Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(|[plus]|)-Methanandamide and JWH-015: Involvement of CB2

摘要

Background:We have previously shown that cannabinoids induce growth inhibition and apoptosis in prostate cancer PC-3 cells, which express high levels of cannabinoid receptor types 1 and 2 (CB1 and CB2). In this study, we investigated the role of CB2 receptor in the anti-proliferative action of cannabinoids and the signal transduction triggered by receptor ligation.