Direct catalytic asymmetric aldol reactions promoted by novel heterobimetallic catalysts possessing strong Bronsted base: a new strategy for the development of Lewis acid-Bronsted base nifunctional catalysts

摘要

Novel heterobimetallic catalysts possessing lithium alkoxide as Bronsted base have been developed. The catalysts were found to be effective in the direct asymmetric aldol reaction of less acidic dialkyl ketones as well as aromatic ketones, affording the aldol products in moderate yield and ee.