首页> 外文期刊>Journal of Surgical Oncology >Prognostic factors after early recurrence in patients who underwent curative resection for hepatocellular carcinoma.
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Prognostic factors after early recurrence in patients who underwent curative resection for hepatocellular carcinoma.

机译:肝细胞癌根治性切除的患者早期复发后的预后因素。

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摘要

BACKGROUND: The prognosis of the patients with early recurrence after curative hepatectomy for hepatocellular carcinoma (HCC) is usually dismal. METHODS: One hundred twenty-four patients underwent curative resection for HCC at Kyungpook National University Hospital from January 2002 to December 2006. An early recurrence was defined as a recurrence within 2 years after a curative resection. The risk factors associated with an early recurrence were analyzed as well as other risk factors correlated with survival after early recurrence. RESULTS: Early disease recurrence developed in 56 patients (45.2%). The risk factors associated with an early recurrence were a tumor size larger than 5 cm (P = 0.001) and the presence of tumor micrometastasis (P < 0.001). The 1 year/2 year overall survival, after early recurrence, was 57.0%/41.0% and the preoperative alpha-fetoprotein, C-reactive protein (CRP), tumor size, macroscopic vascular invasion, and number of tumors were associated with survival on the univariate analysis. The multivariate analysis showed that the independent risk factors for survival, after early disease recurrence, were a preoperative CRP >1.0 mg/dl and macroscopic vascular invasion. (P = 0.004, P < 0.001, respectively). CONCLUSION: The preoperative CRP and macroscopic vascular invasion were associated with the aggressiveness of early recurrent HCC.
机译:背景:治愈性肝切除术后早期复发的肝细胞癌(HCC)患者的预后通常令人沮丧。方法:2002年1月至2006年12月,在庆北国立大学医院对124例HCC进行了根治性切除。早期复发的定义为根治性切除术后2年内复发。分析了与早期复发相关的危险因素,以及与早期复发后存活相关的其他危险因素。结果:56例患者(45.2%)发生早期疾病复发。与早期复发相关的危险因素是肿瘤大小大于5 cm(P = 0.001)和存在肿瘤微转移(P <0.001)。早期复发后的1年/ 2年总生存率为57.0%/ 41.0%,术前甲胎蛋白,C反应蛋白(CRP),肿瘤大小,肉眼可见的血管侵犯和肿瘤数量与生存率相关。单变量分析。多元分析表明,疾病早期复发后,生存的独立危险因素是术前CRP> 1.0 mg / dl和宏观血管侵犯。 (分别为P = 0.004,P <0.001)。结论:术前CRP和宏观血管侵犯与早期复发HCC的侵袭性有关。

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