摘要:Objective To compare the labor analgesia effect of different concentration of ropivacaine and sufentanil, and to research the best combination scheme.Methods 120 primiparas were divided randomly and averagely into three groups, group Ⅰ: ropivacaine 0.05% plus sufentanil 0.25 μg/ml, group Ⅱ: ropivacaine 0.10% plus sufentanil 0.50 μg/ml, group Ⅲ: ropivacaine 0.125% plus sufentanil 0.50 μg/ml.All patients were given epidural anesthesia plus PCA pattorn with double-blind comparative study.The first labor dosage, time of taking effect, satisfactory of parturients, modified bormage scores (MBS), visual analogscale(VAS), duration of the second stage of labor and mode of delivery were recorded.Results Compared group Ⅰwith group Ⅱ, the degree of motor block were not different(P>0.05), but the analgesia effect was significantly higher in group Ⅱ than group Ⅰ(P<0.05).Compared group Ⅱ with group Ⅲ, the stage of labor and mode of delivery were not different(P>0.05), but rate of mild motor block of parturients was remarkably higher in group Ⅲ than group Ⅱ(P<0.05).Conclusion The effect on Ropivacaine 0.10% plus sufentanil 0.50 μg/ml for epidural labor analgesia is good, motor nerve block is slight, and it recommended as the current use of reasonable dosage.%目的 比较不同浓度的罗哌卡因联合舒芬太尼用于分娩镇痛,拟定出最佳组合方案.方法 120例初产妇随机平均分成3组,Ⅰ组为0.05%罗哌卡因+0.25 μg/ml舒芬太尼;Ⅱ组为0.1%罗哌卡因+0.5 μg/ml舒芬太尼;Ⅲ组为0.125%罗哌卡因+0.5 μg/ml舒芬太尼,3组均行硬膜外神经阻滞+可控性镇痛(PCA)模式,双盲对照.观察指标:首剂量、起效时间、产妇满意度、下肢运动神经阻滞评分、VAS评分、第二产程时间以及分娩方式等指标.结果 Ⅰ组和Ⅱ组下肢运动神经阻滞比较,差异无统计学意义(P>0.05),但Ⅱ组镇痛效果好于Ⅰ组(P<0.05);Ⅱ组和Ⅲ组产程时间和分娩方式比较,差异无统计学意义(P>0.05),但是Ⅲ组发生轻微神经阻滞比例明显高于Ⅱ组(P<0.05).结论 0.1%罗哌卡因+0.5 μg/ml舒芬太尼用于分娩镇痛,效果好,运动神经阻滞轻微,是目前建议推广使用的合理剂量.