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Lack of association between XRCC3 rs861539 (C > T) polymorphism and lung cancer risks: An update meta-analysis

机译:XRCC3 rs861539(C> T)多态性与肺癌风险之间缺乏关联:最新荟萃分析

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X-ray repair cross-complementing protein 3 (XRCC3) belongs to DNA double-strand break repair pathway and XRCC3 rs861539 (C > T) polymorphism has been suspected with lung cancer risk. However, results from previous studies are inconclusive and affected by bias. Electronic databases of PubMed, EMBASE, China National Knowledge Infrastructure, and SinoMed were searched. References of relative reviews were also screened. Pooled odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated to estimate the association strength. A number of 18 eligible studies with 6 studies of Asians, 11 of Caucasians, and 1 of African were extracted and analyzed, including 4,896 lung cancer cases and 6,360 controls. No significant correlation between XRCC3 polymorphism and lung cancer risk was observed in homozygote comparison (CC vs. TT; OR = 0.877; 95 % CI, 0.659, 1.168), heterozygote comparison (CT vs. TT; OR = 0.857; 95 % CI, 0.675, 1.089), dominant model (CC/CT vs. TT; OR = 0.862; 95 % CI, 0.663, 1.123), or recessive model (CC vs. CT/TT; OR = 1.047; 95 % CI, 0.956, 1.145). Subgroup analyses of ethnicity and controls did not reveal any significant association with lung cancer risk. No publication bias was detected. In this update meta-analysis of 18 studies and 11,256 participants, we find that XRCC3 rs861539 polymorphism does not contribute to lung cancer risk and there is no difference between Asians and Caucasians.
机译:X射线修复交叉互补蛋白3(XRCC3)属于DNA双链断裂修复途径,并且XRCC3 rs861539(C> T)多态性已被怀疑有患肺癌的风险。但是,以前的研究结果尚无定论,并受偏见影响。搜索PubMed,EMBASE,中国国家知识基础设施和SinoMed的电子数据库。还筛选了相对评价的参考文献。计算合并的优势比(OR)和95%置信区间(CI),以估计关联强度。提取并分析了18项符合条件的研究,其中6项针对亚洲人,11项针对白种人,1项针对非洲人,其中包括4,896例肺癌病例和6,360例对照。在纯合子比较(CC vs.TT; OR = 0.877; 95%CI,0.659,1.168),杂合子比较(CT vs. TT; OR = 0.857; 95%CI,XRCC3多态性与肺癌风险之间未发现显着相关性。 0.675、1.089),优势模型(CC / CT与TT; OR = 0.862; 95%CI,0.663、1.123)或隐性模型(CC与CT / TT; OR = 1.047; 95%CI,0.956、1.145) )。种族和对照的亚组分析未发现与肺癌风险有任何显着相关性。未检测到发布偏差。在这项对18个研究和11,256名参与者进行的最新荟萃分析中,我们发现XRCC3 rs861539多态性不会增加患肺癌的风险,亚洲人和高加索人之间也没有差异。

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