Associations between Lung Cancer Risk and Polymorphisms in the DNA Repair Genes X-ray Repair Cross-complementing Group 1(XRCC1)

摘要

Associations between lung cancer risk and common polymorphisms in the DNA repair genes X-ray repair cross-complementing group 1 (XRCC1) were examined within a case-control study in Nanjing population. We found that the association between XR-CC1 codon 399Gln allele(Arg/Gln and Gln/Gln, OR = 1.790, 95%CI=1.033-3.103, P = 0.038) and lung cancer. Subjects with the Arg/Gln genotype for codon 399 were at statistically increased susceptibility of lung cancer compared to subjects with the Arg/Arg geno-type(OR=1.893,95%CI=1.063-3.369, P = 0.030).We found no direct association between codon 194Arg/Trp genotype and lung cancer susceptibility(OR = 1. 040, 95%CI = 0.600-1. 805, P = 0.888). The risk of lung cancer was modified by the amount of smoking and the smokers(smoking quantity≥20 pack year) with the 399Gln allele(Arg/Gln + Gln/Gln) demonstrated higher risk(OR = 2.536, 95% CI = 1.043-6.165) than nonsmokers without this allele. Our results suggest that polymorphisms of codon 399 in XRCC1 play an important role in susceptibility to lung cancer in Nanjing population.