Genetic variation in the TAS2R38 bitter taste receptor and overweight among adults in Southwest Finland

摘要

Purpose - Polymorphisms in taste receptor genes may be associated with taste sensitivity and possibly with food consumption and body weight. Previous studies relating bitter taste sensitivity to body mass index (BM) had inconsistent findings. This paper aims to investigate the weight and body composition indicators among the TAS2R38 bitter taste receptor genotype groups.Design/methodology/approach - Adults participating in the STEPS study (steps to the healthy development and well-being of children) cohort in Southwest Finland have been investigated. DNA has been extracted from buccal cell samples, and alleles of the gene TAS2R38 have been determined. Measurements at the follow-up visit include weight and height to calculate BM, waist circumference (WC) and body composition with bioimpedance (women n = 757, men n = 714).Findings - The mean BM was 25.3 (SD 5.4) kg/m~2 among women and 26.7 (SD 3.9) kg/m2 among men. BMI, WC and body fat percentage did not differ significantly between the TAS2R38 genotype groups in either gender. The proportion of subjects classified as overweight (BM > 25) did not vary significantly between the genotype groups.Originality/value - The TAS2R38 genotype is not associated with being overweight in this cohort. Determinante of body weight are complex, and the role of other taste genotypes and phenotypes should be investigated in the future.