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Mechanistic PK/PD Modeling of Btk Inhibitors and the Development of PET Tracers for Bacterial Infection Diagnosis

机译：Btk抑制剂的机理性PK / PD建模和用于细菌感染诊断的PET示踪剂的开发

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作者
Zhang, Zhuo.;
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作者单位

State University of New York at Stony Brook.;

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授予单位 State University of New York at Stony Brook.;
学科 Biochemistry.;Pharmacology.
学位 Ph.D.
年度 2017
页码 257 p.
总页数 257
原文格式 PDF
正文语种 eng
中图分类
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专利

1. A Mechanistic PK-Target Occupancy Modeling Approach to Predicting Efficacious Human Dose for an Irreversible BTK Inhibitor [J] . Chung Seung-Wook, Smith Dustin, Bosanac Todd, Journal of pharmacokinetics and pharmacodynamics . 2017,第Suppla期

机译：用于预测不可逆BTK抑制剂有效人剂量的机械PK-靶标占用方法
2. A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy [J] . Fereidoon Daryaee, Zhuo Zhang, Kayla R. Gogarty, Chemical science . 2017,第5期

机译：定量机制PK / PD模型直接将Btk靶标参与度与体内功效联系起来

3. APPROACHES TO DETERMINE PK/PD TARGET OF beta-LACTAMASE INHIBITORS DURING THE DEVELOPMENT OF beta-LACTAM/beta-LACTAMASE INHIBITOR ANTI-BACTERIAL COMBINATION PRODUCTS. [J] . Wei X., Joshi A., Wu K., Clinical Pharmacology and Therapeutics . 2018,第Suppla1期

机译：在β-内酰胺/β-内酰胺酶抑制剂抗细菌组合产物的发育过程中确定β-内酰胺酶抑制剂的PK / Pd靶标的方法。

4. CEA-TCB Clinical Dose Prediction: A Mechanistic PK/PD Modeling Approach [C] . Wenlian Qiao, Jatin Narula, Alison Betts Protein Engineering Summit. . 2018

机译：CEA-TCB临床剂量预测：机械PK / PD造型方法

5. Development of Radiotracers for PET Imaging of Bacterial Infections for PK/PD Analysis of Antibiotics [D] . Gogarty, Kayla Rose. 2017

机译：用于细菌感染PET成像的放射性示踪剂的开发，用于抗生素PK / PD分析

6. A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy [O] . Fereidoon Daryaee, Zhuo Zhang, Kayla R. Gogarty, 2017

机译：定量机制PK / PD模型直接将Btk靶标参与度与体内功效联系起来

7. An update on radiotracer development for molecular imaging of bacterial infections [O] . Mick M. Welling, Albertus W. Hensbergen, Anton Bunschoten, 2019

机译：放射性游粉蛋白发育的更新，用于细菌感染的分子成像

1. 膈下脂肪组织的良性FDG摄取:一个被PET- CT特异描述的生理性示踪剂的新部位 [J] . 张秀梅 . 国际放射医学核医学杂志 . 2005,第003期

2. IDO抑制剂PCC0208009在结肠癌CT26荷瘤小鼠的PK/PD研究 [J] . 姜雪 ,李晓鹏 ,郑爽 . 烟台大学学报（自然科学与工程版） . 2020,第004期

3. 新型FXa抑制剂知非沙班不同溶剂口服给药对犬PK-PD的影响 [J] . 邱小妙 ,张珊 ,石冰卓 . 中国药物评价 . 2018,第003期

4. 全血C反应蛋白联合血常规检验用于儿童细菌性感染诊断的效果分析 [J] . 孟彩霞 . 中国农村卫生 . 2020,第018期

5. 以PK/PD参数探讨围手术期预防性应用抗菌药物的合理性 [J] . 王羽 ,裴云萍 . 药学与临床研究 . 2016,第002期

6. β-内酰胺类/β-内酰胺酶抑制剂复方抗菌药物PK/PD研究 [C] . 朱燕 ,肖永红 . 第8届全国抗菌药物临床药理学术会议 . 2010

7. 68Ga--PSMA--11 PET/CT显像在头颈部的生理性示踪剂分布特征及在唾液腺中的潜在应用 [A] . 赵艳红 . 2020

1. 用于治疗癌症的抗PD-L1抗体和DNA-PK抑制剂的组合 [P] . 中国专利： CN110494161A . 2019-11-22

2. PD-1/PD-L1、TGFβ和DNA-PK联合抑制用于治疗癌症 [P] . 中国专利： CN112512576A . 2021-03-16

3. binding agent; diagnostic composition; diagnostic kit; methods of diagnosing a bacterial infection or differentiating between a bacterial infection and a viral infection; to rule out a bacterial infection in an individual; to rule out a viral infection in an individual; to consider a bacterial infection in an individual; to consider a viral infection in an individual; to distinguish between a bacterial or mixed infection and a viral infection in an individual; to provide a treatment recommendation to an individual; to provide a diagnostic test recommendation to an individual; to rule out an infectious disease; to identify the type of infection; and device for the diagnosis of bacterial infections [P] . 外国专利： BR112017010268A2 . 2018-02-06

机译：粘合剂诊断成分;诊断套件;诊断细菌感染或区分细菌感染和病毒感染的方法;排除个人感染细菌;排除个人的病毒感染;考虑个体中的细菌感染;考虑个人的病毒感染;区分个体的细菌感染或混合感染与病毒感染;向个人提供治疗建议;向个人提供诊断测试建议;排除传染病;确定感染类型;和细菌感染的诊断设备

4. PEPTIDE, PEGUILLED PEPTIDE, COMPOSITION, PHARMACEUTICAL COMPOSITION, BOTTLE, DISINFECTION SOLUTION, METHOD FOR GROWTH INHIBITION, REPLICATION OR INFECTIVITY OF A MICRO-ORGANISM, METHOD FOR INHIBITION OF A BACTERIAL GROWTH, BACTERIAL GROWTH INHIBITION, TREATMENT OF A MICRO-ORGANISM INFECTION IN A SUBJECT AND PREVENTION OF A DISEASE IN A SUBJECT CAUSED BY OR ASSOCIATED WITH A MICRO-ORGANISM INFECTION, METHOD FOR INHIBITING BACTERIAL GROWTH IN A SUBJECT, A METHOD OF TREATMENT OF A BACTERIAL TREATMENT SUBJECT AND TREATMENT OF A DISEASE CAUSED BY OR ASSOCIATED WITH A BACTERIAL INFECTION, METHOD FOR PREVENTING A DISEASE CAUSED BY OR ASSOCIATED WITH A BACTERIAL INFECTION IN A SUBJECT, METHOD FOR INHIBITION OF VIRAL REPLICATION IN A SUBJECT TO A SUBJECT TO A SUBJECT ON A SUBJECT AND TREATMENT OF A DISEASE CAUSED BY OR ASSOCIATED WITH A VIRAL INFECTION IN A SUBJECT, METHOD FOR THE PREVENTION OF A DISEASE CAUSED BY OR ASSOCIATED WITH A VIRAL INFECTION IN A SUBJECT, METHOD FOR DISINFECTING AN INA [P] . 外国专利： BR112017028190A2 . 2018-09-04

机译：肽，规定的肽，成分，药物成分，瓶，消毒溶液，微生物的生长抑制，复制或感染的方法，细菌生长的抑制方法，细菌生长的抑制作用，治疗由微生物感染引起或与之有关的疾病的预防，疾病的抑制方法，一种细菌治疗方法的治疗和一种或多种细菌引起的疾病的治疗感染，预防由细菌感染引起的疾病或与之相关的疾病的方法，在受试者体内抑制病毒复制的方法以及对由细菌引起或与之相关的疾病的治疗在主题中，一种预防由对象中的病毒感染引起或与之相关的疾病的方法，一种用于对INA进行消毒的方法

5. methods for reducing the availability of prokaryotic cells, for increasing prokaryotic antibiotic susceptibility, for treating bacterial infection in a patient, and for exterminating bacteria, inhibiting bacterial development or reducing bacterial virulence, polynucleotide bait, cell, uses of a polynucleotide bait, and of transition factor bait, pharmaceutical composition, cleaning composition, kit, and transition factor bait. [P] . 外国专利： BRPI0919581A2 . 2015-12-08

机译：降低原核细胞可用性，增加原核抗生素敏感性，治疗患者细菌感染以及消灭细菌，抑制细菌发育或降低细菌毒力的方法，多核苷酸诱饵，细胞，多核苷酸诱饵的用途以及过渡因子诱饵，药物组合物，清洁剂，试剂盒和过渡因子诱饵。

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Mechanistic PK/PD Modeling of Btk Inhibitors and the Development of PET Tracers for Bacterial Infection Diagnosis

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