Thiophosphoramide-Based Cooperative Catalysts for Bronsted Acid Promoted Ionic Diels-Alder Reactions

摘要

Over the past several decades, chemists have gathered significant evidence that enzymes could drastically accelerate nucleophilic addition reactions by establishing mutually reinforcing or cooperative hydrogen bonds within a receptor. These observations have inspired the development of various catalytic transformations in which substrate activation is achieved by the formation of multiple hydrogen bonds with a synthetic hydrogen-bond donor (HBD).