This study aimed to discuss the possibility of historical approach in cells teaching for explicit nature of science. The propose of this study was to review literature about the advantages of teaching Nature of Science (NOS) and how to teach NOS through biology history. In Thailand, science curriculum aims to help learners attain an adequate understanding of the Nature of Science (NOS). In general, the NOS involve the process through which scientific knowledge is generated and the characters of science derived from an analysis of eight international science standard documents (IPST (Institute of Promotion of Science and Technology Teaching), 1999). The study will discuss how the history about cells could apply to cells teaching for Thai science curriculum. And, the way of explicit NOS in cells historical teaching approach also will be clarified for enhancing students' understanding of NOS. This study has implications for explicit nature of science in biology teaching.
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