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首页> 外文期刊>Clinical cancer research: an official journal of the American Association for Cancer Research >PI3K/AKT/mTOR Pathway Alterations Promote Malignant Progression and Xenograft Formation in Oligodendroglial Tumors
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PI3K/AKT/mTOR Pathway Alterations Promote Malignant Progression and Xenograft Formation in Oligodendroglial Tumors

机译：PI3K / AKT / MTOR途径改变促进寡突肿瘤中的恶性进展和异种移植物形成

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摘要

Purpose: Oligodendroglioma has a relatively favorable prognosis, however, often undergoes malignant progression. We hypothesized that preclinical models of oligodendroglioma could facilitate identification of therapeutic targets in progressive oligodendroglioma. We established multiple oligodendroglioma xenografts to determine if the PI3K/AKT/mTOR signaling pathway drives tumor progression.
机译：目的：Oligodendroglioma具有相对有利的预后，然而，通常经历恶性进展。 我们假设寡突胶瘤的临床前模型可以有助于鉴定进步少突术中的治疗靶标。 我们建立了多个少曲面术血瘤异种移植物，以确定PI3K / AKT / MTOR信号传导途径是否驱动肿瘤进展。

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    Tateishi Kensuke; Nakamura Taishi; Juratli Tareq A.; Williams Erik A.; Matsushita Yuko; Miyake Shigeta; Nishi Mayuko; Miller Julie J.; Tummala Shilpa S.; Fink Alexandria L.; Lelic Nina; Koerner Mara V. A.; Miyake Yohei; Sasame Jo; Fujimoto Kenji; Tanaka Takahiro; Minamimoto Ryogo; Matsunaga Shigeo; Mukaihara Shigeo; Shuto Takashi; Taguchi Hiroki; Udaka Naoko; Murata Hidetoshi; Ryo Akihide; Yamanaka Shoji; Curry William T.; Dias-Santagata Dora; Yamamoto Tetsuya; Ichimura Koichi; Batchelor Tracy T.; Chi Andrew S.; Iafrate A. John; Wakimoto Hiroaki; Cahill Daniel P.;

  • 作者单位

    Yokohama City Univ Grad Sch Med Dept Neurosurg Yokohama Kanagawa Japan;

    Yokohama City Univ Grad Sch Med Dept Neurosurg Yokohama Kanagawa Japan;

    Harvard Med Sch Massachusetts Gen Hosp Translat Neurooncol Lab Boston MA 02115 USA;

    Harvard Med Sch Massachusetts Gen Hosp Translat Neurooncol Lab Boston MA 02115 USA;

    Natl Canc Ctr Div Brain Tumor Translat Res Tokyo Japan;

    Yokohama City Univ Grad Sch Med Dept Neurosurg Yokohama Kanagawa Japan;

    Yokohama City Univ Med Dept Microbiol Yokohama Kanagawa Japan;

    Harvard Med Sch Massachusetts Gen Hosp Translat Neurooncol Lab Boston MA 02115 USA;

    Harvard Med Sch Massachusetts Gen Hosp Translat Neurooncol Lab Boston MA 02115 USA;

    Harvard Med Sch Massachusetts Gen Hosp Translat Neurooncol Lab Boston MA 02115 USA;

    Harvard Med Sch Massachusetts Gen Hosp Translat Neurooncol Lab Boston MA 02115 USA;

    Harvard Med Sch Massachusetts Gen Hosp Translat Neurooncol Lab Boston MA 02115 USA;

    Yokohama City Univ Grad Sch Med Dept Neurosurg Yokohama Kanagawa Japan;

    Yokohama City Univ Grad Sch Med Dept Neurosurg Yokohama Kanagawa Japan;

    Natl Canc Ctr Div Brain Tumor Translat Res Tokyo Japan;

    Yokohama City Univ Grad Sch Med Dept Neurosurg Yokohama Kanagawa Japan;

    Natl Ctr Global Hlth &

    Med Div Nucl Med Dept Radiol Tokyo Japan;

    Yokohama Rosai Hosp Dept Neurosurg Yokohama Kanagawa Japan;

    Fujisawa Municipal Hosp Dept Neurosurg Fujisawa Kanagawa Japan;

    Yokohama City Univ Grad Sch Med Dept Neurosurg Yokohama Kanagawa Japan;

    Taguchi Neurosurg Clin Dept Neurosurg Yokohama Kanagawa Japan;

    Yokohama City Univ Med Dept Pathol Yokohama Kanagawa Japan;

    Yokohama City Univ Grad Sch Med Dept Neurosurg Yokohama Kanagawa Japan;

    Yokohama City Univ Med Dept Microbiol Yokohama Kanagawa Japan;

    Yokohama City Univ Med Dept Pathol Yokohama Kanagawa Japan;

    Harvard Med Sch Massachusetts Gen Hosp Dept Neurosurg Boston MA 02115 USA;

    Massachusetts Gen Hosp Dept Pathol Boston MA 02114 USA;

    Yokohama City Univ Grad Sch Med Dept Neurosurg Yokohama Kanagawa Japan;

    Natl Canc Ctr Div Brain Tumor Translat Res Tokyo Japan;

    Harvard Med Sch Massachusetts Gen Hosp Translat Neurooncol Lab Boston MA 02115 USA;

    NYU NYU Langone Med Ctr Laura &

    Isaac Perlmutter Canc Ctr New York NY USA;

    Harvard Med Sch Massachusetts Gen Hosp Translat Neurooncol Lab Boston MA 02115 USA;

    Harvard Med Sch Massachusetts Gen Hosp Translat Neurooncol Lab Boston MA 02115 USA;

    Harvard Med Sch Massachusetts Gen Hosp Translat Neurooncol Lab Boston MA 02115 USA;

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  • 正文语种 eng
  • 中图分类 肿瘤学;
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