METHODS OF PREDICTING HEPATOCELLULAR CARCINOMA RECURRENCE BY THE DETERMINATION OF HEPATOCELLULAR CARCINOMA RECURRENCE-ASSOCIATED MOLECULAR BIOMARKERS

摘要

Disclosed is a method to provide an accurate and reliable clinical prediction of the recurrence of human hepatocellular carcinoma (HCC), comprising the determination of a combination of clinicopathological information and novel molecular markers. The method relies on the evaluation of two important clinicopathologic features, namely vascular invasion and cirrhosis, and gene expression profiling of a predictive gene signature. Utilizing this method HCC patients with a high risk of disease recurrence can be identified more reliably and accurately. Based on the newly identified gene signature, disease recurrence could be predicted with up to 88% accuracy in HCC patients.