Suitability of the DRI Hydrocodone/Hydromorphone Immunoassay in the Clinical Environment at a Lower Cutoff: Validation With LC-MS/MS Analysis

Dixon Robert B.; Dasgupta Amitava

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Suitability of the DRI Hydrocodone/Hydromorphone Immunoassay in the Clinical Environment at a Lower Cutoff: Validation With LC-MS/MS Analysis

机译：DRI氢可酮/氢吗啡酮免疫分析法在较低临界值下在临床环境中的适用性：LC-MS / MS分析的验证

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Background: We evaluated the analytical performance of the DRI hydrocodone/hydromorphone assay by comparing semi-quantitative values obtained by this assay with values obtained by a liquid chromatography combined with tandem mass spectrometry (LC-MS/MS) method. We also evaluated the possibility of lowering the cutoff of the DRI assay from 300 to 100 ng/mL.

机译：背景：我们通过比较此测定法获得的半定量值与液相色谱-串联质谱法（LC-MS / MS）获得的值，评估了DRI氢可酮/氢吗啡酮测定的分析性能。我们还评估了将DRI分析的临界值从300 ng / mL降低到100 ng / mL的可能性。

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来源
《Therapeutic Drug Monitoring》 |2016年第6期|共4页
作者
Dixon Robert B.; Dasgupta Amitava;
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正文语种 eng
中图分类生药学（天然药物学）;
关键词
hydrocodone; hydromorphone; DRI immunoassay; LC-MS/MS;

机译：氢可酮;氢吗啡酮;DRI免疫分析;LC-MS / MS;

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专利

1. Suitability of the DRI Hydrocodone/Hydromorphone Immunoassay in the Clinical Environment at a Lower Cutoff: Validation With LC-MS/MS Analysis [J] . Dixon Robert B., Dasgupta Amitava Therapeutic Drug Monitoring . 2016,第6期

机译：DRI氢可酮/氢吗啡酮免疫分析法在较低临界值下在临床环境中的适用性：LC-MS / MS分析的验证
2. Analysis of total and unbound hydromorphone in human plasma by ultrafiltration and LC-MS/MS: Application to clinical trial in patients undergoing open heart surgery [J] . SaariT.I., FechnerJ., IhmsenH., Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2012,第Null期

机译：超滤和LC-MS / MS分析人血浆中总和未结合的氢吗啡酮：在接受心脏直视手术的患者的临床试验中的应用
3. Analysis of Thyroid Hormones in Serum of Baikal Seals and Humans by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) and Immunoassay Methods: Application of the LC-MS/MS Method to Wildlife Tissues [J] . Tatsuya Kunisue, Akifumi Eguchi, Hisato Iwata, Environmental Science & Technology . 2011,第23期

机译：液相色谱-串联质谱（LC-MS / MS）和免疫测定方法分析贝加尔海豹和人类血清中的甲状腺激素：LC-MS / MS方法在野生动物组织中的应用
4. Screening by LC-MS/MS and fast chromatography; an alternative to traditional immunoassay screening in clinical and forensic laboratories? [C] . Stefan Konig, Wolfgang Weinmann American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：通过LC-MS / MS和快速色谱筛选;临床和法医实验室中传统免疫测定筛查的替代方案？
5. Validation and field testing of LC-MS/MS analysis of animal waste markers. [D] . Velaga, Sree Harshitha. 2016

机译：LC-MS / MS分析动物废物标记物的验证和现场测试。
6. Evaluation of a Newly Formulated Enzyme Immunoassay for the Detection of Hydrocodone and Hydromorphone in Pain Management Compliance Testing [O] . Renata Nascimento, Alphonse Poklis, Carl E. Wolf -1

机译：新型酶免疫法在疼痛管理顺应性测试中检测氢可酮和氢吗啡酮的评价
7. Lower Cutoffs for LC-MS/MS Urine Drug Testing Indicates Better Patient Compliance [O] . Kevin Krock 2017

机译：LC-MS / MS尿液测试的较低截止表明患者合规性更好

Suitability of the DRI Hydrocodone/Hydromorphone Immunoassay in the Clinical Environment at a Lower Cutoff: Validation With LC-MS/MS Analysis

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