pharmacodynamics》 |2017年第suppla期|共1页
作者
Campagne Olivia; Delmas Audrey; Fouliard Sylvain; Chenel Marylore; Chichili Gurunadh R.; Li Hua; Alderson Ralph; Scherrmann Jean-Michel; Mager Donald E.;
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作者单位

Inst Rech Int Servier Clin Pharmacokinet &

Pharmacometr Suresnes France;

Inst Rech Int Servier Clin Pharmacokinet &

Pharmacometr Suresnes France;

Inst Rech Int Servier Clin Pharmacokinet &

Pharmacometr Suresnes France;

Inst Rech Int Servier Clin Pharmacokinet &

Pharmacometr Suresnes France;

MacroGenics Inc Rockville MD USA;

MacroGenics Inc Rockville MD USA;

MacroGenics Inc Rockville MD USA;

Univ Paris Descartes Paris Diderot INSERM UMR S 1144 Paris France;

SUNY Buffalo Dept Pharmaceut Sci Buffalo NY USA;

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正文语种 eng
中图分类药学;
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1. Mechanistic Population PK/PD Modeling of a Bispecific Antibody in Nonhuman Primates: Impact of Immunogenicity [J] . Campagne Olivia, Delmas Audrey, Fouliard Sylvain, Journal of pharmacokinetics and pharmacodynamics . 2017,第Suppla期

机译：非人类原始植物中双特异性抗体的机械群体PK / PD建模：免疫原性的影响
2. Mechanistic Projection of First-in-Human Dose for Bispecific Immunomodulatory P-Cadherin LP-DART: An Integrated PK/PD Modeling Approach [J] . Chen X., Haddish-Berhane N., Moore P., Clinical Pharmacology and Therapeutics . 2016,第3期

机译：双特异性免疫调节P-钙黏着蛋白LP-DART的人为剂量的机制投影：集成的PK / PD建模方法
3. Translational PK-PD modeling analysis of MCLA-128, a HER2/HER3 bispecific monoclonal antibody, to predict clinical efficacious exposure and dose [J] . Aurelia H. M. de Vries Schultink, Robert P. Doornbos, Alexer B. H. Bakker, Investigational new drugs. . 2018,第6期

机译：MCLA-128，HER2 / HER3双特异性单克隆抗体的翻译PK-PD建模分析，预测临床有效的暴露和剂量
4. CEA-TCB Clinical Dose Prediction: A Mechanistic PK/PD Modeling Approach [C] . Wenlian Qiao, Jatin Narula, Alison Betts Protein Engineering Summit. . 2018

机译：CEA-TCB临床剂量预测：机械PK / PD造型方法
5. Mechanistic PK/PD Modeling of Btk Inhibitors and the Development of PET Tracers for Bacterial Infection Diagnosis [D] . Zhang, Zhuo. 2017

机译：Btk抑制剂的机理性PK / PD建模和用于细菌感染诊断的PET示踪剂的开发
6. Translational PK-PD modeling analysis of MCLA-128 a HER2/HER3 bispecific monoclonal antibody to predict clinical efficacious exposure and dose [O] . Aurelia H. M. de Vries Schultink, Robert P. Doornbos, Alexander B. H. Bakker, -1

机译：HER2 / HER3双特异性单克隆抗体MCLA-128的转化PK-PD建模分析可预测临床有效暴露量和剂量
7. Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART Molecule in Nonhuman Primates: Evaluation of Activity and Impact of Immunogenicity [O] . Olivia Campagne, Audrey Delmas, Sylvain Fouliard, 2018

机译：非特异性CD3XCD123 Dart分子的综合药代动力学/药效学模型在非人的灵长类动物中：免疫原性的影响和影响的评价
8. Hantaan/Andes virus DNA Vaccine Elicits a Broadly Cross-Reactive Neutralizing Antibody Response in Nonhuman Primates [R] . Hooper, J. W. , Custer, D. M. , Smith, J. , 2006

机译：汉坦/安第斯山脉病毒DNa疫苗在非人类灵长类动物中引发广泛的交叉反应中和抗体反应

Mechanistic Population PK/PD Modeling of a Bispecific Antibody in Nonhuman Primates: Impact of Immunogenicity

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