Nonsyndromic Deafness - Molecular Update

摘要

In most cases, hearing loss is a disorder caused by both genetic and environmental factors. The moleculardescription of deafness has experienced remarkable progress in the last decade, and it is emerging from the use ofcontemporary methods of cell and molecular biology. Currently, through the application of clinical and molecular geneticsit is possible to identify genes associated with inherited, nonsyndromic deafness, and balance dysfunctions of the humancochlea. This brief review provides insights into nonsyndromic hearing loss, since the identification of the molecular basisfor the inner ear function provides the basis for developing rational new approaches to diagnosis, management andtreatment of auditory and vestibular disorders.